Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QH29_LEIMA

TriTrypDb:

LmjF.11.0510 , LMJLV39_110011300 , LMJSD75_110011900

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH29

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.492
CLV_C14_Caspase3-7	480	484	PF00656	0.392
CLV_NRD_NRD_1	245	247	PF00675	0.444
CLV_NRD_NRD_1	309	311	PF00675	0.265
CLV_NRD_NRD_1	388	390	PF00675	0.392
CLV_NRD_NRD_1	454	456	PF00675	0.392
CLV_PCSK_KEX2_1	191	193	PF00082	0.441
CLV_PCSK_KEX2_1	245	247	PF00082	0.455
CLV_PCSK_KEX2_1	309	311	PF00082	0.415
CLV_PCSK_KEX2_1	320	322	PF00082	0.415
CLV_PCSK_KEX2_1	454	456	PF00082	0.508
CLV_PCSK_KEX2_1	556	558	PF00082	0.392
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.441
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.434
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.392
CLV_PCSK_SKI1_1	204	208	PF00082	0.608
CLV_PCSK_SKI1_1	236	240	PF00082	0.470
CLV_PCSK_SKI1_1	298	302	PF00082	0.455
CLV_PCSK_SKI1_1	38	42	PF00082	0.557
CLV_PCSK_SKI1_1	455	459	PF00082	0.392
CLV_PCSK_SKI1_1	543	547	PF00082	0.398
CLV_PCSK_SKI1_1	570	574	PF00082	0.570
DEG_SPOP_SBC_1	131	135	PF00917	0.734
DOC_CKS1_1	374	379	PF01111	0.513
DOC_MAPK_gen_1	245	255	PF00069	0.365
DOC_MAPK_gen_1	36	43	PF00069	0.446
DOC_MAPK_MEF2A_6	248	257	PF00069	0.360
DOC_MAPK_MEF2A_6	460	467	PF00069	0.265
DOC_MAPK_MEF2A_6	524	532	PF00069	0.455
DOC_PP2B_LxvP_1	110	113	PF13499	0.624
DOC_PP2B_LxvP_1	530	533	PF13499	0.265
DOC_PP4_FxxP_1	314	317	PF00568	0.294
DOC_USP7_MATH_1	131	135	PF00917	0.742
DOC_USP7_MATH_1	473	477	PF00917	0.359
DOC_USP7_MATH_1	57	61	PF00917	0.589
DOC_USP7_MATH_1	78	82	PF00917	0.818
DOC_USP7_UBL2_3	149	153	PF12436	0.770
DOC_WW_Pin1_4	373	378	PF00397	0.513
DOC_WW_Pin1_4	403	408	PF00397	0.460
LIG_14-3-3_CanoR_1	102	111	PF00244	0.532
LIG_14-3-3_CanoR_1	204	211	PF00244	0.554
LIG_14-3-3_CanoR_1	36	41	PF00244	0.439
LIG_14-3-3_CanoR_1	454	460	PF00244	0.357
LIG_14-3-3_CanoR_1	561	567	PF00244	0.507
LIG_Actin_WH2_2	293	311	PF00022	0.402
LIG_APCC_ABBA_1	349	354	PF00400	0.455
LIG_BIR_III_4	469	473	PF00653	0.360
LIG_BRCT_BRCA1_1	310	314	PF00533	0.489
LIG_BRCT_BRCA1_1	515	519	PF00533	0.455
LIG_BRCT_BRCA1_1	538	542	PF00533	0.398
LIG_BRCT_BRCA1_1	564	568	PF00533	0.455
LIG_BRCT_BRCA1_2	564	570	PF00533	0.392
LIG_deltaCOP1_diTrp_1	420	429	PF00928	0.455
LIG_FHA_1	1	7	PF00498	0.576
LIG_FHA_1	135	141	PF00498	0.558
LIG_FHA_1	195	201	PF00498	0.499
LIG_FHA_1	205	211	PF00498	0.507
LIG_FHA_1	299	305	PF00498	0.455
LIG_FHA_1	431	437	PF00498	0.398
LIG_FHA_1	513	519	PF00498	0.455
LIG_FHA_2	165	171	PF00498	0.556
LIG_FHA_2	28	34	PF00498	0.384
LIG_FHA_2	374	380	PF00498	0.364
LIG_FHA_2	415	421	PF00498	0.415
LIG_FHA_2	478	484	PF00498	0.440
LIG_GBD_Chelix_1	253	261	PF00786	0.455
LIG_LIR_Apic_2	311	317	PF02991	0.294
LIG_LIR_Apic_2	401	407	PF02991	0.415
LIG_LIR_Gen_1	120	131	PF02991	0.679
LIG_LIR_Gen_1	212	221	PF02991	0.508
LIG_LIR_Gen_1	27	37	PF02991	0.532
LIG_LIR_Gen_1	356	367	PF02991	0.411
LIG_LIR_Nem_3	174	179	PF02991	0.574
LIG_LIR_Nem_3	212	217	PF02991	0.557
LIG_LIR_Nem_3	27	32	PF02991	0.546
LIG_LIR_Nem_3	3	8	PF02991	0.716
LIG_LIR_Nem_3	34	40	PF02991	0.409
LIG_LIR_Nem_3	356	362	PF02991	0.347
LIG_LIR_Nem_3	435	441	PF02991	0.494
LIG_LIR_Nem_3	521	526	PF02991	0.377
LIG_LIR_Nem_3	539	545	PF02991	0.475
LIG_LYPXL_yS_3	445	448	PF13949	0.455
LIG_MYND_3	11	15	PF01753	0.631
LIG_PCNA_yPIPBox_3	243	251	PF02747	0.294
LIG_SH2_CRK	37	41	PF00017	0.476
LIG_SH2_SRC	291	294	PF00017	0.265
LIG_SH2_SRC	364	367	PF00017	0.440
LIG_SH2_STAP1	251	255	PF00017	0.455
LIG_SH2_STAP1	291	295	PF00017	0.398
LIG_SH2_STAT5	142	145	PF00017	0.692
LIG_SH2_STAT5	194	197	PF00017	0.437
LIG_SH2_STAT5	201	204	PF00017	0.393
LIG_SH2_STAT5	29	32	PF00017	0.353
LIG_SH3_3	371	377	PF00018	0.513
LIG_SH3_3	434	440	PF00018	0.398
LIG_SH3_3	552	558	PF00018	0.455
LIG_SH3_3	88	94	PF00018	0.702
LIG_SUMO_SIM_par_1	231	237	PF11976	0.455
LIG_SUMO_SIM_par_1	365	371	PF11976	0.392
LIG_SUMO_SIM_par_1	528	535	PF11976	0.360
LIG_WRC_WIRS_1	542	547	PF05994	0.455
MOD_CK1_1	101	107	PF00069	0.704
MOD_CK1_1	119	125	PF00069	0.484
MOD_CK1_1	134	140	PF00069	0.659
MOD_CK1_1	152	158	PF00069	0.660
MOD_CK1_1	27	33	PF00069	0.391
MOD_CK1_1	406	412	PF00069	0.385
MOD_CK1_1	506	512	PF00069	0.395
MOD_CK1_1	513	519	PF00069	0.401
MOD_CK1_1	537	543	PF00069	0.402
MOD_CK2_1	164	170	PF00069	0.559
MOD_CK2_1	27	33	PF00069	0.353
MOD_CK2_1	373	379	PF00069	0.334
MOD_CK2_1	541	547	PF00069	0.408
MOD_Cter_Amidation	189	192	PF01082	0.473
MOD_GlcNHglycan	137	140	PF01048	0.754
MOD_GlcNHglycan	310	313	PF01048	0.501
MOD_GlcNHglycan	327	330	PF01048	0.308
MOD_GlcNHglycan	353	358	PF01048	0.524
MOD_GlcNHglycan	473	476	PF01048	0.451
MOD_GlcNHglycan	501	504	PF01048	0.420
MOD_GlcNHglycan	8	11	PF01048	0.744
MOD_GlcNHglycan	80	83	PF01048	0.718
MOD_GSK3_1	130	137	PF00069	0.735
MOD_GSK3_1	149	156	PF00069	0.531
MOD_GSK3_1	296	303	PF00069	0.416
MOD_GSK3_1	394	401	PF00069	0.519
MOD_GSK3_1	420	427	PF00069	0.361
MOD_GSK3_1	473	480	PF00069	0.420
MOD_GSK3_1	499	506	PF00069	0.416
MOD_GSK3_1	537	544	PF00069	0.455
MOD_GSK3_1	98	105	PF00069	0.599
MOD_N-GLC_1	135	140	PF02516	0.749
MOD_NEK2_1	296	301	PF00069	0.421
MOD_NEK2_1	308	313	PF00069	0.509
MOD_NEK2_1	352	357	PF00069	0.398
MOD_NEK2_1	424	429	PF00069	0.398
MOD_NEK2_1	498	503	PF00069	0.421
MOD_NEK2_2	473	478	PF00069	0.392
MOD_PIKK_1	513	519	PF00454	0.455
MOD_PIKK_1	58	64	PF00454	0.684
MOD_PKA_1	455	461	PF00069	0.496
MOD_PKA_1	556	562	PF00069	0.402
MOD_PKA_2	101	107	PF00069	0.672
MOD_PKA_2	308	314	PF00069	0.399
MOD_PKA_2	398	404	PF00069	0.392
MOD_PKA_2	506	512	PF00069	0.392
MOD_PKA_2	556	562	PF00069	0.415
MOD_PKB_1	169	177	PF00069	0.535
MOD_Plk_1	119	125	PF00069	0.732
MOD_Plk_1	171	177	PF00069	0.554
MOD_Plk_1	236	242	PF00069	0.455
MOD_Plk_1	353	359	PF00069	0.402
MOD_Plk_1	534	540	PF00069	0.379
MOD_Plk_1	570	576	PF00069	0.526
MOD_Plk_1	58	64	PF00069	0.722
MOD_Plk_1	96	102	PF00069	0.585
MOD_Plk_2-3	541	547	PF00069	0.392
MOD_Plk_4	122	128	PF00069	0.735
MOD_Plk_4	171	177	PF00069	0.605
MOD_Plk_4	24	30	PF00069	0.599
MOD_Plk_4	266	272	PF00069	0.396
MOD_Plk_4	36	42	PF00069	0.344
MOD_Plk_4	398	404	PF00069	0.433
MOD_Plk_4	444	450	PF00069	0.398
MOD_ProDKin_1	373	379	PF00069	0.513
MOD_ProDKin_1	403	409	PF00069	0.460
MOD_SUMO_rev_2	489	494	PF00179	0.389
TRG_DiLeu_BaEn_2	540	546	PF01217	0.519
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.344
TRG_ENDOCYTIC_2	29	32	PF00928	0.544
TRG_ENDOCYTIC_2	291	294	PF00928	0.393
TRG_ENDOCYTIC_2	359	362	PF00928	0.434
TRG_ENDOCYTIC_2	364	367	PF00928	0.451
TRG_ENDOCYTIC_2	37	40	PF00928	0.397
TRG_ENDOCYTIC_2	445	448	PF00928	0.468
TRG_ENDOCYTIC_2	523	526	PF00928	0.398
TRG_ER_diArg_1	245	248	PF00400	0.435
TRG_ER_diArg_1	308	310	PF00400	0.265
TRG_ER_diArg_1	453	455	PF00400	0.392
TRG_ER_diArg_1	494	497	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I436	Leptomonas seymouri	40%	98%
A0A3Q8IB87	Leishmania donovani	94%	100%
A4H6H6	Leishmania braziliensis	76%	100%
A4HEA1	Leishmania braziliensis	24%	100%
A4HUW6	Leishmania infantum	94%	100%
E9ANJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%