Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein Associated with Differentiation, putative

Species:

Leishmania major

UniProt:

Q4QH15_LEIMA

TriTrypDb:

LmjF.11.0650 , LMJLV39_110013200 , LMJSD75_110013700

Length:

641

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 121
NetGPI	no	yes: 0, no: 121

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	114
GO:0110165	cellular anatomical entity	1	114
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

Q4QH15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH15

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	54
GO:0022857	transmembrane transporter activity	2	54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.329
CLV_NRD_NRD_1	228	230	PF00675	0.251
CLV_NRD_NRD_1	309	311	PF00675	0.424
CLV_NRD_NRD_1	323	325	PF00675	0.556
CLV_NRD_NRD_1	457	459	PF00675	0.358
CLV_NRD_NRD_1	597	599	PF00675	0.354
CLV_PCSK_KEX2_1	20	22	PF00082	0.357
CLV_PCSK_KEX2_1	228	230	PF00082	0.245
CLV_PCSK_KEX2_1	308	310	PF00082	0.296
CLV_PCSK_KEX2_1	323	325	PF00082	0.575
CLV_PCSK_KEX2_1	457	459	PF00082	0.350
CLV_PCSK_KEX2_1	559	561	PF00082	0.564
CLV_PCSK_KEX2_1	597	599	PF00082	0.351
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.355
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.610
CLV_PCSK_PC7_1	16	22	PF00082	0.418
CLV_PCSK_PC7_1	304	310	PF00082	0.288
CLV_PCSK_PC7_1	593	599	PF00082	0.401
CLV_PCSK_SKI1_1	229	233	PF00082	0.319
CLV_PCSK_SKI1_1	245	249	PF00082	0.235
CLV_PCSK_SKI1_1	27	31	PF00082	0.256
CLV_PCSK_SKI1_1	515	519	PF00082	0.288
CLV_PCSK_SKI1_1	597	601	PF00082	0.369
DEG_APCC_DBOX_1	206	214	PF00400	0.360
DEG_APCC_DBOX_1	26	34	PF00400	0.463
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.246
DOC_MAPK_gen_1	274	282	PF00069	0.340
DOC_MAPK_gen_1	457	466	PF00069	0.523
DOC_MAPK_MEF2A_6	274	282	PF00069	0.306
DOC_MAPK_MEF2A_6	459	468	PF00069	0.524
DOC_MAPK_MEF2A_6	564	573	PF00069	0.301
DOC_MAPK_RevD_3	294	310	PF00069	0.466
DOC_PP2B_LxvP_1	485	488	PF13499	0.431
DOC_PP2B_LxvP_1	49	52	PF13499	0.367
DOC_PP2B_LxvP_1	492	495	PF13499	0.298
DOC_PP4_FxxP_1	78	81	PF00568	0.318
DOC_USP7_MATH_1	2	6	PF00917	0.700
DOC_USP7_MATH_1	261	265	PF00917	0.349
DOC_USP7_MATH_1	340	344	PF00917	0.710
DOC_USP7_MATH_1	355	359	PF00917	0.744
DOC_USP7_MATH_1	425	429	PF00917	0.317
DOC_USP7_UBL2_3	520	524	PF12436	0.524
DOC_USP7_UBL2_3	555	559	PF12436	0.424
DOC_WW_Pin1_4	237	242	PF00397	0.518
LIG_14-3-3_CanoR_1	20	28	PF00244	0.562
LIG_14-3-3_CanoR_1	329	336	PF00244	0.803
LIG_14-3-3_CanoR_1	445	451	PF00244	0.306
LIG_14-3-3_CanoR_1	57	65	PF00244	0.346
LIG_14-3-3_CanoR_1	591	596	PF00244	0.570
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_deltaCOP1_diTrp_1	391	397	PF00928	0.508
LIG_FHA_1	119	125	PF00498	0.307
LIG_FHA_1	136	142	PF00498	0.318
LIG_FHA_1	199	205	PF00498	0.377
LIG_FHA_1	232	238	PF00498	0.444
LIG_FHA_1	261	267	PF00498	0.331
LIG_FHA_1	282	288	PF00498	0.377
LIG_FHA_1	301	307	PF00498	0.531
LIG_FHA_1	387	393	PF00498	0.499
LIG_FHA_1	412	418	PF00498	0.312
LIG_FHA_1	428	434	PF00498	0.288
LIG_FHA_1	46	52	PF00498	0.316
LIG_FHA_1	465	471	PF00498	0.468
LIG_FHA_1	472	478	PF00498	0.322
LIG_FHA_1	582	588	PF00498	0.378
LIG_FHA_1	68	74	PF00498	0.337
LIG_FHA_2	368	374	PF00498	0.562
LIG_FHA_2	82	88	PF00498	0.469
LIG_Integrin_RGD_1	607	609	PF01839	0.281
LIG_LIR_Apic_2	371	377	PF02991	0.532
LIG_LIR_Apic_2	87	91	PF02991	0.476
LIG_LIR_Gen_1	129	137	PF02991	0.349
LIG_LIR_Gen_1	185	195	PF02991	0.267
LIG_LIR_Gen_1	288	299	PF02991	0.350
LIG_LIR_Gen_1	406	415	PF02991	0.344
LIG_LIR_Gen_1	84	94	PF02991	0.399
LIG_LIR_Nem_3	129	133	PF02991	0.310
LIG_LIR_Nem_3	163	167	PF02991	0.337
LIG_LIR_Nem_3	174	179	PF02991	0.324
LIG_LIR_Nem_3	185	190	PF02991	0.247
LIG_LIR_Nem_3	288	294	PF02991	0.290
LIG_LIR_Nem_3	35	39	PF02991	0.356
LIG_LIR_Nem_3	406	410	PF02991	0.323
LIG_LIR_Nem_3	449	453	PF02991	0.538
LIG_LIR_Nem_3	547	551	PF02991	0.339
LIG_LIR_Nem_3	84	89	PF02991	0.354
LIG_NRBOX	428	434	PF00104	0.219
LIG_Pex14_1	244	248	PF04695	0.454
LIG_Pex14_2	175	179	PF04695	0.305
LIG_Pex14_2	190	194	PF04695	0.349
LIG_Pex14_2	246	250	PF04695	0.330
LIG_Pex14_2	403	407	PF04695	0.360
LIG_Pex14_2	43	47	PF04695	0.352
LIG_Pex14_2	450	454	PF04695	0.548
LIG_Pex14_2	78	82	PF04695	0.410
LIG_PTB_Apo_2	409	416	PF02174	0.301
LIG_SH2_CRK	291	295	PF00017	0.468
LIG_SH2_CRK	86	90	PF00017	0.464
LIG_SH2_GRB2like	269	272	PF00017	0.352
LIG_SH2_PTP2	374	377	PF00017	0.524
LIG_SH2_SRC	216	219	PF00017	0.576
LIG_SH2_SRC	496	499	PF00017	0.346
LIG_SH2_STAP1	45	49	PF00017	0.340
LIG_SH2_STAP1	549	553	PF00017	0.280
LIG_SH2_STAT3	236	239	PF00017	0.462
LIG_SH2_STAT3	549	552	PF00017	0.334
LIG_SH2_STAT5	149	152	PF00017	0.495
LIG_SH2_STAT5	187	190	PF00017	0.312
LIG_SH2_STAT5	236	239	PF00017	0.474
LIG_SH2_STAT5	259	262	PF00017	0.322
LIG_SH2_STAT5	269	272	PF00017	0.275
LIG_SH2_STAT5	374	377	PF00017	0.533
LIG_SH2_STAT5	496	499	PF00017	0.319
LIG_SH2_STAT5	549	552	PF00017	0.300
LIG_SH2_STAT5	88	91	PF00017	0.484
LIG_SH3_3	293	299	PF00018	0.358
LIG_SH3_3	564	570	PF00018	0.309
LIG_Sin3_3	47	54	PF02671	0.179
LIG_SUMO_SIM_anti_2	284	291	PF11976	0.302
LIG_SUMO_SIM_anti_2	627	634	PF11976	0.726
LIG_SUMO_SIM_par_1	29	35	PF11976	0.413
LIG_SUMO_SIM_par_1	92	98	PF11976	0.330
LIG_TRAF2_1	222	225	PF00917	0.407
LIG_TYR_ITIM	289	294	PF00017	0.339
LIG_WRC_WIRS_1	127	132	PF05994	0.365
LIG_WRC_WIRS_1	172	177	PF05994	0.364
LIG_WRC_WIRS_1	33	38	PF05994	0.429
LIG_WRC_WIRS_1	447	452	PF05994	0.244
LIG_WRC_WIRS_1	592	597	PF05994	0.540
MOD_CK1_1	219	225	PF00069	0.536
MOD_CK1_1	35	41	PF00069	0.312
MOD_CK1_1	67	73	PF00069	0.321
MOD_CK1_1	98	104	PF00069	0.326
MOD_CK2_1	2	8	PF00069	0.692
MOD_CK2_1	219	225	PF00069	0.436
MOD_CK2_1	328	334	PF00069	0.771
MOD_CK2_1	446	452	PF00069	0.364
MOD_CMANNOS	393	396	PF00535	0.357
MOD_Cter_Amidation	226	229	PF01082	0.160
MOD_GlcNHglycan	168	171	PF01048	0.320
MOD_GlcNHglycan	263	266	PF01048	0.344
MOD_GlcNHglycan	341	345	PF01048	0.455
MOD_GlcNHglycan	440	443	PF01048	0.315
MOD_GlcNHglycan	530	533	PF01048	0.294
MOD_GlcNHglycan	579	582	PF01048	0.360
MOD_GSK3_1	145	152	PF00069	0.487
MOD_GSK3_1	281	288	PF00069	0.366
MOD_GSK3_1	340	347	PF00069	0.685
MOD_GSK3_1	35	42	PF00069	0.333
MOD_GSK3_1	427	434	PF00069	0.292
MOD_GSK3_1	472	479	PF00069	0.323
MOD_GSK3_1	530	537	PF00069	0.323
MOD_GSK3_1	577	584	PF00069	0.372
MOD_LATS_1	589	595	PF00433	0.605
MOD_N-GLC_1	198	203	PF02516	0.179
MOD_N-GLC_1	317	322	PF02516	0.547
MOD_N-GLC_1	411	416	PF02516	0.555
MOD_N-GLC_1	58	63	PF02516	0.514
MOD_N-GLC_2	386	388	PF02516	0.218
MOD_NEK2_1	104	109	PF00069	0.290
MOD_NEK2_1	160	165	PF00069	0.392
MOD_NEK2_1	197	202	PF00069	0.290
MOD_NEK2_1	32	37	PF00069	0.308
MOD_NEK2_1	395	400	PF00069	0.275
MOD_NEK2_1	420	425	PF00069	0.415
MOD_NEK2_1	446	451	PF00069	0.361
MOD_NEK2_1	528	533	PF00069	0.306
MOD_NEK2_1	534	539	PF00069	0.296
MOD_NEK2_1	577	582	PF00069	0.340
MOD_NEK2_2	81	86	PF00069	0.483
MOD_PIKK_1	182	188	PF00454	0.347
MOD_PIKK_1	231	237	PF00454	0.518
MOD_PIKK_1	452	458	PF00454	0.522
MOD_PIKK_1	506	512	PF00454	0.370
MOD_PIKK_1	58	64	PF00454	0.254
MOD_PKA_1	20	26	PF00069	0.553
MOD_PKA_1	308	314	PF00069	0.594
MOD_PKA_2	20	26	PF00069	0.558
MOD_PKA_2	308	314	PF00069	0.596
MOD_PKA_2	322	328	PF00069	0.741
MOD_PKA_2	631	637	PF00069	0.754
MOD_PKB_1	591	599	PF00069	0.419
MOD_Plk_1	317	323	PF00069	0.652
MOD_Plk_1	344	350	PF00069	0.767
MOD_Plk_1	411	417	PF00069	0.323
MOD_Plk_2-3	317	323	PF00069	0.704
MOD_Plk_4	142	148	PF00069	0.331
MOD_Plk_4	171	177	PF00069	0.371
MOD_Plk_4	282	288	PF00069	0.342
MOD_Plk_4	379	385	PF00069	0.536
MOD_Plk_4	411	417	PF00069	0.313
MOD_Plk_4	431	437	PF00069	0.324
MOD_Plk_4	446	452	PF00069	0.318
MOD_Plk_4	473	479	PF00069	0.323
MOD_Plk_4	534	540	PF00069	0.304
MOD_Plk_4	81	87	PF00069	0.371
MOD_Plk_4	95	101	PF00069	0.292
MOD_ProDKin_1	237	243	PF00069	0.518
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.323
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.318
TRG_ENDOCYTIC_2	187	190	PF00928	0.311
TRG_ENDOCYTIC_2	291	294	PF00928	0.308
TRG_ENDOCYTIC_2	592	595	PF00928	0.527
TRG_ENDOCYTIC_2	86	89	PF00928	0.488
TRG_ER_diArg_1	20	22	PF00400	0.507
TRG_ER_diArg_1	228	230	PF00400	0.473
TRG_ER_diArg_1	308	310	PF00400	0.540
TRG_ER_diArg_1	597	599	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	40%	100%
A0A0N1HT40	Leptomonas seymouri	45%	100%
A0A0N1HZC2	Leptomonas seymouri	30%	100%
A0A0N1IKC5	Leptomonas seymouri	55%	100%
A0A0N1PB63	Leptomonas seymouri	28%	97%
A0A0N1PD04	Leptomonas seymouri	23%	100%
A0A0N1PFR4	Leptomonas seymouri	27%	97%
A0A0S4JR45	Bodo saltans	29%	100%
A0A1X0NKK0	Trypanosomatidae	32%	100%
A0A1X0NM09	Trypanosomatidae	31%	100%
A0A1X0NRW5	Trypanosomatidae	39%	92%
A0A1X0NV13	Trypanosomatidae	50%	99%
A0A1X0NV19	Trypanosomatidae	50%	100%
A0A1X0NV27	Trypanosomatidae	51%	100%
A0A1X0NVH8	Trypanosomatidae	43%	97%
A0A1X0NVM7	Trypanosomatidae	47%	99%
A0A1X0NWQ1	Trypanosomatidae	46%	100%
A0A1X0NZE6	Trypanosomatidae	33%	100%
A0A1X0NZU2	Trypanosomatidae	30%	99%
A0A1X0NZU5	Trypanosomatidae	34%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	30%	100%
A0A381MMW5	Leishmania infantum	31%	98%
A0A3Q8I7Y9	Leishmania donovani	48%	100%
A0A3Q8IEC4	Leishmania donovani	30%	99%
A0A3Q8IF95	Leishmania donovani	29%	100%
A0A3Q8IIT5	Leishmania donovani	25%	95%
A0A3Q8ISY9	Leishmania donovani	41%	100%
A0A3R7JSQ9	Trypanosoma rangeli	27%	100%
A0A3R7KKN8	Trypanosoma rangeli	29%	100%
A0A3R7MAQ7	Trypanosoma rangeli	36%	91%
A0A3R7N3S6	Trypanosoma rangeli	22%	99%
A0A3R7N415	Trypanosoma rangeli	27%	100%
A0A3R7N921	Trypanosoma rangeli	30%	100%
A0A3R7R443	Trypanosoma rangeli	28%	100%
A0A3S7WRJ4	Leishmania donovani	95%	100%
A0A3S7WRJ5	Leishmania donovani	52%	92%
A0A3S7WRL4	Leishmania donovani	47%	100%
A0A3S7WRS3	Leishmania donovani	24%	100%
A0A3S7WSR4	Leishmania donovani	55%	100%
A0A3S7WWU1	Leishmania donovani	26%	97%
A0A3S7X2G0	Leishmania donovani	30%	98%
A0A3S7X2K5	Leishmania donovani	30%	100%
A0A3S7XB11	Leishmania donovani	31%	100%
A0A422MSE4	Trypanosoma rangeli	46%	100%
A0A422MSP6	Trypanosoma rangeli	32%	100%
A0A422MST9	Trypanosoma rangeli	27%	100%
A0A422MU68	Trypanosoma rangeli	28%	100%
A4H6J0	Leishmania braziliensis	82%	100%
A4H6J1	Leishmania braziliensis	54%	98%
A4H6J3	Leishmania braziliensis	47%	100%
A4H6Q5	Leishmania braziliensis	25%	100%
A4HC19	Leishmania braziliensis	28%	99%
A4HHG2	Leishmania braziliensis	26%	95%
A4HHG3	Leishmania braziliensis	30%	99%
A4HHG4	Leishmania braziliensis	31%	98%
A4HJW3	Leishmania braziliensis	41%	100%
A4HPE2	Leishmania braziliensis	31%	100%
A4HUX5	Leishmania infantum	95%	100%
A4HUX6	Leishmania infantum	52%	92%
A4HUX7	Leishmania infantum	46%	100%
A4HUX8	Leishmania infantum	47%	100%
A4HV40	Leishmania infantum	24%	100%
A4HZF5	Leishmania infantum	29%	100%
A4HZJ4	Leishmania infantum	26%	97%
A4I4L2	Leishmania infantum	25%	95%
A4I7C5	Leishmania infantum	41%	100%
A4ICI3	Leishmania infantum	31%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AE01	Leishmania major	31%	98%
E9AE09	Leishmania major	26%	99%
E9AE10	Leishmania major	25%	99%
E9AE11	Leishmania major	31%	99%
E9AGK5	Leishmania infantum	55%	100%
E9AHJ0	Leishmania infantum	31%	99%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	95%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	98%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4Q1E4	Leishmania major	31%	100%
Q4Q5T8	Leishmania major	40%	100%
Q4QC27	Leishmania major	26%	100%
Q4QC28	Leishmania major	28%	100%
Q4QFY5	Leishmania major	54%	100%
Q4QGU8	Leishmania major	23%	100%
Q4QH10	Leishmania major	47%	100%
Q4QH11	Leishmania major	46%	100%
Q4QH12	Leishmania major	46%	100%
Q4QH13	Leishmania major	47%	100%
Q4QH14	Leishmania major	51%	98%
V5B647	Trypanosoma cruzi	47%	100%
V5B983	Trypanosoma cruzi	32%	100%
V5BBB1	Trypanosoma cruzi	43%	100%
V5BFV8	Trypanosoma cruzi	30%	96%
V5BQY6	Trypanosoma cruzi	37%	91%
V5BVP0	Trypanosoma cruzi	48%	100%
V5DT25	Trypanosoma cruzi	49%	100%