PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Short C-terminal domain/PUB domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGY7_LEIMA

TriTrypDb:

LmjF.11.0920 , LMJLV39_110015900 , LMJSD75_110016500

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.744
CLV_C14_Caspase3-7	370	374	PF00656	0.581
CLV_C14_Caspase3-7	477	481	PF00656	0.571
CLV_NRD_NRD_1	19	21	PF00675	0.628
CLV_NRD_NRD_1	200	202	PF00675	0.410
CLV_NRD_NRD_1	287	289	PF00675	0.531
CLV_NRD_NRD_1	496	498	PF00675	0.567
CLV_NRD_NRD_1	528	530	PF00675	0.597
CLV_NRD_NRD_1	553	555	PF00675	0.720
CLV_NRD_NRD_1	557	559	PF00675	0.756
CLV_NRD_NRD_1	564	566	PF00675	0.788
CLV_PCSK_FUR_1	17	21	PF00082	0.472
CLV_PCSK_FUR_1	494	498	PF00082	0.632
CLV_PCSK_FUR_1	526	530	PF00082	0.694
CLV_PCSK_KEX2_1	19	21	PF00082	0.714
CLV_PCSK_KEX2_1	200	202	PF00082	0.353
CLV_PCSK_KEX2_1	287	289	PF00082	0.533
CLV_PCSK_KEX2_1	496	498	PF00082	0.577
CLV_PCSK_KEX2_1	523	525	PF00082	0.552
CLV_PCSK_KEX2_1	528	530	PF00082	0.562
CLV_PCSK_KEX2_1	552	554	PF00082	0.708
CLV_PCSK_KEX2_1	557	559	PF00082	0.689
CLV_PCSK_KEX2_1	564	566	PF00082	0.638
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.673
CLV_PCSK_PC7_1	519	525	PF00082	0.688
CLV_PCSK_PC7_1	553	559	PF00082	0.783
CLV_PCSK_SKI1_1	13	17	PF00082	0.613
CLV_PCSK_SKI1_1	25	29	PF00082	0.509
CLV_PCSK_SKI1_1	59	63	PF00082	0.473
CLV_PCSK_SKI1_1	64	68	PF00082	0.486
DEG_APCC_DBOX_1	313	321	PF00400	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SCF_FBW7_1	156	162	PF00400	0.532
DEG_SCF_FBW7_1	475	482	PF00400	0.686
DEG_SPOP_SBC_1	29	33	PF00917	0.537
DEG_SPOP_SBC_1	566	570	PF00917	0.809
DEG_SPOP_SBC_1	615	619	PF00917	0.819
DOC_CKS1_1	156	161	PF01111	0.524
DOC_MAPK_MEF2A_6	266	273	PF00069	0.340
DOC_MAPK_MEF2A_6	296	304	PF00069	0.569
DOC_MAPK_MEF2A_6	422	429	PF00069	0.501
DOC_PP2B_LxvP_1	120	123	PF13499	0.809
DOC_PP4_FxxP_1	436	439	PF00568	0.683
DOC_PP4_MxPP_1	606	609	PF00568	0.544
DOC_USP7_MATH_1	103	107	PF00917	0.646
DOC_USP7_MATH_1	125	129	PF00917	0.732
DOC_USP7_MATH_1	138	142	PF00917	0.656
DOC_USP7_MATH_1	154	158	PF00917	0.554
DOC_USP7_MATH_1	161	165	PF00917	0.715
DOC_USP7_MATH_1	217	221	PF00917	0.501
DOC_USP7_MATH_1	238	242	PF00917	0.690
DOC_USP7_MATH_1	29	33	PF00917	0.679
DOC_USP7_MATH_1	400	404	PF00917	0.579
DOC_USP7_MATH_1	449	453	PF00917	0.739
DOC_USP7_MATH_1	479	483	PF00917	0.676
DOC_USP7_MATH_1	514	518	PF00917	0.602
DOC_USP7_MATH_1	566	570	PF00917	0.827
DOC_USP7_MATH_1	615	619	PF00917	0.721
DOC_USP7_MATH_1	80	84	PF00917	0.713
DOC_USP7_MATH_1	91	95	PF00917	0.729
DOC_USP7_UBL2_3	333	337	PF12436	0.592
DOC_WW_Pin1_4	105	110	PF00397	0.671
DOC_WW_Pin1_4	121	126	PF00397	0.710
DOC_WW_Pin1_4	127	132	PF00397	0.756
DOC_WW_Pin1_4	155	160	PF00397	0.572
DOC_WW_Pin1_4	312	317	PF00397	0.801
DOC_WW_Pin1_4	350	355	PF00397	0.737
DOC_WW_Pin1_4	475	480	PF00397	0.470
DOC_WW_Pin1_4	604	609	PF00397	0.706
DOC_WW_Pin1_4	87	92	PF00397	0.724
LIG_14-3-3_CanoR_1	140	145	PF00244	0.612
LIG_14-3-3_CanoR_1	592	602	PF00244	0.700
LIG_BIR_III_4	115	119	PF00653	0.748
LIG_BRCT_BRCA1_1	140	144	PF00533	0.667
LIG_CaM_IQ_9	489	505	PF13499	0.560
LIG_deltaCOP1_diTrp_1	145	151	PF00928	0.537
LIG_EVH1_2	169	173	PF00568	0.600
LIG_FHA_1	151	157	PF00498	0.633
LIG_FHA_1	409	415	PF00498	0.612
LIG_FHA_1	441	447	PF00498	0.768
LIG_FHA_1	468	474	PF00498	0.681
LIG_FHA_1	594	600	PF00498	0.607
LIG_FHA_2	110	116	PF00498	0.765
LIG_FHA_2	141	147	PF00498	0.555
LIG_FHA_2	365	371	PF00498	0.552
LIG_FHA_2	463	469	PF00498	0.642
LIG_FHA_2	49	55	PF00498	0.534
LIG_FHA_2	584	590	PF00498	0.754
LIG_GBD_Chelix_1	269	277	PF00786	0.414
LIG_LIR_Gen_1	373	382	PF02991	0.582
LIG_LIR_Nem_3	145	150	PF02991	0.543
LIG_LIR_Nem_3	196	202	PF02991	0.364
LIG_LIR_Nem_3	225	229	PF02991	0.462
LIG_LIR_Nem_3	413	418	PF02991	0.559
LIG_NRBOX	182	188	PF00104	0.501
LIG_SH2_CRK	199	203	PF00017	0.376
LIG_SH2_CRK	415	419	PF00017	0.552
LIG_SH2_NCK_1	389	393	PF00017	0.607
LIG_SH2_SRC	389	392	PF00017	0.545
LIG_SH2_STAP1	389	393	PF00017	0.626
LIG_SH2_STAP1	469	473	PF00017	0.609
LIG_SH2_STAT3	289	292	PF00017	0.682
LIG_SH2_STAT3	469	472	PF00017	0.688
LIG_SH2_STAT5	111	114	PF00017	0.758
LIG_SH2_STAT5	2	5	PF00017	0.520
LIG_SH2_STAT5	280	283	PF00017	0.529
LIG_SH2_STAT5	361	364	PF00017	0.516
LIG_SH2_STAT5	366	369	PF00017	0.487
LIG_SH2_STAT5	469	472	PF00017	0.616
LIG_SH3_1	191	197	PF00018	0.307
LIG_SH3_3	119	125	PF00018	0.742
LIG_SH3_3	153	159	PF00018	0.473
LIG_SH3_3	191	197	PF00018	0.501
LIG_SH3_3	318	324	PF00018	0.665
LIG_SH3_3	349	355	PF00018	0.666
LIG_SUMO_SIM_anti_2	596	603	PF11976	0.656
LIG_TRAF2_1	143	146	PF00917	0.537
LIG_TRAF2_1	51	54	PF00917	0.543
LIG_WRC_WIRS_1	223	228	PF05994	0.462
LIG_WRC_WIRS_1	63	68	PF05994	0.576
MOD_CK1_1	105	111	PF00069	0.741
MOD_CK1_1	132	138	PF00069	0.688
MOD_CK1_1	164	170	PF00069	0.679
MOD_CK1_1	346	352	PF00069	0.755
MOD_CK1_1	4	10	PF00069	0.606
MOD_CK1_1	404	410	PF00069	0.590
MOD_CK1_1	568	574	PF00069	0.732
MOD_CK1_1	575	581	PF00069	0.680
MOD_CK1_1	607	613	PF00069	0.724
MOD_CK1_1	65	71	PF00069	0.572
MOD_CK1_1	83	89	PF00069	0.773
MOD_CK1_1	94	100	PF00069	0.827
MOD_CK2_1	140	146	PF00069	0.565
MOD_CK2_1	212	218	PF00069	0.501
MOD_CK2_1	364	370	PF00069	0.571
MOD_CK2_1	48	54	PF00069	0.519
MOD_CK2_1	538	544	PF00069	0.606
MOD_CK2_1	583	589	PF00069	0.748
MOD_CK2_1	83	89	PF00069	0.796
MOD_GlcNHglycan	105	108	PF01048	0.756
MOD_GlcNHglycan	127	130	PF01048	0.728
MOD_GlcNHglycan	166	169	PF01048	0.766
MOD_GlcNHglycan	218	222	PF01048	0.378
MOD_GlcNHglycan	240	243	PF01048	0.687
MOD_GlcNHglycan	345	348	PF01048	0.773
MOD_GlcNHglycan	458	461	PF01048	0.574
MOD_GlcNHglycan	534	537	PF01048	0.733
MOD_GlcNHglycan	538	543	PF01048	0.696
MOD_GlcNHglycan	574	577	PF01048	0.751
MOD_GlcNHglycan	75	78	PF01048	0.711
MOD_GlcNHglycan	83	86	PF01048	0.692
MOD_GSK3_1	105	112	PF00069	0.657
MOD_GSK3_1	121	128	PF00069	0.750
MOD_GSK3_1	132	139	PF00069	0.795
MOD_GSK3_1	150	157	PF00069	0.571
MOD_GSK3_1	236	243	PF00069	0.773
MOD_GSK3_1	346	353	PF00069	0.721
MOD_GSK3_1	400	407	PF00069	0.610
MOD_GSK3_1	449	456	PF00069	0.720
MOD_GSK3_1	475	482	PF00069	0.453
MOD_GSK3_1	565	572	PF00069	0.725
MOD_GSK3_1	574	581	PF00069	0.751
MOD_GSK3_1	604	611	PF00069	0.721
MOD_GSK3_1	81	88	PF00069	0.804
MOD_GSK3_1	91	98	PF00069	0.815
MOD_LATS_1	550	556	PF00433	0.787
MOD_LATS_1	563	569	PF00433	0.566
MOD_N-GLC_1	103	108	PF02516	0.781
MOD_N-GLC_1	125	130	PF02516	0.739
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	150	155	PF00069	0.552
MOD_NEK2_1	28	33	PF00069	0.736
MOD_NEK2_1	294	299	PF00069	0.595
MOD_NEK2_1	375	380	PF00069	0.533
MOD_NEK2_1	447	452	PF00069	0.677
MOD_NEK2_1	455	460	PF00069	0.787
MOD_NEK2_1	462	467	PF00069	0.609
MOD_NEK2_1	96	101	PF00069	0.634
MOD_NEK2_2	514	519	PF00069	0.603
MOD_PIKK_1	19	25	PF00454	0.548
MOD_PIKK_1	440	446	PF00454	0.686
MOD_PIKK_1	48	54	PF00454	0.675
MOD_PIKK_1	543	549	PF00454	0.675
MOD_PKA_1	19	25	PF00069	0.545
MOD_PKA_1	552	558	PF00069	0.791
MOD_PKA_2	19	25	PF00069	0.545
MOD_PKA_2	202	208	PF00069	0.424
MOD_PKA_2	552	558	PF00069	0.739
MOD_PKB_1	17	25	PF00069	0.471
MOD_Plk_1	467	473	PF00069	0.694
MOD_Plk_1	514	520	PF00069	0.603
MOD_Plk_2-3	212	218	PF00069	0.501
MOD_Plk_2-3	364	370	PF00069	0.571
MOD_Plk_4	357	363	PF00069	0.639
MOD_Plk_4	404	410	PF00069	0.585
MOD_Plk_4	450	456	PF00069	0.660
MOD_ProDKin_1	105	111	PF00069	0.674
MOD_ProDKin_1	121	127	PF00069	0.712
MOD_ProDKin_1	155	161	PF00069	0.584
MOD_ProDKin_1	312	318	PF00069	0.803
MOD_ProDKin_1	350	356	PF00069	0.729
MOD_ProDKin_1	475	481	PF00069	0.463
MOD_ProDKin_1	604	610	PF00069	0.711
MOD_ProDKin_1	87	93	PF00069	0.727
MOD_SUMO_for_1	522	525	PF00179	0.673
MOD_SUMO_rev_2	141	150	PF00179	0.551
MOD_SUMO_rev_2	53	61	PF00179	0.586
TRG_DiLeu_BaEn_4	145	151	PF01217	0.518
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.501
TRG_ENDOCYTIC_2	199	202	PF00928	0.426
TRG_ENDOCYTIC_2	415	418	PF00928	0.577
TRG_ER_diArg_1	199	201	PF00400	0.410
TRG_ER_diArg_1	287	289	PF00400	0.533
TRG_ER_diArg_1	494	497	PF00400	0.604
TRG_ER_diArg_1	526	529	PF00400	0.583
TRG_ER_diArg_1	552	554	PF00400	0.732
TRG_NES_CRM1_1	292	305	PF08389	0.629
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ9	Leptomonas seymouri	42%	100%
A0A3S7WRQ6	Leishmania donovani	90%	100%
A4H6L8	Leishmania braziliensis	72%	100%
A4HV01	Leishmania infantum	91%	100%
D0A7E7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ANN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%