Putative 40S ribosomal protein S21

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S21, putative

Species:

Leishmania major

UniProt:

Q4QH01_LEIMA

TriTrypDb:

LmjF.11.0780 , LMJLV39_110014300 , LMJSD75_110014900

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0015935	small ribosomal subunit	4	2
GO:0022627	cytosolic small ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	2
GO:0044391	ribosomal subunit	3	2
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	2
GO:0005840	ribosome	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12

Expansion

Sequence features

Q4QH01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH01

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	2
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0019538	protein metabolic process	3	14
GO:0031123	RNA 3'-end processing	7	2
GO:0031125	rRNA 3'-end processing	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0034660	ncRNA metabolic process	6	2
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0043628	regulatory ncRNA 3'-end processing	8	2
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	14
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.726
CLV_NRD_NRD_1	19	21	PF00675	0.295
CLV_PCSK_KEX2_1	91	93	PF00082	0.723
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.735
DOC_PP2B_LxvP_1	16	19	PF13499	0.495
DOC_USP7_MATH_1	93	97	PF00917	0.660
DOC_USP7_UBL2_3	100	104	PF12436	0.729
DOC_USP7_UBL2_3	91	95	PF12436	0.629
LIG_APCC_ABBA_1	4	9	PF00400	0.409
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_FHA_1	23	29	PF00498	0.495
LIG_FHA_1	52	58	PF00498	0.488
LIG_FHA_2	25	31	PF00498	0.519
LIG_SH2_STAT5	17	20	PF00017	0.505
LIG_SH2_STAT5	62	65	PF00017	0.484
LIG_SH3_4	100	107	PF00018	0.666
LIG_UBA3_1	82	89	PF00899	0.616
MOD_CK2_1	24	30	PF00069	0.546
MOD_CK2_1	62	68	PF00069	0.546
MOD_GSK3_1	62	69	PF00069	0.564
MOD_GSK3_1	91	98	PF00069	0.709
MOD_N-GLC_1	50	55	PF02516	0.306
MOD_PIKK_1	62	68	PF00454	0.546
MOD_PKA_1	91	97	PF00069	0.676
MOD_PKA_2	91	97	PF00069	0.684
MOD_Plk_4	24	30	PF00069	0.534
TRG_NLS_MonoExtN_4	158	164	PF00514	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JW77	Bodo saltans	48%	82%
A0A3Q8I928	Leishmania donovani	91%	95%
A0A3S5IRM7	Trypanosoma rangeli	61%	100%
A0A3S7WRK8	Leishmania donovani	91%	100%
A0A422NQH8	Trypanosoma rangeli	65%	100%
A4H6K1	Leishmania braziliensis	84%	99%
A4HUY6	Leishmania infantum	95%	100%
D0A7G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	84%
D0A7G5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	85%
E9ANM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
E9ANM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BWF3	Trypanosoma cruzi	63%	74%