Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH04_LEIMA

TriTrypDb:

LmjF.11.0740 , LMJLV39_110014100 , LMJSD75_110014700

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.728
CLV_NRD_NRD_1	207	209	PF00675	0.760
CLV_NRD_NRD_1	332	334	PF00675	0.571
CLV_PCSK_KEX2_1	326	328	PF00082	0.582
CLV_PCSK_KEX2_1	332	334	PF00082	0.529
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.684
CLV_PCSK_SKI1_1	283	287	PF00082	0.551
CLV_PCSK_SKI1_1	63	67	PF00082	0.595
CLV_PCSK_SKI1_1	90	94	PF00082	0.620
DOC_CYCLIN_yCln2_LP_2	14	17	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.473
DOC_PP2B_LxvP_1	14	17	PF13499	0.639
DOC_PP2B_LxvP_1	260	263	PF13499	0.477
DOC_USP7_MATH_1	130	134	PF00917	0.721
DOC_USP7_UBL2_3	198	202	PF12436	0.577
DOC_WW_Pin1_4	209	214	PF00397	0.758
DOC_WW_Pin1_4	215	220	PF00397	0.750
DOC_WW_Pin1_4	371	376	PF00397	0.765
LIG_14-3-3_CanoR_1	228	232	PF00244	0.679
LIG_14-3-3_CanoR_1	301	309	PF00244	0.762
LIG_14-3-3_CanoR_1	414	420	PF00244	0.613
LIG_Actin_WH2_2	390	407	PF00022	0.610
LIG_Actin_WH2_2	88	105	PF00022	0.615
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_4	7	11	PF00653	0.688
LIG_CSL_BTD_1	216	219	PF09270	0.765
LIG_CtBP_PxDLS_1	263	267	PF00389	0.710
LIG_FHA_1	339	345	PF00498	0.618
LIG_FHA_1	371	377	PF00498	0.734
LIG_FHA_1	389	395	PF00498	0.539
LIG_FHA_1	415	421	PF00498	0.614
LIG_FHA_2	1	7	PF00498	0.692
LIG_FHA_2	198	204	PF00498	0.666
LIG_FHA_2	228	234	PF00498	0.743
LIG_FHA_2	245	251	PF00498	0.357
LIG_FHA_2	27	33	PF00498	0.585
LIG_FHA_2	376	382	PF00498	0.719
LIG_FHA_2	40	46	PF00498	0.624
LIG_FHA_2	84	90	PF00498	0.740
LIG_LIR_Apic_2	150	155	PF02991	0.706
LIG_LIR_Gen_1	337	345	PF02991	0.659
LIG_LIR_Nem_3	216	220	PF02991	0.725
LIG_Pex14_1	217	221	PF04695	0.746
LIG_PTB_Apo_2	313	320	PF02174	0.754
LIG_SH2_CRK	152	156	PF00017	0.686
LIG_SH2_SRC	128	131	PF00017	0.650
LIG_SH2_STAP1	31	35	PF00017	0.599
LIG_SH2_STAT5	128	131	PF00017	0.690
LIG_SH2_STAT5	244	247	PF00017	0.479
LIG_SH2_STAT5	339	342	PF00017	0.641
LIG_SH2_STAT5	85	88	PF00017	0.623
LIG_SH3_3	14	20	PF00018	0.608
LIG_SH3_3	160	166	PF00018	0.688
LIG_SH3_3	353	359	PF00018	0.578
LIG_SUMO_SIM_par_1	135	140	PF11976	0.477
LIG_UBA3_1	286	293	PF00899	0.564
MOD_CK1_1	105	111	PF00069	0.629
MOD_CK1_1	201	207	PF00069	0.591
MOD_CK1_1	296	302	PF00069	0.700
MOD_CK1_1	413	419	PF00069	0.691
MOD_CK2_1	197	203	PF00069	0.606
MOD_CK2_1	318	324	PF00069	0.685
MOD_CK2_1	375	381	PF00069	0.718
MOD_GlcNHglycan	104	107	PF01048	0.652
MOD_GlcNHglycan	132	135	PF01048	0.647
MOD_GlcNHglycan	276	280	PF01048	0.630
MOD_GlcNHglycan	304	307	PF01048	0.729
MOD_GlcNHglycan	405	408	PF01048	0.526
MOD_GlcNHglycan	420	423	PF01048	0.467
MOD_GlcNHglycan	47	50	PF01048	0.664
MOD_GlcNHglycan	55	59	PF01048	0.624
MOD_GSK3_1	139	146	PF00069	0.579
MOD_GSK3_1	197	204	PF00069	0.584
MOD_GSK3_1	209	216	PF00069	0.617
MOD_GSK3_1	22	29	PF00069	0.671
MOD_GSK3_1	240	247	PF00069	0.645
MOD_GSK3_1	262	269	PF00069	0.592
MOD_GSK3_1	296	303	PF00069	0.762
MOD_GSK3_1	308	315	PF00069	0.733
MOD_GSK3_1	340	347	PF00069	0.574
MOD_GSK3_1	37	44	PF00069	0.624
MOD_GSK3_1	371	378	PF00069	0.748
MOD_GSK3_1	410	417	PF00069	0.638
MOD_GSK3_1	98	105	PF00069	0.623
MOD_N-GLC_1	118	123	PF02516	0.650
MOD_N-GLC_1	213	218	PF02516	0.734
MOD_N-GLC_1	293	298	PF02516	0.494
MOD_N-GLC_2	232	234	PF02516	0.723
MOD_NEK2_1	23	28	PF00069	0.609
MOD_NEK2_1	266	271	PF00069	0.605
MOD_NEK2_1	275	280	PF00069	0.585
MOD_NEK2_1	300	305	PF00069	0.772
MOD_NEK2_1	98	103	PF00069	0.567
MOD_NEK2_2	400	405	PF00069	0.685
MOD_PIKK_1	252	258	PF00454	0.559
MOD_PK_1	428	434	PF00069	0.618
MOD_PK_1	88	94	PF00069	0.702
MOD_PKA_2	227	233	PF00069	0.706
MOD_PKA_2	300	306	PF00069	0.774
MOD_PKA_2	368	374	PF00069	0.730
MOD_PKA_2	413	419	PF00069	0.655
MOD_Plk_1	213	219	PF00069	0.760
MOD_Plk_1	76	82	PF00069	0.663
MOD_Plk_1	88	94	PF00069	0.604
MOD_Plk_4	143	149	PF00069	0.707
MOD_Plk_4	201	207	PF00069	0.633
MOD_Plk_4	23	29	PF00069	0.647
MOD_Plk_4	240	246	PF00069	0.492
MOD_Plk_4	340	346	PF00069	0.580
MOD_ProDKin_1	209	215	PF00069	0.759
MOD_ProDKin_1	371	377	PF00069	0.758
TRG_ENDOCYTIC_2	339	342	PF00928	0.641
TRG_ER_diArg_1	332	334	PF00400	0.560
TRG_ER_diArg_1	60	63	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P309	Leptomonas seymouri	57%	100%
A0A0S4JRC7	Bodo saltans	27%	100%
A0A1X0ND00	Trypanosomatidae	41%	100%
A0A3S5H6J0	Leishmania donovani	93%	100%
A0A422NQE0	Trypanosoma rangeli	41%	100%
A4H6J9	Leishmania braziliensis	80%	100%
A4HUY4	Leishmania infantum	93%	100%
D0A7G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ANL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DT29	Trypanosoma cruzi	40%	100%