LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania major
UniProt:
Q4QH10_LEIMA
TriTrypDb:
LmjF.11.0680 , LMJLV39_110013500 * , LMJSD75_110014100 *
Length:
537

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 99
NetGPI no yes: 0, no: 99
Cellular components
Term Name Level Count
GO:0016020 membrane 2 94
GO:0110165 cellular anatomical entity 1 94

Expansion

Sequence features

Q4QH10
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH10

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 43
GO:0022857 transmembrane transporter activity 2 43

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 348 350 PF00675 0.385
CLV_NRD_NRD_1 488 490 PF00675 0.359
CLV_NRD_NRD_1 495 497 PF00675 0.380
CLV_NRD_NRD_1 89 91 PF00675 0.428
CLV_PCSK_KEX2_1 348 350 PF00082 0.368
CLV_PCSK_KEX2_1 488 490 PF00082 0.360
CLV_PCSK_KEX2_1 494 496 PF00082 0.367
CLV_PCSK_KEX2_1 89 91 PF00082 0.445
CLV_PCSK_PC1ET2_1 348 350 PF00082 0.391
CLV_PCSK_SKI1_1 381 385 PF00082 0.521
CLV_PCSK_SKI1_1 488 492 PF00082 0.354
DEG_Kelch_Keap1_1 252 257 PF01344 0.735
DOC_CKS1_1 117 122 PF01111 0.238
DOC_CYCLIN_yClb5_NLxxxL_5 465 474 PF00134 0.208
DOC_CYCLIN_yCln2_LP_2 117 123 PF00134 0.234
DOC_MAPK_gen_1 348 357 PF00069 0.565
DOC_MAPK_gen_1 443 453 PF00069 0.410
DOC_MAPK_gen_1 89 96 PF00069 0.521
DOC_MAPK_MEF2A_6 181 190 PF00069 0.483
DOC_MAPK_MEF2A_6 350 359 PF00069 0.557
DOC_MAPK_MEF2A_6 455 464 PF00069 0.309
DOC_PP2B_LxvP_1 376 379 PF13499 0.411
DOC_PP4_FxxP_1 14 17 PF00568 0.314
DOC_PP4_FxxP_1 361 364 PF00568 0.414
DOC_SPAK_OSR1_1 59 63 PF12202 0.348
DOC_USP7_MATH_1 197 201 PF00917 0.337
DOC_USP7_MATH_1 379 383 PF00917 0.405
DOC_USP7_MATH_1 388 392 PF00917 0.320
DOC_USP7_MATH_1 503 507 PF00917 0.687
DOC_WW_Pin1_4 116 121 PF00397 0.381
DOC_WW_Pin1_4 301 306 PF00397 0.411
DOC_WW_Pin1_4 310 315 PF00397 0.424
LIG_14-3-3_CanoR_1 156 164 PF00244 0.547
LIG_14-3-3_CanoR_1 241 247 PF00244 0.559
LIG_14-3-3_CanoR_1 336 342 PF00244 0.298
LIG_14-3-3_CanoR_1 354 360 PF00244 0.407
LIG_Actin_WH2_2 483 500 PF00022 0.637
LIG_BIR_II_1 1 5 PF00653 0.150
LIG_BRCT_BRCA1_1 303 307 PF00533 0.374
LIG_BRCT_BRCA1_1 70 74 PF00533 0.409
LIG_EH1_1 125 133 PF00400 0.404
LIG_FHA_1 197 203 PF00498 0.332
LIG_FHA_1 242 248 PF00498 0.630
LIG_FHA_1 269 275 PF00498 0.525
LIG_FHA_1 277 283 PF00498 0.495
LIG_FHA_1 311 317 PF00498 0.403
LIG_FHA_1 336 342 PF00498 0.387
LIG_FHA_1 363 369 PF00498 0.332
LIG_FHA_1 399 405 PF00498 0.304
LIG_FHA_1 469 475 PF00498 0.391
LIG_FHA_2 18 24 PF00498 0.467
LIG_FHA_2 258 264 PF00498 0.603
LIG_GBD_Chelix_1 188 196 PF00786 0.305
LIG_GBD_Chelix_1 426 434 PF00786 0.379
LIG_GBD_Chelix_1 79 87 PF00786 0.514
LIG_GBD_Chelix_1 93 101 PF00786 0.425
LIG_IRF3_LxIS_1 477 482 PF10401 0.535
LIG_LIR_Apic_2 23 27 PF02991 0.512
LIG_LIR_Apic_2 261 267 PF02991 0.567
LIG_LIR_Apic_2 358 364 PF02991 0.375
LIG_LIR_Gen_1 20 30 PF02991 0.478
LIG_LIR_Gen_1 226 237 PF02991 0.352
LIG_LIR_Gen_1 281 290 PF02991 0.329
LIG_LIR_Gen_1 296 305 PF02991 0.378
LIG_LIR_Gen_1 475 486 PF02991 0.368
LIG_LIR_Nem_3 20 25 PF02991 0.451
LIG_LIR_Nem_3 281 286 PF02991 0.302
LIG_LIR_Nem_3 288 293 PF02991 0.316
LIG_LIR_Nem_3 296 300 PF02991 0.327
LIG_LIR_Nem_3 304 310 PF02991 0.303
LIG_LIR_Nem_3 340 345 PF02991 0.578
LIG_LIR_Nem_3 475 481 PF02991 0.318
LIG_LIR_Nem_3 48 52 PF02991 0.308
LIG_LIR_Nem_3 482 486 PF02991 0.495
LIG_NRBOX 39 45 PF00104 0.276
LIG_NRBOX 430 436 PF00104 0.297
LIG_NRBOX 469 475 PF00104 0.474
LIG_PAM2_1 115 127 PF00658 0.226
LIG_Pex14_2 297 301 PF04695 0.373
LIG_Rb_pABgroove_1 68 76 PF01858 0.158
LIG_RPA_C_Fungi 85 97 PF08784 0.241
LIG_SH2_CRK 18 22 PF00017 0.319
LIG_SH2_PTP2 264 267 PF00017 0.424
LIG_SH2_SRC 478 481 PF00017 0.486
LIG_SH2_STAT3 172 175 PF00017 0.401
LIG_SH2_STAT5 123 126 PF00017 0.332
LIG_SH2_STAT5 13 16 PF00017 0.298
LIG_SH2_STAT5 172 175 PF00017 0.429
LIG_SH2_STAT5 183 186 PF00017 0.299
LIG_SH2_STAT5 195 198 PF00017 0.301
LIG_SH2_STAT5 24 27 PF00017 0.399
LIG_SH2_STAT5 264 267 PF00017 0.431
LIG_SH2_STAT5 31 34 PF00017 0.321
LIG_SH2_STAT5 345 348 PF00017 0.487
LIG_SH2_STAT5 478 481 PF00017 0.349
LIG_SH3_2 509 514 PF14604 0.752
LIG_SH3_3 191 197 PF00018 0.311
LIG_SH3_3 231 237 PF00018 0.363
LIG_SH3_3 455 461 PF00018 0.388
LIG_SH3_3 506 512 PF00018 0.609
LIG_SUMO_SIM_anti_2 185 190 PF11976 0.384
LIG_SUMO_SIM_anti_2 365 371 PF11976 0.310
LIG_SUMO_SIM_anti_2 399 404 PF11976 0.331
LIG_SUMO_SIM_par_1 129 134 PF11976 0.361
LIG_SUMO_SIM_par_1 365 371 PF11976 0.308
LIG_SUMO_SIM_par_1 401 407 PF11976 0.291
LIG_SUMO_SIM_par_1 65 71 PF11976 0.331
LIG_TRFH_1 13 17 PF08558 0.362
LIG_TYR_ITIM 16 21 PF00017 0.336
LIG_UBA3_1 306 315 PF00899 0.500
MOD_CDK_SPK_2 310 315 PF00069 0.301
MOD_CK1_1 110 116 PF00069 0.431
MOD_CK1_1 155 161 PF00069 0.536
MOD_CK1_1 252 258 PF00069 0.620
MOD_CK1_1 276 282 PF00069 0.386
MOD_CK1_1 308 314 PF00069 0.426
MOD_CK1_1 484 490 PF00069 0.468
MOD_CK1_1 529 535 PF00069 0.467
MOD_CK1_1 68 74 PF00069 0.358
MOD_CK2_1 337 343 PF00069 0.406
MOD_CK2_1 516 522 PF00069 0.544
MOD_GlcNHglycan 104 107 PF01048 0.319
MOD_GlcNHglycan 199 202 PF01048 0.334
MOD_GlcNHglycan 249 254 PF01048 0.566
MOD_GlcNHglycan 307 310 PF01048 0.371
MOD_GlcNHglycan 320 323 PF01048 0.319
MOD_GlcNHglycan 331 334 PF01048 0.290
MOD_GlcNHglycan 518 521 PF01048 0.660
MOD_GSK3_1 143 150 PF00069 0.391
MOD_GSK3_1 269 276 PF00069 0.429
MOD_GSK3_1 301 308 PF00069 0.427
MOD_GSK3_1 318 325 PF00069 0.311
MOD_GSK3_1 468 475 PF00069 0.386
MOD_GSK3_1 81 88 PF00069 0.404
MOD_N-GLC_1 301 306 PF02516 0.455
MOD_N-GLC_1 468 473 PF02516 0.283
MOD_NEK2_1 182 187 PF00069 0.347
MOD_NEK2_1 273 278 PF00069 0.377
MOD_NEK2_1 316 321 PF00069 0.417
MOD_NEK2_1 337 342 PF00069 0.400
MOD_NEK2_1 396 401 PF00069 0.336
MOD_NEK2_1 45 50 PF00069 0.336
MOD_NEK2_1 468 473 PF00069 0.334
MOD_NEK2_1 479 484 PF00069 0.336
MOD_NEK2_1 96 101 PF00069 0.386
MOD_NEK2_2 17 22 PF00069 0.235
MOD_PIKK_1 171 177 PF00454 0.474
MOD_PIKK_1 208 214 PF00454 0.439
MOD_PIKK_1 343 349 PF00454 0.462
MOD_PIKK_1 68 74 PF00454 0.426
MOD_PKA_2 155 161 PF00069 0.398
MOD_PKA_2 240 246 PF00069 0.426
MOD_PKA_2 335 341 PF00069 0.297
MOD_PKA_2 484 490 PF00069 0.376
MOD_Plk_1 316 322 PF00069 0.437
MOD_Plk_1 468 474 PF00069 0.304
MOD_Plk_2-3 257 263 PF00069 0.636
MOD_Plk_4 17 23 PF00069 0.376
MOD_Plk_4 269 275 PF00069 0.395
MOD_Plk_4 278 284 PF00069 0.320
MOD_Plk_4 322 328 PF00069 0.301
MOD_Plk_4 337 343 PF00069 0.367
MOD_Plk_4 363 369 PF00069 0.337
MOD_Plk_4 398 404 PF00069 0.322
MOD_Plk_4 53 59 PF00069 0.396
MOD_Plk_4 65 71 PF00069 0.322
MOD_Plk_4 75 81 PF00069 0.311
MOD_Plk_4 96 102 PF00069 0.356
MOD_ProDKin_1 116 122 PF00069 0.476
MOD_ProDKin_1 301 307 PF00069 0.514
MOD_ProDKin_1 310 316 PF00069 0.532
MOD_SUMO_rev_2 155 164 PF00179 0.451
TRG_DiLeu_BaLyEn_6 430 435 PF01217 0.322
TRG_DiLeu_BaLyEn_6 458 463 PF01217 0.378
TRG_ENDOCYTIC_2 123 126 PF00928 0.292
TRG_ENDOCYTIC_2 13 16 PF00928 0.307
TRG_ENDOCYTIC_2 18 21 PF00928 0.320
TRG_ENDOCYTIC_2 183 186 PF00928 0.362
TRG_ENDOCYTIC_2 22 25 PF00928 0.419
TRG_ENDOCYTIC_2 421 424 PF00928 0.271
TRG_ENDOCYTIC_2 478 481 PF00928 0.383
TRG_ENDOCYTIC_2 483 486 PF00928 0.391
TRG_ER_diArg_1 488 490 PF00400 0.447
TRG_ER_diArg_1 494 496 PF00400 0.455
TRG_Pf-PMV_PEXEL_1 433 438 PF00026 0.394
TRG_Pf-PMV_PEXEL_1 489 493 PF00026 0.471
TRG_Pf-PMV_PEXEL_1 495 499 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 37% 84%
A0A0N1HT40 Leptomonas seymouri 73% 94%
A0A0N1HZC2 Leptomonas seymouri 28% 86%
A0A0N1IKC5 Leptomonas seymouri 47% 88%
A0A0N1PB63 Leptomonas seymouri 26% 81%
A0A0S4JR45 Bodo saltans 31% 100%
A0A1X0NKK0 Trypanosomatidae 33% 88%
A0A1X0NL32 Trypanosomatidae 35% 86%
A0A1X0NM09 Trypanosomatidae 32% 88%
A0A1X0NRW5 Trypanosomatidae 39% 77%
A0A1X0NV13 Trypanosomatidae 50% 83%
A0A1X0NV19 Trypanosomatidae 48% 90%
A0A1X0NV27 Trypanosomatidae 48% 90%
A0A1X0NVH8 Trypanosomatidae 47% 81%
A0A1X0NVM7 Trypanosomatidae 53% 83%
A0A1X0NWQ1 Trypanosomatidae 45% 84%
A0A1X0NZE6 Trypanosomatidae 33% 90%
A0A1X0NZU2 Trypanosomatidae 28% 83%
A0A1X0NZU5 Trypanosomatidae 33% 91%
A0A1X0NZW1 Trypanosomatidae 29% 89%
A0A1X0P0M7 Trypanosomatidae 32% 91%
A0A3Q8I7Y9 Leishmania donovani 97% 100%
A0A3Q8IF95 Leishmania donovani 28% 100%
A0A3Q8ISY9 Leishmania donovani 36% 85%
A0A3R7JPZ0 Trypanosoma rangeli 26% 100%
A0A3R7JSQ9 Trypanosoma rangeli 28% 100%
A0A3R7KKN8 Trypanosoma rangeli 30% 90%
A0A3R7MAQ7 Trypanosoma rangeli 35% 76%
A0A3R7N415 Trypanosoma rangeli 30% 89%
A0A3R7N921 Trypanosoma rangeli 27% 100%
A0A3R7R443 Trypanosoma rangeli 30% 90%
A0A3R7R6N6 Trypanosoma rangeli 26% 100%
A0A3S7WRJ4 Leishmania donovani 48% 84%
A0A3S7WRJ5 Leishmania donovani 42% 77%
A0A3S7WRL4 Leishmania donovani 96% 86%
A0A3S7WSR4 Leishmania donovani 45% 88%
A0A3S7WWU1 Leishmania donovani 26% 81%
A0A3S7XB11 Leishmania donovani 28% 88%
A0A422MSE4 Trypanosoma rangeli 48% 100%
A0A422MSP6 Trypanosoma rangeli 33% 100%
A0A422MST9 Trypanosoma rangeli 28% 89%
A0A422MU68 Trypanosoma rangeli 27% 100%
A4H6J0 Leishmania braziliensis 46% 84%
A4H6J1 Leishmania braziliensis 44% 82%
A4H6J3 Leishmania braziliensis 86% 93%
A4H7F9 Leishmania braziliensis 43% 100%
A4HC19 Leishmania braziliensis 25% 83%
A4HJW3 Leishmania braziliensis 36% 84%
A4HPE2 Leishmania braziliensis 28% 87%
A4HUX5 Leishmania infantum 48% 84%
A4HUX6 Leishmania infantum 42% 77%
A4HUX7 Leishmania infantum 95% 86%
A4HUX8 Leishmania infantum 93% 92%
A4HZF5 Leishmania infantum 28% 100%
A4HZJ4 Leishmania infantum 26% 81%
A4I7C5 Leishmania infantum 36% 85%
A4ICI3 Leishmania infantum 28% 88%
C9ZL97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 90%
C9ZL98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 92%
C9ZL99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 90%
C9ZLA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 92%
C9ZLA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 90%
C9ZTR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 90%
C9ZTR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 89%
C9ZTR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 98%
C9ZTR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 90%
C9ZTR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 92%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 90%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 91%
D0A7H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 98%
D0AAQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 79%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 86%
E9AGK5 Leishmania infantum 45% 88%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 84%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 82%
E9ANL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 94%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 89%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 91%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 87%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 81%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 85%
Q4Q1E4 Leishmania major 29% 100%
Q4Q5T8 Leishmania major 36% 100%
Q4QC27 Leishmania major 26% 100%
Q4QC28 Leishmania major 31% 100%
Q4QFY5 Leishmania major 45% 100%
Q4QH11 Leishmania major 100% 98%
Q4QH12 Leishmania major 100% 98%
Q4QH13 Leishmania major 99% 98%
Q4QH14 Leishmania major 41% 82%
Q4QH15 Leishmania major 47% 100%
V5B647 Trypanosoma cruzi 46% 85%
V5B983 Trypanosoma cruzi 33% 92%
V5BBB1 Trypanosoma cruzi 45% 91%
V5BFV8 Trypanosoma cruzi 29% 80%
V5BQY6 Trypanosoma cruzi 37% 76%
V5BVP0 Trypanosoma cruzi 48% 91%
V5DT25 Trypanosoma cruzi 55% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS