Putative pumillio protein 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumillio protein 10, putative

Species:

Leishmania major

UniProt:

Q4QH33_LEIMA

TriTrypDb:

LmjF.11.0470 , LMJLV39_110010100 , LMJSD75_110010300

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH33

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.475
CLV_C14_Caspase3-7	159	163	PF00656	0.750
CLV_C14_Caspase3-7	480	484	PF00656	0.479
CLV_NRD_NRD_1	113	115	PF00675	0.684
CLV_NRD_NRD_1	190	192	PF00675	0.528
CLV_NRD_NRD_1	32	34	PF00675	0.618
CLV_NRD_NRD_1	361	363	PF00675	0.520
CLV_NRD_NRD_1	40	42	PF00675	0.592
CLV_NRD_NRD_1	521	523	PF00675	0.386
CLV_NRD_NRD_1	528	530	PF00675	0.434
CLV_PCSK_FUR_1	16	20	PF00082	0.621
CLV_PCSK_FUR_1	30	34	PF00082	0.651
CLV_PCSK_FUR_1	375	379	PF00082	0.518
CLV_PCSK_KEX2_1	115	117	PF00082	0.680
CLV_PCSK_KEX2_1	18	20	PF00082	0.563
CLV_PCSK_KEX2_1	190	192	PF00082	0.528
CLV_PCSK_KEX2_1	32	34	PF00082	0.540
CLV_PCSK_KEX2_1	361	363	PF00082	0.484
CLV_PCSK_KEX2_1	366	368	PF00082	0.443
CLV_PCSK_KEX2_1	377	379	PF00082	0.293
CLV_PCSK_KEX2_1	428	430	PF00082	0.524
CLV_PCSK_KEX2_1	521	523	PF00082	0.499
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.680
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.574
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.460
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.346
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.524
CLV_PCSK_PC7_1	362	368	PF00082	0.516
CLV_PCSK_SKI1_1	213	217	PF00082	0.564
CLV_PCSK_SKI1_1	316	320	PF00082	0.755
CLV_PCSK_SKI1_1	362	366	PF00082	0.502
CLV_PCSK_SKI1_1	649	653	PF00082	0.539
CLV_Separin_Metazoa	372	376	PF03568	0.434
DEG_APCC_DBOX_1	361	369	PF00400	0.518
DEG_SCF_FBW7_1	298	304	PF00400	0.614
DEG_SPOP_SBC_1	109	113	PF00917	0.549
DOC_CKS1_1	298	303	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	603	609	PF00134	0.426
DOC_MAPK_DCC_7	617	625	PF00069	0.294
DOC_MAPK_gen_1	366	373	PF00069	0.496
DOC_MAPK_gen_1	38	48	PF00069	0.699
DOC_MAPK_MEF2A_6	366	373	PF00069	0.521
DOC_MAPK_MEF2A_6	617	625	PF00069	0.294
DOC_PP2B_LxvP_1	71	74	PF13499	0.573
DOC_SPAK_OSR1_1	630	634	PF12202	0.368
DOC_USP7_MATH_1	156	160	PF00917	0.767
DOC_USP7_MATH_1	202	206	PF00917	0.550
DOC_USP7_MATH_1	591	595	PF00917	0.433
DOC_USP7_UBL2_3	315	319	PF12436	0.637
DOC_USP7_UBL2_3	38	42	PF12436	0.713
DOC_WW_Pin1_4	297	302	PF00397	0.588
DOC_WW_Pin1_4	587	592	PF00397	0.495
LIG_14-3-3_CanoR_1	191	197	PF00244	0.466
LIG_14-3-3_CanoR_1	233	241	PF00244	0.478
LIG_14-3-3_CanoR_1	255	264	PF00244	0.520
LIG_14-3-3_CanoR_1	271	277	PF00244	0.292
LIG_14-3-3_CanoR_1	333	342	PF00244	0.514
LIG_14-3-3_CanoR_1	378	383	PF00244	0.430
LIG_14-3-3_CanoR_1	504	512	PF00244	0.505
LIG_14-3-3_CanoR_1	649	655	PF00244	0.502
LIG_14-3-3_CanoR_1	716	725	PF00244	0.540
LIG_Actin_RPEL_3	355	374	PF02755	0.521
LIG_APCC_ABBA_1	407	412	PF00400	0.504
LIG_BIR_III_4	672	676	PF00653	0.562
LIG_BRCT_BRCA1_1	647	651	PF00533	0.524
LIG_EH1_1	431	439	PF00400	0.419
LIG_EH1_1	475	483	PF00400	0.390
LIG_EH1_1	630	638	PF00400	0.460
LIG_FHA_1	174	180	PF00498	0.633
LIG_FHA_1	334	340	PF00498	0.528
LIG_FHA_1	378	384	PF00498	0.498
LIG_FHA_1	388	394	PF00498	0.584
LIG_FHA_1	506	512	PF00498	0.526
LIG_FHA_1	558	564	PF00498	0.476
LIG_FHA_1	606	612	PF00498	0.533
LIG_FHA_1	658	664	PF00498	0.392
LIG_FHA_1	97	103	PF00498	0.755
LIG_FHA_2	132	138	PF00498	0.555
LIG_FHA_2	257	263	PF00498	0.557
LIG_FHA_2	26	32	PF00498	0.508
LIG_FHA_2	597	603	PF00498	0.433
LIG_GBD_Chelix_1	192	200	PF00786	0.428
LIG_GBD_Chelix_1	433	441	PF00786	0.479
LIG_Integrin_isoDGR_2	188	190	PF01839	0.309
LIG_Integrin_isoDGR_2	628	630	PF01839	0.356
LIG_LIR_Gen_1	543	554	PF02991	0.441
LIG_LIR_Gen_1	599	607	PF02991	0.414
LIG_LIR_Gen_1	648	655	PF02991	0.461
LIG_LIR_LC3C_4	517	520	PF02991	0.350
LIG_LIR_Nem_3	10	15	PF02991	0.565
LIG_LIR_Nem_3	543	549	PF02991	0.448
LIG_LIR_Nem_3	599	604	PF02991	0.400
LIG_LIR_Nem_3	648	654	PF02991	0.497
LIG_MAD2	45	53	PF02301	0.661
LIG_NRBOX	351	357	PF00104	0.558
LIG_NRBOX	382	388	PF00104	0.466
LIG_NRBOX	663	669	PF00104	0.460
LIG_PCNA_PIPBox_1	78	87	PF02747	0.549
LIG_PCNA_yPIPBox_3	428	438	PF02747	0.459
LIG_PCNA_yPIPBox_3	556	568	PF02747	0.399
LIG_PCNA_yPIPBox_3	658	668	PF02747	0.411
LIG_Pex14_2	733	737	PF04695	0.410
LIG_PTB_Apo_2	545	552	PF02174	0.496
LIG_PTB_Phospho_1	545	551	PF10480	0.496
LIG_REV1ctd_RIR_1	731	740	PF16727	0.429
LIG_RPA_C_Fungi	665	677	PF08784	0.548
LIG_SH2_CRK	85	89	PF00017	0.592
LIG_SH2_NCK_1	551	555	PF00017	0.390
LIG_SH2_NCK_1	85	89	PF00017	0.592
LIG_SH2_STAP1	592	596	PF00017	0.378
LIG_SH2_STAP1	85	89	PF00017	0.605
LIG_SH2_STAT5	551	554	PF00017	0.447
LIG_SH2_STAT5	562	565	PF00017	0.319
LIG_SH3_3	299	305	PF00018	0.625
LIG_SH3_3	340	346	PF00018	0.462
LIG_SH3_3	45	51	PF00018	0.699
LIG_Sin3_3	149	156	PF02671	0.617
LIG_SUMO_SIM_anti_2	168	182	PF11976	0.587
LIG_SUMO_SIM_par_1	477	483	PF11976	0.418
LIG_TRAF2_1	121	124	PF00917	0.657
LIG_TRAF2_1	324	327	PF00917	0.746
LIG_TRAF2_1	745	748	PF00917	0.667
LIG_UBA3_1	523	530	PF00899	0.405
LIG_UBA3_1	667	676	PF00899	0.437
MOD_CK1_1	105	111	PF00069	0.701
MOD_CK1_1	243	249	PF00069	0.542
MOD_CK1_1	285	291	PF00069	0.430
MOD_CK1_1	297	303	PF00069	0.663
MOD_CK1_1	389	395	PF00069	0.627
MOD_CK1_1	489	495	PF00069	0.485
MOD_CK1_1	569	575	PF00069	0.499
MOD_CK1_1	720	726	PF00069	0.546
MOD_CK1_1	96	102	PF00069	0.728
MOD_CK2_1	203	209	PF00069	0.495
MOD_CK2_1	23	29	PF00069	0.700
MOD_CK2_1	256	262	PF00069	0.567
MOD_CK2_1	303	309	PF00069	0.739
MOD_CK2_1	489	495	PF00069	0.476
MOD_CK2_1	596	602	PF00069	0.395
MOD_Cter_Amidation	1	4	PF01082	0.576
MOD_Cter_Amidation	188	191	PF01082	0.529
MOD_Cter_Amidation	311	314	PF01082	0.746
MOD_GlcNHglycan	104	107	PF01048	0.713
MOD_GlcNHglycan	158	161	PF01048	0.764
MOD_GlcNHglycan	235	238	PF01048	0.479
MOD_GlcNHglycan	305	308	PF01048	0.756
MOD_GlcNHglycan	329	332	PF01048	0.723
MOD_GlcNHglycan	347	350	PF01048	0.494
MOD_GlcNHglycan	447	450	PF01048	0.586
MOD_GlcNHglycan	465	468	PF01048	0.488
MOD_GlcNHglycan	491	494	PF01048	0.556
MOD_GlcNHglycan	568	571	PF01048	0.519
MOD_GlcNHglycan	712	715	PF01048	0.540
MOD_GlcNHglycan	719	722	PF01048	0.447
MOD_GSK3_1	101	108	PF00069	0.742
MOD_GSK3_1	131	138	PF00069	0.453
MOD_GSK3_1	192	199	PF00069	0.462
MOD_GSK3_1	266	273	PF00069	0.518
MOD_GSK3_1	296	303	PF00069	0.620
MOD_GSK3_1	373	380	PF00069	0.480
MOD_GSK3_1	389	396	PF00069	0.533
MOD_GSK3_1	525	532	PF00069	0.455
MOD_GSK3_1	557	564	PF00069	0.493
MOD_GSK3_1	583	590	PF00069	0.494
MOD_GSK3_1	686	693	PF00069	0.428
MOD_GSK3_1	720	727	PF00069	0.525
MOD_GSK3_1	93	100	PF00069	0.693
MOD_N-GLC_1	505	510	PF02516	0.479
MOD_N-GLC_1	686	691	PF02516	0.546
MOD_NEK2_1	101	106	PF00069	0.798
MOD_NEK2_1	135	140	PF00069	0.503
MOD_NEK2_1	143	148	PF00069	0.557
MOD_NEK2_1	196	201	PF00069	0.484
MOD_NEK2_1	23	28	PF00069	0.640
MOD_NEK2_1	280	285	PF00069	0.534
MOD_NEK2_1	296	301	PF00069	0.524
MOD_NEK2_1	373	378	PF00069	0.488
MOD_NEK2_1	386	391	PF00069	0.469
MOD_NEK2_1	557	562	PF00069	0.504
MOD_NEK2_1	566	571	PF00069	0.479
MOD_NEK2_1	7	12	PF00069	0.627
MOD_PIKK_1	143	149	PF00454	0.586
MOD_PIKK_1	381	387	PF00454	0.519
MOD_PIKK_1	657	663	PF00454	0.391
MOD_PKA_1	377	383	PF00069	0.535
MOD_PKA_1	529	535	PF00069	0.462
MOD_PKA_2	256	262	PF00069	0.524
MOD_PKA_2	270	276	PF00069	0.344
MOD_PKA_2	285	291	PF00069	0.413
MOD_PKA_2	332	338	PF00069	0.595
MOD_PKA_2	377	383	PF00069	0.523
MOD_PKA_2	643	649	PF00069	0.499
MOD_PKA_2	657	663	PF00069	0.430
MOD_PKA_2	717	723	PF00069	0.536
MOD_PKB_1	255	263	PF00069	0.551
MOD_Plk_1	173	179	PF00069	0.653
MOD_Plk_1	680	686	PF00069	0.553
MOD_Plk_4	131	137	PF00069	0.466
MOD_Plk_4	175	181	PF00069	0.478
MOD_Plk_4	192	198	PF00069	0.397
MOD_Plk_4	378	384	PF00069	0.379
MOD_Plk_4	477	483	PF00069	0.425
MOD_Plk_4	514	520	PF00069	0.393
MOD_Plk_4	569	575	PF00069	0.523
MOD_Plk_4	607	613	PF00069	0.500
MOD_Plk_4	680	686	PF00069	0.532
MOD_Plk_4	695	701	PF00069	0.316
MOD_Plk_4	707	713	PF00069	0.383
MOD_Plk_4	720	726	PF00069	0.528
MOD_Plk_4	97	103	PF00069	0.684
MOD_ProDKin_1	297	303	PF00069	0.604
MOD_ProDKin_1	587	593	PF00069	0.489
MOD_SUMO_rev_2	37	43	PF00179	0.687
MOD_SUMO_rev_2	90	96	PF00179	0.548
TRG_DiLeu_BaEn_1	553	558	PF01217	0.484
TRG_DiLeu_BaEn_4	220	226	PF01217	0.463
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.472
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.480
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.489
TRG_ENDOCYTIC_2	85	88	PF00928	0.567
TRG_ER_diArg_1	190	192	PF00400	0.532
TRG_ER_diArg_1	254	257	PF00400	0.529
TRG_ER_diArg_1	520	522	PF00400	0.500
TRG_ER_diArg_1	715	718	PF00400	0.401
TRG_ER_diArg_1	9	12	PF00400	0.663
TRG_NES_CRM1_1	37	49	PF08389	0.606
TRG_NES_CRM1_1	415	427	PF08389	0.507
TRG_NES_CRM1_1	728	743	PF08389	0.517
TRG_NLS_MonoCore_2	113	118	PF00514	0.782
TRG_NLS_MonoCore_2	312	317	PF00514	0.767
TRG_NLS_MonoExtC_3	113	118	PF00514	0.696
TRG_NLS_MonoExtN_4	313	318	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	630	634	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F3	Leptomonas seymouri	69%	100%
A0A0S4IWW4	Bodo saltans	34%	100%
A0A1X0NV47	Trypanosomatidae	37%	100%
A0A3Q8I8Y6	Leishmania donovani	94%	100%
A0A3R7MZX0	Trypanosoma rangeli	38%	100%
A4H6G3	Leishmania braziliensis	85%	100%
A4HUV8	Leishmania infantum	93%	100%
D0A7J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ANJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DSY9	Trypanosoma cruzi	38%	100%