Calmodulin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGZ0_LEIMA

TriTrypDb:

LmjF.11.0890 , LMJLV39_110015600 , LMJSD75_110016200

Length:

1012

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

Q4QGZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.535
CLV_C14_Caspase3-7	24	28	PF00656	0.701
CLV_C14_Caspase3-7	509	513	PF00656	0.539
CLV_C14_Caspase3-7	567	571	PF00656	0.355
CLV_C14_Caspase3-7	929	933	PF00656	0.741
CLV_NRD_NRD_1	633	635	PF00675	0.613
CLV_NRD_NRD_1	648	650	PF00675	0.397
CLV_NRD_NRD_1	661	663	PF00675	0.343
CLV_NRD_NRD_1	887	889	PF00675	0.437
CLV_PCSK_FUR_1	631	635	PF00082	0.641
CLV_PCSK_KEX2_1	631	633	PF00082	0.677
CLV_PCSK_KEX2_1	637	639	PF00082	0.621
CLV_PCSK_KEX2_1	648	650	PF00082	0.378
CLV_PCSK_KEX2_1	661	663	PF00082	0.343
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.652
CLV_PCSK_PC7_1	633	639	PF00082	0.660
CLV_PCSK_SKI1_1	1006	1010	PF00082	0.559
CLV_PCSK_SKI1_1	146	150	PF00082	0.643
CLV_PCSK_SKI1_1	391	395	PF00082	0.401
CLV_PCSK_SKI1_1	542	546	PF00082	0.447
CLV_PCSK_SKI1_1	583	587	PF00082	0.410
CLV_PCSK_SKI1_1	633	637	PF00082	0.558
CLV_PCSK_SKI1_1	641	645	PF00082	0.402
CLV_PCSK_SKI1_1	680	684	PF00082	0.562
CLV_PCSK_SKI1_1	832	836	PF00082	0.657
CLV_PCSK_SKI1_1	998	1002	PF00082	0.482
DEG_APCC_DBOX_1	145	153	PF00400	0.647
DEG_APCC_DBOX_1	770	778	PF00400	0.406
DEG_APCC_DBOX_1	997	1005	PF00400	0.501
DEG_SCF_TRCP1_1	492	498	PF00400	0.573
DOC_CDC14_PxL_1	850	858	PF14671	0.558
DOC_CKS1_1	17	22	PF01111	0.754
DOC_CKS1_1	8	13	PF01111	0.797
DOC_CYCLIN_RxL_1	319	327	PF00134	0.404
DOC_CYCLIN_RxL_1	445	457	PF00134	0.493
DOC_CYCLIN_RxL_1	531	541	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	747	750	PF00134	0.521
DOC_MAPK_gen_1	156	163	PF00069	0.570
DOC_MAPK_gen_1	445	455	PF00069	0.419
DOC_MAPK_gen_1	531	540	PF00069	0.447
DOC_MAPK_gen_1	996	1003	PF00069	0.536
DOC_MAPK_MEF2A_6	913	920	PF00069	0.582
DOC_MAPK_MEF2A_6	996	1005	PF00069	0.547
DOC_MAPK_NFAT4_5	996	1004	PF00069	0.543
DOC_PP1_RVXF_1	278	285	PF00149	0.585
DOC_PP2B_LxvP_1	466	469	PF13499	0.726
DOC_PP2B_LxvP_1	747	750	PF13499	0.521
DOC_PP4_FxxP_1	430	433	PF00568	0.627
DOC_USP7_MATH_1	1008	1012	PF00917	0.636
DOC_USP7_MATH_1	207	211	PF00917	0.672
DOC_USP7_MATH_1	232	236	PF00917	0.680
DOC_USP7_MATH_1	334	338	PF00917	0.571
DOC_USP7_MATH_1	367	371	PF00917	0.541
DOC_USP7_MATH_1	75	79	PF00917	0.722
DOC_USP7_MATH_1	925	929	PF00917	0.626
DOC_USP7_MATH_1	978	982	PF00917	0.682
DOC_USP7_MATH_1	985	989	PF00917	0.625
DOC_USP7_UBL2_3	391	395	PF12436	0.401
DOC_USP7_UBL2_3	637	641	PF12436	0.653
DOC_WW_Pin1_4	1006	1011	PF00397	0.450
DOC_WW_Pin1_4	16	21	PF00397	0.678
DOC_WW_Pin1_4	205	210	PF00397	0.575
DOC_WW_Pin1_4	353	358	PF00397	0.507
DOC_WW_Pin1_4	524	529	PF00397	0.493
DOC_WW_Pin1_4	63	68	PF00397	0.732
DOC_WW_Pin1_4	7	12	PF00397	0.739
DOC_WW_Pin1_4	832	837	PF00397	0.678
DOC_WW_Pin1_4	892	897	PF00397	0.593
LIG_14-3-3_CanoR_1	505	511	PF00244	0.467
LIG_14-3-3_CanoR_1	638	647	PF00244	0.554
LIG_14-3-3_CanoR_1	648	657	PF00244	0.447
LIG_14-3-3_CanoR_1	767	771	PF00244	0.548
LIG_14-3-3_CanoR_1	867	874	PF00244	0.454
LIG_BRCT_BRCA1_1	238	242	PF00533	0.704
LIG_Clathr_ClatBox_1	964	968	PF01394	0.535
LIG_deltaCOP1_diTrp_1	515	523	PF00928	0.439
LIG_FHA_1	190	196	PF00498	0.592
LIG_FHA_1	392	398	PF00498	0.404
LIG_FHA_1	413	419	PF00498	0.690
LIG_FHA_1	605	611	PF00498	0.412
LIG_FHA_1	893	899	PF00498	0.596
LIG_FHA_1	913	919	PF00498	0.250
LIG_FHA_2	247	253	PF00498	0.696
LIG_FHA_2	411	417	PF00498	0.576
LIG_FHA_2	559	565	PF00498	0.480
LIG_FHA_2	681	687	PF00498	0.472
LIG_FHA_2	767	773	PF00498	0.598
LIG_FHA_2	787	793	PF00498	0.448
LIG_FHA_2	867	873	PF00498	0.459
LIG_FHA_2	92	98	PF00498	0.703
LIG_Integrin_RGD_1	346	348	PF01839	0.683
LIG_IRF3_LxIS_1	788	794	PF10401	0.467
LIG_IRF3_LxIS_1	856	862	PF10401	0.545
LIG_LIR_Apic_2	15	20	PF02991	0.785
LIG_LIR_Apic_2	427	433	PF02991	0.635
LIG_LIR_Apic_2	668	672	PF02991	0.518
LIG_LIR_Gen_1	325	336	PF02991	0.474
LIG_LIR_Gen_1	370	381	PF02991	0.527
LIG_LIR_Gen_1	515	525	PF02991	0.426
LIG_LIR_Gen_1	673	682	PF02991	0.508
LIG_LIR_Gen_1	792	802	PF02991	0.515
LIG_LIR_Nem_3	215	221	PF02991	0.582
LIG_LIR_Nem_3	288	293	PF02991	0.532
LIG_LIR_Nem_3	325	331	PF02991	0.474
LIG_LIR_Nem_3	370	376	PF02991	0.532
LIG_LIR_Nem_3	432	437	PF02991	0.517
LIG_LIR_Nem_3	515	520	PF02991	0.457
LIG_LIR_Nem_3	673	677	PF02991	0.551
LIG_LIR_Nem_3	792	798	PF02991	0.510
LIG_MYND_3	853	857	PF01753	0.483
LIG_NRBOX	713	719	PF00104	0.491
LIG_NRBOX	776	782	PF00104	0.565
LIG_NRBOX	902	908	PF00104	0.577
LIG_PCNA_yPIPBox_3	602	611	PF02747	0.580
LIG_Pex14_1	214	218	PF04695	0.592
LIG_SH2_CRK	328	332	PF00017	0.480
LIG_SH2_CRK	532	536	PF00017	0.335
LIG_SH2_CRK	575	579	PF00017	0.447
LIG_SH2_CRK	795	799	PF00017	0.465
LIG_SH2_GRB2like	373	376	PF00017	0.525
LIG_SH2_NCK_1	328	332	PF00017	0.402
LIG_SH2_PTP2	17	20	PF00017	0.735
LIG_SH2_STAP1	272	276	PF00017	0.519
LIG_SH2_STAP1	285	289	PF00017	0.354
LIG_SH2_STAT3	530	533	PF00017	0.566
LIG_SH2_STAT3	719	722	PF00017	0.634
LIG_SH2_STAT5	17	20	PF00017	0.812
LIG_SH2_STAT5	296	299	PF00017	0.539
LIG_SH2_STAT5	373	376	PF00017	0.512
LIG_SH2_STAT5	584	587	PF00017	0.421
LIG_SH2_STAT5	669	672	PF00017	0.407
LIG_SH2_STAT5	909	912	PF00017	0.520
LIG_SH3_1	893	899	PF00018	0.596
LIG_SH3_3	133	139	PF00018	0.601
LIG_SH3_3	154	160	PF00018	0.604
LIG_SH3_3	197	203	PF00018	0.576
LIG_SH3_3	2	8	PF00018	0.736
LIG_SH3_3	415	421	PF00018	0.624
LIG_SH3_3	422	428	PF00018	0.635
LIG_SH3_3	751	757	PF00018	0.538
LIG_SH3_3	893	899	PF00018	0.596
LIG_SUMO_SIM_anti_2	561	567	PF11976	0.382
LIG_SUMO_SIM_par_1	322	327	PF11976	0.408
LIG_SUMO_SIM_par_1	564	570	PF11976	0.335
LIG_SUMO_SIM_par_1	797	803	PF11976	0.327
LIG_SUMO_SIM_par_1	857	862	PF11976	0.501
LIG_SUMO_SIM_par_1	963	968	PF11976	0.527
LIG_TRAF2_1	414	417	PF00917	0.451
LIG_TRAF2_1	470	473	PF00917	0.732
LIG_TRAF2_1	478	481	PF00917	0.745
LIG_TRAF2_1	482	485	PF00917	0.711
LIG_TRAF2_1	687	690	PF00917	0.409
LIG_TRAF2_1	710	713	PF00917	0.561
LIG_TRAF2_1	837	840	PF00917	0.613
LIG_TYR_ITIM	326	331	PF00017	0.480
LIG_TYR_ITIM	371	376	PF00017	0.533
LIG_TYR_ITIM	573	578	PF00017	0.447
LIG_TYR_ITIM	793	798	PF00017	0.470
LIG_UBA3_1	1000	1006	PF00899	0.637
LIG_WW_3	725	729	PF00397	0.519
MOD_CDC14_SPxK_1	356	359	PF00782	0.480
MOD_CDK_SPK_2	892	897	PF00069	0.509
MOD_CDK_SPxK_1	353	359	PF00069	0.496
MOD_CDK_SPxxK_3	16	23	PF00069	0.768
MOD_CDK_SPxxK_3	524	531	PF00069	0.507
MOD_CK1_1	208	214	PF00069	0.633
MOD_CK1_1	236	242	PF00069	0.704
MOD_CK1_1	337	343	PF00069	0.515
MOD_CK1_1	558	564	PF00069	0.480
MOD_CK1_1	766	772	PF00069	0.481
MOD_CK1_1	912	918	PF00069	0.561
MOD_CK1_1	986	992	PF00069	0.658
MOD_CK2_1	246	252	PF00069	0.706
MOD_CK2_1	410	416	PF00069	0.443
MOD_CK2_1	558	564	PF00069	0.480
MOD_CK2_1	649	655	PF00069	0.564
MOD_CK2_1	680	686	PF00069	0.340
MOD_CK2_1	810	816	PF00069	0.401
MOD_CK2_1	866	872	PF00069	0.468
MOD_CK2_1	960	966	PF00069	0.586
MOD_GlcNHglycan	113	116	PF01048	0.604
MOD_GlcNHglycan	146	149	PF01048	0.691
MOD_GlcNHglycan	187	190	PF01048	0.630
MOD_GlcNHglycan	235	238	PF01048	0.738
MOD_GlcNHglycan	339	342	PF01048	0.521
MOD_GlcNHglycan	403	407	PF01048	0.514
MOD_GlcNHglycan	492	495	PF01048	0.703
MOD_GlcNHglycan	625	628	PF01048	0.675
MOD_GlcNHglycan	641	644	PF01048	0.322
MOD_GlcNHglycan	651	654	PF01048	0.432
MOD_GlcNHglycan	960	963	PF01048	0.491
MOD_GlcNHglycan	980	983	PF01048	0.684
MOD_GSK3_1	12	19	PF00069	0.751
MOD_GSK3_1	185	192	PF00069	0.628
MOD_GSK3_1	232	239	PF00069	0.687
MOD_GSK3_1	555	562	PF00069	0.566
MOD_GSK3_1	600	607	PF00069	0.585
MOD_GSK3_1	872	879	PF00069	0.551
MOD_N-GLC_1	367	372	PF02516	0.426
MOD_N-GLC_1	559	564	PF02516	0.335
MOD_N-GLC_1	737	742	PF02516	0.521
MOD_N-GLC_1	817	822	PF02516	0.420
MOD_NEK2_1	324	329	PF00069	0.480
MOD_NEK2_1	37	42	PF00069	0.615
MOD_NEK2_1	538	543	PF00069	0.363
MOD_NEK2_1	665	670	PF00069	0.471
MOD_NEK2_1	706	711	PF00069	0.467
MOD_NEK2_1	763	768	PF00069	0.452
MOD_NEK2_1	791	796	PF00069	0.468
MOD_NEK2_1	817	822	PF00069	0.322
MOD_NEK2_1	859	864	PF00069	0.555
MOD_NEK2_1	878	883	PF00069	0.420
MOD_NEK2_1	919	924	PF00069	0.487
MOD_NEK2_2	285	290	PF00069	0.483
MOD_NEK2_2	367	372	PF00069	0.445
MOD_PIKK_1	246	252	PF00454	0.810
MOD_PIKK_1	73	79	PF00454	0.805
MOD_PIKK_1	775	781	PF00454	0.526
MOD_PKA_1	633	639	PF00069	0.588
MOD_PKA_2	633	639	PF00069	0.627
MOD_PKA_2	766	772	PF00069	0.546
MOD_PKA_2	866	872	PF00069	0.453
MOD_PKA_2	912	918	PF00069	0.554
MOD_PKB_1	631	639	PF00069	0.620
MOD_Plk_1	285	291	PF00069	0.484
MOD_Plk_1	324	330	PF00069	0.480
MOD_Plk_1	367	373	PF00069	0.427
MOD_Plk_1	559	565	PF00069	0.335
MOD_Plk_1	791	797	PF00069	0.473
MOD_Plk_1	938	944	PF00069	0.637
MOD_Plk_1	983	989	PF00069	0.710
MOD_Plk_4	285	291	PF00069	0.484
MOD_Plk_4	600	606	PF00069	0.470
MOD_Plk_4	665	671	PF00069	0.515
MOD_Plk_4	673	679	PF00069	0.510
MOD_Plk_4	800	806	PF00069	0.515
MOD_Plk_4	902	908	PF00069	0.577
MOD_Plk_4	919	925	PF00069	0.325
MOD_Plk_4	946	952	PF00069	0.458
MOD_Plk_4	960	966	PF00069	0.433
MOD_ProDKin_1	1006	1012	PF00069	0.463
MOD_ProDKin_1	16	22	PF00069	0.671
MOD_ProDKin_1	205	211	PF00069	0.578
MOD_ProDKin_1	353	359	PF00069	0.503
MOD_ProDKin_1	524	530	PF00069	0.496
MOD_ProDKin_1	63	69	PF00069	0.731
MOD_ProDKin_1	7	13	PF00069	0.741
MOD_ProDKin_1	832	838	PF00069	0.670
MOD_ProDKin_1	892	898	PF00069	0.588
TRG_DiLeu_BaEn_1	713	718	PF01217	0.566
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.516
TRG_DiLeu_BaLyEn_6	995	1000	PF01217	0.479
TRG_ENDOCYTIC_2	218	221	PF00928	0.571
TRG_ENDOCYTIC_2	31	34	PF00928	0.551
TRG_ENDOCYTIC_2	328	331	PF00928	0.480
TRG_ENDOCYTIC_2	373	376	PF00928	0.525
TRG_ENDOCYTIC_2	434	437	PF00928	0.486
TRG_ENDOCYTIC_2	532	535	PF00928	0.413
TRG_ENDOCYTIC_2	575	578	PF00928	0.447
TRG_ENDOCYTIC_2	795	798	PF00928	0.464
TRG_ER_diArg_1	631	634	PF00400	0.679
TRG_ER_diArg_1	647	649	PF00400	0.397
TRG_ER_diArg_1	660	662	PF00400	0.353
TRG_NES_CRM1_1	259	273	PF08389	0.518
TRG_NES_CRM1_1	852	865	PF08389	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE6	Leptomonas seymouri	52%	97%
A0A1X0NWD9	Trypanosomatidae	33%	100%
A0A3S7WRP9	Leishmania donovani	92%	100%
A0A422MZT7	Trypanosoma rangeli	33%	100%
A4H6L5	Leishmania braziliensis	81%	100%
A4HUZ8	Leishmania infantum	93%	100%
D0A7F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ANN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5C1B4	Trypanosoma cruzi	33%	100%