CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 47, putative

Species:

Leishmania major

UniProt:

Q4QH20_LEIMA

TriTrypDb:

LmjF.11.0600 , LMJLV39_110012700 , LMJSD75_110013300

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH20

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.699
CLV_C14_Caspase3-7	180	184	PF00656	0.675
CLV_C14_Caspase3-7	187	191	PF00656	0.564
CLV_NRD_NRD_1	28	30	PF00675	0.421
CLV_NRD_NRD_1	383	385	PF00675	0.542
CLV_NRD_NRD_1	393	395	PF00675	0.565
CLV_NRD_NRD_1	456	458	PF00675	0.654
CLV_NRD_NRD_1	478	480	PF00675	0.747
CLV_NRD_NRD_1	498	500	PF00675	0.622
CLV_NRD_NRD_1	582	584	PF00675	0.705
CLV_NRD_NRD_1	77	79	PF00675	0.709
CLV_PCSK_KEX2_1	266	268	PF00082	0.496
CLV_PCSK_KEX2_1	28	30	PF00082	0.570
CLV_PCSK_KEX2_1	383	385	PF00082	0.537
CLV_PCSK_KEX2_1	393	395	PF00082	0.565
CLV_PCSK_KEX2_1	456	458	PF00082	0.654
CLV_PCSK_KEX2_1	478	480	PF00082	0.747
CLV_PCSK_KEX2_1	497	499	PF00082	0.624
CLV_PCSK_KEX2_1	582	584	PF00082	0.718
CLV_PCSK_KEX2_1	77	79	PF00082	0.619
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.486
CLV_PCSK_PC7_1	493	499	PF00082	0.659
CLV_PCSK_SKI1_1	295	299	PF00082	0.613
CLV_PCSK_SKI1_1	37	41	PF00082	0.543
CLV_PCSK_SKI1_1	5	9	PF00082	0.498
DEG_SCF_TRCP1_1	589	594	PF00400	0.679
DEG_SPOP_SBC_1	339	343	PF00917	0.612
DEG_SPOP_SBC_1	435	439	PF00917	0.606
DEG_SPOP_SBC_1	513	517	PF00917	0.659
DEG_SPOP_SBC_1	95	99	PF00917	0.609
DOC_ANK_TNKS_1	77	84	PF00023	0.654
DOC_CKS1_1	13	18	PF01111	0.431
DOC_CKS1_1	279	284	PF01111	0.594
DOC_CKS1_1	288	293	PF01111	0.491
DOC_MAPK_gen_1	170	179	PF00069	0.569
DOC_PP1_RVXF_1	238	244	PF00149	0.523
DOC_USP7_MATH_1	123	127	PF00917	0.718
DOC_USP7_MATH_1	136	140	PF00917	0.619
DOC_USP7_MATH_1	141	145	PF00917	0.560
DOC_USP7_MATH_1	154	158	PF00917	0.633
DOC_USP7_MATH_1	289	293	PF00917	0.585
DOC_USP7_MATH_1	435	439	PF00917	0.680
DOC_USP7_MATH_1	512	516	PF00917	0.700
DOC_USP7_MATH_1	71	75	PF00917	0.739
DOC_USP7_UBL2_3	155	159	PF12436	0.662
DOC_WW_Pin1_4	12	17	PF00397	0.442
DOC_WW_Pin1_4	137	142	PF00397	0.713
DOC_WW_Pin1_4	150	155	PF00397	0.617
DOC_WW_Pin1_4	192	197	PF00397	0.577
DOC_WW_Pin1_4	200	205	PF00397	0.609
DOC_WW_Pin1_4	269	274	PF00397	0.628
DOC_WW_Pin1_4	278	283	PF00397	0.559
DOC_WW_Pin1_4	287	292	PF00397	0.499
DOC_WW_Pin1_4	340	345	PF00397	0.598
DOC_WW_Pin1_4	426	431	PF00397	0.651
DOC_WW_Pin1_4	499	504	PF00397	0.720
LIG_14-3-3_CanoR_1	363	368	PF00244	0.475
LIG_APCC_ABBAyCdc20_2	384	390	PF00400	0.561
LIG_BRCT_BRCA1_1	125	129	PF00533	0.728
LIG_BRCT_BRCA1_1	194	198	PF00533	0.631
LIG_BRCT_BRCA1_1	437	441	PF00533	0.644
LIG_BRCT_BRCA1_1	501	505	PF00533	0.671
LIG_eIF4E_1	593	599	PF01652	0.660
LIG_FHA_1	22	28	PF00498	0.450
LIG_FHA_1	275	281	PF00498	0.626
LIG_FHA_1	327	333	PF00498	0.599
LIG_FHA_1	86	92	PF00498	0.597
LIG_FHA_2	246	252	PF00498	0.430
LIG_FHA_2	288	294	PF00498	0.609
LIG_FHA_2	364	370	PF00498	0.468
LIG_Integrin_isoDGR_2	446	448	PF01839	0.570
LIG_LIR_Apic_2	411	417	PF02991	0.733
LIG_LIR_Gen_1	221	230	PF02991	0.581
LIG_LIR_Gen_1	334	344	PF02991	0.714
LIG_LIR_Gen_1	48	57	PF02991	0.379
LIG_LIR_Nem_3	221	227	PF02991	0.607
LIG_LIR_Nem_3	321	325	PF02991	0.548
LIG_LIR_Nem_3	334	339	PF02991	0.574
LIG_LIR_Nem_3	356	362	PF02991	0.478
LIG_LIR_Nem_3	438	444	PF02991	0.695
LIG_LIR_Nem_3	48	52	PF02991	0.389
LIG_Pex14_2	129	133	PF04695	0.593
LIG_PTB_Apo_2	374	381	PF02174	0.619
LIG_PTB_Apo_2	483	490	PF02174	0.664
LIG_PTB_Phospho_1	374	380	PF10480	0.616
LIG_PTB_Phospho_1	483	489	PF10480	0.664
LIG_SH2_CRK	224	228	PF00017	0.681
LIG_SH2_CRK	270	274	PF00017	0.552
LIG_SH2_CRK	336	340	PF00017	0.647
LIG_SH2_CRK	427	431	PF00017	0.630
LIG_SH2_GRB2like	474	477	PF00017	0.697
LIG_SH2_NCK_1	336	340	PF00017	0.647
LIG_SH2_NCK_1	500	504	PF00017	0.642
LIG_SH2_PTP2	49	52	PF00017	0.350
LIG_SH2_STAP1	336	340	PF00017	0.647
LIG_SH2_STAT3	568	571	PF00017	0.713
LIG_SH2_STAT5	380	383	PF00017	0.614
LIG_SH2_STAT5	49	52	PF00017	0.356
LIG_SH3_3	211	217	PF00018	0.808
LIG_SH3_3	250	256	PF00018	0.488
LIG_SH3_3	276	282	PF00018	0.586
LIG_SH3_3	327	333	PF00018	0.572
LIG_SH3_4	155	162	PF00018	0.641
LIG_SUMO_SIM_par_1	328	335	PF11976	0.611
LIG_SUMO_SIM_par_1	88	94	PF11976	0.621
LIG_TYR_ITIM	47	52	PF00017	0.382
MOD_CDC14_SPxK_1	272	275	PF00782	0.609
MOD_CDK_SPK_2	150	155	PF00069	0.713
MOD_CDK_SPxK_1	269	275	PF00069	0.615
MOD_CK1_1	137	143	PF00069	0.664
MOD_CK1_1	14	20	PF00069	0.520
MOD_CK1_1	396	402	PF00069	0.701
MOD_CK1_1	408	414	PF00069	0.632
MOD_CK1_1	437	443	PF00069	0.617
MOD_CK1_1	472	478	PF00069	0.607
MOD_CK1_1	538	544	PF00069	0.738
MOD_CK1_1	566	572	PF00069	0.649
MOD_CK1_1	96	102	PF00069	0.692
MOD_CK2_1	245	251	PF00069	0.565
MOD_CK2_1	287	293	PF00069	0.614
MOD_CK2_1	474	480	PF00069	0.706
MOD_CK2_1	547	553	PF00069	0.700
MOD_CK2_1	58	64	PF00069	0.500
MOD_GlcNHglycan	113	116	PF01048	0.654
MOD_GlcNHglycan	143	146	PF01048	0.644
MOD_GlcNHglycan	156	159	PF01048	0.684
MOD_GlcNHglycan	16	19	PF01048	0.483
MOD_GlcNHglycan	395	398	PF01048	0.572
MOD_GlcNHglycan	407	410	PF01048	0.691
MOD_GlcNHglycan	411	414	PF01048	0.728
MOD_GlcNHglycan	452	455	PF01048	0.669
MOD_GlcNHglycan	480	484	PF01048	0.689
MOD_GlcNHglycan	589	592	PF01048	0.699
MOD_GlcNHglycan	60	63	PF01048	0.518
MOD_GlcNHglycan	84	88	PF01048	0.664
MOD_GSK3_1	137	144	PF00069	0.626
MOD_GSK3_1	150	157	PF00069	0.748
MOD_GSK3_1	177	184	PF00069	0.788
MOD_GSK3_1	188	195	PF00069	0.619
MOD_GSK3_1	196	203	PF00069	0.595
MOD_GSK3_1	274	281	PF00069	0.658
MOD_GSK3_1	349	356	PF00069	0.564
MOD_GSK3_1	403	410	PF00069	0.718
MOD_GSK3_1	435	442	PF00069	0.651
MOD_GSK3_1	499	506	PF00069	0.841
MOD_GSK3_1	538	545	PF00069	0.656
MOD_GSK3_1	587	594	PF00069	0.764
MOD_GSK3_1	60	67	PF00069	0.583
MOD_GSK3_1	7	14	PF00069	0.618
MOD_GSK3_1	94	101	PF00069	0.775
MOD_N-GLC_1	228	233	PF02516	0.602
MOD_N-GLC_1	485	490	PF02516	0.663
MOD_NEK2_1	129	134	PF00069	0.622
MOD_NEK2_1	259	264	PF00069	0.501
MOD_NEK2_1	325	330	PF00069	0.498
MOD_NEK2_1	338	343	PF00069	0.584
MOD_NEK2_1	388	393	PF00069	0.571
MOD_NEK2_1	405	410	PF00069	0.653
MOD_NEK2_1	436	441	PF00069	0.573
MOD_NEK2_1	587	592	PF00069	0.664
MOD_NEK2_2	124	129	PF00069	0.782
MOD_OFUCOSY	53	59	PF10250	0.507
MOD_PIKK_1	101	107	PF00454	0.601
MOD_PIKK_1	295	301	PF00454	0.629
MOD_PIKK_1	415	421	PF00454	0.677
MOD_PIKK_1	469	475	PF00454	0.592
MOD_PIKK_1	566	572	PF00454	0.701
MOD_PKA_1	393	399	PF00069	0.599
MOD_PKA_2	177	183	PF00069	0.679
MOD_PKA_2	393	399	PF00069	0.599
MOD_PKA_2	538	544	PF00069	0.635
MOD_PKA_2	547	553	PF00069	0.700
MOD_PKA_2	64	70	PF00069	0.645
MOD_Plk_1	218	224	PF00069	0.529
MOD_Plk_1	325	331	PF00069	0.504
MOD_Plk_1	485	491	PF00069	0.674
MOD_Plk_2-3	181	187	PF00069	0.691
MOD_Plk_2-3	188	194	PF00069	0.563
MOD_Plk_4	124	130	PF00069	0.626
MOD_Plk_4	326	332	PF00069	0.586
MOD_Plk_4	349	355	PF00069	0.623
MOD_Plk_4	363	369	PF00069	0.423
MOD_Plk_4	514	520	PF00069	0.562
MOD_ProDKin_1	12	18	PF00069	0.438
MOD_ProDKin_1	137	143	PF00069	0.711
MOD_ProDKin_1	150	156	PF00069	0.613
MOD_ProDKin_1	192	198	PF00069	0.579
MOD_ProDKin_1	200	206	PF00069	0.610
MOD_ProDKin_1	269	275	PF00069	0.632
MOD_ProDKin_1	278	284	PF00069	0.562
MOD_ProDKin_1	287	293	PF00069	0.497
MOD_ProDKin_1	340	346	PF00069	0.599
MOD_ProDKin_1	426	432	PF00069	0.649
MOD_ProDKin_1	499	505	PF00069	0.720
MOD_SUMO_rev_2	32	39	PF00179	0.400
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.481
TRG_ENDOCYTIC_2	224	227	PF00928	0.680
TRG_ENDOCYTIC_2	322	325	PF00928	0.543
TRG_ENDOCYTIC_2	336	339	PF00928	0.564
TRG_ENDOCYTIC_2	49	52	PF00928	0.389
TRG_ER_diArg_1	220	223	PF00400	0.777
TRG_ER_diArg_1	27	29	PF00400	0.420
TRG_ER_diArg_1	392	394	PF00400	0.571
TRG_ER_diArg_1	497	499	PF00400	0.830
TRG_NES_CRM1_1	35	48	PF08389	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T4	Leptomonas seymouri	47%	100%
A0A3Q8I8Z7	Leishmania donovani	91%	100%
A4H6I6	Leishmania braziliensis	70%	98%
A4HUX1	Leishmania infantum	91%	100%
E9ANK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%