START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGZ1_LEIMA

TriTrypDb:

LmjF.11.0880 , LMJLV39_110015400 , LMJSD75_110016000

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGZ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	20
GO:0008289	lipid binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.371
CLV_PCSK_KEX2_1	10	12	PF00082	0.667
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.667
DEG_Nend_UBRbox_4	1	3	PF02207	0.426
DOC_CKS1_1	33	38	PF01111	0.416
DOC_MAPK_gen_1	75	84	PF00069	0.413
DOC_PP1_RVXF_1	276	282	PF00149	0.430
DOC_USP7_UBL2_3	282	286	PF12436	0.421
DOC_WW_Pin1_4	112	117	PF00397	0.418
DOC_WW_Pin1_4	155	160	PF00397	0.289
DOC_WW_Pin1_4	294	299	PF00397	0.444
DOC_WW_Pin1_4	32	37	PF00397	0.385
LIG_14-3-3_CanoR_1	141	146	PF00244	0.405
LIG_CtBP_PxDLS_1	251	255	PF00389	0.230
LIG_deltaCOP1_diTrp_1	293	301	PF00928	0.390
LIG_FHA_1	216	222	PF00498	0.245
LIG_FHA_1	253	259	PF00498	0.276
LIG_FHA_2	113	119	PF00498	0.371
LIG_FHA_2	24	30	PF00498	0.544
LIG_FHA_2	240	246	PF00498	0.258
LIG_FHA_2	62	68	PF00498	0.279
LIG_LIR_Apic_2	32	36	PF02991	0.314
LIG_LIR_Gen_1	118	128	PF02991	0.239
LIG_LIR_Gen_1	180	190	PF02991	0.284
LIG_LIR_Nem_3	118	123	PF02991	0.243
LIG_LIR_Nem_3	130	135	PF02991	0.301
LIG_LIR_Nem_3	180	185	PF02991	0.306
LIG_LIR_Nem_3	58	62	PF02991	0.297
LIG_LYPXL_SIV_4	209	217	PF13949	0.230
LIG_NRBOX	118	124	PF00104	0.405
LIG_Pex14_2	128	132	PF04695	0.289
LIG_Pex14_2	277	281	PF04695	0.443
LIG_PTAP_UEV_1	24	29	PF05743	0.391
LIG_PTB_Apo_2	162	169	PF02174	0.300
LIG_SH2_CRK	120	124	PF00017	0.300
LIG_SH2_CRK	33	37	PF00017	0.377
LIG_SH2_CRK	51	55	PF00017	0.331
LIG_SH2_NCK_1	76	80	PF00017	0.488
LIG_SH2_STAP1	290	294	PF00017	0.363
LIG_SH2_STAT3	240	243	PF00017	0.306
LIG_SH2_STAT5	182	185	PF00017	0.348
LIG_SH2_STAT5	210	213	PF00017	0.320
LIG_SH2_STAT5	220	223	PF00017	0.269
LIG_SH2_STAT5	240	243	PF00017	0.122
LIG_SH2_STAT5	257	260	PF00017	0.229
LIG_SH2_STAT5	290	293	PF00017	0.427
LIG_SH2_STAT5	60	63	PF00017	0.482
LIG_SH3_3	10	16	PF00018	0.682
LIG_SH3_3	22	28	PF00018	0.608
LIG_SUMO_SIM_par_1	250	255	PF11976	0.230
LIG_WRC_WIRS_1	59	64	PF05994	0.390
LIG_WW_1	195	198	PF00397	0.230
MOD_CK1_1	146	152	PF00069	0.355
MOD_CK1_1	215	221	PF00069	0.308
MOD_CK1_1	323	329	PF00069	0.507
MOD_CK1_1	40	46	PF00069	0.487
MOD_CK2_1	112	118	PF00069	0.450
MOD_CK2_1	23	29	PF00069	0.560
MOD_GlcNHglycan	110	113	PF01048	0.520
MOD_GlcNHglycan	145	148	PF01048	0.457
MOD_GlcNHglycan	191	194	PF01048	0.329
MOD_GlcNHglycan	229	232	PF01048	0.439
MOD_GlcNHglycan	324	328	PF01048	0.468
MOD_GlcNHglycan	39	42	PF01048	0.427
MOD_GSK3_1	108	115	PF00069	0.352
MOD_GSK3_1	185	192	PF00069	0.352
MOD_GSK3_1	19	26	PF00069	0.617
MOD_GSK3_1	61	68	PF00069	0.391
MOD_N-GLC_1	185	190	PF02516	0.291
MOD_N-GLC_1	311	316	PF02516	0.374
MOD_NEK2_1	143	148	PF00069	0.385
MOD_NEK2_1	185	190	PF00069	0.277
MOD_PIKK_1	239	245	PF00454	0.282
MOD_PIKK_1	40	46	PF00454	0.294
MOD_PKA_1	320	326	PF00069	0.487
MOD_PKA_1	87	93	PF00069	0.430
MOD_Plk_1	185	191	PF00069	0.230
MOD_Plk_1	311	317	PF00069	0.383
MOD_Plk_1	323	329	PF00069	0.432
MOD_Plk_2-3	303	309	PF00069	0.602
MOD_Plk_4	236	242	PF00069	0.269
MOD_ProDKin_1	112	118	PF00069	0.420
MOD_ProDKin_1	155	161	PF00069	0.289
MOD_ProDKin_1	294	300	PF00069	0.446
MOD_ProDKin_1	32	38	PF00069	0.391
MOD_SUMO_for_1	310	313	PF00179	0.480
MOD_SUMO_rev_2	81	90	PF00179	0.466
TRG_DiLeu_BaEn_1	118	123	PF01217	0.272
TRG_ENDOCYTIC_2	120	123	PF00928	0.309
TRG_ENDOCYTIC_2	182	185	PF00928	0.349
TRG_ER_FFAT_2	29	38	PF00635	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4D8	Leptomonas seymouri	75%	98%
A0A0S4INS4	Bodo saltans	39%	100%
A0A0S4KH88	Bodo saltans	33%	84%
A0A1X0NV84	Trypanosomatidae	53%	100%
A0A1X0P910	Trypanosomatidae	36%	87%
A0A3Q8IBA5	Leishmania donovani	94%	100%
A0A3Q8IJ21	Leishmania donovani	36%	90%
A0A3R7KCX0	Trypanosoma rangeli	37%	90%
A0A422MZR8	Trypanosoma rangeli	49%	100%
A4H6L4	Leishmania braziliensis	80%	100%
A4HHT0	Leishmania braziliensis	36%	90%
A4HUZ7	Leishmania infantum	94%	80%
A4I4Z0	Leishmania infantum	36%	90%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	89%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AED5	Leishmania major	33%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	90%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q9JMD3	Mus musculus	33%	100%
Q9Y365	Homo sapiens	34%	100%
V5BC62	Trypanosoma cruzi	39%	90%
V5DT41	Trypanosoma cruzi	50%	100%