MIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH03_LEIMA

TriTrypDb:

LmjF.11.0750 , LMJLV39_110014200 , LMJSD75_110014800

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.514
CLV_NRD_NRD_1	58	60	PF00675	0.388
CLV_PCSK_KEX2_1	47	49	PF00082	0.440
CLV_PCSK_KEX2_1	58	60	PF00082	0.353
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.395
CLV_PCSK_SKI1_1	58	62	PF00082	0.375
DEG_APCC_DBOX_1	58	66	PF00400	0.381
DOC_CKS1_1	185	190	PF01111	0.583
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.572
DOC_MAPK_MEF2A_6	75	82	PF00069	0.389
DOC_MAPK_NFAT4_5	75	83	PF00069	0.384
DOC_PP2B_LxvP_1	139	142	PF13499	0.639
DOC_PP2B_LxvP_1	199	202	PF13499	0.643
DOC_PP4_FxxP_1	164	167	PF00568	0.517
DOC_USP7_MATH_1	128	132	PF00917	0.528
DOC_USP7_MATH_1	83	87	PF00917	0.426
DOC_WW_Pin1_4	184	189	PF00397	0.688
LIG_14-3-3_CanoR_1	32	41	PF00244	0.376
LIG_APCC_ABBA_1	69	74	PF00400	0.351
LIG_APCC_ABBAyCdc20_2	68	74	PF00400	0.353
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BIR_III_3	1	5	PF00653	0.441
LIG_EVH1_2	107	111	PF00568	0.539
LIG_FAT_LD_1	192	200	PF03623	0.638
LIG_FHA_1	185	191	PF00498	0.628
LIG_FHA_2	34	40	PF00498	0.419
LIG_LIR_Apic_2	163	167	PF02991	0.551
LIG_LIR_Apic_2	170	175	PF02991	0.562
LIG_LIR_Nem_3	159	164	PF02991	0.515
LIG_PTAP_UEV_1	149	154	PF05743	0.528
LIG_SH2_STAP1	34	38	PF00017	0.456
LIG_SH2_STAP1	9	13	PF00017	0.408
LIG_SH2_STAT3	9	12	PF00017	0.487
LIG_SH2_STAT5	172	175	PF00017	0.563
LIG_SH2_STAT5	34	37	PF00017	0.404
LIG_SH3_3	139	145	PF00018	0.618
LIG_SH3_3	147	153	PF00018	0.702
LIG_SH3_3	182	188	PF00018	0.597
LIG_Sin3_3	76	83	PF02671	0.384
MOD_CK1_1	129	135	PF00069	0.741
MOD_CK1_1	43	49	PF00069	0.419
MOD_CK2_1	33	39	PF00069	0.419
MOD_CK2_1	64	70	PF00069	0.558
MOD_GlcNHglycan	112	115	PF01048	0.574
MOD_GlcNHglycan	121	124	PF01048	0.728
MOD_GlcNHglycan	150	153	PF01048	0.677
MOD_GlcNHglycan	85	88	PF01048	0.452
MOD_GlcNHglycan	98	102	PF01048	0.568
MOD_GSK3_1	148	155	PF00069	0.710
MOD_GSK3_1	97	104	PF00069	0.721
MOD_N-GLC_1	83	88	PF02516	0.506
MOD_NEK2_1	110	115	PF00069	0.626
MOD_PIKK_1	152	158	PF00454	0.765
MOD_Plk_1	97	103	PF00069	0.544
MOD_Plk_4	134	140	PF00069	0.549
MOD_ProDKin_1	184	190	PF00069	0.686
MOD_SUMO_rev_2	159	167	PF00179	0.550
TRG_DiLeu_BaEn_1	74	79	PF01217	0.399
TRG_ENDOCYTIC_2	161	164	PF00928	0.512
TRG_ER_diArg_1	58	60	PF00400	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I225	Leptomonas seymouri	60%	100%
A0A1X0NDQ9	Trypanosomatidae	36%	100%
A0A3Q8I937	Leishmania donovani	92%	100%
A0A3R7KJF9	Trypanosoma rangeli	42%	100%
A4H6K0	Leishmania braziliensis	71%	100%
A4HUY5	Leishmania infantum	92%	100%
E9ANM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DT71	Trypanosoma cruzi	40%	100%