LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family, putative
Species:
Leishmania major
UniProt:
Q4QGZ4_LEIMA
TriTrypDb:
LmjF.11.0850 , LMJLV39_110015100 , LMJSD75_110015700 *
Length:
482

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q4QGZ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGZ4

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 4
GO:0008152 metabolic process 1 4
GO:0009987 cellular process 1 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044255 cellular lipid metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016298 lipase activity 4 4
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 4
GO:0034338 short-chain carboxylesterase activity 5 4
GO:0047372 acylglycerol lipase activity 5 4
GO:0052689 carboxylic ester hydrolase activity 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 79 85 PF00089 0.449
CLV_NRD_NRD_1 192 194 PF00675 0.515
CLV_NRD_NRD_1 336 338 PF00675 0.510
CLV_NRD_NRD_1 81 83 PF00675 0.532
CLV_PCSK_FUR_1 78 82 PF00082 0.436
CLV_PCSK_KEX2_1 192 194 PF00082 0.515
CLV_PCSK_KEX2_1 80 82 PF00082 0.439
CLV_PCSK_SKI1_1 338 342 PF00082 0.538
CLV_PCSK_SKI1_1 344 348 PF00082 0.546
CLV_PCSK_SKI1_1 35 39 PF00082 0.325
CLV_PCSK_SKI1_1 356 360 PF00082 0.526
CLV_PCSK_SKI1_1 473 477 PF00082 0.496
CLV_PCSK_SKI1_1 65 69 PF00082 0.534
CLV_Separin_Metazoa 219 223 PF03568 0.376
DEG_APCC_DBOX_1 343 351 PF00400 0.366
DEG_Nend_Nbox_1 1 3 PF02207 0.612
DEG_SCF_FBW7_2 453 459 PF00400 0.365
DEG_SPOP_SBC_1 145 149 PF00917 0.368
DOC_CDC14_PxL_1 176 184 PF14671 0.291
DOC_CDC14_PxL_1 30 38 PF14671 0.344
DOC_CKS1_1 249 254 PF01111 0.367
DOC_CKS1_1 296 301 PF01111 0.368
DOC_CKS1_1 453 458 PF01111 0.374
DOC_MAPK_DCC_7 248 257 PF00069 0.394
DOC_MAPK_gen_1 10 19 PF00069 0.601
DOC_MAPK_gen_1 404 412 PF00069 0.280
DOC_MAPK_gen_1 78 87 PF00069 0.257
DOC_MAPK_MEF2A_6 22 30 PF00069 0.387
DOC_MAPK_MEF2A_6 253 262 PF00069 0.311
DOC_MAPK_MEF2A_6 404 412 PF00069 0.232
DOC_PP1_RVXF_1 14 20 PF00149 0.434
DOC_PP1_RVXF_1 171 178 PF00149 0.347
DOC_PP1_RVXF_1 33 39 PF00149 0.278
DOC_PP2B_LxvP_1 218 221 PF13499 0.378
DOC_PP2B_LxvP_1 400 403 PF13499 0.215
DOC_PP2B_PxIxI_1 255 261 PF00149 0.350
DOC_PP4_FxxP_1 177 180 PF00568 0.330
DOC_PP4_FxxP_1 359 362 PF00568 0.413
DOC_PP4_FxxP_1 386 389 PF00568 0.308
DOC_PP4_FxxP_1 83 86 PF00568 0.323
DOC_SPAK_OSR1_1 193 197 PF12202 0.298
DOC_USP7_MATH_1 110 114 PF00917 0.360
DOC_USP7_MATH_1 139 143 PF00917 0.358
DOC_USP7_MATH_1 145 149 PF00917 0.449
DOC_USP7_MATH_1 161 165 PF00917 0.531
DOC_USP7_MATH_1 195 199 PF00917 0.283
DOC_USP7_MATH_1 425 429 PF00917 0.299
DOC_USP7_MATH_1 431 435 PF00917 0.248
DOC_WW_Pin1_4 153 158 PF00397 0.503
DOC_WW_Pin1_4 213 218 PF00397 0.287
DOC_WW_Pin1_4 248 253 PF00397 0.392
DOC_WW_Pin1_4 295 300 PF00397 0.326
DOC_WW_Pin1_4 385 390 PF00397 0.333
DOC_WW_Pin1_4 404 409 PF00397 0.329
DOC_WW_Pin1_4 452 457 PF00397 0.297
LIG_14-3-3_CanoR_1 10 19 PF00244 0.578
LIG_14-3-3_CanoR_1 317 323 PF00244 0.367
LIG_14-3-3_CanoR_1 368 375 PF00244 0.336
LIG_14-3-3_CanoR_1 430 440 PF00244 0.217
LIG_BRCT_BRCA1_1 224 228 PF00533 0.338
LIG_CSL_BTD_1 400 403 PF09270 0.351
LIG_eIF4E_1 31 37 PF01652 0.394
LIG_FHA_1 12 18 PF00498 0.565
LIG_FHA_1 186 192 PF00498 0.298
LIG_FHA_1 213 219 PF00498 0.318
LIG_FHA_1 227 233 PF00498 0.221
LIG_FHA_1 405 411 PF00498 0.274
LIG_FHA_1 437 443 PF00498 0.381
LIG_FHA_2 214 220 PF00498 0.361
LIG_FHA_2 225 231 PF00498 0.306
LIG_FHA_2 279 285 PF00498 0.319
LIG_IBAR_NPY_1 436 438 PF08397 0.206
LIG_Integrin_RGD_1 461 463 PF01839 0.553
LIG_LIR_Apic_2 135 141 PF02991 0.382
LIG_LIR_Gen_1 307 318 PF02991 0.348
LIG_LIR_Nem_3 307 313 PF02991 0.342
LIG_LIR_Nem_3 321 327 PF02991 0.405
LIG_LIR_Nem_3 426 432 PF02991 0.300
LIG_LIR_Nem_3 435 441 PF02991 0.332
LIG_Pex14_2 224 228 PF04695 0.317
LIG_SH2_CRK 324 328 PF00017 0.359
LIG_SH2_CRK 95 99 PF00017 0.263
LIG_SH2_GRB2like 378 381 PF00017 0.400
LIG_SH2_NCK_1 310 314 PF00017 0.353
LIG_SH2_NCK_1 328 332 PF00017 0.275
LIG_SH2_NCK_1 393 397 PF00017 0.237
LIG_SH2_SRC 136 139 PF00017 0.229
LIG_SH2_SRC 378 381 PF00017 0.211
LIG_SH2_STAP1 119 123 PF00017 0.316
LIG_SH2_STAP1 438 442 PF00017 0.238
LIG_SH2_STAT3 127 130 PF00017 0.342
LIG_SH2_STAT3 239 242 PF00017 0.224
LIG_SH2_STAT5 136 139 PF00017 0.363
LIG_SH2_STAT5 190 193 PF00017 0.268
LIG_SH2_STAT5 234 237 PF00017 0.301
LIG_SH2_STAT5 239 242 PF00017 0.329
LIG_SH2_STAT5 272 275 PF00017 0.275
LIG_SH2_STAT5 378 381 PF00017 0.292
LIG_SH2_STAT5 438 441 PF00017 0.286
LIG_SH3_1 112 118 PF00018 0.245
LIG_SH3_3 112 118 PF00018 0.307
LIG_SH3_3 293 299 PF00018 0.368
LIG_SH3_3 303 309 PF00018 0.301
LIG_SH3_3 439 445 PF00018 0.239
LIG_SH3_3 55 61 PF00018 0.445
LIG_SUMO_SIM_anti_2 66 71 PF11976 0.343
LIG_SUMO_SIM_par_1 301 307 PF11976 0.319
LIG_TRAF2_1 388 391 PF00917 0.275
LIG_TYR_ITIM 322 327 PF00017 0.367
MOD_CDK_SPK_2 248 253 PF00069 0.286
MOD_CK1_1 143 149 PF00069 0.471
MOD_CK1_1 50 56 PF00069 0.578
MOD_CK2_1 213 219 PF00069 0.460
MOD_CK2_1 224 230 PF00069 0.389
MOD_CK2_1 278 284 PF00069 0.468
MOD_CK2_1 385 391 PF00069 0.346
MOD_CK2_1 462 468 PF00069 0.417
MOD_CMANNOS 44 47 PF00535 0.305
MOD_GlcNHglycan 100 103 PF01048 0.365
MOD_GlcNHglycan 112 115 PF01048 0.405
MOD_GlcNHglycan 163 166 PF01048 0.500
MOD_GlcNHglycan 224 227 PF01048 0.342
MOD_GlcNHglycan 292 295 PF01048 0.487
MOD_GlcNHglycan 300 303 PF01048 0.357
MOD_GlcNHglycan 318 321 PF01048 0.287
MOD_GSK3_1 11 18 PF00069 0.547
MOD_GSK3_1 139 146 PF00069 0.516
MOD_GSK3_1 149 156 PF00069 0.584
MOD_GSK3_1 222 229 PF00069 0.308
MOD_GSK3_1 298 305 PF00069 0.328
MOD_N-GLC_1 183 188 PF02516 0.392
MOD_N-GLC_1 379 384 PF02516 0.468
MOD_N-GLC_1 415 420 PF02516 0.209
MOD_NEK2_1 183 188 PF00069 0.365
MOD_NEK2_1 2 7 PF00069 0.591
MOD_NEK2_1 224 229 PF00069 0.328
MOD_NEK2_1 318 323 PF00069 0.419
MOD_NEK2_2 4 9 PF00069 0.346
MOD_PK_1 368 374 PF00069 0.372
MOD_PKA_2 11 17 PF00069 0.457
MOD_PKA_2 316 322 PF00069 0.516
MOD_PKA_2 367 373 PF00069 0.376
MOD_PKA_2 50 56 PF00069 0.521
MOD_Plk_1 415 421 PF00069 0.495
MOD_Plk_1 425 431 PF00069 0.295
MOD_Plk_1 65 71 PF00069 0.391
MOD_Plk_4 103 109 PF00069 0.318
MOD_Plk_4 265 271 PF00069 0.335
MOD_Plk_4 318 324 PF00069 0.407
MOD_Plk_4 436 442 PF00069 0.387
MOD_Plk_4 65 71 PF00069 0.478
MOD_ProDKin_1 153 159 PF00069 0.654
MOD_ProDKin_1 213 219 PF00069 0.357
MOD_ProDKin_1 248 254 PF00069 0.502
MOD_ProDKin_1 295 301 PF00069 0.404
MOD_ProDKin_1 385 391 PF00069 0.418
MOD_ProDKin_1 404 410 PF00069 0.409
MOD_ProDKin_1 452 458 PF00069 0.367
TRG_DiLeu_BaEn_1 466 471 PF01217 0.366
TRG_DiLeu_BaLyEn_6 253 258 PF01217 0.406
TRG_DiLeu_BaLyEn_6 395 400 PF01217 0.246
TRG_ENDOCYTIC_2 310 313 PF00928 0.403
TRG_ENDOCYTIC_2 324 327 PF00928 0.487
TRG_ER_diArg_1 10 13 PF00400 0.272
TRG_ER_diArg_1 191 193 PF00400 0.393
TRG_ER_diArg_1 403 406 PF00400 0.438
TRG_ER_diArg_1 77 80 PF00400 0.516
TRG_ER_diArg_1 81 83 PF00400 0.276
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 271 275 PF00026 0.301
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.413
TRG_Pf-PMV_PEXEL_1 356 360 PF00026 0.404
TRG_Pf-PMV_PEXEL_1 430 435 PF00026 0.494

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 32% 100%
A0A0N1HZ60 Leptomonas seymouri 64% 100%
A0A0N1I523 Leptomonas seymouri 29% 100%
A0A0N1I5Q2 Leptomonas seymouri 36% 95%
A0A0N1I7U8 Leptomonas seymouri 31% 100%
A0A0S4JMS7 Bodo saltans 31% 100%
A0A0S4JTS9 Bodo saltans 30% 100%
A0A1X0NEW5 Trypanosomatidae 31% 100%
A0A1X0NSK7 Trypanosomatidae 31% 100%
A0A1X0NUZ6 Trypanosomatidae 30% 100%
A0A3S5H6J1 Leishmania donovani 96% 100%
A0A3S7X2V6 Leishmania donovani 32% 100%
A0A422NB49 Trypanosoma rangeli 34% 100%
A0A422NQC5 Trypanosoma rangeli 37% 100%
A4H6L0 Leishmania braziliensis 34% 98%
A4HHU6 Leishmania braziliensis 31% 100%
A4HUZ4 Leishmania infantum 96% 100%
A4I4Z6 Leishmania infantum 32% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
Q02891 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q0VC00 Bos taurus 24% 100%
Q18610 Caenorhabditis elegans 20% 100%
Q24093 Drosophila melanogaster 23% 100%
Q3T0A0 Bos taurus 25% 100%
Q40863 Picea glauca 28% 100%
Q4Q7V8 Leishmania major 30% 98%
Q4QGZ5 Leishmania major 36% 100%
Q5RK23 Rattus norvegicus 23% 100%
Q8WU67 Homo sapiens 24% 100%
Q91ZH7 Mus musculus 24% 100%
Q96SE0 Homo sapiens 23% 100%
Q9QZC8 Mus musculus 23% 100%
V5AZF4 Trypanosoma cruzi 35% 100%
V5BBC2 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS