This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 12 |
| NetGPI | no | yes: 0, no: 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 12 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
Related structures:
AlphaFold database: Q4QH22
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005488 | binding | 1 | 8 |
| GO:0020037 | heme binding | 4 | 8 |
| GO:0046906 | tetrapyrrole binding | 3 | 8 |
| GO:0097159 | organic cyclic compound binding | 2 | 8 |
| GO:1901363 | heterocyclic compound binding | 2 | 8 |
| GO:0043167 | ion binding | 2 | 6 |
| GO:0043169 | cation binding | 3 | 6 |
| GO:0046872 | metal ion binding | 4 | 6 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 112 | 114 | PF00675 | 0.462 |
| CLV_NRD_NRD_1 | 88 | 90 | PF00675 | 0.357 |
| CLV_PCSK_KEX2_1 | 107 | 109 | PF00082 | 0.435 |
| CLV_PCSK_KEX2_1 | 112 | 114 | PF00082 | 0.502 |
| CLV_PCSK_PC1ET2_1 | 107 | 109 | PF00082 | 0.435 |
| CLV_PCSK_PC7_1 | 108 | 114 | PF00082 | 0.409 |
| DOC_USP7_MATH_1 | 83 | 87 | PF00917 | 0.601 |
| DOC_USP7_UBL2_3 | 90 | 94 | PF12436 | 0.639 |
| DOC_WW_Pin1_4 | 95 | 100 | PF00397 | 0.660 |
| LIG_14-3-3_CanoR_1 | 7 | 12 | PF00244 | 0.576 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.619 |
| LIG_BRCT_BRCA1_1 | 72 | 76 | PF00533 | 0.462 |
| LIG_FHA_1 | 66 | 72 | PF00498 | 0.533 |
| LIG_FHA_2 | 104 | 110 | PF00498 | 0.687 |
| LIG_FHA_2 | 16 | 22 | PF00498 | 0.471 |
| LIG_LIR_Gen_1 | 10 | 15 | PF02991 | 0.483 |
| LIG_LIR_Gen_1 | 21 | 32 | PF02991 | 0.398 |
| LIG_LIR_Nem_3 | 10 | 14 | PF02991 | 0.453 |
| LIG_LIR_Nem_3 | 57 | 63 | PF02991 | 0.442 |
| LIG_NRBOX | 136 | 142 | PF00104 | 0.426 |
| LIG_Pex14_1 | 24 | 28 | PF04695 | 0.442 |
| LIG_SH2_CRK | 28 | 32 | PF00017 | 0.442 |
| LIG_SH2_STAP1 | 28 | 32 | PF00017 | 0.446 |
| LIG_SH2_STAT5 | 139 | 142 | PF00017 | 0.460 |
| LIG_SUMO_SIM_par_1 | 29 | 35 | PF11976 | 0.442 |
| LIG_TRAF2_1 | 10 | 13 | PF00917 | 0.446 |
| LIG_TYR_ITIM | 26 | 31 | PF00017 | 0.438 |
| MOD_CDK_SPxxK_3 | 95 | 102 | PF00069 | 0.672 |
| MOD_CK1_1 | 59 | 65 | PF00069 | 0.435 |
| MOD_CK2_1 | 103 | 109 | PF00069 | 0.675 |
| MOD_CK2_1 | 7 | 13 | PF00069 | 0.462 |
| MOD_GlcNHglycan | 1 | 4 | PF01048 | 0.468 |
| MOD_GSK3_1 | 59 | 66 | PF00069 | 0.448 |
| MOD_NEK2_1 | 32 | 37 | PF00069 | 0.442 |
| MOD_NEK2_1 | 54 | 59 | PF00069 | 0.533 |
| MOD_NEK2_1 | 70 | 75 | PF00069 | 0.533 |
| MOD_PKA_1 | 94 | 100 | PF00069 | 0.705 |
| MOD_Plk_4 | 72 | 78 | PF00069 | 0.525 |
| MOD_ProDKin_1 | 95 | 101 | PF00069 | 0.658 |
| MOD_SUMO_rev_2 | 82 | 88 | PF00179 | 0.546 |
| TRG_ENDOCYTIC_2 | 28 | 31 | PF00928 | 0.437 |
| TRG_ER_diArg_1 | 111 | 113 | PF00400 | 0.696 |
| TRG_Pf-PMV_PEXEL_1 | 36 | 40 | PF00026 | 0.275 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I073 | Leptomonas seymouri | 37% | 100% |
| A0A0N1IJC6 | Leptomonas seymouri | 66% | 100% |
| A0A0S4J0V9 | Bodo saltans | 49% | 100% |
| A0A0S4J2K9 | Bodo saltans | 54% | 100% |
| A0A0S4JCD1 | Bodo saltans | 29% | 100% |
| A0A1X0NV37 | Trypanosomatidae | 51% | 100% |
| A0A3Q8I926 | Leishmania donovani | 95% | 100% |
| A0A3S7WQZ7 | Leishmania donovani | 35% | 100% |
| A0A422MYR2 | Trypanosoma rangeli | 48% | 100% |
| A4H5X6 | Leishmania braziliensis | 32% | 100% |
| A4H6J2 | Leishmania braziliensis | 80% | 100% |
| A4HU71 | Leishmania infantum | 35% | 100% |
| A4HUW0 | Leishmania infantum | 94% | 100% |
| B7GCG7 | Phaeodactylum tricornutum (strain CCAP 1055/1) | 36% | 100% |
| D0A7I2 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 49% | 100% |
| E9AJH1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 67% |
| E9AN01 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
| E9ANK3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 94% | 100% |
| O04354 | Borago officinalis | 33% | 100% |
| O48845 | Arabidopsis thaliana | 29% | 100% |
| P00171 | Bos taurus | 40% | 100% |
| P00173 | Rattus norvegicus | 40% | 100% |
| P40312 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 35% | 100% |
| P49096 | Musca domestica | 30% | 100% |
| P49098 | Nicotiana tabacum | 33% | 100% |
| P49099 | Nicotiana tabacum | 32% | 100% |
| P49100 | Oryza sativa subsp. japonica | 36% | 100% |
| P56395 | Mus musculus | 40% | 100% |
| Q4QHM6 | Leishmania major | 35% | 100% |
| Q9HFV1 | Rhizopus stolonifer | 35% | 100% |
| Q9V4N3 | Drosophila melanogaster | 32% | 100% |
| Q9Y706 | Mortierella alpina | 33% | 100% |
| Q9ZNV4 | Arabidopsis thaliana | 35% | 100% |
| Q9ZWT2 | Arabidopsis thaliana | 36% | 100% |
| V5BRX2 | Trypanosoma cruzi | 49% | 100% |