HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QGY1_LEIMA

TriTrypDb:

LmjF.11.0980 , LMJLV39_110016900 , LMJSD75_110017400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	2
GO:0000812	Swr1 complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0070603	SWI/SNF superfamily-type complex	3	2
GO:0097346	INO80-type complex	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1904949	ATPase complex	3	2
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QGY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0031491	nucleosome binding	3	2
GO:0044877	protein-containing complex binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.597
CLV_NRD_NRD_1	164	166	PF00675	0.755
CLV_NRD_NRD_1	172	174	PF00675	0.752
CLV_NRD_NRD_1	207	209	PF00675	0.679
CLV_NRD_NRD_1	217	219	PF00675	0.593
CLV_NRD_NRD_1	237	239	PF00675	0.689
CLV_NRD_NRD_1	300	302	PF00675	0.712
CLV_NRD_NRD_1	348	350	PF00675	0.673
CLV_NRD_NRD_1	368	370	PF00675	0.494
CLV_NRD_NRD_1	402	404	PF00675	0.671
CLV_NRD_NRD_1	405	407	PF00675	0.660
CLV_NRD_NRD_1	87	89	PF00675	0.638
CLV_PCSK_FUR_1	403	407	PF00082	0.684
CLV_PCSK_KEX2_1	164	166	PF00082	0.762
CLV_PCSK_KEX2_1	171	173	PF00082	0.754
CLV_PCSK_KEX2_1	207	209	PF00082	0.679
CLV_PCSK_KEX2_1	219	221	PF00082	0.570
CLV_PCSK_KEX2_1	34	36	PF00082	0.557
CLV_PCSK_KEX2_1	348	350	PF00082	0.673
CLV_PCSK_KEX2_1	368	370	PF00082	0.494
CLV_PCSK_KEX2_1	404	406	PF00082	0.684
CLV_PCSK_KEX2_1	83	85	PF00082	0.765
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.562
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.676
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.557
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.684
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.636
CLV_PCSK_SKI1_1	271	275	PF00082	0.532
CLV_PCSK_SKI1_1	353	357	PF00082	0.672
CLV_PCSK_SKI1_1	461	465	PF00082	0.332
CLV_PCSK_SKI1_1	478	482	PF00082	0.388
DEG_SCF_TRCP1_1	413	418	PF00400	0.613
DEG_SPOP_SBC_1	296	300	PF00917	0.684
DEG_SPOP_SBC_1	372	376	PF00917	0.549
DOC_ANK_TNKS_1	207	214	PF00023	0.630
DOC_CYCLIN_RxL_1	474	483	PF00134	0.527
DOC_MAPK_gen_1	258	265	PF00069	0.516
DOC_PP1_RVXF_1	476	483	PF00149	0.548
DOC_PP4_FxxP_1	393	396	PF00568	0.544
DOC_PP4_FxxP_1	428	431	PF00568	0.639
DOC_PP4_FxxP_1	52	55	PF00568	0.597
DOC_USP7_MATH_1	187	191	PF00917	0.646
DOC_USP7_MATH_1	243	247	PF00917	0.627
DOC_USP7_MATH_1	251	255	PF00917	0.511
DOC_USP7_MATH_1	294	298	PF00917	0.754
DOC_USP7_MATH_1	306	310	PF00917	0.622
DOC_USP7_MATH_1	367	371	PF00917	0.679
DOC_USP7_MATH_1	373	377	PF00917	0.623
DOC_USP7_MATH_1	41	45	PF00917	0.584
DOC_USP7_MATH_1	55	59	PF00917	0.512
DOC_WW_Pin1_4	283	288	PF00397	0.628
LIG_14-3-3_CanoR_1	19	27	PF00244	0.553
LIG_14-3-3_CanoR_1	301	308	PF00244	0.763
LIG_14-3-3_CanoR_1	353	361	PF00244	0.680
LIG_14-3-3_CanoR_1	368	372	PF00244	0.587
LIG_14-3-3_CanoR_1	459	468	PF00244	0.532
LIG_14-3-3_CanoR_1	92	99	PF00244	0.625
LIG_Actin_WH2_2	465	483	PF00022	0.607
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_FHA_1	105	111	PF00498	0.532
LIG_FHA_1	381	387	PF00498	0.544
LIG_FHA_1	390	396	PF00498	0.463
LIG_FHA_1	415	421	PF00498	0.552
LIG_FHA_1	475	481	PF00498	0.589
LIG_FHA_2	270	276	PF00498	0.532
LIG_FHA_2	354	360	PF00498	0.667
LIG_FHA_2	375	381	PF00498	0.636
LIG_GBD_Chelix_1	255	263	PF00786	0.475
LIG_LIR_Apic_2	392	396	PF02991	0.520
LIG_LIR_Apic_2	427	431	PF02991	0.637
LIG_LIR_Apic_2	49	55	PF02991	0.599
LIG_LIR_Gen_1	23	33	PF02991	0.547
LIG_LIR_Gen_1	337	346	PF02991	0.765
LIG_LIR_Gen_1	462	473	PF02991	0.532
LIG_LIR_Nem_3	127	131	PF02991	0.495
LIG_LIR_Nem_3	23	29	PF02991	0.556
LIG_LIR_Nem_3	337	341	PF02991	0.631
LIG_LIR_Nem_3	454	458	PF02991	0.532
LIG_LIR_Nem_3	462	468	PF02991	0.479
LIG_PDZ_Class_2	479	484	PF00595	0.567
LIG_SH2_CRK	455	459	PF00017	0.532
LIG_SH2_SRC	117	120	PF00017	0.507
LIG_SH2_SRC	314	317	PF00017	0.609
LIG_SH2_STAT5	117	120	PF00017	0.649
LIG_SH2_STAT5	314	317	PF00017	0.795
LIG_SH3_3	164	170	PF00018	0.575
LIG_SH3_3	281	287	PF00018	0.672
LIG_SUMO_SIM_par_1	198	205	PF11976	0.681
LIG_TRAF2_1	356	359	PF00917	0.666
LIG_TRFH_1	332	336	PF08558	0.631
MOD_CDK_SPxxK_3	283	290	PF00069	0.635
MOD_CK1_1	132	138	PF00069	0.514
MOD_CK1_1	182	188	PF00069	0.780
MOD_CK1_1	190	196	PF00069	0.711
MOD_CK1_1	286	292	PF00069	0.656
MOD_CK1_1	297	303	PF00069	0.582
MOD_CK1_1	374	380	PF00069	0.555
MOD_CK1_1	414	420	PF00069	0.541
MOD_CK1_1	66	72	PF00069	0.589
MOD_CK1_1	73	79	PF00069	0.604
MOD_CK2_1	269	275	PF00069	0.529
MOD_CK2_1	353	359	PF00069	0.700
MOD_CK2_1	374	380	PF00069	0.650
MOD_CK2_1	7	13	PF00069	0.435
MOD_GlcNHglycan	135	138	PF01048	0.621
MOD_GlcNHglycan	144	147	PF01048	0.567
MOD_GlcNHglycan	181	184	PF01048	0.659
MOD_GlcNHglycan	193	196	PF01048	0.607
MOD_GlcNHglycan	241	244	PF01048	0.660
MOD_GlcNHglycan	245	248	PF01048	0.645
MOD_GlcNHglycan	413	416	PF01048	0.666
MOD_GlcNHglycan	65	68	PF01048	0.776
MOD_GlcNHglycan	69	72	PF01048	0.753
MOD_GlcNHglycan	9	12	PF01048	0.583
MOD_GSK3_1	129	136	PF00069	0.537
MOD_GSK3_1	138	145	PF00069	0.582
MOD_GSK3_1	182	189	PF00069	0.739
MOD_GSK3_1	191	198	PF00069	0.648
MOD_GSK3_1	239	246	PF00069	0.602
MOD_GSK3_1	296	303	PF00069	0.670
MOD_GSK3_1	330	337	PF00069	0.572
MOD_GSK3_1	367	374	PF00069	0.634
MOD_GSK3_1	376	383	PF00069	0.551
MOD_GSK3_1	411	418	PF00069	0.634
MOD_GSK3_1	62	69	PF00069	0.697
MOD_N-GLC_1	411	416	PF02516	0.638
MOD_NEK2_1	106	111	PF00069	0.463
MOD_NEK2_1	191	196	PF00069	0.620
MOD_NEK2_1	371	376	PF00069	0.681
MOD_NEK2_1	62	67	PF00069	0.708
MOD_NEK2_2	117	122	PF00069	0.510
MOD_NEK2_2	382	387	PF00069	0.493
MOD_PKA_1	404	410	PF00069	0.622
MOD_PKA_1	88	94	PF00069	0.656
MOD_PKA_2	18	24	PF00069	0.538
MOD_PKA_2	228	234	PF00069	0.686
MOD_PKA_2	300	306	PF00069	0.734
MOD_PKA_2	367	373	PF00069	0.688
MOD_PKA_2	404	410	PF00069	0.622
MOD_PKA_2	91	97	PF00069	0.631
MOD_Plk_1	269	275	PF00069	0.529
MOD_Plk_1	42	48	PF00069	0.589
MOD_Plk_4	251	257	PF00069	0.548
MOD_Plk_4	55	61	PF00069	0.714
MOD_ProDKin_1	283	289	PF00069	0.631
MOD_SUMO_for_1	259	262	PF00179	0.511
MOD_SUMO_rev_2	144	153	PF00179	0.653
MOD_SUMO_rev_2	235	240	PF00179	0.629
MOD_SUMO_rev_2	309	315	PF00179	0.636
TRG_DiLeu_BaEn_2	21	27	PF01217	0.513
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.635
TRG_ENDOCYTIC_2	338	341	PF00928	0.777
TRG_ENDOCYTIC_2	455	458	PF00928	0.532
TRG_ER_diArg_1	206	208	PF00400	0.686
TRG_ER_diArg_1	218	221	PF00400	0.573
TRG_ER_diArg_1	367	369	PF00400	0.653
TRG_ER_diArg_1	403	406	PF00400	0.683
TRG_ER_diArg_1	458	461	PF00400	0.532
TRG_NLS_Bipartite_1	207	223	PF00514	0.678
TRG_NLS_MonoCore_2	218	223	PF00514	0.682
TRG_NLS_MonoCore_2	402	407	PF00514	0.680
TRG_NLS_MonoExtC_3	217	222	PF00514	0.681
TRG_NLS_MonoExtC_3	403	408	PF00514	0.686
TRG_NLS_MonoExtN_4	169	175	PF00514	0.557
TRG_NLS_MonoExtN_4	218	223	PF00514	0.680
TRG_NLS_MonoExtN_4	403	408	PF00514	0.686
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I947	Leishmania donovani	92%	100%
A4H6M4	Leishmania braziliensis	73%	100%
A4HV07	Leishmania infantum	92%	100%
E9ANP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%