Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF563), putative

Species:

Leishmania major

UniProt:

Q4QH26_LEIMA

TriTrypDb:

LmjF.11.0540 , LMJLV39_110011600 , LMJSD75_110012200

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QH26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH26

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.458
CLV_MEL_PAP_1	585	591	PF00089	0.556
CLV_NRD_NRD_1	100	102	PF00675	0.702
CLV_NRD_NRD_1	327	329	PF00675	0.711
CLV_NRD_NRD_1	387	389	PF00675	0.687
CLV_NRD_NRD_1	44	46	PF00675	0.477
CLV_NRD_NRD_1	6	8	PF00675	0.518
CLV_PCSK_FUR_1	42	46	PF00082	0.492
CLV_PCSK_KEX2_1	115	117	PF00082	0.746
CLV_PCSK_KEX2_1	327	329	PF00082	0.741
CLV_PCSK_KEX2_1	387	389	PF00082	0.688
CLV_PCSK_KEX2_1	44	46	PF00082	0.439
CLV_PCSK_KEX2_1	8	10	PF00082	0.508
CLV_PCSK_KEX2_1	99	101	PF00082	0.692
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.670
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.508
CLV_PCSK_SKI1_1	415	419	PF00082	0.701
CLV_PCSK_SKI1_1	477	481	PF00082	0.470
CLV_PCSK_SKI1_1	600	604	PF00082	0.632
DEG_APCC_DBOX_1	414	422	PF00400	0.442
DOC_CYCLIN_RxL_1	474	484	PF00134	0.276
DOC_MAPK_FxFP_2	613	616	PF00069	0.417
DOC_MAPK_gen_1	259	267	PF00069	0.399
DOC_MAPK_gen_1	48	58	PF00069	0.496
DOC_MAPK_gen_1	548	555	PF00069	0.393
DOC_MAPK_JIP1_4	475	481	PF00069	0.242
DOC_MAPK_MEF2A_6	266	275	PF00069	0.437
DOC_MAPK_MEF2A_6	523	531	PF00069	0.325
DOC_PP2B_LxvP_1	308	311	PF13499	0.424
DOC_PP2B_LxvP_1	465	468	PF13499	0.201
DOC_PP4_FxxP_1	102	105	PF00568	0.445
DOC_PP4_FxxP_1	196	199	PF00568	0.479
DOC_PP4_FxxP_1	345	348	PF00568	0.362
DOC_PP4_FxxP_1	613	616	PF00568	0.417
DOC_USP7_MATH_1	114	118	PF00917	0.433
DOC_USP7_MATH_1	127	131	PF00917	0.518
DOC_USP7_MATH_1	136	140	PF00917	0.460
DOC_USP7_MATH_1	188	192	PF00917	0.493
DOC_USP7_MATH_1	206	210	PF00917	0.367
DOC_USP7_MATH_1	294	298	PF00917	0.428
DOC_USP7_MATH_1	355	359	PF00917	0.446
DOC_USP7_MATH_1	392	396	PF00917	0.490
DOC_USP7_MATH_1	489	493	PF00917	0.288
DOC_WW_Pin1_4	12	17	PF00397	0.681
DOC_WW_Pin1_4	198	203	PF00397	0.494
DOC_WW_Pin1_4	212	217	PF00397	0.382
DOC_WW_Pin1_4	344	349	PF00397	0.448
DOC_WW_Pin1_4	351	356	PF00397	0.476
DOC_WW_Pin1_4	379	384	PF00397	0.607
DOC_WW_Pin1_4	387	392	PF00397	0.450
DOC_WW_Pin1_4	429	434	PF00397	0.298
DOC_WW_Pin1_4	542	547	PF00397	0.395
LIG_14-3-3_CanoR_1	103	112	PF00244	0.465
LIG_14-3-3_CanoR_1	131	141	PF00244	0.436
LIG_14-3-3_CanoR_1	159	164	PF00244	0.459
LIG_14-3-3_CanoR_1	181	186	PF00244	0.475
LIG_14-3-3_CanoR_1	223	231	PF00244	0.435
LIG_14-3-3_CanoR_1	48	54	PF00244	0.592
LIG_14-3-3_CanoR_1	548	553	PF00244	0.281
LIG_Actin_WH2_2	280	298	PF00022	0.377
LIG_APCC_ABBA_1	622	627	PF00400	0.330
LIG_BRCT_BRCA1_1	358	362	PF00533	0.454
LIG_deltaCOP1_diTrp_1	423	429	PF00928	0.459
LIG_eIF4E_1	356	362	PF01652	0.488
LIG_eIF4E_1	474	480	PF01652	0.259
LIG_FHA_1	105	111	PF00498	0.455
LIG_FHA_1	247	253	PF00498	0.387
LIG_FHA_1	262	268	PF00498	0.390
LIG_FHA_1	287	293	PF00498	0.440
LIG_FHA_1	310	316	PF00498	0.473
LIG_FHA_1	405	411	PF00498	0.494
LIG_FHA_1	454	460	PF00498	0.246
LIG_FHA_1	482	488	PF00498	0.307
LIG_FHA_1	563	569	PF00498	0.497
LIG_FHA_1	617	623	PF00498	0.376
LIG_FHA_2	299	305	PF00498	0.488
LIG_FHA_2	549	555	PF00498	0.290
LIG_GBD_Chelix_1	124	132	PF00786	0.569
LIG_Integrin_RGD_1	328	330	PF01839	0.630
LIG_KLC1_Yacidic_2	506	511	PF13176	0.288
LIG_LIR_Apic_2	194	199	PF02991	0.420
LIG_LIR_Gen_1	123	133	PF02991	0.456
LIG_LIR_Gen_1	282	292	PF02991	0.435
LIG_LIR_Nem_3	282	288	PF02991	0.433
LIG_MYND_3	410	414	PF01753	0.425
LIG_PCNA_yPIPBox_3	159	167	PF02747	0.317
LIG_PTB_Apo_2	204	211	PF02174	0.464
LIG_PTB_Phospho_1	204	210	PF10480	0.468
LIG_SH2_CRK	577	581	PF00017	0.336
LIG_SH2_SRC	524	527	PF00017	0.284
LIG_SH2_STAP1	524	528	PF00017	0.312
LIG_SH2_STAP1	82	86	PF00017	0.346
LIG_SH2_STAT3	419	422	PF00017	0.456
LIG_SH2_STAT5	169	172	PF00017	0.402
LIG_SH2_STAT5	204	207	PF00017	0.499
LIG_SH2_STAT5	225	228	PF00017	0.364
LIG_SH2_STAT5	509	512	PF00017	0.317
LIG_SH3_2	383	388	PF14604	0.471
LIG_SH3_3	196	202	PF00018	0.468
LIG_SH3_3	380	386	PF00018	0.627
LIG_SH3_3	561	567	PF00018	0.443
LIG_SH3_3	577	583	PF00018	0.418
LIG_SH3_3	590	596	PF00018	0.406
LIG_SUMO_SIM_anti_2	67	74	PF11976	0.247
LIG_SUMO_SIM_par_1	565	572	PF11976	0.400
LIG_SUMO_SIM_par_1	67	74	PF11976	0.258
LIG_TRAF2_1	439	442	PF00917	0.361
LIG_TRAF2_1	596	599	PF00917	0.434
LIG_WRC_WIRS_1	615	620	PF05994	0.392
LIG_WRPW_2	555	558	PF00400	0.363
LIG_WW_3	384	388	PF00397	0.479
LIG_WW_3	545	549	PF00397	0.382
MOD_CDC14_SPxK_1	545	548	PF00782	0.410
MOD_CDK_SPK_2	198	203	PF00069	0.494
MOD_CDK_SPxK_1	542	548	PF00069	0.398
MOD_CK1_1	179	185	PF00069	0.478
MOD_CK1_1	191	197	PF00069	0.450
MOD_CK1_1	254	260	PF00069	0.509
MOD_CK1_1	261	267	PF00069	0.447
MOD_CK1_1	32	38	PF00069	0.602
MOD_CK1_1	390	396	PF00069	0.456
MOD_CK1_1	454	460	PF00069	0.325
MOD_CK1_1	461	467	PF00069	0.324
MOD_CK1_1	562	568	PF00069	0.474
MOD_CK2_1	343	349	PF00069	0.414
MOD_CK2_1	436	442	PF00069	0.285
MOD_CK2_1	548	554	PF00069	0.286
MOD_GlcNHglycan	112	115	PF01048	0.659
MOD_GlcNHglycan	116	119	PF01048	0.625
MOD_GlcNHglycan	193	196	PF01048	0.715
MOD_GlcNHglycan	23	26	PF01048	0.412
MOD_GlcNHglycan	296	299	PF01048	0.656
MOD_GlcNHglycan	336	340	PF01048	0.679
MOD_GlcNHglycan	605	608	PF01048	0.591
MOD_GSK3_1	110	117	PF00069	0.572
MOD_GSK3_1	127	134	PF00069	0.439
MOD_GSK3_1	206	213	PF00069	0.438
MOD_GSK3_1	251	258	PF00069	0.492
MOD_GSK3_1	294	301	PF00069	0.440
MOD_GSK3_1	351	358	PF00069	0.466
MOD_GSK3_1	451	458	PF00069	0.325
MOD_N-GLC_1	191	196	PF02516	0.674
MOD_N-GLC_1	206	211	PF02516	0.698
MOD_N-GLC_1	356	361	PF02516	0.649
MOD_N-GLC_1	374	379	PF02516	0.583
MOD_N-GLC_1	436	441	PF02516	0.537
MOD_N-GLC_1	489	494	PF02516	0.488
MOD_NEK2_1	110	115	PF00069	0.576
MOD_NEK2_1	335	340	PF00069	0.551
MOD_NEK2_1	361	366	PF00069	0.547
MOD_NEK2_1	403	408	PF00069	0.461
MOD_NEK2_1	452	457	PF00069	0.400
MOD_NEK2_1	470	475	PF00069	0.283
MOD_NEK2_1	57	62	PF00069	0.309
MOD_NEK2_1	602	607	PF00069	0.489
MOD_NEK2_1	64	69	PF00069	0.336
MOD_NEK2_1	71	76	PF00069	0.583
MOD_OFUCOSY	63	68	PF10250	0.210
MOD_PIKK_1	136	142	PF00454	0.457
MOD_PIKK_1	309	315	PF00454	0.417
MOD_PIKK_1	361	367	PF00454	0.420
MOD_PIKK_1	562	568	PF00454	0.405
MOD_PIKK_1	71	77	PF00454	0.494
MOD_PK_1	159	165	PF00069	0.353
MOD_PKA_2	254	260	PF00069	0.543
MOD_PKA_2	482	488	PF00069	0.318
MOD_Plk_1	191	197	PF00069	0.504
MOD_Plk_1	206	212	PF00069	0.337
MOD_Plk_1	356	362	PF00069	0.456
MOD_Plk_1	436	442	PF00069	0.288
MOD_Plk_1	489	495	PF00069	0.288
MOD_Plk_4	241	247	PF00069	0.424
MOD_Plk_4	311	317	PF00069	0.476
MOD_Plk_4	356	362	PF00069	0.488
MOD_Plk_4	455	461	PF00069	0.331
MOD_ProDKin_1	12	18	PF00069	0.681
MOD_ProDKin_1	198	204	PF00069	0.493
MOD_ProDKin_1	212	218	PF00069	0.379
MOD_ProDKin_1	344	350	PF00069	0.448
MOD_ProDKin_1	351	357	PF00069	0.480
MOD_ProDKin_1	379	385	PF00069	0.607
MOD_ProDKin_1	387	393	PF00069	0.446
MOD_ProDKin_1	429	435	PF00069	0.298
MOD_ProDKin_1	542	548	PF00069	0.398
TRG_DiLeu_BaEn_1	598	603	PF01217	0.408
TRG_ENDOCYTIC_2	126	129	PF00928	0.458
TRG_ENDOCYTIC_2	524	527	PF00928	0.312
TRG_ENDOCYTIC_2	577	580	PF00928	0.314
TRG_ENDOCYTIC_2	615	618	PF00928	0.333
TRG_ER_diArg_1	36	39	PF00400	0.653
TRG_ER_diArg_1	386	388	PF00400	0.489
TRG_ER_diArg_1	41	44	PF00400	0.653
TRG_ER_diArg_1	445	448	PF00400	0.261
TRG_ER_diArg_1	547	550	PF00400	0.437
TRG_ER_diArg_1	6	9	PF00400	0.695
TRG_ER_diArg_1	99	101	PF00400	0.495
TRG_NLS_MonoExtC_3	6	12	PF00514	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV1	Leptomonas seymouri	28%	100%
A0A0N1PD55	Leptomonas seymouri	46%	100%
A0A1X0NW39	Trypanosomatidae	23%	100%
A0A3Q8IHF7	Leishmania donovani	93%	100%
A4H6H9	Leishmania braziliensis	80%	99%
A4HUW3	Leishmania infantum	93%	100%
E9ANK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BJI5	Trypanosoma cruzi	22%	100%