Putative pumillio protein 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumillio protein 10, putative

Species:

Leishmania major

UniProt:

Q4QH33_LEIMA

TriTrypDb:

LmjF.11.0470 , LMJLV39_110010100 , LMJSD75_110010300

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QH33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH33

Function

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Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.475
CLV_C14_Caspase3-7	159	163	PF00656	0.750
CLV_C14_Caspase3-7	480	484	PF00656	0.479
CLV_NRD_NRD_1	113	115	PF00675	0.684
CLV_NRD_NRD_1	190	192	PF00675	0.528
CLV_NRD_NRD_1	32	34	PF00675	0.618
CLV_NRD_NRD_1	361	363	PF00675	0.520
CLV_NRD_NRD_1	40	42	PF00675	0.592
CLV_NRD_NRD_1	521	523	PF00675	0.386
CLV_NRD_NRD_1	528	530	PF00675	0.434

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F3	Leptomonas seymouri	69%	100%
A0A0S4IWW4	Bodo saltans	34%	100%
A0A1X0NV47	Trypanosomatidae	37%	100%
A0A3Q8I8Y6	Leishmania donovani	94%	100%
A0A3R7MZX0	Trypanosoma rangeli	38%	100%
A4H6G3	Leishmania braziliensis	85%	100%
A4HUV8	Leishmania infantum	93%	100%
D0A7J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ANJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DSY9	Trypanosoma cruzi	38%	100%

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