LeishMANIAdb
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Ski2_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ski2_N domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QGY4_LEIMA
TriTrypDb:
LmjF.11.0950 * , LMJLV39_110016500 * , LMJSD75_110017100 *
Length:
413

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGY4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGY4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.598
CLV_C14_Caspase3-7 398 402 PF00656 0.514
CLV_C14_Caspase3-7 57 61 PF00656 0.541
CLV_NRD_NRD_1 191 193 PF00675 0.486
CLV_NRD_NRD_1 204 206 PF00675 0.552
CLV_NRD_NRD_1 213 215 PF00675 0.525
CLV_NRD_NRD_1 304 306 PF00675 0.616
CLV_NRD_NRD_1 39 41 PF00675 0.593
CLV_PCSK_KEX2_1 204 206 PF00082 0.552
CLV_PCSK_KEX2_1 213 215 PF00082 0.525
CLV_PCSK_KEX2_1 304 306 PF00082 0.642
CLV_PCSK_KEX2_1 309 311 PF00082 0.654
CLV_PCSK_KEX2_1 39 41 PF00082 0.585
CLV_PCSK_PC1ET2_1 309 311 PF00082 0.755
CLV_PCSK_PC7_1 305 311 PF00082 0.565
CLV_PCSK_SKI1_1 214 218 PF00082 0.506
CLV_PCSK_SKI1_1 46 50 PF00082 0.606
DEG_SPOP_SBC_1 3 7 PF00917 0.617
DEG_SPOP_SBC_1 91 95 PF00917 0.502
DOC_CKS1_1 104 109 PF01111 0.494
DOC_MAPK_gen_1 192 202 PF00069 0.535
DOC_MAPK_gen_1 210 220 PF00069 0.503
DOC_MAPK_HePTP_8 190 202 PF00069 0.431
DOC_MAPK_MEF2A_6 193 202 PF00069 0.439
DOC_MAPK_MEF2A_6 213 222 PF00069 0.459
DOC_USP7_MATH_1 19 23 PF00917 0.513
DOC_USP7_MATH_1 235 239 PF00917 0.746
DOC_USP7_MATH_1 3 7 PF00917 0.608
DOC_WW_Pin1_4 103 108 PF00397 0.521
DOC_WW_Pin1_4 141 146 PF00397 0.613
LIG_BIR_II_1 1 5 PF00653 0.511
LIG_deltaCOP1_diTrp_1 109 113 PF00928 0.534
LIG_EH_1 74 78 PF12763 0.491
LIG_FHA_1 147 153 PF00498 0.459
LIG_FHA_1 377 383 PF00498 0.668
LIG_FHA_2 104 110 PF00498 0.560
LIG_FHA_2 112 118 PF00498 0.609
LIG_LIR_Gen_1 109 117 PF02991 0.536
LIG_LIR_Gen_1 272 282 PF02991 0.581
LIG_LIR_Nem_3 109 113 PF02991 0.534
LIG_LIR_Nem_3 272 278 PF02991 0.586
LIG_LIR_Nem_3 81 86 PF02991 0.650
LIG_PDZ_Class_3 408 413 PF00595 0.648
LIG_Pex14_2 48 52 PF04695 0.543
LIG_SH2_CRK 275 279 PF00017 0.585
LIG_SH2_NCK_1 275 279 PF00017 0.639
LIG_SH2_STAT5 299 302 PF00017 0.613
LIG_SH2_STAT5 47 50 PF00017 0.558
LIG_SH3_1 205 211 PF00018 0.526
LIG_SH3_2 142 147 PF14604 0.556
LIG_SH3_2 208 213 PF14604 0.517
LIG_SH3_3 101 107 PF00018 0.613
LIG_SH3_3 139 145 PF00018 0.565
LIG_SH3_3 165 171 PF00018 0.478
LIG_SH3_3 179 185 PF00018 0.371
LIG_SH3_3 203 209 PF00018 0.567
LIG_SH3_3 215 221 PF00018 0.572
LIG_SH3_3 70 76 PF00018 0.575
LIG_SUMO_SIM_anti_2 280 287 PF11976 0.581
LIG_SUMO_SIM_par_1 175 181 PF11976 0.504
LIG_SUMO_SIM_par_1 244 249 PF11976 0.481
LIG_WW_3 207 211 PF00397 0.520
LIG_WW_3 41 45 PF00397 0.518
MOD_CDC14_SPxK_1 144 147 PF00782 0.602
MOD_CDK_SPxK_1 141 147 PF00069 0.613
MOD_CK1_1 14 20 PF00069 0.721
MOD_CK1_1 2 8 PF00069 0.622
MOD_CK1_1 280 286 PF00069 0.603
MOD_CK2_1 103 109 PF00069 0.531
MOD_CK2_1 122 128 PF00069 0.587
MOD_CK2_1 225 231 PF00069 0.550
MOD_CK2_1 60 66 PF00069 0.541
MOD_Cter_Amidation 302 305 PF01082 0.573
MOD_GlcNHglycan 1 4 PF01048 0.635
MOD_GlcNHglycan 121 125 PF01048 0.636
MOD_GlcNHglycan 128 132 PF01048 0.636
MOD_GlcNHglycan 13 16 PF01048 0.715
MOD_GlcNHglycan 227 230 PF01048 0.605
MOD_GlcNHglycan 271 274 PF01048 0.638
MOD_GlcNHglycan 279 282 PF01048 0.573
MOD_GlcNHglycan 301 304 PF01048 0.703
MOD_GlcNHglycan 329 332 PF01048 0.602
MOD_GlcNHglycan 336 340 PF01048 0.593
MOD_GSK3_1 13 20 PF00069 0.622
MOD_GSK3_1 269 276 PF00069 0.641
MOD_GSK3_1 343 350 PF00069 0.733
MOD_GSK3_1 56 63 PF00069 0.532
MOD_N-GLC_1 20 25 PF02516 0.551
MOD_NEK2_1 246 251 PF00069 0.571
MOD_NEK2_1 308 313 PF00069 0.540
MOD_NEK2_1 327 332 PF00069 0.582
MOD_NEK2_1 335 340 PF00069 0.592
MOD_NEK2_2 161 166 PF00069 0.368
MOD_PKA_2 11 17 PF00069 0.645
MOD_PKA_2 117 123 PF00069 0.643
MOD_PKA_2 146 152 PF00069 0.584
MOD_PKA_2 188 194 PF00069 0.475
MOD_Plk_1 127 133 PF00069 0.592
MOD_Plk_1 172 178 PF00069 0.444
MOD_Plk_1 246 252 PF00069 0.570
MOD_Plk_2-3 60 66 PF00069 0.541
MOD_Plk_4 280 286 PF00069 0.629
MOD_ProDKin_1 103 109 PF00069 0.522
MOD_ProDKin_1 141 147 PF00069 0.613
MOD_SUMO_for_1 102 105 PF00179 0.599
MOD_SUMO_for_1 132 135 PF00179 0.598
MOD_SUMO_rev_2 291 300 PF00179 0.560
TRG_DiLeu_BaLyEn_6 323 328 PF01217 0.590
TRG_ENDOCYTIC_2 275 278 PF00928 0.649
TRG_ENDOCYTIC_2 79 82 PF00928 0.499
TRG_ER_diArg_1 198 201 PF00400 0.520
TRG_ER_diArg_1 204 206 PF00400 0.552
TRG_ER_diArg_1 212 214 PF00400 0.523
TRG_ER_diArg_1 39 41 PF00400 0.548
TRG_ER_diArg_1 43 46 PF00400 0.522
TRG_NLS_MonoExtC_3 308 314 PF00514 0.626

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6I1 Leptomonas seymouri 47% 79%
A0A3Q8IHH5 Leishmania donovani 90% 100%
A4H6M1 Leishmania braziliensis 74% 80%
A4HV04 Leishmania infantum 90% 100%
E9ANN9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS