EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGZ8_LEIMA

TriTrypDb:

LmjF.11.0810 , LMJLV39_110014700 , LMJSD75_110015300

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGZ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.647
CLV_C14_Caspase3-7	491	495	PF00656	0.611
CLV_C14_Caspase3-7	629	633	PF00656	0.546
CLV_C14_Caspase3-7	701	705	PF00656	0.552
CLV_C14_Caspase3-7	89	93	PF00656	0.512
CLV_NRD_NRD_1	12	14	PF00675	0.465
CLV_NRD_NRD_1	171	173	PF00675	0.439
CLV_NRD_NRD_1	22	24	PF00675	0.401
CLV_NRD_NRD_1	270	272	PF00675	0.308
CLV_NRD_NRD_1	389	391	PF00675	0.524
CLV_NRD_NRD_1	420	422	PF00675	0.587
CLV_NRD_NRD_1	455	457	PF00675	0.502
CLV_NRD_NRD_1	540	542	PF00675	0.491
CLV_NRD_NRD_1	776	778	PF00675	0.466
CLV_NRD_NRD_1	858	860	PF00675	0.547
CLV_NRD_NRD_1	903	905	PF00675	0.425
CLV_NRD_NRD_1	917	919	PF00675	0.562
CLV_PCSK_KEX2_1	171	173	PF00082	0.439
CLV_PCSK_KEX2_1	21	23	PF00082	0.465
CLV_PCSK_KEX2_1	270	272	PF00082	0.308
CLV_PCSK_KEX2_1	540	542	PF00082	0.528
CLV_PCSK_KEX2_1	776	778	PF00082	0.587
CLV_PCSK_KEX2_1	858	860	PF00082	0.545
CLV_PCSK_KEX2_1	903	905	PF00082	0.443
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.556
CLV_PCSK_SKI1_1	136	140	PF00082	0.576
CLV_PCSK_SKI1_1	22	26	PF00082	0.558
CLV_PCSK_SKI1_1	27	31	PF00082	0.519
CLV_PCSK_SKI1_1	347	351	PF00082	0.520
CLV_PCSK_SKI1_1	48	52	PF00082	0.438
CLV_PCSK_SKI1_1	600	604	PF00082	0.532
CLV_PCSK_SKI1_1	714	718	PF00082	0.417
CLV_PCSK_SKI1_1	843	847	PF00082	0.546
CLV_PCSK_SKI1_1	898	902	PF00082	0.561
CLV_PCSK_SKI1_1	904	908	PF00082	0.504
DEG_APCC_DBOX_1	346	354	PF00400	0.517
DEG_APCC_DBOX_1	406	414	PF00400	0.449
DEG_SCF_FBW7_2	124	129	PF00400	0.529
DEG_SPOP_SBC_1	496	500	PF00917	0.641
DEG_SPOP_SBC_1	504	508	PF00917	0.559
DEG_SPOP_SBC_1	510	514	PF00917	0.501
DOC_CKS1_1	671	676	PF01111	0.497
DOC_CYCLIN_RxL_1	169	179	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	656	662	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	934	940	PF00134	0.417
DOC_MAPK_DCC_7	669	677	PF00069	0.420
DOC_MAPK_gen_1	289	297	PF00069	0.464
DOC_MAPK_gen_1	561	568	PF00069	0.498
DOC_MAPK_gen_1	645	652	PF00069	0.538
DOC_MAPK_MEF2A_6	561	568	PF00069	0.457
DOC_MAPK_RevD_3	444	457	PF00069	0.437
DOC_PP1_RVXF_1	712	719	PF00149	0.478
DOC_PP2B_LxvP_1	150	153	PF13499	0.530
DOC_PP2B_LxvP_1	502	505	PF13499	0.651
DOC_PP2B_LxvP_1	656	659	PF13499	0.441
DOC_PP2B_LxvP_1	934	937	PF13499	0.406
DOC_PP4_FxxP_1	255	258	PF00568	0.603
DOC_PP4_MxPP_1	445	448	PF00568	0.507
DOC_USP7_MATH_1	109	113	PF00917	0.561
DOC_USP7_MATH_1	224	228	PF00917	0.624
DOC_USP7_MATH_1	363	367	PF00917	0.549
DOC_USP7_MATH_1	520	524	PF00917	0.662
DOC_USP7_MATH_1	553	557	PF00917	0.478
DOC_USP7_MATH_1	582	586	PF00917	0.482
DOC_USP7_MATH_1	739	743	PF00917	0.628
DOC_USP7_MATH_1	823	827	PF00917	0.594
DOC_USP7_MATH_1	853	857	PF00917	0.665
DOC_USP7_MATH_1	86	90	PF00917	0.675
DOC_USP7_MATH_1	863	867	PF00917	0.671
DOC_WW_Pin1_4	116	121	PF00397	0.683
DOC_WW_Pin1_4	122	127	PF00397	0.618
DOC_WW_Pin1_4	408	413	PF00397	0.523
DOC_WW_Pin1_4	463	468	PF00397	0.563
DOC_WW_Pin1_4	55	60	PF00397	0.600
DOC_WW_Pin1_4	670	675	PF00397	0.496
DOC_WW_Pin1_4	704	709	PF00397	0.645
DOC_WW_Pin1_4	793	798	PF00397	0.558
LIG_14-3-3_CanoR_1	116	120	PF00244	0.597
LIG_14-3-3_CanoR_1	133	139	PF00244	0.434
LIG_14-3-3_CanoR_1	164	168	PF00244	0.605
LIG_14-3-3_CanoR_1	259	267	PF00244	0.510
LIG_14-3-3_CanoR_1	324	333	PF00244	0.561
LIG_14-3-3_CanoR_1	40	49	PF00244	0.397
LIG_14-3-3_CanoR_1	437	447	PF00244	0.473
LIG_14-3-3_CanoR_1	456	461	PF00244	0.504
LIG_14-3-3_CanoR_1	497	505	PF00244	0.669
LIG_14-3-3_CanoR_1	714	719	PF00244	0.414
LIG_14-3-3_CanoR_1	777	785	PF00244	0.481
LIG_14-3-3_CanoR_1	801	807	PF00244	0.550
LIG_14-3-3_CanoR_1	903	911	PF00244	0.432
LIG_Actin_WH2_2	598	615	PF00022	0.494
LIG_BIR_III_2	550	554	PF00653	0.473
LIG_BIR_III_4	87	91	PF00653	0.532
LIG_BRCT_BRCA1_1	544	548	PF00533	0.470
LIG_BRCT_BRCA1_1	65	69	PF00533	0.489
LIG_BRCT_BRCA1_1	780	784	PF00533	0.439
LIG_FHA_1	149	155	PF00498	0.589
LIG_FHA_1	160	166	PF00498	0.596
LIG_FHA_1	241	247	PF00498	0.717
LIG_FHA_1	290	296	PF00498	0.398
LIG_FHA_1	439	445	PF00498	0.456
LIG_FHA_1	497	503	PF00498	0.760
LIG_FHA_1	596	602	PF00498	0.472
LIG_FHA_1	903	909	PF00498	0.490
LIG_FHA_2	123	129	PF00498	0.553
LIG_FHA_2	359	365	PF00498	0.575
LIG_FHA_2	382	388	PF00498	0.615
LIG_FHA_2	489	495	PF00498	0.615
LIG_FHA_2	49	55	PF00498	0.560
LIG_FHA_2	601	607	PF00498	0.581
LIG_FHA_2	627	633	PF00498	0.591
LIG_FHA_2	687	693	PF00498	0.525
LIG_FXI_DFP_1	30	34	PF00024	0.372
LIG_FXI_DFP_1	414	418	PF00024	0.418
LIG_FXI_DFP_1	661	665	PF00024	0.397
LIG_LIR_Apic_2	253	258	PF02991	0.573
LIG_LIR_Gen_1	28	36	PF02991	0.416
LIG_LIR_Gen_1	286	295	PF02991	0.422
LIG_LIR_Gen_1	416	425	PF02991	0.515
LIG_LIR_Gen_1	43	50	PF02991	0.395
LIG_LIR_Gen_1	95	105	PF02991	0.399
LIG_LIR_LC3C_4	263	267	PF02991	0.313
LIG_LIR_LC3C_4	499	504	PF02991	0.602
LIG_LIR_Nem_3	28	33	PF02991	0.391
LIG_LIR_Nem_3	281	287	PF02991	0.449
LIG_LIR_Nem_3	345	349	PF02991	0.418
LIG_LIR_Nem_3	416	420	PF02991	0.479
LIG_LIR_Nem_3	43	49	PF02991	0.383
LIG_LIR_Nem_3	470	476	PF02991	0.388
LIG_LIR_Nem_3	832	838	PF02991	0.365
LIG_LIR_Nem_3	95	101	PF02991	0.397
LIG_MAD2	63	71	PF02301	0.531
LIG_MLH1_MIPbox_1	544	548	PF16413	0.470
LIG_MLH1_MIPbox_1	780	784	PF16413	0.443
LIG_PCNA_PIPBox_1	679	688	PF02747	0.527
LIG_Pex14_2	25	29	PF04695	0.430
LIG_Pex14_2	660	664	PF04695	0.401
LIG_RPA_C_Fungi	11	23	PF08784	0.502
LIG_RPA_C_Fungi	266	278	PF08784	0.300
LIG_SH2_CRK	458	462	PF00017	0.528
LIG_SH2_GRB2like	98	101	PF00017	0.507
LIG_SH2_NCK_1	280	284	PF00017	0.491
LIG_SH2_NCK_1	458	462	PF00017	0.558
LIG_SH2_NCK_1	731	735	PF00017	0.532
LIG_SH2_SRC	280	283	PF00017	0.516
LIG_SH2_STAP1	280	284	PF00017	0.491
LIG_SH2_STAP1	98	102	PF00017	0.519
LIG_SH2_STAT5	326	329	PF00017	0.546
LIG_SH2_STAT5	382	385	PF00017	0.614
LIG_SH2_STAT5	458	461	PF00017	0.433
LIG_SH2_STAT5	474	477	PF00017	0.323
LIG_SH2_STAT5	715	718	PF00017	0.411
LIG_SH2_STAT5	921	924	PF00017	0.452
LIG_SH2_STAT5	959	962	PF00017	0.383
LIG_SH3_3	336	342	PF00018	0.665
LIG_SH3_3	457	463	PF00018	0.570
LIG_SH3_3	668	674	PF00018	0.524
LIG_SH3_3	934	940	PF00018	0.565
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.423
LIG_SUMO_SIM_par_1	967	975	PF11976	0.605
LIG_TRAF2_1	126	129	PF00917	0.568
LIG_TRAF2_1	261	264	PF00917	0.439
LIG_TRFH_1	312	316	PF08558	0.502
LIG_WRC_WIRS_1	26	31	PF05994	0.467
LIG_WRC_WIRS_1	5	10	PF05994	0.472
LIG_WRC_WIRS_1	715	720	PF05994	0.507
MOD_CDC14_SPxK_1	707	710	PF00782	0.431
MOD_CDK_SPxK_1	704	710	PF00069	0.430
MOD_CDK_SPxK_1	793	799	PF00069	0.561
MOD_CDK_SPxxK_3	408	415	PF00069	0.524
MOD_CK1_1	111	117	PF00069	0.405
MOD_CK1_1	118	124	PF00069	0.551
MOD_CK1_1	245	251	PF00069	0.643
MOD_CK1_1	3	9	PF00069	0.547
MOD_CK1_1	328	334	PF00069	0.411
MOD_CK1_1	466	472	PF00069	0.508
MOD_CK1_1	483	489	PF00069	0.539
MOD_CK1_1	506	512	PF00069	0.717
MOD_CK1_1	698	704	PF00069	0.534
MOD_CK1_1	742	748	PF00069	0.725
MOD_CK1_1	877	883	PF00069	0.666
MOD_CK1_1	91	97	PF00069	0.575
MOD_CK2_1	122	128	PF00069	0.479
MOD_CK2_1	176	182	PF00069	0.591
MOD_CK2_1	258	264	PF00069	0.532
MOD_CK2_1	381	387	PF00069	0.619
MOD_CK2_1	55	61	PF00069	0.451
MOD_CK2_1	600	606	PF00069	0.481
MOD_CK2_1	686	692	PF00069	0.421
MOD_CK2_1	815	821	PF00069	0.436
MOD_Cter_Amidation	19	22	PF01082	0.524
MOD_GlcNHglycan	111	114	PF01048	0.600
MOD_GlcNHglycan	176	179	PF01048	0.591
MOD_GlcNHglycan	226	229	PF01048	0.707
MOD_GlcNHglycan	260	263	PF01048	0.476
MOD_GlcNHglycan	339	342	PF01048	0.613
MOD_GlcNHglycan	364	368	PF01048	0.634
MOD_GlcNHglycan	485	488	PF01048	0.642
MOD_GlcNHglycan	508	511	PF01048	0.685
MOD_GlcNHglycan	544	547	PF01048	0.476
MOD_GlcNHglycan	555	558	PF01048	0.449
MOD_GlcNHglycan	584	587	PF01048	0.539
MOD_GlcNHglycan	622	625	PF01048	0.516
MOD_GlcNHglycan	700	703	PF01048	0.541
MOD_GlcNHglycan	737	740	PF01048	0.636
MOD_GlcNHglycan	748	751	PF01048	0.658
MOD_GlcNHglycan	817	820	PF01048	0.529
MOD_GlcNHglycan	825	828	PF01048	0.516
MOD_GlcNHglycan	87	91	PF01048	0.677
MOD_GlcNHglycan	876	879	PF01048	0.641
MOD_GSK3_1	111	118	PF00069	0.644
MOD_GSK3_1	159	166	PF00069	0.467
MOD_GSK3_1	174	181	PF00069	0.464
MOD_GSK3_1	240	247	PF00069	0.645
MOD_GSK3_1	289	296	PF00069	0.404
MOD_GSK3_1	325	332	PF00069	0.492
MOD_GSK3_1	363	370	PF00069	0.587
MOD_GSK3_1	378	385	PF00069	0.536
MOD_GSK3_1	426	433	PF00069	0.439
MOD_GSK3_1	505	512	PF00069	0.717
MOD_GSK3_1	525	532	PF00069	0.262
MOD_GSK3_1	582	589	PF00069	0.499
MOD_GSK3_1	688	695	PF00069	0.429
MOD_GSK3_1	735	742	PF00069	0.632
MOD_GSK3_1	74	81	PF00069	0.446
MOD_NEK2_1	1	6	PF00069	0.632
MOD_NEK2_1	176	181	PF00069	0.577
MOD_NEK2_1	25	30	PF00069	0.474
MOD_NEK2_1	372	377	PF00069	0.506
MOD_NEK2_1	402	407	PF00069	0.441
MOD_NEK2_1	542	547	PF00069	0.441
MOD_NEK2_1	587	592	PF00069	0.558
MOD_NEK2_1	612	617	PF00069	0.522
MOD_NEK2_1	748	753	PF00069	0.648
MOD_NEK2_1	838	843	PF00069	0.432
MOD_NEK2_2	218	223	PF00069	0.716
MOD_NEK2_2	863	868	PF00069	0.505
MOD_NEK2_2	889	894	PF00069	0.478
MOD_PIKK_1	353	359	PF00454	0.584
MOD_PIKK_1	394	400	PF00454	0.481
MOD_PIKK_1	438	444	PF00454	0.546
MOD_PIKK_1	480	486	PF00454	0.604
MOD_PIKK_1	595	601	PF00454	0.472
MOD_PIKK_1	686	692	PF00454	0.544
MOD_PIKK_1	853	859	PF00454	0.537
MOD_PIKK_1	877	883	PF00454	0.591
MOD_PK_1	242	248	PF00069	0.598
MOD_PKA_1	456	462	PF00069	0.510
MOD_PKA_2	115	121	PF00069	0.533
MOD_PKA_2	163	169	PF00069	0.603
MOD_PKA_2	258	264	PF00069	0.560
MOD_PKA_2	39	45	PF00069	0.392
MOD_PKA_2	496	502	PF00069	0.742
MOD_PKA_2	612	618	PF00069	0.458
MOD_PKA_2	902	908	PF00069	0.419
MOD_Plk_1	218	224	PF00069	0.648
MOD_Plk_1	329	335	PF00069	0.590
MOD_Plk_1	725	731	PF00069	0.575
MOD_Plk_1	967	973	PF00069	0.524
MOD_Plk_4	245	251	PF00069	0.722
MOD_Plk_4	25	31	PF00069	0.450
MOD_Plk_4	299	305	PF00069	0.582
MOD_Plk_4	378	384	PF00069	0.575
MOD_Plk_4	525	531	PF00069	0.542
MOD_Plk_4	695	701	PF00069	0.521
MOD_Plk_4	714	720	PF00069	0.334
MOD_Plk_4	967	973	PF00069	0.524
MOD_ProDKin_1	116	122	PF00069	0.674
MOD_ProDKin_1	408	414	PF00069	0.519
MOD_ProDKin_1	463	469	PF00069	0.560
MOD_ProDKin_1	55	61	PF00069	0.595
MOD_ProDKin_1	670	676	PF00069	0.495
MOD_ProDKin_1	704	710	PF00069	0.644
MOD_ProDKin_1	793	799	PF00069	0.561
TRG_DiLeu_BaEn_1	449	454	PF01217	0.443
TRG_DiLeu_BaEn_1	942	947	PF01217	0.507
TRG_DiLeu_BaEn_2	344	350	PF01217	0.457
TRG_ENDOCYTIC_2	287	290	PF00928	0.435
TRG_ENDOCYTIC_2	346	349	PF00928	0.370
TRG_ENDOCYTIC_2	473	476	PF00928	0.386
TRG_ENDOCYTIC_2	715	718	PF00928	0.388
TRG_ENDOCYTIC_2	835	838	PF00928	0.360
TRG_ENDOCYTIC_2	959	962	PF00928	0.368
TRG_ENDOCYTIC_2	98	101	PF00928	0.382
TRG_ER_diArg_1	131	134	PF00400	0.586
TRG_ER_diArg_1	170	172	PF00400	0.421
TRG_ER_diArg_1	22	24	PF00400	0.452
TRG_ER_diArg_1	269	271	PF00400	0.415
TRG_ER_diArg_1	276	279	PF00400	0.420
TRG_ER_diArg_1	432	435	PF00400	0.501
TRG_ER_diArg_1	540	542	PF00400	0.531
TRG_ER_diArg_1	776	778	PF00400	0.522
TRG_ER_diArg_1	858	860	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ9	Leptomonas seymouri	58%	100%
A0A0S4JMU3	Bodo saltans	33%	100%
A0A1X0NV98	Trypanosomatidae	38%	98%
A0A3Q8I908	Leishmania donovani	94%	100%
A0A3R7KQI0	Trypanosoma rangeli	37%	100%
A4H6K5	Leishmania braziliensis	84%	100%
A4HUZ0	Leishmania infantum	95%	100%
D0A7F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DT33	Trypanosoma cruzi	39%	100%