Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH07_LEIMA

TriTrypDb:

LmjF.11.0710 , LMJLV39_110013800 , LMJSD75_110014400

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.678
CLV_NRD_NRD_1	194	196	PF00675	0.594
CLV_NRD_NRD_1	285	287	PF00675	0.489
CLV_NRD_NRD_1	349	351	PF00675	0.419
CLV_NRD_NRD_1	381	383	PF00675	0.446
CLV_NRD_NRD_1	417	419	PF00675	0.486
CLV_NRD_NRD_1	446	448	PF00675	0.575
CLV_NRD_NRD_1	97	99	PF00675	0.522
CLV_PCSK_FUR_1	95	99	PF00082	0.451
CLV_PCSK_KEX2_1	116	118	PF00082	0.706
CLV_PCSK_KEX2_1	194	196	PF00082	0.594
CLV_PCSK_KEX2_1	285	287	PF00082	0.415
CLV_PCSK_KEX2_1	348	350	PF00082	0.419
CLV_PCSK_KEX2_1	381	383	PF00082	0.446
CLV_PCSK_KEX2_1	416	418	PF00082	0.438
CLV_PCSK_KEX2_1	446	448	PF00082	0.461
CLV_PCSK_KEX2_1	97	99	PF00082	0.459
CLV_PCSK_PC7_1	442	448	PF00082	0.448
CLV_PCSK_PC7_1	93	99	PF00082	0.386
CLV_PCSK_SKI1_1	195	199	PF00082	0.617
CLV_PCSK_SKI1_1	290	294	PF00082	0.594
CLV_PCSK_SKI1_1	334	338	PF00082	0.485
CLV_PCSK_SKI1_1	382	386	PF00082	0.490
CLV_PCSK_SKI1_1	398	402	PF00082	0.516
DEG_APCC_DBOX_1	437	445	PF00400	0.517
DEG_APCC_DBOX_1	81	89	PF00400	0.536
DEG_SPOP_SBC_1	110	114	PF00917	0.559
DOC_CKS1_1	227	232	PF01111	0.612
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.694
DOC_MAPK_gen_1	47	57	PF00069	0.555
DOC_MAPK_MEF2A_6	50	57	PF00069	0.557
DOC_MAPK_NFAT4_5	50	58	PF00069	0.557
DOC_PP1_RVXF_1	15	21	PF00149	0.410
DOC_PP2B_LxvP_1	218	221	PF13499	0.695
DOC_PP2B_LxvP_1	224	227	PF13499	0.643
DOC_USP7_MATH_1	109	113	PF00917	0.628
DOC_USP7_MATH_1	124	128	PF00917	0.746
DOC_USP7_MATH_1	179	183	PF00917	0.779
DOC_USP7_MATH_1	189	193	PF00917	0.667
DOC_USP7_MATH_1	411	415	PF00917	0.504
DOC_WW_Pin1_4	166	171	PF00397	0.695
DOC_WW_Pin1_4	173	178	PF00397	0.689
DOC_WW_Pin1_4	196	201	PF00397	0.751
DOC_WW_Pin1_4	226	231	PF00397	0.652
LIG_14-3-3_CanoR_1	116	121	PF00244	0.649
LIG_14-3-3_CanoR_1	266	270	PF00244	0.493
LIG_14-3-3_CanoR_1	273	283	PF00244	0.507
LIG_14-3-3_CanoR_1	316	323	PF00244	0.501
LIG_14-3-3_CanoR_1	438	442	PF00244	0.471
LIG_Actin_WH2_2	319	336	PF00022	0.510
LIG_BRCT_BRCA1_1	227	231	PF00533	0.565
LIG_FHA_1	144	150	PF00498	0.585
LIG_FHA_1	243	249	PF00498	0.497
LIG_FHA_1	63	69	PF00498	0.601
LIG_FHA_2	276	282	PF00498	0.553
LIG_GBD_Chelix_1	401	409	PF00786	0.457
LIG_LIR_Gen_1	26	35	PF02991	0.480
LIG_LIR_Nem_3	26	32	PF02991	0.479
LIG_LYPXL_yS_3	367	370	PF13949	0.538
LIG_MYND_1	196	200	PF01753	0.594
LIG_PTB_Apo_2	216	223	PF02174	0.593
LIG_PTB_Phospho_1	216	222	PF10480	0.589
LIG_SH2_STAP1	75	79	PF00017	0.554
LIG_SH2_STAT3	222	225	PF00017	0.617
LIG_SH2_STAT3	75	78	PF00017	0.436
LIG_SH2_STAT5	29	32	PF00017	0.486
LIG_SH2_STAT5	294	297	PF00017	0.454
LIG_SH3_3	224	230	PF00018	0.607
LIG_SUMO_SIM_anti_2	299	308	PF11976	0.445
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.464
LIG_SUMO_SIM_par_1	145	150	PF11976	0.553
LIG_SUMO_SIM_par_1	247	254	PF11976	0.543
LIG_TRAF2_1	336	339	PF00917	0.441
LIG_TRAF2_1	457	460	PF00917	0.541
LIG_TYR_ITIM	448	453	PF00017	0.578
MOD_CK1_1	119	125	PF00069	0.732
MOD_CK1_1	234	240	PF00069	0.706
MOD_CK1_1	51	57	PF00069	0.574
MOD_CK2_1	142	148	PF00069	0.609
MOD_Cter_Amidation	95	98	PF01082	0.542
MOD_GlcNHglycan	191	194	PF01048	0.642
MOD_GlcNHglycan	233	236	PF01048	0.666
MOD_GSK3_1	100	107	PF00069	0.548
MOD_GSK3_1	124	131	PF00069	0.704
MOD_GSK3_1	143	150	PF00069	0.543
MOD_GSK3_1	173	180	PF00069	0.676
MOD_NEK2_1	147	152	PF00069	0.686
MOD_NEK2_1	437	442	PF00069	0.552
MOD_NEK2_2	179	184	PF00069	0.579
MOD_PIKK_1	33	39	PF00454	0.440
MOD_PKA_1	116	122	PF00069	0.759
MOD_PKA_2	116	122	PF00069	0.759
MOD_PKA_2	265	271	PF00069	0.461
MOD_PKA_2	27	33	PF00069	0.526
MOD_PKA_2	275	281	PF00069	0.473
MOD_PKA_2	315	321	PF00069	0.500
MOD_PKA_2	360	366	PF00069	0.571
MOD_PKA_2	437	443	PF00069	0.552
MOD_PKA_2	62	68	PF00069	0.557
MOD_PKB_1	98	106	PF00069	0.640
MOD_Plk_1	142	148	PF00069	0.676
MOD_Plk_1	305	311	PF00069	0.508
MOD_Plk_1	51	57	PF00069	0.538
MOD_Plk_1	69	75	PF00069	0.330
MOD_Plk_1	7	13	PF00069	0.505
MOD_Plk_2-3	143	149	PF00069	0.601
MOD_Plk_2-3	455	461	PF00069	0.607
MOD_ProDKin_1	166	172	PF00069	0.693
MOD_ProDKin_1	173	179	PF00069	0.690
MOD_ProDKin_1	196	202	PF00069	0.750
MOD_ProDKin_1	226	232	PF00069	0.656
MOD_SUMO_for_1	32	35	PF00179	0.523
MOD_SUMO_for_1	409	412	PF00179	0.479
MOD_SUMO_rev_2	289	295	PF00179	0.414
MOD_SUMO_rev_2	420	430	PF00179	0.621
TRG_DiLeu_BaEn_1	213	218	PF01217	0.583
TRG_DiLeu_BaEn_4	253	259	PF01217	0.419
TRG_DiLeu_BaEn_4	420	426	PF01217	0.436
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.433
TRG_ENDOCYTIC_2	29	32	PF00928	0.486
TRG_ENDOCYTIC_2	367	370	PF00928	0.538
TRG_ENDOCYTIC_2	450	453	PF00928	0.535
TRG_ER_diArg_1	116	118	PF00400	0.753
TRG_ER_diArg_1	194	196	PF00400	0.594
TRG_ER_diArg_1	348	350	PF00400	0.468
TRG_ER_diArg_1	416	418	PF00400	0.459
TRG_ER_diArg_1	446	448	PF00400	0.575
TRG_ER_diArg_1	95	98	PF00400	0.465
TRG_NES_CRM1_1	331	347	PF08389	0.447
TRG_NES_CRM1_1	426	439	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P310	Leptomonas seymouri	53%	85%
A0A0S4IYQ0	Bodo saltans	26%	100%
A0A1X0NVG8	Trypanosomatidae	31%	100%
A0A3Q8IB95	Leishmania donovani	95%	100%
A0A3R7L4W3	Trypanosoma rangeli	34%	100%
A4H6J6	Leishmania braziliensis	81%	85%
A4HUY1	Leishmania infantum	96%	85%
E9ANL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5C199	Trypanosoma cruzi	34%	100%