Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QH34_LEIMA

TriTrypDb:

LmjF.11.0460 , LMJLV39_110010000 , LMJSD75_110010200

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.690
CLV_C14_Caspase3-7	418	422	PF00656	0.629
CLV_C14_Caspase3-7	579	583	PF00656	0.631
CLV_MEL_PAP_1	69	75	PF00089	0.796
CLV_NRD_NRD_1	2	4	PF00675	0.711
CLV_NRD_NRD_1	277	279	PF00675	0.650
CLV_NRD_NRD_1	296	298	PF00675	0.599
CLV_NRD_NRD_1	590	592	PF00675	0.603
CLV_NRD_NRD_1	92	94	PF00675	0.637
CLV_PCSK_KEX2_1	2	4	PF00082	0.692
CLV_PCSK_KEX2_1	277	279	PF00082	0.650
CLV_PCSK_KEX2_1	296	298	PF00082	0.599
CLV_PCSK_KEX2_1	590	592	PF00082	0.706
CLV_PCSK_KEX2_1	608	610	PF00082	0.724
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.724
CLV_PCSK_SKI1_1	3	7	PF00082	0.674
CLV_PCSK_SKI1_1	560	564	PF00082	0.729
CLV_PCSK_SKI1_1	590	594	PF00082	0.712
CLV_PCSK_SKI1_1	608	612	PF00082	0.657
DEG_APCC_DBOX_1	559	567	PF00400	0.653
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DEG_SPOP_SBC_1	182	186	PF00917	0.740
DEG_SPOP_SBC_1	535	539	PF00917	0.583
DOC_CYCLIN_RxL_1	587	597	PF00134	0.701
DOC_MAPK_gen_1	222	231	PF00069	0.737
DOC_MAPK_gen_1	290	300	PF00069	0.682
DOC_MAPK_MEF2A_6	293	302	PF00069	0.605
DOC_PP1_RVXF_1	589	596	PF00149	0.627
DOC_PP2B_LxvP_1	171	174	PF13499	0.793
DOC_SPAK_OSR1_1	180	184	PF12202	0.707
DOC_USP7_MATH_1	111	115	PF00917	0.732
DOC_USP7_MATH_1	176	180	PF00917	0.717
DOC_USP7_MATH_1	187	191	PF00917	0.695
DOC_USP7_MATH_1	38	42	PF00917	0.770
DOC_USP7_MATH_1	428	432	PF00917	0.670
DOC_USP7_MATH_1	496	500	PF00917	0.671
DOC_USP7_MATH_1	535	539	PF00917	0.734
DOC_USP7_MATH_1	84	88	PF00917	0.712
DOC_WW_Pin1_4	183	188	PF00397	0.818
DOC_WW_Pin1_4	204	209	PF00397	0.773
DOC_WW_Pin1_4	30	35	PF00397	0.776
DOC_WW_Pin1_4	389	394	PF00397	0.740
DOC_WW_Pin1_4	421	426	PF00397	0.768
DOC_WW_Pin1_4	440	445	PF00397	0.427
DOC_WW_Pin1_4	608	613	PF00397	0.704
LIG_14-3-3_CanoR_1	133	138	PF00244	0.726
LIG_14-3-3_CanoR_1	180	188	PF00244	0.720
LIG_14-3-3_CanoR_1	225	229	PF00244	0.633
LIG_14-3-3_CanoR_1	241	250	PF00244	0.597
LIG_14-3-3_CanoR_1	297	303	PF00244	0.546
LIG_14-3-3_CanoR_1	432	440	PF00244	0.640
LIG_14-3-3_CanoR_1	590	596	PF00244	0.711
LIG_14-3-3_CanoR_1	67	72	PF00244	0.674
LIG_Actin_WH2_2	261	279	PF00022	0.709
LIG_BRCT_BRCA1_1	629	633	PF00533	0.705
LIG_BRCT_BRCA1_1	69	73	PF00533	0.699
LIG_CaM_IQ_9	295	310	PF13499	0.666
LIG_FHA_1	183	189	PF00498	0.814
LIG_FHA_1	362	368	PF00498	0.643
LIG_FHA_1	399	405	PF00498	0.655
LIG_FHA_1	432	438	PF00498	0.711
LIG_FHA_1	46	52	PF00498	0.644
LIG_FHA_1	535	541	PF00498	0.724
LIG_FHA_1	595	601	PF00498	0.617
LIG_FHA_1	635	641	PF00498	0.708
LIG_FHA_1	73	79	PF00498	0.758
LIG_FHA_2	400	406	PF00498	0.753
LIG_FHA_2	577	583	PF00498	0.745
LIG_FHA_2	609	615	PF00498	0.650
LIG_Integrin_isoDGR_2	131	133	PF01839	0.633
LIG_IRF3_LxIS_1	294	301	PF10401	0.651
LIG_LIR_Gen_1	227	235	PF02991	0.674
LIG_LIR_Gen_1	461	471	PF02991	0.696
LIG_LIR_Nem_3	215	220	PF02991	0.616
LIG_LIR_Nem_3	227	231	PF02991	0.649
LIG_LIR_Nem_3	461	466	PF02991	0.695
LIG_LIR_Nem_3	630	636	PF02991	0.704
LIG_MYND_1	169	173	PF01753	0.686
LIG_NBox_RRM_1	615	625	PF00076	0.647
LIG_PCNA_PIPBox_1	269	278	PF02747	0.708
LIG_Pex14_1	213	217	PF04695	0.621
LIG_PTAP_UEV_1	105	110	PF05743	0.700
LIG_SH2_GRB2like	547	550	PF00017	0.698
LIG_SH2_NCK_1	253	257	PF00017	0.707
LIG_SH2_PTP2	228	231	PF00017	0.678
LIG_SH2_STAP1	636	640	PF00017	0.723
LIG_SH2_STAT3	547	550	PF00017	0.560
LIG_SH2_STAT5	228	231	PF00017	0.678
LIG_SH2_STAT5	368	371	PF00017	0.712
LIG_SH2_STAT5	436	439	PF00017	0.722
LIG_SH2_STAT5	547	550	PF00017	0.574
LIG_SH2_STAT5	636	639	PF00017	0.642
LIG_SH3_1	172	178	PF00018	0.722
LIG_SH3_2	175	180	PF14604	0.697
LIG_SH3_2	62	67	PF14604	0.692
LIG_SH3_3	103	109	PF00018	0.703
LIG_SH3_3	167	173	PF00018	0.737
LIG_SH3_3	205	211	PF00018	0.681
LIG_SH3_3	244	250	PF00018	0.674
LIG_SH3_3	390	396	PF00018	0.644
LIG_SH3_3	59	65	PF00018	0.674
LIG_SH3_5	249	253	PF00018	0.678
LIG_SUMO_SIM_par_1	456	462	PF11976	0.615
LIG_TRAF2_1	255	258	PF00917	0.673
LIG_TRAF2_1	337	340	PF00917	0.809
LIG_WRC_WIRS_1	460	465	PF05994	0.701
LIG_WW_3	290	294	PF00397	0.719
MOD_CK1_1	127	133	PF00069	0.808
MOD_CK1_1	18	24	PF00069	0.695
MOD_CK1_1	224	230	PF00069	0.641
MOD_CK1_1	326	332	PF00069	0.710
MOD_CK1_1	392	398	PF00069	0.731
MOD_CK1_1	431	437	PF00069	0.662
MOD_CK1_1	459	465	PF00069	0.694
MOD_CK1_1	594	600	PF00069	0.636
MOD_CK1_1	87	93	PF00069	0.796
MOD_CK2_1	224	230	PF00069	0.641
MOD_CK2_1	251	257	PF00069	0.662
MOD_CK2_1	283	289	PF00069	0.761
MOD_CK2_1	421	427	PF00069	0.763
MOD_CK2_1	496	502	PF00069	0.673
MOD_GlcNHglycan	106	109	PF01048	0.695
MOD_GlcNHglycan	189	192	PF01048	0.727
MOD_GlcNHglycan	243	246	PF01048	0.743
MOD_GlcNHglycan	252	256	PF01048	0.760
MOD_GlcNHglycan	261	264	PF01048	0.458
MOD_GlcNHglycan	285	288	PF01048	0.788
MOD_GlcNHglycan	3	6	PF01048	0.797
MOD_GlcNHglycan	330	333	PF01048	0.749
MOD_GlcNHglycan	413	416	PF01048	0.813
MOD_GlcNHglycan	488	491	PF01048	0.629
MOD_GlcNHglycan	498	501	PF01048	0.564
MOD_GlcNHglycan	86	89	PF01048	0.811
MOD_GSK3_1	15	22	PF00069	0.745
MOD_GSK3_1	183	190	PF00069	0.728
MOD_GSK3_1	319	326	PF00069	0.662
MOD_GSK3_1	348	355	PF00069	0.711
MOD_GSK3_1	395	402	PF00069	0.591
MOD_GSK3_1	431	438	PF00069	0.630
MOD_GSK3_1	492	499	PF00069	0.777
MOD_GSK3_1	67	74	PF00069	0.693
MOD_GSK3_1	79	86	PF00069	0.716
MOD_N-GLC_1	118	123	PF02516	0.741
MOD_N-GLC_1	124	129	PF02516	0.674
MOD_N-GLC_1	133	138	PF02516	0.537
MOD_N-GLC_1	327	332	PF02516	0.816
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	181	186	PF00069	0.742
MOD_NEK2_1	298	303	PF00069	0.660
MOD_NEK2_1	50	55	PF00069	0.777
MOD_NEK2_1	79	84	PF00069	0.716
MOD_NEK2_2	636	641	PF00069	0.727
MOD_PIKK_1	320	326	PF00454	0.697
MOD_PK_1	133	139	PF00069	0.722
MOD_PK_1	67	73	PF00069	0.798
MOD_PKA_2	1	7	PF00069	0.737
MOD_PKA_2	221	227	PF00069	0.618
MOD_PKA_2	283	289	PF00069	0.769
MOD_PKA_2	431	437	PF00069	0.710
MOD_PKA_2	576	582	PF00069	0.647
MOD_PKA_2	71	77	PF00069	0.796
MOD_Plk_1	124	130	PF00069	0.728
MOD_Plk_1	133	139	PF00069	0.702
MOD_Plk_1	144	150	PF00069	0.452
MOD_Plk_1	528	534	PF00069	0.545
MOD_Plk_4	124	130	PF00069	0.746
MOD_Plk_4	144	150	PF00069	0.420
MOD_Plk_4	224	230	PF00069	0.730
MOD_Plk_4	450	456	PF00069	0.760
MOD_Plk_4	459	465	PF00069	0.617
MOD_Plk_4	522	528	PF00069	0.725
MOD_Plk_4	636	642	PF00069	0.724
MOD_ProDKin_1	183	189	PF00069	0.815
MOD_ProDKin_1	204	210	PF00069	0.765
MOD_ProDKin_1	30	36	PF00069	0.776
MOD_ProDKin_1	389	395	PF00069	0.741
MOD_ProDKin_1	421	427	PF00069	0.761
MOD_ProDKin_1	440	446	PF00069	0.427
MOD_ProDKin_1	608	614	PF00069	0.707
MOD_SUMO_for_1	337	340	PF00179	0.605
MOD_SUMO_rev_2	87	95	PF00179	0.660
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.650
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.661
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.622
TRG_ENDOCYTIC_2	228	231	PF00928	0.678
TRG_ER_diArg_1	1	3	PF00400	0.674
TRG_ER_diArg_1	149	152	PF00400	0.741
TRG_ER_diArg_1	276	278	PF00400	0.593
TRG_ER_diArg_1	296	298	PF00400	0.370
TRG_ER_diArg_1	590	592	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P315	Leptomonas seymouri	35%	100%
A0A3Q8I910	Leishmania donovani	92%	100%
A4H6G2	Leishmania braziliensis	73%	97%
A4HUV7	Leishmania infantum	92%	100%
E9ANJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%