Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania major

UniProt:

Q4QH17_LEIMA

TriTrypDb:

LmjF.11.0630 , LMJLV39_110013000 , LMJSD75_110013000 , LMJSD75_110013100

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 8
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	22
GO:0110165	cellular anatomical entity	1	22

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Expansion

Sequence features

Q4QH17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH17

PDB structure(s): 5nth_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	22
GO:0006807	nitrogen compound metabolic process	2	22
GO:0008152	metabolic process	1	22
GO:0019538	protein metabolic process	3	22
GO:0043170	macromolecule metabolic process	3	22
GO:0044238	primary metabolic process	2	22
GO:0071704	organic substance metabolic process	2	22
GO:1901564	organonitrogen compound metabolic process	3	22

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0004177	aminopeptidase activity	5	22
GO:0005488	binding	1	22
GO:0008233	peptidase activity	3	22
GO:0008235	metalloexopeptidase activity	5	22
GO:0008237	metallopeptidase activity	4	22
GO:0008238	exopeptidase activity	4	22
GO:0016787	hydrolase activity	2	22
GO:0030145	manganese ion binding	6	22
GO:0043167	ion binding	2	22

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	92	94	PF00675	0.284
CLV_PCSK_KEX2_1	5	7	PF00082	0.550
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.550
CLV_PCSK_SKI1_1	188	192	PF00082	0.457
CLV_PCSK_SKI1_1	337	341	PF00082	0.511
CLV_PCSK_SKI1_1	392	396	PF00082	0.389
CLV_PCSK_SKI1_1	62	66	PF00082	0.435
CLV_Separin_Metazoa	194	198	PF03568	0.381
DEG_COP1_1	403	412	PF00400	0.454
DEG_SPOP_SBC_1	105	109	PF00917	0.260

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E6	Leptomonas seymouri	41%	100%
A0A0N1PAS4	Leptomonas seymouri	76%	100%
A0A0S4IQ79	Bodo saltans	41%	100%
A0A1X0NWR5	Trypanosomatidae	50%	100%
A0A1X0P4M9	Trypanosomatidae	40%	100%
A0A3R7JY84	Trypanosoma rangeli	50%	100%
A0A3R7N130	Trypanosoma rangeli	41%	96%
A0A3S7WRP1	Leishmania donovani	96%	100%
A0A3S7X742	Leishmania donovani	44%	100%
A4H6I8	Leishmania braziliensis	85%	100%

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