PUF nine target 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PUF nine target 1

Gene product:

PUF nine target 1

Species:

Leishmania major

UniProt:

Q4QH06_LEIMA

TriTrypDb:

LmjF.11.0720 , LMJLV39_110013900 , LMJSD75_110014500

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	600	604	PF00656	0.667
CLV_C14_Caspase3-7	617	621	PF00656	0.485
CLV_NRD_NRD_1	298	300	PF00675	0.581
CLV_NRD_NRD_1	351	353	PF00675	0.722
CLV_NRD_NRD_1	358	360	PF00675	0.667
CLV_NRD_NRD_1	515	517	PF00675	0.506
CLV_PCSK_KEX2_1	298	300	PF00082	0.597
CLV_PCSK_KEX2_1	351	353	PF00082	0.616
CLV_PCSK_KEX2_1	357	359	PF00082	0.668
CLV_PCSK_KEX2_1	4	6	PF00082	0.532
CLV_PCSK_KEX2_1	510	512	PF00082	0.588
CLV_PCSK_KEX2_1	514	516	PF00082	0.587
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.478
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.588
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.587
CLV_PCSK_PC7_1	511	517	PF00082	0.550
CLV_PCSK_SKI1_1	320	324	PF00082	0.452
CLV_PCSK_SKI1_1	35	39	PF00082	0.409
CLV_PCSK_SKI1_1	392	396	PF00082	0.643
CLV_PCSK_SKI1_1	426	430	PF00082	0.620
CLV_PCSK_SKI1_1	510	514	PF00082	0.557
CLV_PCSK_SKI1_1	515	519	PF00082	0.561
DEG_APCC_DBOX_1	239	247	PF00400	0.535
DEG_SPOP_SBC_1	613	617	PF00917	0.622
DOC_CYCLIN_RxL_1	387	397	PF00134	0.636
DOC_CYCLIN_RxL_1	4	16	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.611
DOC_MAPK_gen_1	181	188	PF00069	0.360
DOC_MAPK_gen_1	298	308	PF00069	0.593
DOC_MAPK_gen_1	32	42	PF00069	0.444
DOC_MAPK_gen_1	4	12	PF00069	0.421
DOC_PP1_RVXF_1	588	594	PF00149	0.655
DOC_PP2B_LxvP_1	431	434	PF13499	0.618
DOC_PP2B_LxvP_1	610	613	PF13499	0.730
DOC_PP4_FxxP_1	182	185	PF00568	0.300
DOC_PP4_FxxP_1	258	261	PF00568	0.616
DOC_USP7_MATH_1	247	251	PF00917	0.673
DOC_USP7_MATH_1	374	378	PF00917	0.664
DOC_USP7_MATH_1	379	383	PF00917	0.707
DOC_USP7_MATH_1	403	407	PF00917	0.760
DOC_USP7_MATH_1	44	48	PF00917	0.407
DOC_USP7_MATH_1	534	538	PF00917	0.637
DOC_USP7_MATH_1	569	573	PF00917	0.569
DOC_USP7_MATH_1	87	91	PF00917	0.394
DOC_USP7_UBL2_3	510	514	PF12436	0.584
DOC_USP7_UBL2_3	518	522	PF12436	0.597
DOC_USP7_UBL2_3	60	64	PF12436	0.468
DOC_WW_Pin1_4	281	286	PF00397	0.742
DOC_WW_Pin1_4	408	413	PF00397	0.628
DOC_WW_Pin1_4	429	434	PF00397	0.650
DOC_WW_Pin1_4	436	441	PF00397	0.782
DOC_WW_Pin1_4	530	535	PF00397	0.660
DOC_WW_Pin1_4	576	581	PF00397	0.730
DOC_WW_Pin1_4	630	635	PF00397	0.704
LIG_14-3-3_CanoR_1	109	113	PF00244	0.360
LIG_14-3-3_CanoR_1	231	235	PF00244	0.492
LIG_14-3-3_CanoR_1	277	282	PF00244	0.679
LIG_14-3-3_CanoR_1	35	43	PF00244	0.430
LIG_14-3-3_CanoR_1	636	641	PF00244	0.688
LIG_BRCT_BRCA1_1	379	383	PF00533	0.663
LIG_CtBP_PxDLS_1	447	451	PF00389	0.708
LIG_DLG_GKlike_1	636	643	PF00625	0.566
LIG_eIF4E_1	6	12	PF01652	0.296
LIG_FHA_1	147	153	PF00498	0.300
LIG_FHA_1	208	214	PF00498	0.300
LIG_FHA_1	263	269	PF00498	0.530
LIG_FHA_1	328	334	PF00498	0.488
LIG_FHA_1	626	632	PF00498	0.699
LIG_FHA_2	162	168	PF00498	0.360
LIG_FHA_2	204	210	PF00498	0.384
LIG_FHA_2	489	495	PF00498	0.506
LIG_FHA_2	598	604	PF00498	0.625
LIG_Integrin_RGD_1	202	204	PF01839	0.360
LIG_LIR_Apic_2	180	185	PF02991	0.300
LIG_LIR_Apic_2	233	238	PF02991	0.556
LIG_LIR_Apic_2	256	261	PF02991	0.602
LIG_LIR_Gen_1	101	110	PF02991	0.483
LIG_LIR_Gen_1	123	133	PF02991	0.369
LIG_LIR_Gen_1	167	176	PF02991	0.442
LIG_LIR_Gen_1	204	213	PF02991	0.300
LIG_LIR_Gen_1	463	474	PF02991	0.362
LIG_LIR_Gen_1	494	502	PF02991	0.605
LIG_LIR_Gen_1	639	644	PF02991	0.564
LIG_LIR_Gen_1	75	81	PF02991	0.418
LIG_LIR_Nem_3	101	105	PF02991	0.460
LIG_LIR_Nem_3	123	129	PF02991	0.369
LIG_LIR_Nem_3	167	171	PF02991	0.403
LIG_LIR_Nem_3	204	208	PF02991	0.279
LIG_LIR_Nem_3	233	237	PF02991	0.554
LIG_LIR_Nem_3	463	469	PF02991	0.359
LIG_LIR_Nem_3	639	643	PF02991	0.630
LIG_LIR_Nem_3	75	80	PF02991	0.425
LIG_LIR_Nem_3	90	94	PF02991	0.331
LIG_PCNA_yPIPBox_3	516	530	PF02747	0.598
LIG_PCNA_yPIPBox_3	623	636	PF02747	0.621
LIG_PDZ_Class_1	648	653	PF00595	0.680
LIG_Pex14_2	131	135	PF04695	0.300
LIG_Pex14_2	80	84	PF04695	0.415
LIG_RPA_C_Fungi	354	366	PF08784	0.649
LIG_SH2_CRK	235	239	PF00017	0.557
LIG_SH2_CRK	466	470	PF00017	0.282
LIG_SH2_CRK	640	644	PF00017	0.613
LIG_SH2_CRK	66	70	PF00017	0.485
LIG_SH2_NCK_1	229	233	PF00017	0.470
LIG_SH2_NCK_1	235	239	PF00017	0.497
LIG_SH2_PTP2	102	105	PF00017	0.538
LIG_SH2_STAP1	481	485	PF00017	0.478
LIG_SH2_STAT3	481	484	PF00017	0.527
LIG_SH2_STAT5	102	105	PF00017	0.479
LIG_SH2_STAT5	151	154	PF00017	0.300
LIG_SH2_STAT5	196	199	PF00017	0.308
LIG_SH2_STAT5	219	222	PF00017	0.448
LIG_SH2_STAT5	328	331	PF00017	0.416
LIG_SH2_STAT5	640	643	PF00017	0.620
LIG_SH2_STAT5	91	94	PF00017	0.332
LIG_SH3_1	279	285	PF00018	0.650
LIG_SH3_1	442	448	PF00018	0.535
LIG_SH3_3	279	285	PF00018	0.675
LIG_SH3_3	442	448	PF00018	0.643
LIG_SH3_3	498	504	PF00018	0.655
LIG_SH3_3	574	580	PF00018	0.633
LIG_Sin3_3	126	133	PF02671	0.376
LIG_SUMO_SIM_par_1	286	291	PF11976	0.672
LIG_SUMO_SIM_par_1	321	327	PF11976	0.433
LIG_SUMO_SIM_par_1	627	633	PF11976	0.600
LIG_SxIP_EBH_1	466	476	PF03271	0.410
LIG_TRAF2_1	457	460	PF00917	0.440
LIG_TYR_ITIM	464	469	PF00017	0.273
LIG_UBA3_1	322	326	PF00899	0.417
LIG_WRC_WIRS_1	77	82	PF05994	0.386
MOD_CDC14_SPxK_1	633	636	PF00782	0.588
MOD_CDK_SPK_2	530	535	PF00069	0.660
MOD_CDK_SPK_2	576	581	PF00069	0.635
MOD_CDK_SPxK_1	436	442	PF00069	0.551
MOD_CDK_SPxK_1	630	636	PF00069	0.593
MOD_CK1_1	177	183	PF00069	0.300
MOD_CK1_1	327	333	PF00069	0.490
MOD_CK1_1	377	383	PF00069	0.676
MOD_CK1_1	449	455	PF00069	0.658
MOD_CK1_1	496	502	PF00069	0.563
MOD_CK1_1	539	545	PF00069	0.592
MOD_CK1_1	602	608	PF00069	0.671
MOD_CK1_1	615	621	PF00069	0.694
MOD_CK1_1	625	631	PF00069	0.612
MOD_CK1_1	639	645	PF00069	0.603
MOD_CK2_1	280	286	PF00069	0.659
MOD_CK2_1	403	409	PF00069	0.574
MOD_CK2_1	454	460	PF00069	0.475
MOD_CK2_1	488	494	PF00069	0.480
MOD_CMANNOS	23	26	PF00535	0.389
MOD_Cter_Amidation	355	358	PF01082	0.655
MOD_GlcNHglycan	176	179	PF01048	0.304
MOD_GlcNHglycan	272	275	PF01048	0.724
MOD_GlcNHglycan	290	293	PF01048	0.608
MOD_GlcNHglycan	370	373	PF01048	0.676
MOD_GlcNHglycan	406	409	PF01048	0.679
MOD_GlcNHglycan	456	459	PF01048	0.444
MOD_GlcNHglycan	494	498	PF01048	0.622
MOD_GlcNHglycan	536	539	PF01048	0.612
MOD_GlcNHglycan	541	544	PF01048	0.619
MOD_GlcNHglycan	562	565	PF01048	0.717
MOD_GlcNHglycan	571	574	PF01048	0.634
MOD_GlcNHglycan	595	598	PF01048	0.728
MOD_GlcNHglycan	650	653	PF01048	0.685
MOD_GSK3_1	170	177	PF00069	0.360
MOD_GSK3_1	191	198	PF00069	0.364
MOD_GSK3_1	203	210	PF00069	0.295
MOD_GSK3_1	247	254	PF00069	0.614
MOD_GSK3_1	277	284	PF00069	0.765
MOD_GSK3_1	308	315	PF00069	0.564
MOD_GSK3_1	374	381	PF00069	0.681
MOD_GSK3_1	404	411	PF00069	0.690
MOD_GSK3_1	44	51	PF00069	0.432
MOD_GSK3_1	446	453	PF00069	0.680
MOD_GSK3_1	476	483	PF00069	0.524
MOD_GSK3_1	530	537	PF00069	0.781
MOD_GSK3_1	593	600	PF00069	0.674
MOD_GSK3_1	602	609	PF00069	0.701
MOD_GSK3_1	612	619	PF00069	0.752
MOD_GSK3_1	639	646	PF00069	0.667
MOD_LATS_1	144	150	PF00433	0.360
MOD_N-GLC_1	174	179	PF02516	0.360
MOD_N-GLC_1	597	602	PF02516	0.664
MOD_N-GLC_1	622	627	PF02516	0.602
MOD_NEK2_1	13	18	PF00069	0.436
MOD_NEK2_1	288	293	PF00069	0.647
MOD_NEK2_1	308	313	PF00069	0.589
MOD_NEK2_1	450	455	PF00069	0.551
MOD_NEK2_1	488	493	PF00069	0.467
MOD_NEK2_1	506	511	PF00069	0.606
MOD_NEK2_1	591	596	PF00069	0.719
MOD_NEK2_1	606	611	PF00069	0.669
MOD_NEK2_1	614	619	PF00069	0.589
MOD_NEK2_1	76	81	PF00069	0.378
MOD_NEK2_2	622	627	PF00069	0.602
MOD_PIKK_1	253	259	PF00454	0.544
MOD_PIKK_1	421	427	PF00454	0.621
MOD_PIKK_1	480	486	PF00454	0.485
MOD_PK_1	476	482	PF00069	0.536
MOD_PKA_2	108	114	PF00069	0.360
MOD_PKA_2	230	236	PF00069	0.486
MOD_PKA_2	294	300	PF00069	0.624
MOD_PKA_2	591	597	PF00069	0.730
MOD_PKB_1	357	365	PF00069	0.665
MOD_PKB_1	590	598	PF00069	0.562
MOD_Plk_1	174	180	PF00069	0.360
MOD_Plk_1	18	24	PF00069	0.488
MOD_Plk_1	203	209	PF00069	0.311
MOD_Plk_1	247	253	PF00069	0.558
MOD_Plk_1	308	314	PF00069	0.566
MOD_Plk_1	493	499	PF00069	0.589
MOD_Plk_1	602	608	PF00069	0.661
MOD_Plk_1	622	628	PF00069	0.470
MOD_Plk_2-3	48	54	PF00069	0.446
MOD_Plk_4	230	236	PF00069	0.486
MOD_Plk_4	308	314	PF00069	0.556
MOD_Plk_4	324	330	PF00069	0.380
MOD_Plk_4	476	482	PF00069	0.536
MOD_Plk_4	625	631	PF00069	0.656
MOD_Plk_4	76	82	PF00069	0.385
MOD_ProDKin_1	281	287	PF00069	0.740
MOD_ProDKin_1	408	414	PF00069	0.627
MOD_ProDKin_1	429	435	PF00069	0.651
MOD_ProDKin_1	436	442	PF00069	0.783
MOD_ProDKin_1	530	536	PF00069	0.656
MOD_ProDKin_1	576	582	PF00069	0.730
MOD_ProDKin_1	630	636	PF00069	0.707
MOD_SUMO_rev_2	315	322	PF00179	0.514
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.566
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.370
TRG_ENDOCYTIC_2	102	105	PF00928	0.479
TRG_ENDOCYTIC_2	168	171	PF00928	0.376
TRG_ENDOCYTIC_2	466	469	PF00928	0.282
TRG_ENDOCYTIC_2	495	498	PF00928	0.550
TRG_ENDOCYTIC_2	640	643	PF00928	0.620
TRG_ENDOCYTIC_2	66	69	PF00928	0.420
TRG_ER_diArg_1	298	301	PF00400	0.614
TRG_ER_diArg_1	351	353	PF00400	0.632
TRG_ER_diArg_1	357	359	PF00400	0.665
TRG_ER_diArg_1	590	593	PF00400	0.573
TRG_NLS_MonoExtC_3	513	518	PF00514	0.571
TRG_NLS_MonoExtN_4	511	518	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q1	Leptomonas seymouri	75%	100%
A0A3S5H6I9	Leishmania donovani	92%	100%
A4H6J7	Leishmania braziliensis	80%	100%
A4HUY2	Leishmania infantum	92%	100%
D0A7G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ANL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%