DUF1421 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGZ7_LEIMA

TriTrypDb:

LmjF.11.0820 , LMJLV39_110014800 , LMJSD75_110015400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	99	101	PF00082	0.522
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.522
CLV_PCSK_SKI1_1	68	72	PF00082	0.644
CLV_PCSK_SKI1_1	92	96	PF00082	0.504
DEG_Nend_UBRbox_2	1	3	PF02207	0.674
DEG_SIAH_1	177	185	PF03145	0.732
DEG_SPOP_SBC_1	169	173	PF00917	0.722
DOC_PP1_RVXF_1	66	73	PF00149	0.581
DOC_PP4_FxxP_1	72	75	PF00568	0.588
DOC_PP4_MxPP_1	202	205	PF00568	0.706
DOC_PP4_MxPP_1	289	292	PF00568	0.826
DOC_USP7_MATH_1	105	109	PF00917	0.544
DOC_USP7_MATH_1	169	173	PF00917	0.737
DOC_USP7_MATH_1	332	336	PF00917	0.684
DOC_WW_Pin1_4	174	179	PF00397	0.670
DOC_WW_Pin1_4	180	185	PF00397	0.689
DOC_WW_Pin1_4	4	9	PF00397	0.689
LIG_14-3-3_CanoR_1	170	178	PF00244	0.656
LIG_14-3-3_CanoR_1	318	324	PF00244	0.730
LIG_14-3-3_CanoR_1	68	73	PF00244	0.568
LIG_deltaCOP1_diTrp_1	226	234	PF00928	0.644
LIG_FHA_1	129	135	PF00498	0.500
LIG_FHA_1	69	75	PF00498	0.673
LIG_FHA_1	80	86	PF00498	0.487
LIG_LIR_Apic_2	71	75	PF02991	0.569
LIG_PTB_Apo_2	32	39	PF02174	0.645
LIG_SH2_NCK_1	323	327	PF00017	0.631
LIG_SH2_STAP1	296	300	PF00017	0.656
LIG_SH2_STAP1	54	58	PF00017	0.584
LIG_SH2_STAT3	222	225	PF00017	0.708
LIG_SH3_1	285	291	PF00018	0.798
LIG_SH3_3	285	291	PF00018	0.682
LIG_SH3_3	5	11	PF00018	0.644
LIG_SUMO_SIM_par_1	57	64	PF11976	0.581
LIG_TRAF2_1	23	26	PF00917	0.734
MOD_CK1_1	172	178	PF00069	0.731
MOD_CK1_1	319	325	PF00069	0.805
MOD_CK2_1	58	64	PF00069	0.549
MOD_CK2_1	80	86	PF00069	0.546
MOD_GlcNHglycan	212	215	PF01048	0.734
MOD_GlcNHglycan	272	275	PF01048	0.782
MOD_GlcNHglycan	334	337	PF01048	0.677
MOD_GlcNHglycan	82	85	PF01048	0.523
MOD_GSK3_1	164	171	PF00069	0.677
MOD_N-GLC_1	68	73	PF02516	0.568
MOD_NEK2_1	143	148	PF00069	0.567
MOD_PIKK_1	143	149	PF00454	0.651
MOD_PIKK_1	156	162	PF00454	0.603
MOD_PIKK_1	164	170	PF00454	0.637
MOD_PIKK_1	172	178	PF00454	0.600
MOD_PIKK_1	316	322	PF00454	0.728
MOD_PKA_2	169	175	PF00069	0.653
MOD_Plk_1	116	122	PF00069	0.531
MOD_Plk_1	68	74	PF00069	0.566
MOD_Plk_4	26	32	PF00069	0.570
MOD_Plk_4	58	64	PF00069	0.549
MOD_ProDKin_1	174	180	PF00069	0.670
MOD_ProDKin_1	182	188	PF00069	0.698
MOD_ProDKin_1	4	10	PF00069	0.688
TRG_DiLeu_BaEn_1	137	142	PF01217	0.569
TRG_DiLeu_BaEn_3	25	31	PF01217	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL54	Leptomonas seymouri	61%	71%
A0A3S7WRM1	Leishmania donovani	98%	100%
A4H6K6	Leishmania braziliensis	82%	73%
A4HUZ1	Leishmania infantum	98%	100%
E9ANM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%