Putative amino acid permease/transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease/transporter, putative

Species:

Leishmania major

UniProt:

Q4QH28_LEIMA

TriTrypDb:

LmjF.11.0520 , LMJLV39_110011400 , LMJSD75_110012000

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QH28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH28

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	23
GO:0015203	polyamine transmembrane transporter activity	3	23
GO:0022857	transmembrane transporter activity	2	23
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.335
CLV_NRD_NRD_1	454	456	PF00675	0.448
CLV_PCSK_FUR_1	302	306	PF00082	0.284
CLV_PCSK_KEX2_1	301	303	PF00082	0.292
CLV_PCSK_KEX2_1	304	306	PF00082	0.286
CLV_PCSK_KEX2_1	454	456	PF00082	0.465
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.276
CLV_PCSK_SKI1_1	256	260	PF00082	0.415
CLV_PCSK_SKI1_1	429	433	PF00082	0.363
CLV_PCSK_SKI1_1	454	458	PF00082	0.370
DEG_Nend_Nbox_1	1	3	PF02207	0.271
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.446
DOC_MAPK_gen_1	107	116	PF00069	0.280
DOC_MAPK_MEF2A_6	343	351	PF00069	0.321
DOC_MAPK_MEF2A_6	373	382	PF00069	0.527
DOC_PP1_RVXF_1	427	434	PF00149	0.622
DOC_PP1_RVXF_1	59	65	PF00149	0.339
DOC_PP4_FxxP_1	365	368	PF00568	0.446
DOC_USP7_MATH_1	224	228	PF00917	0.367
DOC_USP7_MATH_1	244	248	PF00917	0.358
DOC_USP7_MATH_1	381	385	PF00917	0.365
DOC_USP7_MATH_1	49	53	PF00917	0.450
DOC_USP7_MATH_1	73	77	PF00917	0.403
DOC_WW_Pin1_4	138	143	PF00397	0.304
LIG_14-3-3_CanoR_1	174	183	PF00244	0.379
LIG_14-3-3_CanoR_1	429	434	PF00244	0.610
LIG_Actin_WH2_2	139	155	PF00022	0.182
LIG_Clathr_ClatBox_1	332	336	PF01394	0.353
LIG_CtBP_PxDLS_1	232	236	PF00389	0.225
LIG_deltaCOP1_diTrp_1	171	175	PF00928	0.484
LIG_FHA_1	1	7	PF00498	0.333
LIG_FHA_1	115	121	PF00498	0.253
LIG_FHA_1	171	177	PF00498	0.556
LIG_FHA_1	276	282	PF00498	0.422
LIG_FHA_1	397	403	PF00498	0.289
LIG_FHA_2	189	195	PF00498	0.502
LIG_GBD_Chelix_1	386	394	PF00786	0.217
LIG_LIR_Apic_2	217	221	PF02991	0.320
LIG_LIR_Gen_1	106	116	PF02991	0.134
LIG_LIR_Gen_1	141	149	PF02991	0.254
LIG_LIR_Gen_1	169	179	PF02991	0.489
LIG_LIR_Gen_1	240	250	PF02991	0.296
LIG_LIR_Gen_1	312	323	PF02991	0.382
LIG_LIR_Gen_1	414	421	PF02991	0.403
LIG_LIR_Gen_1	432	437	PF02991	0.625
LIG_LIR_Gen_1	76	87	PF02991	0.311
LIG_LIR_Nem_3	106	111	PF02991	0.330
LIG_LIR_Nem_3	169	175	PF02991	0.456
LIG_LIR_Nem_3	240	246	PF02991	0.283
LIG_LIR_Nem_3	312	318	PF02991	0.318
LIG_LIR_Nem_3	320	326	PF02991	0.279
LIG_LIR_Nem_3	350	354	PF02991	0.371
LIG_LIR_Nem_3	414	420	PF02991	0.309
LIG_LIR_Nem_3	432	436	PF02991	0.559
LIG_LIR_Nem_3	76	82	PF02991	0.323
LIG_LIR_Nem_3	89	94	PF02991	0.248
LIG_LYPXL_S_1	357	361	PF13949	0.318
LIG_LYPXL_S_1	86	90	PF13949	0.477
LIG_LYPXL_yS_3	358	361	PF13949	0.443
LIG_LYPXL_yS_3	87	90	PF13949	0.262
LIG_MAD2	429	437	PF02301	0.518
LIG_NRBOX	110	116	PF00104	0.333
LIG_NRBOX	144	150	PF00104	0.375
LIG_Pex14_1	238	242	PF04695	0.258
LIG_Pex14_1	311	315	PF04695	0.442
LIG_Pex14_2	156	160	PF04695	0.465
LIG_Pex14_2	365	369	PF04695	0.486
LIG_Pex14_2	411	415	PF04695	0.339
LIG_PTB_Apo_2	81	88	PF02174	0.250
LIG_PTB_Phospho_1	81	87	PF10480	0.262
LIG_SH2_GRB2like	157	160	PF00017	0.469
LIG_SH2_PTP2	218	221	PF00017	0.320
LIG_SH2_PTP2	79	82	PF00017	0.225
LIG_SH2_SRC	165	168	PF00017	0.497
LIG_SH2_SRC	218	221	PF00017	0.320
LIG_SH2_STAP1	118	122	PF00017	0.308
LIG_SH2_STAP1	2	6	PF00017	0.319
LIG_SH2_STAT3	147	150	PF00017	0.426
LIG_SH2_STAT5	147	150	PF00017	0.316
LIG_SH2_STAT5	157	160	PF00017	0.443
LIG_SH2_STAT5	165	168	PF00017	0.453
LIG_SH2_STAT5	2	5	PF00017	0.306
LIG_SH2_STAT5	218	221	PF00017	0.294
LIG_SH2_STAT5	360	363	PF00017	0.524
LIG_SH2_STAT5	417	420	PF00017	0.364
LIG_SH2_STAT5	69	72	PF00017	0.300
LIG_SH2_STAT5	79	82	PF00017	0.249
LIG_SH2_STAT5	94	97	PF00017	0.231
LIG_SH3_3	155	161	PF00018	0.530
LIG_SH3_3	193	199	PF00018	0.436
LIG_SH3_3	26	32	PF00018	0.192
LIG_SH3_3	356	362	PF00018	0.460
LIG_SH3_3	431	437	PF00018	0.643
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.413
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.408
LIG_SUMO_SIM_anti_2	389	396	PF11976	0.319
LIG_SUMO_SIM_par_1	132	139	PF11976	0.347
LIG_SUMO_SIM_par_1	21	27	PF11976	0.347
LIG_SUMO_SIM_par_1	331	336	PF11976	0.388
LIG_SUMO_SIM_par_1	344	350	PF11976	0.413
LIG_SUMO_SIM_par_1	39	45	PF11976	0.387
LIG_SxIP_EBH_1	201	214	PF03271	0.394
LIG_TYR_ITIM	77	82	PF00017	0.267
LIG_UBA3_1	57	61	PF00899	0.530
LIG_WRC_WIRS_1	1	6	PF05994	0.376
LIG_WRC_WIRS_1	348	353	PF05994	0.399
LIG_WRC_WIRS_1	412	417	PF05994	0.434
LIG_WRC_WIRS_1	430	435	PF05994	0.586
MOD_CK1_1	177	183	PF00069	0.463
MOD_CK1_1	439	445	PF00069	0.721
MOD_CK2_1	181	187	PF00069	0.471
MOD_CK2_1	188	194	PF00069	0.421
MOD_CK2_1	460	466	PF00069	0.585
MOD_GlcNHglycan	183	186	PF01048	0.286
MOD_GlcNHglycan	265	268	PF01048	0.319
MOD_GlcNHglycan	272	275	PF01048	0.299
MOD_GlcNHglycan	282	285	PF01048	0.298
MOD_GlcNHglycan	6	9	PF01048	0.467
MOD_GSK3_1	129	136	PF00069	0.321
MOD_GSK3_1	166	173	PF00069	0.507
MOD_GSK3_1	177	184	PF00069	0.429
MOD_GSK3_1	199	206	PF00069	0.467
MOD_GSK3_1	233	240	PF00069	0.280
MOD_GSK3_1	270	277	PF00069	0.301
MOD_GSK3_1	305	312	PF00069	0.447
MOD_GSK3_1	317	324	PF00069	0.314
MOD_GSK3_1	382	389	PF00069	0.309
MOD_GSK3_1	407	414	PF00069	0.353
MOD_GSK3_1	432	439	PF00069	0.654
MOD_GSK3_1	95	102	PF00069	0.240
MOD_NEK2_1	114	119	PF00069	0.170
MOD_NEK2_1	175	180	PF00069	0.463
MOD_NEK2_1	233	238	PF00069	0.350
MOD_NEK2_1	268	273	PF00069	0.279
MOD_NEK2_1	275	280	PF00069	0.417
MOD_NEK2_1	322	327	PF00069	0.341
MOD_NEK2_1	382	387	PF00069	0.345
MOD_NEK2_1	4	9	PF00069	0.302
MOD_NEK2_1	411	416	PF00069	0.349
MOD_NEK2_1	95	100	PF00069	0.311
MOD_PKA_2	439	445	PF00069	0.598
MOD_Plk_1	170	176	PF00069	0.459
MOD_Plk_1	244	250	PF00069	0.315
MOD_Plk_4	129	135	PF00069	0.325
MOD_Plk_4	188	194	PF00069	0.520
MOD_Plk_4	203	209	PF00069	0.433
MOD_Plk_4	21	27	PF00069	0.304
MOD_Plk_4	314	320	PF00069	0.287
MOD_Plk_4	322	328	PF00069	0.311
MOD_Plk_4	386	392	PF00069	0.300
MOD_Plk_4	396	402	PF00069	0.261
MOD_Plk_4	407	413	PF00069	0.306
MOD_Plk_4	429	435	PF00069	0.602
MOD_Plk_4	73	79	PF00069	0.293
MOD_Plk_4	86	92	PF00069	0.273
MOD_ProDKin_1	138	144	PF00069	0.304
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.317
TRG_ENDOCYTIC_2	358	361	PF00928	0.450
TRG_ENDOCYTIC_2	417	420	PF00928	0.334
TRG_ENDOCYTIC_2	69	72	PF00928	0.305
TRG_ENDOCYTIC_2	79	82	PF00928	0.252
TRG_ENDOCYTIC_2	87	90	PF00928	0.252
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T0	Leptomonas seymouri	69%	80%
A0A0N1PGN1	Leptomonas seymouri	35%	89%
A0A0S4IJF6	Bodo saltans	26%	80%
A0A0S4ISA5	Bodo saltans	22%	81%
A0A0S4JBT0	Bodo saltans	25%	90%
A0A1X0NNQ0	Trypanosomatidae	32%	74%
A0A1X0NV66	Trypanosomatidae	53%	89%
A0A1X0P501	Trypanosomatidae	37%	86%
A0A3R7M6P3	Trypanosoma rangeli	33%	76%
A0A3R7N0T9	Trypanosoma rangeli	53%	92%
A0A3S5IRV3	Trypanosoma rangeli	35%	92%
A0A3S7WRN2	Leishmania donovani	95%	100%
A0A3S7XA01	Leishmania donovani	36%	90%
A2X8M8	Oryza sativa subsp. indica	28%	88%
A4H6H7	Leishmania braziliensis	82%	100%
A4HNB0	Leishmania braziliensis	36%	90%
A4HUW5	Leishmania infantum	94%	100%
A4IBY1	Leishmania infantum	36%	90%
C9ZYM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
D0A7J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	92%
E9AFR8	Leishmania major	36%	100%
E9ANJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	90%
Q6Z8D0	Oryza sativa subsp. japonica	28%	88%
Q9C6S4	Arabidopsis thaliana	27%	97%
Q9C6S5	Arabidopsis thaliana	28%	94%
Q9FFL1	Arabidopsis thaliana	29%	95%
Q9LH39	Arabidopsis thaliana	26%	97%
Q9LHN7	Arabidopsis thaliana	27%	97%
V5BCQ1	Trypanosoma cruzi	38%	100%
V5DDZ5	Trypanosoma cruzi	32%	74%