LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania major
UniProt:
Q4QH11_LEIMA
TriTrypDb:
LmjF.11.0675 , LMJLV39_110013500 , LMJSD75_110014100
Length:
546

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 99
NetGPI no yes: 0, no: 99
Cellular components
Term Name Level Count
GO:0016020 membrane 2 94
GO:0110165 cellular anatomical entity 1 94

Expansion

Sequence features

Q4QH11
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 43
GO:0022857 transmembrane transporter activity 2 43

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 116 118 PF00675 0.358
CLV_NRD_NRD_1 375 377 PF00675 0.322
CLV_NRD_NRD_1 515 517 PF00675 0.299
CLV_NRD_NRD_1 522 524 PF00675 0.331
CLV_PCSK_KEX2_1 116 118 PF00082 0.375
CLV_PCSK_KEX2_1 375 377 PF00082 0.305
CLV_PCSK_KEX2_1 515 517 PF00082 0.301
CLV_PCSK_KEX2_1 521 523 PF00082 0.322
CLV_PCSK_PC1ET2_1 375 377 PF00082 0.328
CLV_PCSK_SKI1_1 408 412 PF00082 0.479
CLV_PCSK_SKI1_1 515 519 PF00082 0.312
DEG_Kelch_Keap1_1 279 284 PF01344 0.651
DEG_Nend_Nbox_1 1 3 PF02207 0.359
DOC_CKS1_1 144 149 PF01111 0.190
DOC_CYCLIN_yClb5_NLxxxL_5 492 501 PF00134 0.214
DOC_CYCLIN_yCln2_LP_2 144 150 PF00134 0.190
DOC_MAPK_gen_1 116 123 PF00069 0.528
DOC_MAPK_gen_1 375 384 PF00069 0.515
DOC_MAPK_gen_1 470 480 PF00069 0.374
DOC_MAPK_MEF2A_6 208 217 PF00069 0.489
DOC_MAPK_MEF2A_6 377 386 PF00069 0.518
DOC_MAPK_MEF2A_6 482 491 PF00069 0.283
DOC_PP2B_LxvP_1 403 406 PF13499 0.349
DOC_PP4_FxxP_1 388 391 PF00568 0.420
DOC_PP4_FxxP_1 41 44 PF00568 0.323
DOC_SPAK_OSR1_1 86 90 PF12202 0.320
DOC_USP7_MATH_1 224 228 PF00917 0.346
DOC_USP7_MATH_1 4 8 PF00917 0.276
DOC_USP7_MATH_1 406 410 PF00917 0.349
DOC_USP7_MATH_1 415 419 PF00917 0.328
DOC_USP7_MATH_1 530 534 PF00917 0.651
DOC_WW_Pin1_4 143 148 PF00397 0.337
DOC_WW_Pin1_4 328 333 PF00397 0.380
DOC_WW_Pin1_4 337 342 PF00397 0.367
DOC_WW_Pin1_4 541 546 PF00397 0.632
LIG_14-3-3_CanoR_1 183 191 PF00244 0.506
LIG_14-3-3_CanoR_1 26 34 PF00244 0.333
LIG_14-3-3_CanoR_1 268 274 PF00244 0.522
LIG_14-3-3_CanoR_1 363 369 PF00244 0.306
LIG_14-3-3_CanoR_1 381 387 PF00244 0.412
LIG_Actin_WH2_2 510 527 PF00022 0.602
LIG_BRCT_BRCA1_1 330 334 PF00533 0.351
LIG_BRCT_BRCA1_1 6 10 PF00533 0.306
LIG_BRCT_BRCA1_1 97 101 PF00533 0.415
LIG_EH1_1 152 160 PF00400 0.410
LIG_FHA_1 224 230 PF00498 0.340
LIG_FHA_1 269 275 PF00498 0.594
LIG_FHA_1 296 302 PF00498 0.477
LIG_FHA_1 304 310 PF00498 0.458
LIG_FHA_1 338 344 PF00498 0.350
LIG_FHA_1 363 369 PF00498 0.394
LIG_FHA_1 390 396 PF00498 0.340
LIG_FHA_1 426 432 PF00498 0.312
LIG_FHA_1 496 502 PF00498 0.398
LIG_FHA_2 285 291 PF00498 0.516
LIG_FHA_2 45 51 PF00498 0.469
LIG_GBD_Chelix_1 120 128 PF00786 0.430
LIG_GBD_Chelix_1 215 223 PF00786 0.313
LIG_GBD_Chelix_1 453 461 PF00786 0.386
LIG_IRF3_LxIS_1 504 509 PF10401 0.487
LIG_LIR_Apic_2 288 294 PF02991 0.505
LIG_LIR_Apic_2 385 391 PF02991 0.382
LIG_LIR_Apic_2 50 54 PF02991 0.469
LIG_LIR_Gen_1 253 264 PF02991 0.360
LIG_LIR_Gen_1 308 317 PF02991 0.482
LIG_LIR_Gen_1 323 332 PF02991 0.352
LIG_LIR_Gen_1 47 57 PF02991 0.421
LIG_LIR_Gen_1 502 513 PF02991 0.333
LIG_LIR_Gen_1 7 17 PF02991 0.296
LIG_LIR_Nem_3 308 313 PF02991 0.463
LIG_LIR_Nem_3 315 320 PF02991 0.324
LIG_LIR_Nem_3 323 327 PF02991 0.336
LIG_LIR_Nem_3 331 337 PF02991 0.289
LIG_LIR_Nem_3 367 372 PF02991 0.419
LIG_LIR_Nem_3 47 52 PF02991 0.375
LIG_LIR_Nem_3 502 508 PF02991 0.326
LIG_LIR_Nem_3 509 513 PF02991 0.468
LIG_LIR_Nem_3 7 13 PF02991 0.283
LIG_LIR_Nem_3 75 79 PF02991 0.263
LIG_NRBOX 457 463 PF00104 0.306
LIG_NRBOX 496 502 PF00104 0.476
LIG_NRBOX 66 72 PF00104 0.284
LIG_PAM2_1 142 154 PF00658 0.190
LIG_Pex14_2 324 328 PF04695 0.381
LIG_Rb_pABgroove_1 95 103 PF01858 0.160
LIG_RPA_C_Fungi 112 124 PF08784 0.169
LIG_SH2_CRK 45 49 PF00017 0.327
LIG_SH2_PTP2 291 294 PF00017 0.349
LIG_SH2_SRC 505 508 PF00017 0.444
LIG_SH2_STAP1 8 12 PF00017 0.362
LIG_SH2_STAT3 199 202 PF00017 0.294
LIG_SH2_STAT5 150 153 PF00017 0.331
LIG_SH2_STAT5 199 202 PF00017 0.322
LIG_SH2_STAT5 210 213 PF00017 0.307
LIG_SH2_STAT5 222 225 PF00017 0.309
LIG_SH2_STAT5 291 294 PF00017 0.356
LIG_SH2_STAT5 372 375 PF00017 0.422
LIG_SH2_STAT5 40 43 PF00017 0.306
LIG_SH2_STAT5 505 508 PF00017 0.299
LIG_SH2_STAT5 51 54 PF00017 0.348
LIG_SH2_STAT5 58 61 PF00017 0.329
LIG_SH3_2 536 541 PF14604 0.624
LIG_SH3_3 218 224 PF00018 0.320
LIG_SH3_3 258 264 PF00018 0.370
LIG_SH3_3 482 488 PF00018 0.353
LIG_SH3_3 533 539 PF00018 0.505
LIG_SUMO_SIM_anti_2 212 217 PF11976 0.391
LIG_SUMO_SIM_anti_2 392 398 PF11976 0.318
LIG_SUMO_SIM_anti_2 426 431 PF11976 0.339
LIG_SUMO_SIM_par_1 156 161 PF11976 0.368
LIG_SUMO_SIM_par_1 392 398 PF11976 0.316
LIG_SUMO_SIM_par_1 428 434 PF11976 0.299
LIG_SUMO_SIM_par_1 92 98 PF11976 0.339
LIG_TRFH_1 40 44 PF08558 0.370
LIG_TYR_ITIM 43 48 PF00017 0.344
LIG_UBA3_1 333 342 PF00899 0.456
MOD_CDK_SPK_2 337 342 PF00069 0.234
MOD_CK1_1 137 143 PF00069 0.386
MOD_CK1_1 182 188 PF00069 0.477
MOD_CK1_1 279 285 PF00069 0.500
MOD_CK1_1 303 309 PF00069 0.342
MOD_CK1_1 335 341 PF00069 0.386
MOD_CK1_1 511 517 PF00069 0.413
MOD_CK1_1 95 101 PF00069 0.365
MOD_CK2_1 364 370 PF00069 0.334
MOD_GlcNHglycan 13 16 PF01048 0.328
MOD_GlcNHglycan 131 134 PF01048 0.327
MOD_GlcNHglycan 226 229 PF01048 0.342
MOD_GlcNHglycan 276 281 PF01048 0.486
MOD_GlcNHglycan 334 337 PF01048 0.366
MOD_GlcNHglycan 347 350 PF01048 0.356
MOD_GlcNHglycan 358 361 PF01048 0.285
MOD_GSK3_1 108 115 PF00069 0.348
MOD_GSK3_1 170 177 PF00069 0.339
MOD_GSK3_1 22 29 PF00069 0.349
MOD_GSK3_1 296 303 PF00069 0.369
MOD_GSK3_1 328 335 PF00069 0.396
MOD_GSK3_1 345 352 PF00069 0.351
MOD_GSK3_1 495 502 PF00069 0.393
MOD_N-GLC_1 328 333 PF02516 0.417
MOD_N-GLC_1 495 500 PF02516 0.291
MOD_NEK2_1 123 128 PF00069 0.393
MOD_NEK2_1 13 18 PF00069 0.331
MOD_NEK2_1 209 214 PF00069 0.355
MOD_NEK2_1 300 305 PF00069 0.312
MOD_NEK2_1 343 348 PF00069 0.365
MOD_NEK2_1 364 369 PF00069 0.334
MOD_NEK2_1 423 428 PF00069 0.344
MOD_NEK2_1 495 500 PF00069 0.342
MOD_NEK2_1 506 511 PF00069 0.310
MOD_NEK2_1 72 77 PF00069 0.302
MOD_NEK2_2 44 49 PF00069 0.243
MOD_PIKK_1 198 204 PF00454 0.386
MOD_PIKK_1 235 241 PF00454 0.349
MOD_PIKK_1 370 376 PF00454 0.393
MOD_PIKK_1 95 101 PF00454 0.432
MOD_PKA_2 182 188 PF00069 0.342
MOD_PKA_2 267 273 PF00069 0.372
MOD_PKA_2 362 368 PF00069 0.305
MOD_PKA_2 511 517 PF00069 0.323
MOD_Plk_1 343 349 PF00069 0.389
MOD_Plk_1 495 501 PF00069 0.313
MOD_Plk_2-3 284 290 PF00069 0.510
MOD_Plk_4 102 108 PF00069 0.319
MOD_Plk_4 123 129 PF00069 0.364
MOD_Plk_4 296 302 PF00069 0.328
MOD_Plk_4 305 311 PF00069 0.330
MOD_Plk_4 349 355 PF00069 0.309
MOD_Plk_4 364 370 PF00069 0.299
MOD_Plk_4 390 396 PF00069 0.333
MOD_Plk_4 425 431 PF00069 0.332
MOD_Plk_4 44 50 PF00069 0.383
MOD_Plk_4 80 86 PF00069 0.330
MOD_Plk_4 92 98 PF00069 0.330
MOD_ProDKin_1 143 149 PF00069 0.413
MOD_ProDKin_1 328 334 PF00069 0.474
MOD_ProDKin_1 337 343 PF00069 0.456
MOD_SUMO_rev_2 182 191 PF00179 0.392
TRG_DiLeu_BaLyEn_6 457 462 PF01217 0.327
TRG_DiLeu_BaLyEn_6 485 490 PF01217 0.388
TRG_ENDOCYTIC_2 150 153 PF00928 0.300
TRG_ENDOCYTIC_2 210 213 PF00928 0.369
TRG_ENDOCYTIC_2 40 43 PF00928 0.316
TRG_ENDOCYTIC_2 448 451 PF00928 0.279
TRG_ENDOCYTIC_2 45 48 PF00928 0.328
TRG_ENDOCYTIC_2 49 52 PF00928 0.348
TRG_ENDOCYTIC_2 505 508 PF00928 0.343
TRG_ENDOCYTIC_2 510 513 PF00928 0.348
TRG_ER_diArg_1 515 517 PF00400 0.376
TRG_ER_diArg_1 521 523 PF00400 0.409
TRG_Pf-PMV_PEXEL_1 460 465 PF00026 0.355
TRG_Pf-PMV_PEXEL_1 516 520 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 522 526 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 38% 86%
A0A0N1HT40 Leptomonas seymouri 74% 96%
A0A0N1HZC2 Leptomonas seymouri 28% 87%
A0A0N1IKC5 Leptomonas seymouri 47% 90%
A0A0N1PB63 Leptomonas seymouri 26% 83%
A0A0S4JR45 Bodo saltans 31% 100%
A0A1X0NKK0 Trypanosomatidae 33% 90%
A0A1X0NL32 Trypanosomatidae 35% 87%
A0A1X0NM09 Trypanosomatidae 32% 89%
A0A1X0NRW5 Trypanosomatidae 40% 78%
A0A1X0NV13 Trypanosomatidae 50% 84%
A0A1X0NV19 Trypanosomatidae 48% 91%
A0A1X0NV27 Trypanosomatidae 48% 91%
A0A1X0NVH8 Trypanosomatidae 47% 83%
A0A1X0NVM7 Trypanosomatidae 53% 85%
A0A1X0NWQ1 Trypanosomatidae 45% 85%
A0A1X0NZE6 Trypanosomatidae 32% 91%
A0A1X0NZU2 Trypanosomatidae 28% 85%
A0A1X0NZU5 Trypanosomatidae 34% 93%
A0A1X0NZW1 Trypanosomatidae 29% 91%
A0A1X0P0M7 Trypanosomatidae 32% 92%
A0A3Q8I7Y9 Leishmania donovani 97% 100%
A0A3Q8IF95 Leishmania donovani 28% 100%
A0A3Q8ISY9 Leishmania donovani 37% 86%
A0A3R7JPZ0 Trypanosoma rangeli 26% 100%
A0A3R7JSQ9 Trypanosoma rangeli 28% 100%
A0A3R7KKN8 Trypanosoma rangeli 30% 92%
A0A3R7MAQ7 Trypanosoma rangeli 36% 77%
A0A3R7N415 Trypanosoma rangeli 30% 91%
A0A3R7N921 Trypanosoma rangeli 28% 100%
A0A3R7R443 Trypanosoma rangeli 30% 91%
A0A3R7R6N6 Trypanosoma rangeli 26% 100%
A0A3S7WRJ4 Leishmania donovani 47% 85%
A0A3S7WRJ5 Leishmania donovani 42% 78%
A0A3S7WRL4 Leishmania donovani 97% 88%
A0A3S7WSR4 Leishmania donovani 45% 90%
A0A3S7WWU1 Leishmania donovani 27% 82%
A0A3S7XB11 Leishmania donovani 28% 90%
A0A422MSE4 Trypanosoma rangeli 48% 100%
A0A422MSP6 Trypanosoma rangeli 33% 100%
A0A422MST9 Trypanosoma rangeli 28% 91%
A0A422MU68 Trypanosoma rangeli 27% 100%
A4H6J0 Leishmania braziliensis 46% 85%
A4H6J1 Leishmania braziliensis 45% 84%
A4H6J3 Leishmania braziliensis 86% 95%
A4H7F9 Leishmania braziliensis 43% 100%
A4HC19 Leishmania braziliensis 26% 85%
A4HJW3 Leishmania braziliensis 38% 86%
A4HPE2 Leishmania braziliensis 28% 89%
A4HUX5 Leishmania infantum 47% 85%
A4HUX6 Leishmania infantum 42% 78%
A4HUX7 Leishmania infantum 96% 88%
A4HUX8 Leishmania infantum 96% 93%
A4HZF5 Leishmania infantum 28% 100%
A4HZJ4 Leishmania infantum 27% 82%
A4I7C5 Leishmania infantum 37% 86%
A4ICI3 Leishmania infantum 28% 90%
C9ZL97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 92%
C9ZL98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 94%
C9ZL99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 92%
C9ZLA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 93%
C9ZLA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 92%
C9ZTR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 92%
C9ZTR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 90%
C9ZTR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZTR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 91%
C9ZTR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 93%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 91%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 92%
D0A7H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0AAQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 80%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 87%
E9AGK5 Leishmania infantum 45% 90%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 85%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 84%
E9ANL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 95%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 91%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 92%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 89%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 83%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 86%
Q4Q1E4 Leishmania major 29% 100%
Q4Q5T8 Leishmania major 37% 100%
Q4QC27 Leishmania major 27% 100%
Q4QC28 Leishmania major 31% 100%
Q4QFY5 Leishmania major 45% 100%
Q4QH10 Leishmania major 100% 100%
Q4QH12 Leishmania major 100% 100%
Q4QH13 Leishmania major 100% 100%
Q4QH14 Leishmania major 41% 84%
Q4QH15 Leishmania major 46% 100%
V5B647 Trypanosoma cruzi 47% 87%
V5B983 Trypanosoma cruzi 33% 93%
V5BBB1 Trypanosoma cruzi 45% 93%
V5BFV8 Trypanosoma cruzi 30% 81%
V5BQY6 Trypanosoma cruzi 38% 77%
V5BVP0 Trypanosoma cruzi 50% 93%
V5DT25 Trypanosoma cruzi 56% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS