LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania major
UniProt:
Q4QH25_LEIMA
TriTrypDb:
LmjF.11.0550 , LMJLV39_110011700 * , LMJSD75_110012300
Length:
550

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 4
GO:0016020 membrane 2 20
GO:0110165 cellular anatomical entity 1 20

Expansion

Sequence features

Q4QH25
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH25

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0015851 nucleobase transport 5 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 20
GO:0005337 nucleoside transmembrane transporter activity 4 20
GO:0015205 nucleobase transmembrane transporter activity 3 3
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 20
GO:0022857 transmembrane transporter activity 2 20
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 421 425 PF00656 0.245
CLV_NRD_NRD_1 216 218 PF00675 0.280
CLV_NRD_NRD_1 235 237 PF00675 0.420
CLV_NRD_NRD_1 449 451 PF00675 0.260
CLV_NRD_NRD_1 454 456 PF00675 0.249
CLV_PCSK_KEX2_1 216 218 PF00082 0.282
CLV_PCSK_KEX2_1 449 451 PF00082 0.265
CLV_PCSK_SKI1_1 237 241 PF00082 0.451
CLV_PCSK_SKI1_1 303 307 PF00082 0.420
CLV_PCSK_SKI1_1 443 447 PF00082 0.482
CLV_PCSK_SKI1_1 456 460 PF00082 0.292
CLV_PCSK_SKI1_1 465 469 PF00082 0.307
CLV_PCSK_SKI1_1 56 60 PF00082 0.507
DEG_SCF_FBW7_1 509 515 PF00400 0.445
DOC_CDC14_PxL_1 466 474 PF14671 0.298
DOC_CKS1_1 509 514 PF01111 0.503
DOC_CYCLIN_yClb1_LxF_4 56 62 PF00134 0.293
DOC_MAPK_DCC_7 465 474 PF00069 0.358
DOC_MAPK_gen_1 272 278 PF00069 0.643
DOC_MAPK_gen_1 393 400 PF00069 0.499
DOC_MAPK_MEF2A_6 465 474 PF00069 0.337
DOC_MIT_MIM_1 437 447 PF04212 0.271
DOC_PP1_RVXF_1 463 469 PF00149 0.330
DOC_PP2B_LxvP_1 106 109 PF13499 0.397
DOC_PP2B_PxIxI_1 413 419 PF00149 0.255
DOC_USP7_MATH_1 175 179 PF00917 0.254
DOC_USP7_MATH_1 210 214 PF00917 0.412
DOC_USP7_MATH_1 26 30 PF00917 0.408
DOC_USP7_MATH_1 419 423 PF00917 0.342
DOC_USP7_MATH_1 510 514 PF00917 0.448
DOC_USP7_MATH_1 536 540 PF00917 0.424
DOC_USP7_UBL2_3 479 483 PF12436 0.256
DOC_WW_Pin1_4 48 53 PF00397 0.397
DOC_WW_Pin1_4 505 510 PF00397 0.419
LIG_14-3-3_CanoR_1 375 383 PF00244 0.553
LIG_14-3-3_CanoR_1 443 448 PF00244 0.329
LIG_14-3-3_CanoR_1 84 88 PF00244 0.513
LIG_Actin_WH2_2 158 176 PF00022 0.309
LIG_BIR_II_1 1 5 PF00653 0.527
LIG_BRCT_BRCA1_1 201 205 PF00533 0.277
LIG_BRCT_BRCA1_1 495 499 PF00533 0.325
LIG_BRCT_BRCA1_1 50 54 PF00533 0.354
LIG_BRCT_BRCA1_1 85 89 PF00533 0.521
LIG_Clathr_ClatBox_1 88 92 PF01394 0.328
LIG_Clathr_ClatBox_1 97 101 PF01394 0.381
LIG_EH1_1 61 69 PF00400 0.359
LIG_eIF4E_1 435 441 PF01652 0.285
LIG_FHA_1 10 16 PF00498 0.385
LIG_FHA_1 151 157 PF00498 0.568
LIG_FHA_1 184 190 PF00498 0.302
LIG_FHA_1 357 363 PF00498 0.647
LIG_FHA_1 377 383 PF00498 0.503
LIG_FHA_1 403 409 PF00498 0.323
LIG_FHA_1 427 433 PF00498 0.391
LIG_FHA_1 462 468 PF00498 0.367
LIG_FHA_1 509 515 PF00498 0.540
LIG_FHA_2 240 246 PF00498 0.588
LIG_FHA_2 344 350 PF00498 0.725
LIG_FHA_2 376 382 PF00498 0.469
LIG_FHA_2 514 520 PF00498 0.459
LIG_GBD_Chelix_1 165 173 PF00786 0.359
LIG_LIR_Gen_1 139 149 PF02991 0.497
LIG_LIR_Gen_1 178 189 PF02991 0.367
LIG_LIR_Gen_1 202 211 PF02991 0.260
LIG_LIR_Gen_1 424 435 PF02991 0.328
LIG_LIR_LC3C_4 12 16 PF02991 0.271
LIG_LIR_Nem_3 115 119 PF02991 0.313
LIG_LIR_Nem_3 139 144 PF02991 0.480
LIG_LIR_Nem_3 178 184 PF02991 0.342
LIG_LIR_Nem_3 188 194 PF02991 0.357
LIG_LIR_Nem_3 202 208 PF02991 0.372
LIG_LIR_Nem_3 36 41 PF02991 0.385
LIG_LIR_Nem_3 409 413 PF02991 0.363
LIG_LIR_Nem_3 424 430 PF02991 0.304
LIG_LIR_Nem_3 446 451 PF02991 0.351
LIG_LYPXL_S_1 395 399 PF13949 0.353
LIG_LYPXL_S_1 412 416 PF13949 0.285
LIG_LYPXL_yS_3 396 399 PF13949 0.353
LIG_LYPXL_yS_3 413 416 PF13949 0.285
LIG_PALB2_WD40_1 422 430 PF16756 0.245
LIG_Pex14_1 229 233 PF04695 0.550
LIG_Pex14_2 81 85 PF04695 0.517
LIG_PTB_Apo_2 135 142 PF02174 0.300
LIG_PTB_Phospho_1 135 141 PF10480 0.300
LIG_Rb_pABgroove_1 294 302 PF01858 0.579
LIG_REV1ctd_RIR_1 302 311 PF16727 0.611
LIG_SH2_CRK 116 120 PF00017 0.295
LIG_SH2_CRK 181 185 PF00017 0.293
LIG_SH2_CRK 38 42 PF00017 0.307
LIG_SH2_CRK 62 66 PF00017 0.359
LIG_SH2_NCK_1 507 511 PF00017 0.410
LIG_SH2_NCK_1 62 66 PF00017 0.356
LIG_SH2_STAP1 181 185 PF00017 0.333
LIG_SH2_STAP1 214 218 PF00017 0.507
LIG_SH2_STAP1 300 304 PF00017 0.608
LIG_SH2_STAT5 127 130 PF00017 0.357
LIG_SH2_STAT5 135 138 PF00017 0.355
LIG_SH2_STAT5 191 194 PF00017 0.343
LIG_SH2_STAT5 218 221 PF00017 0.522
LIG_SH2_STAT5 233 236 PF00017 0.698
LIG_SH2_STAT5 264 267 PF00017 0.649
LIG_SH2_STAT5 40 43 PF00017 0.322
LIG_SH2_STAT5 410 413 PF00017 0.359
LIG_SH2_STAT5 487 490 PF00017 0.398
LIG_SH2_STAT5 62 65 PF00017 0.271
LIG_SH3_3 143 149 PF00018 0.465
LIG_SH3_3 18 24 PF00018 0.262
LIG_SH3_3 506 512 PF00018 0.405
LIG_Sin3_3 529 536 PF02671 0.255
LIG_SUMO_SIM_anti_2 101 107 PF11976 0.327
LIG_SUMO_SIM_anti_2 164 170 PF11976 0.266
LIG_SUMO_SIM_par_1 416 422 PF11976 0.265
LIG_SUMO_SIM_par_1 456 462 PF11976 0.488
LIG_TRAF2_1 314 317 PF00917 0.652
LIG_TRFH_1 318 322 PF08558 0.619
LIG_TYR_ITIM 189 194 PF00017 0.359
LIG_TYR_ITIM 411 416 PF00017 0.285
LIG_UBA3_1 471 479 PF00899 0.302
LIG_WRC_WIRS_1 403 408 PF05994 0.300
LIG_WRC_WIRS_1 78 83 PF05994 0.539
MOD_CK1_1 159 165 PF00069 0.303
MOD_CK1_1 29 35 PF00069 0.310
MOD_CK1_1 343 349 PF00069 0.655
MOD_CK1_1 508 514 PF00069 0.507
MOD_CK2_1 265 271 PF00069 0.709
MOD_CK2_1 343 349 PF00069 0.678
MOD_CK2_1 375 381 PF00069 0.484
MOD_CK2_1 513 519 PF00069 0.477
MOD_GlcNHglycan 158 161 PF01048 0.330
MOD_GlcNHglycan 181 184 PF01048 0.410
MOD_GlcNHglycan 201 204 PF01048 0.324
MOD_GlcNHglycan 28 31 PF01048 0.535
MOD_GlcNHglycan 287 290 PF01048 0.519
MOD_GlcNHglycan 346 349 PF01048 0.549
MOD_GlcNHglycan 421 424 PF01048 0.592
MOD_GSK3_1 169 176 PF00069 0.364
MOD_GSK3_1 179 186 PF00069 0.308
MOD_GSK3_1 340 347 PF00069 0.695
MOD_GSK3_1 402 409 PF00069 0.326
MOD_GSK3_1 501 508 PF00069 0.368
MOD_GSK3_1 73 80 PF00069 0.558
MOD_N-GLC_1 330 335 PF02516 0.566
MOD_N-GLC_1 435 440 PF02516 0.206
MOD_N-GLC_1 76 81 PF02516 0.319
MOD_NEK2_1 136 141 PF00069 0.358
MOD_NEK2_1 156 161 PF00069 0.393
MOD_NEK2_1 169 174 PF00069 0.349
MOD_NEK2_1 177 182 PF00069 0.257
MOD_NEK2_1 185 190 PF00069 0.260
MOD_NEK2_1 222 227 PF00069 0.636
MOD_NEK2_1 406 411 PF00069 0.357
MOD_NEK2_1 459 464 PF00069 0.345
MOD_NEK2_1 493 498 PF00069 0.339
MOD_NEK2_1 499 504 PF00069 0.329
MOD_NEK2_1 9 14 PF00069 0.316
MOD_NEK2_1 91 96 PF00069 0.337
MOD_PIKK_1 183 189 PF00454 0.268
MOD_PIKK_1 312 318 PF00454 0.643
MOD_PIKK_1 330 336 PF00454 0.608
MOD_PIKK_1 340 346 PF00454 0.615
MOD_PIKK_1 353 359 PF00454 0.613
MOD_PKA_2 222 228 PF00069 0.565
MOD_PKA_2 83 89 PF00069 0.482
MOD_Plk_1 76 82 PF00069 0.517
MOD_Plk_1 91 97 PF00069 0.300
MOD_Plk_4 10 16 PF00069 0.340
MOD_Plk_4 161 167 PF00069 0.321
MOD_Plk_4 185 191 PF00069 0.315
MOD_Plk_4 29 35 PF00069 0.302
MOD_Plk_4 294 300 PF00069 0.665
MOD_Plk_4 443 449 PF00069 0.273
MOD_Plk_4 501 507 PF00069 0.377
MOD_Plk_4 536 542 PF00069 0.335
MOD_Plk_4 60 66 PF00069 0.344
MOD_Plk_4 77 83 PF00069 0.553
MOD_ProDKin_1 48 54 PF00069 0.392
MOD_ProDKin_1 505 511 PF00069 0.419
MOD_SUMO_rev_2 267 274 PF00179 0.629
TRG_DiLeu_BaLyEn_6 440 445 PF01217 0.377
TRG_DiLeu_BaLyEn_6 467 472 PF01217 0.410
TRG_ENDOCYTIC_2 116 119 PF00928 0.295
TRG_ENDOCYTIC_2 141 144 PF00928 0.480
TRG_ENDOCYTIC_2 181 184 PF00928 0.320
TRG_ENDOCYTIC_2 191 194 PF00928 0.328
TRG_ENDOCYTIC_2 38 41 PF00928 0.310
TRG_ENDOCYTIC_2 396 399 PF00928 0.353
TRG_ENDOCYTIC_2 413 416 PF00928 0.297
TRG_ENDOCYTIC_2 62 65 PF00928 0.326
TRG_ER_diArg_1 216 218 PF00400 0.481
TRG_ER_diArg_1 448 450 PF00400 0.499
TRG_Pf-PMV_PEXEL_1 263 267 PF00026 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 47% 100%
A0A0N1I1J0 Leptomonas seymouri 56% 100%
A0A0N1PBQ1 Leptomonas seymouri 37% 100%
A0A0S4JBS4 Bodo saltans 31% 100%
A0A3Q8ICX7 Leishmania donovani 37% 100%
A0A3S7XAS5 Leishmania donovani 31% 100%
A4H6I0 Leishmania braziliensis 72% 99%
A4H7A5 Leishmania braziliensis 36% 100%
A4HG96 Leishmania braziliensis 23% 100%
A4HP60 Leishmania braziliensis 32% 100%
A4HUW2 Leishmania infantum 90% 100%
A4HVP9 Leishmania infantum 37% 100%
A4IDG6 Leishmania infantum 31% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4Q1M9 Leishmania major 32% 93%
Q4QG33 Leishmania major 34% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS