SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGY6_LEIMA

TriTrypDb:

LmjF.11.0930 , LMJLV39_110016300 , LMJSD75_110016900

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.474
CLV_NRD_NRD_1	20	22	PF00675	0.584
CLV_NRD_NRD_1	341	343	PF00675	0.650
CLV_NRD_NRD_1	354	356	PF00675	0.674
CLV_NRD_NRD_1	357	359	PF00675	0.702
CLV_NRD_NRD_1	49	51	PF00675	0.585
CLV_NRD_NRD_1	83	85	PF00675	0.587
CLV_PCSK_FUR_1	338	342	PF00082	0.702
CLV_PCSK_FUR_1	355	359	PF00082	0.600
CLV_PCSK_KEX2_1	279	281	PF00082	0.553
CLV_PCSK_KEX2_1	308	310	PF00082	0.696
CLV_PCSK_KEX2_1	340	342	PF00082	0.647
CLV_PCSK_KEX2_1	354	356	PF00082	0.652
CLV_PCSK_KEX2_1	357	359	PF00082	0.658
CLV_PCSK_KEX2_1	49	51	PF00082	0.599
CLV_PCSK_KEX2_1	83	85	PF00082	0.600
CLV_PCSK_KEX2_1	87	89	PF00082	0.550
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.538
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.696
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.600
CLV_PCSK_PC7_1	83	89	PF00082	0.539
CLV_PCSK_SKI1_1	119	123	PF00082	0.474
CLV_PCSK_SKI1_1	159	163	PF00082	0.668
CLV_PCSK_SKI1_1	172	176	PF00082	0.720
CLV_PCSK_SKI1_1	308	312	PF00082	0.687
CLV_Separin_Metazoa	64	68	PF03568	0.463
DEG_SPOP_SBC_1	54	58	PF00917	0.512
DOC_CKS1_1	289	294	PF01111	0.482
DOC_CYCLIN_yClb5_NLxxxL_5	22	30	PF00134	0.627
DOC_MAPK_gen_1	21	28	PF00069	0.623
DOC_MAPK_MEF2A_6	21	30	PF00069	0.627
DOC_MAPK_NFAT4_5	21	29	PF00069	0.608
DOC_USP7_MATH_1	20	24	PF00917	0.579
DOC_USP7_MATH_1	247	251	PF00917	0.523
DOC_USP7_MATH_1	298	302	PF00917	0.648
DOC_USP7_MATH_1	327	331	PF00917	0.639
DOC_USP7_UBL2_3	132	136	PF12436	0.604
DOC_USP7_UBL2_3	184	188	PF12436	0.707
DOC_USP7_UBL2_3	311	315	PF12436	0.683
DOC_WW_Pin1_4	233	238	PF00397	0.712
DOC_WW_Pin1_4	288	293	PF00397	0.477
DOC_WW_Pin1_4	318	323	PF00397	0.743
DOC_WW_Pin1_4	333	338	PF00397	0.621
DOC_WW_Pin1_4	66	71	PF00397	0.494
LIG_14-3-3_CanoR_1	272	277	PF00244	0.511
LIG_14-3-3_CanoR_1	302	306	PF00244	0.494
LIG_FHA_1	234	240	PF00498	0.658
LIG_FHA_1	25	31	PF00498	0.578
LIG_FHA_1	289	295	PF00498	0.654
LIG_FHA_1	55	61	PF00498	0.601
LIG_FHA_2	177	183	PF00498	0.607
LIG_LIR_Gen_1	154	161	PF02991	0.653
LIG_LIR_Gen_1	254	265	PF02991	0.621
LIG_LIR_Gen_1	61	70	PF02991	0.583
LIG_LIR_Nem_3	154	160	PF02991	0.600
LIG_LIR_Nem_3	164	170	PF02991	0.537
LIG_LIR_Nem_3	254	260	PF02991	0.528
LIG_LIR_Nem_3	61	65	PF02991	0.517
LIG_LIR_Nem_3	69	75	PF02991	0.484
LIG_NRP_CendR_1	374	377	PF00754	0.645
LIG_SH2_PTP2	257	260	PF00017	0.614
LIG_SH2_STAT5	257	260	PF00017	0.551
LIG_SH2_STAT5	265	268	PF00017	0.492
LIG_SH3_1	150	156	PF00018	0.646
LIG_SH3_3	150	156	PF00018	0.698
LIG_SH3_3	222	228	PF00018	0.645
LIG_SH3_3	255	261	PF00018	0.575
LIG_SH3_3	282	288	PF00018	0.559
LIG_SH3_4	311	318	PF00018	0.683
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.629
LIG_TRAF2_1	121	124	PF00917	0.557
LIG_TRAF2_1	144	147	PF00917	0.630
LIG_TRAF2_1	217	220	PF00917	0.491
LIG_TRAF2_1	261	264	PF00917	0.502
MOD_CDK_SPK_2	333	338	PF00069	0.721
MOD_CDK_SPK_2	66	71	PF00069	0.480
MOD_CDK_SPxxK_3	333	340	PF00069	0.611
MOD_CK1_1	251	257	PF00069	0.592
MOD_CK1_1	301	307	PF00069	0.581
MOD_CK1_1	336	342	PF00069	0.636
MOD_CK1_1	34	40	PF00069	0.541
MOD_CK1_1	370	376	PF00069	0.681
MOD_CK2_1	176	182	PF00069	0.593
MOD_CK2_1	184	190	PF00069	0.625
MOD_CK2_1	214	220	PF00069	0.521
MOD_CK2_1	345	351	PF00069	0.708
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.606
MOD_GlcNHglycan	216	219	PF01048	0.539
MOD_GlcNHglycan	268	271	PF01048	0.592
MOD_GlcNHglycan	280	283	PF01048	0.551
MOD_GlcNHglycan	33	36	PF01048	0.540
MOD_GlcNHglycan	51	54	PF01048	0.552
MOD_GlcNHglycan	57	60	PF01048	0.527
MOD_GlcNHglycan	75	78	PF01048	0.427
MOD_GSK3_1	191	198	PF00069	0.693
MOD_GSK3_1	199	206	PF00069	0.660
MOD_GSK3_1	20	27	PF00069	0.601
MOD_GSK3_1	228	235	PF00069	0.692
MOD_GSK3_1	247	254	PF00069	0.423
MOD_GSK3_1	30	37	PF00069	0.400
MOD_GSK3_1	327	334	PF00069	0.721
MOD_GSK3_1	336	343	PF00069	0.715
MOD_GSK3_1	346	353	PF00069	0.680
MOD_GSK3_1	49	56	PF00069	0.550
MOD_N-GLC_1	24	29	PF02516	0.639
MOD_N-GLC_1	31	36	PF02516	0.604
MOD_N-GLC_1	318	323	PF02516	0.711
MOD_NEK2_1	232	237	PF00069	0.627
MOD_NEK2_1	30	35	PF00069	0.495
MOD_NEK2_1	65	70	PF00069	0.470
MOD_PK_1	272	278	PF00069	0.614
MOD_PKA_1	278	284	PF00069	0.545
MOD_PKA_1	340	346	PF00069	0.702
MOD_PKA_1	49	55	PF00069	0.610
MOD_PKA_2	20	26	PF00069	0.644
MOD_PKA_2	301	307	PF00069	0.552
MOD_PKA_2	340	346	PF00069	0.707
MOD_PKA_2	370	376	PF00069	0.657
MOD_PKA_2	49	55	PF00069	0.609
MOD_PKB_1	338	346	PF00069	0.719
MOD_Plk_1	162	168	PF00069	0.568
MOD_Plk_1	24	30	PF00069	0.643
MOD_Plk_1	263	269	PF00069	0.500
MOD_Plk_4	253	259	PF00069	0.623
MOD_Plk_4	272	278	PF00069	0.614
MOD_ProDKin_1	233	239	PF00069	0.710
MOD_ProDKin_1	288	294	PF00069	0.480
MOD_ProDKin_1	318	324	PF00069	0.743
MOD_ProDKin_1	333	339	PF00069	0.619
MOD_ProDKin_1	66	72	PF00069	0.496
MOD_SUMO_for_1	161	164	PF00179	0.649
MOD_SUMO_for_1	183	186	PF00179	0.698
MOD_SUMO_rev_2	171	177	PF00179	0.691
MOD_SUMO_rev_2	178	185	PF00179	0.717
TRG_DiLeu_BaEn_1	220	225	PF01217	0.508
TRG_DiLeu_BaEn_2	146	152	PF01217	0.652
TRG_ENDOCYTIC_2	257	260	PF00928	0.614
TRG_ER_diArg_1	337	340	PF00400	0.637
TRG_ER_diArg_1	354	357	PF00400	0.670
TRG_ER_diArg_1	82	84	PF00400	0.585
TRG_NLS_MonoExtC_3	307	312	PF00514	0.678
TRG_NLS_MonoExtN_4	306	312	PF00514	0.621
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D2	Leptomonas seymouri	55%	84%
A0A1X0NWL9	Trypanosomatidae	33%	80%
A0A3R7LWS6	Trypanosoma rangeli	34%	81%
A0A3S7WRS1	Leishmania donovani	95%	100%
A4H6L9	Leishmania braziliensis	86%	100%
A4HV02	Leishmania infantum	95%	100%
E9ANN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DT45	Trypanosoma cruzi	36%	81%