Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania major

UniProt:

Q4QH17_LEIMA

TriTrypDb:

LmjF.11.0630 , LMJLV39_110013000 , LMJSD75_110013000 , LMJSD75_110013100

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 8
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

Q4QH17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH17

PDB structure(s): 5nth_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	22
GO:0006807	nitrogen compound metabolic process	2	22
GO:0008152	metabolic process	1	22
GO:0019538	protein metabolic process	3	22
GO:0043170	macromolecule metabolic process	3	22
GO:0044238	primary metabolic process	2	22
GO:0071704	organic substance metabolic process	2	22
GO:1901564	organonitrogen compound metabolic process	3	22

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0004177	aminopeptidase activity	5	22
GO:0005488	binding	1	22
GO:0008233	peptidase activity	3	22
GO:0008235	metalloexopeptidase activity	5	22
GO:0008237	metallopeptidase activity	4	22
GO:0008238	exopeptidase activity	4	22
GO:0016787	hydrolase activity	2	22
GO:0030145	manganese ion binding	6	22
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0046914	transition metal ion binding	5	22
GO:0070006	metalloaminopeptidase activity	6	22
GO:0140096	catalytic activity, acting on a protein	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	92	94	PF00675	0.284
CLV_PCSK_KEX2_1	5	7	PF00082	0.550
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.550
CLV_PCSK_SKI1_1	188	192	PF00082	0.457
CLV_PCSK_SKI1_1	337	341	PF00082	0.511
CLV_PCSK_SKI1_1	392	396	PF00082	0.389
CLV_PCSK_SKI1_1	62	66	PF00082	0.435
CLV_Separin_Metazoa	194	198	PF03568	0.381
DEG_COP1_1	403	412	PF00400	0.454
DEG_SPOP_SBC_1	105	109	PF00917	0.260
DEG_SPOP_SBC_1	481	485	PF00917	0.252
DOC_CKS1_1	220	225	PF01111	0.492
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.406
DOC_MAPK_gen_1	503	511	PF00069	0.445
DOC_MAPK_gen_1	93	101	PF00069	0.407
DOC_MAPK_MEF2A_6	176	185	PF00069	0.433
DOC_MAPK_MEF2A_6	503	511	PF00069	0.415
DOC_MAPK_NFAT4_5	176	184	PF00069	0.479
DOC_PP1_RVXF_1	60	67	PF00149	0.284
DOC_PP4_FxxP_1	504	507	PF00568	0.332
DOC_PP4_FxxP_1	66	69	PF00568	0.355
DOC_USP7_MATH_1	106	110	PF00917	0.441
DOC_USP7_MATH_1	127	131	PF00917	0.514
DOC_USP7_MATH_1	144	148	PF00917	0.423
DOC_USP7_MATH_1	426	430	PF00917	0.481
DOC_USP7_MATH_1	481	485	PF00917	0.380
DOC_USP7_MATH_1	487	491	PF00917	0.381
DOC_USP7_UBL2_3	172	176	PF12436	0.546
DOC_WW_Pin1_4	219	224	PF00397	0.443
DOC_WW_Pin1_4	469	474	PF00397	0.393
LIG_14-3-3_CanoR_1	188	196	PF00244	0.533
LIG_14-3-3_CanoR_1	197	202	PF00244	0.548
LIG_14-3-3_CanoR_1	343	352	PF00244	0.395
LIG_14-3-3_CanoR_1	93	101	PF00244	0.516
LIG_Actin_WH2_2	46	64	PF00022	0.252
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_4	388	392	PF00653	0.365
LIG_BRCT_BRCA1_1	500	504	PF00533	0.355
LIG_BRCT_BRCA1_1	62	66	PF00533	0.391
LIG_DLG_GKlike_1	116	124	PF00625	0.483
LIG_FHA_1	190	196	PF00498	0.490
LIG_FHA_1	353	359	PF00498	0.374
LIG_FHA_2	31	37	PF00498	0.436
LIG_FHA_2	385	391	PF00498	0.367
LIG_FHA_2	84	90	PF00498	0.374
LIG_LIR_Apic_2	278	284	PF02991	0.443
LIG_LIR_Apic_2	467	473	PF02991	0.395
LIG_LIR_Apic_2	501	507	PF02991	0.330
LIG_LIR_Apic_2	63	69	PF02991	0.395
LIG_LIR_Gen_1	229	240	PF02991	0.373
LIG_LIR_Gen_1	33	40	PF02991	0.532
LIG_LIR_Gen_1	344	354	PF02991	0.514
LIG_LIR_Nem_3	229	235	PF02991	0.373
LIG_LIR_Nem_3	257	263	PF02991	0.373
LIG_LIR_Nem_3	33	37	PF02991	0.482
LIG_LIR_Nem_3	344	349	PF02991	0.514
LIG_LIR_Nem_3	454	460	PF02991	0.365
LIG_LIR_Nem_3	529	535	PF02991	0.448
LIG_LYPXL_yS_3	457	460	PF13949	0.332
LIG_Pex14_2	504	508	PF04695	0.425
LIG_Pex14_3	530	535	PF04695	0.314
LIG_SH2_CRK	260	264	PF00017	0.373
LIG_SH2_CRK	281	285	PF00017	0.443
LIG_SH2_CRK	470	474	PF00017	0.362
LIG_SH2_NCK_1	232	236	PF00017	0.492
LIG_SH2_SRC	232	235	PF00017	0.332
LIG_SH2_STAP1	163	167	PF00017	0.550
LIG_SH2_STAP1	232	236	PF00017	0.393
LIG_SH2_STAP1	239	243	PF00017	0.335
LIG_SH2_STAP1	435	439	PF00017	0.284
LIG_SH2_STAP1	96	100	PF00017	0.395
LIG_SH2_STAT3	174	177	PF00017	0.562
LIG_SH2_STAT5	140	143	PF00017	0.432
LIG_SH2_STAT5	163	166	PF00017	0.507
LIG_SH2_STAT5	21	24	PF00017	0.372
LIG_SH2_STAT5	461	464	PF00017	0.404
LIG_SH2_STAT5	494	497	PF00017	0.360
LIG_SH2_STAT5	67	70	PF00017	0.403
LIG_SH2_STAT5	96	99	PF00017	0.408
LIG_SH3_3	138	144	PF00018	0.500
LIG_SH3_3	217	223	PF00018	0.386
LIG_Sin3_3	332	339	PF02671	0.492
LIG_SUMO_SIM_anti_2	371	378	PF11976	0.409
LIG_SUMO_SIM_anti_2	381	388	PF11976	0.409
LIG_TRAF2_1	130	133	PF00917	0.394
LIG_TYR_ITIM	230	235	PF00017	0.492
LIG_TYR_ITIM	455	460	PF00017	0.332
MOD_CK1_1	30	36	PF00069	0.530
MOD_CK1_1	378	384	PF00069	0.397
MOD_CK1_1	38	44	PF00069	0.530
MOD_CK1_1	483	489	PF00069	0.474
MOD_CK1_1	60	66	PF00069	0.449
MOD_CK2_1	116	122	PF00069	0.516
MOD_CK2_1	127	133	PF00069	0.453
MOD_CK2_1	384	390	PF00069	0.365
MOD_CK2_1	434	440	PF00069	0.465
MOD_CK2_1	8	14	PF00069	0.541
MOD_CK2_1	83	89	PF00069	0.516
MOD_Cter_Amidation	91	94	PF01082	0.284
MOD_GlcNHglycan	1	4	PF01048	0.709
MOD_GlcNHglycan	18	21	PF01048	0.452
MOD_GlcNHglycan	324	327	PF01048	0.486
MOD_GlcNHglycan	377	380	PF01048	0.381
MOD_GlcNHglycan	446	449	PF01048	0.397
MOD_GlcNHglycan	451	454	PF01048	0.380
MOD_GlcNHglycan	485	488	PF01048	0.485
MOD_GSK3_1	104	111	PF00069	0.430
MOD_GSK3_1	23	30	PF00069	0.511
MOD_GSK3_1	313	320	PF00069	0.453
MOD_GSK3_1	482	489	PF00069	0.394
MOD_GSK3_1	517	524	PF00069	0.483
MOD_GSK3_1	79	86	PF00069	0.517
MOD_N-GLC_1	30	35	PF02516	0.422
MOD_N-GLC_1	350	355	PF02516	0.470
MOD_N-GLC_1	481	486	PF02516	0.302
MOD_NEK2_1	226	231	PF00069	0.373
MOD_NEK2_1	322	327	PF00069	0.478
MOD_NEK2_1	341	346	PF00069	0.314
MOD_NEK2_2	80	85	PF00069	0.470
MOD_PIKK_1	189	195	PF00454	0.547
MOD_PK_1	197	203	PF00069	0.363
MOD_PK_1	8	14	PF00069	0.571
MOD_PKB_1	6	14	PF00069	0.532
MOD_Plk_1	13	19	PF00069	0.513
MOD_Plk_1	245	251	PF00069	0.355
MOD_Plk_1	30	36	PF00069	0.433
MOD_Plk_1	350	356	PF00069	0.498
MOD_Plk_1	57	63	PF00069	0.464
MOD_Plk_4	226	232	PF00069	0.486
MOD_Plk_4	245	251	PF00069	0.284
MOD_Plk_4	526	532	PF00069	0.409
MOD_Plk_4	60	66	PF00069	0.431
MOD_Plk_4	8	14	PF00069	0.571
MOD_ProDKin_1	219	225	PF00069	0.443
MOD_ProDKin_1	469	475	PF00069	0.393
TRG_DiLeu_BaEn_4	132	138	PF01217	0.300
TRG_ENDOCYTIC_2	232	235	PF00928	0.492
TRG_ENDOCYTIC_2	260	263	PF00928	0.365
TRG_ENDOCYTIC_2	457	460	PF00928	0.353
TRG_ENDOCYTIC_2	96	99	PF00928	0.483
TRG_NES_CRM1_1	205	217	PF08389	0.509
TRG_NLS_MonoCore_2	4	9	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E6	Leptomonas seymouri	41%	100%
A0A0N1PAS4	Leptomonas seymouri	76%	100%
A0A0S4IQ79	Bodo saltans	41%	100%
A0A1X0NWR5	Trypanosomatidae	50%	100%
A0A1X0P4M9	Trypanosomatidae	40%	100%
A0A3R7JY84	Trypanosoma rangeli	50%	100%
A0A3R7N130	Trypanosoma rangeli	41%	96%
A0A3S7WRP1	Leishmania donovani	96%	100%
A0A3S7X742	Leishmania donovani	44%	100%
A4H6I8	Leishmania braziliensis	85%	100%
A4HLW7	Leishmania braziliensis	44%	100%
A4HUX3	Leishmania infantum	96%	100%
A4I996	Leishmania infantum	44%	100%
A6T0V4	Janthinobacterium sp. (strain Marseille)	30%	100%
A9IIK3	Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)	30%	100%
B2JET5	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	28%	100%
B4F2N1	Proteus mirabilis (strain HI4320)	30%	100%
B8HTK3	Cyanothece sp. (strain PCC 7425 / ATCC 29141)	28%	100%
C4LA51	Tolumonas auensis (strain DSM 9187 / TA4)	30%	100%
C5CCM4	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	32%	100%
D0A654	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	95%
D0A7H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ANK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B496	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
P28838	Homo sapiens	28%	100%
P28839	Sus scrofa	27%	100%
Q1CTV6	Helicobacter pylori (strain HPAG1)	32%	100%
Q1H4U4	Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)	28%	100%
Q1LJJ6	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	31%	100%
Q21KZ5	Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)	30%	100%
Q21WL3	Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)	30%	100%
Q2KWX0	Bordetella avium (strain 197N)	29%	100%
Q2YB18	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)	29%	100%
Q315M7	Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)	29%	100%
Q3M9J6	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	28%	100%
Q46XT9	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	31%	100%
Q4Q3T0	Leishmania major	43%	96%
Q5FFZ5	Ehrlichia ruminantium (strain Gardel)	30%	100%
Q5HAP2	Ehrlichia ruminantium (strain Welgevonden)	30%	100%
Q5R7G6	Pongo abelii	37%	100%
Q68XM6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	29%	100%
Q6NSR8	Mus musculus	37%	100%
Q7W5K6	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	29%	100%
Q8D295	Wigglesworthia glossinidia brevipalpis	27%	100%
Q8KD74	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	33%	100%
Q8NDH3	Homo sapiens	37%	100%
Q9KTX5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	32%	100%
Q9PH08	Xylella fastidiosa (strain 9a5c)	31%	100%
V5BTR1	Trypanosoma cruzi	41%	97%
V5BWE3	Trypanosoma cruzi	48%	100%