Putative inositol-1,4,5-trisphosphate (IP3) 5-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QGX8_LEIMA

TriTrypDb:

LmjF.11.1010 , LMJLV39_110017200 , LMJSD75_110017700

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGX8

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006066	alcohol metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019751	polyol metabolic process	4	2
GO:0019932	second-messenger-mediated signaling	4	2
GO:0035556	intracellular signal transduction	3	2
GO:0043647	inositol phosphate metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046164	alcohol catabolic process	4	2
GO:0046174	polyol catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	2
GO:0046855	obsolete inositol phosphate dephosphorylation	5	2
GO:0048016	inositol phosphate-mediated signaling	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071545	inositol phosphate catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901575	organic substance catabolic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901616	organic hydroxy compound catabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0046030	inositol trisphosphate phosphatase activity	7	7
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	8	6
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	8	6
GO:0052743	inositol tetrakisphosphate phosphatase activity	7	6
GO:0052745	inositol phosphate phosphatase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.543
CLV_C14_Caspase3-7	96	100	PF00656	0.621
CLV_NRD_NRD_1	256	258	PF00675	0.740
CLV_NRD_NRD_1	360	362	PF00675	0.381
CLV_NRD_NRD_1	403	405	PF00675	0.475
CLV_NRD_NRD_1	455	457	PF00675	0.375
CLV_PCSK_KEX2_1	256	258	PF00082	0.740
CLV_PCSK_KEX2_1	403	405	PF00082	0.475
CLV_PCSK_KEX2_1	457	459	PF00082	0.535
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.535
CLV_PCSK_PC7_1	453	459	PF00082	0.543
CLV_PCSK_SKI1_1	362	366	PF00082	0.463
CLV_PCSK_SKI1_1	390	394	PF00082	0.417
CLV_PCSK_SKI1_1	406	410	PF00082	0.385
CLV_PCSK_SKI1_1	438	442	PF00082	0.379
CLV_PCSK_SKI1_1	617	621	PF00082	0.355
DEG_APCC_DBOX_1	119	127	PF00400	0.356
DEG_APCC_DBOX_1	181	189	PF00400	0.476
DEG_ODPH_VHL_1	582	594	PF01847	0.502
DEG_SPOP_SBC_1	523	527	PF00917	0.645
DOC_AGCK_PIF_3	685	688	PF00069	0.458
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.455
DOC_MAPK_gen_1	359	369	PF00069	0.467
DOC_MAPK_gen_1	84	94	PF00069	0.563
DOC_MAPK_JIP1_4	33	39	PF00069	0.476
DOC_MAPK_MEF2A_6	29	38	PF00069	0.532
DOC_MAPK_MEF2A_6	361	369	PF00069	0.452
DOC_MAPK_NFAT4_5	362	370	PF00069	0.454
DOC_PP1_RVXF_1	615	621	PF00149	0.357
DOC_PP2B_LxvP_1	324	327	PF13499	0.388
DOC_PP2B_LxvP_1	581	584	PF13499	0.574
DOC_PP4_FxxP_1	312	315	PF00568	0.366
DOC_PP4_FxxP_1	469	472	PF00568	0.442
DOC_PP4_FxxP_1	86	89	PF00568	0.660
DOC_SPAK_OSR1_1	20	24	PF12202	0.673
DOC_SPAK_OSR1_1	481	485	PF12202	0.450
DOC_USP7_MATH_1	136	140	PF00917	0.550
DOC_USP7_MATH_1	306	310	PF00917	0.352
DOC_USP7_MATH_1	357	361	PF00917	0.420
DOC_USP7_MATH_1	392	396	PF00917	0.530
DOC_USP7_MATH_1	413	417	PF00917	0.425
DOC_USP7_MATH_1	574	578	PF00917	0.668
DOC_USP7_MATH_1	588	592	PF00917	0.543
DOC_USP7_MATH_1	642	646	PF00917	0.777
DOC_USP7_MATH_1	78	82	PF00917	0.679
DOC_USP7_MATH_1	9	13	PF00917	0.674
DOC_USP7_UBL2_3	199	203	PF12436	0.522
DOC_WW_Pin1_4	102	107	PF00397	0.524
DOC_WW_Pin1_4	153	158	PF00397	0.737
DOC_WW_Pin1_4	159	164	PF00397	0.692
DOC_WW_Pin1_4	175	180	PF00397	0.417
DOC_WW_Pin1_4	2	7	PF00397	0.640
DOC_WW_Pin1_4	311	316	PF00397	0.372
DOC_WW_Pin1_4	393	398	PF00397	0.426
DOC_WW_Pin1_4	538	543	PF00397	0.623
DOC_WW_Pin1_4	57	62	PF00397	0.675
DOC_WW_Pin1_4	584	589	PF00397	0.682
DOC_WW_Pin1_4	597	602	PF00397	0.486
DOC_WW_Pin1_4	63	68	PF00397	0.726
LIG_14-3-3_CanoR_1	125	129	PF00244	0.394
LIG_14-3-3_CanoR_1	20	24	PF00244	0.673
LIG_14-3-3_CanoR_1	214	218	PF00244	0.549
LIG_14-3-3_CanoR_1	245	255	PF00244	0.670
LIG_14-3-3_CanoR_1	256	261	PF00244	0.795
LIG_14-3-3_CanoR_1	575	585	PF00244	0.650
LIG_14-3-3_CanoR_1	632	637	PF00244	0.652
LIG_APCC_ABBA_1	381	386	PF00400	0.463
LIG_APCC_ABBA_1	425	430	PF00400	0.348
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	21	25	PF00533	0.593
LIG_BRCT_BRCA1_1	308	312	PF00533	0.348
LIG_BRCT_BRCA1_1	313	317	PF00533	0.382
LIG_BRCT_BRCA1_1	350	354	PF00533	0.407
LIG_BRCT_BRCA1_1	75	79	PF00533	0.625
LIG_deltaCOP1_diTrp_1	463	469	PF00928	0.427
LIG_FHA_1	176	182	PF00498	0.567
LIG_FHA_1	213	219	PF00498	0.472
LIG_FHA_1	222	228	PF00498	0.396
LIG_FHA_1	247	253	PF00498	0.600
LIG_FHA_1	291	297	PF00498	0.665
LIG_FHA_1	3	9	PF00498	0.680
LIG_FHA_1	38	44	PF00498	0.377
LIG_FHA_1	403	409	PF00498	0.349
LIG_FHA_1	439	445	PF00498	0.334
LIG_FHA_1	567	573	PF00498	0.647
LIG_FHA_2	256	262	PF00498	0.707
LIG_FHA_2	472	478	PF00498	0.532
LIG_FHA_2	548	554	PF00498	0.681
LIG_FHA_2	57	63	PF00498	0.712
LIG_GSK3_LRP6_1	157	162	PF00069	0.697
LIG_LIR_Apic_2	309	315	PF02991	0.357
LIG_LIR_Apic_2	467	472	PF02991	0.443
LIG_LIR_Apic_2	85	89	PF02991	0.653
LIG_LIR_Gen_1	301	312	PF02991	0.375
LIG_LIR_Gen_1	463	473	PF02991	0.439
LIG_LIR_Gen_1	511	517	PF02991	0.495
LIG_LIR_Gen_1	675	684	PF02991	0.359
LIG_LIR_Gen_1	76	86	PF02991	0.695
LIG_LIR_Gen_1	90	98	PF02991	0.548
LIG_LIR_Nem_3	301	307	PF02991	0.397
LIG_LIR_Nem_3	314	320	PF02991	0.408
LIG_LIR_Nem_3	330	334	PF02991	0.429
LIG_LIR_Nem_3	463	469	PF02991	0.427
LIG_LIR_Nem_3	511	515	PF02991	0.636
LIG_LIR_Nem_3	682	688	PF02991	0.282
LIG_LIR_Nem_3	76	82	PF02991	0.682
LIG_LIR_Nem_3	90	94	PF02991	0.537
LIG_Pex14_2	205	209	PF04695	0.386
LIG_Pex14_2	21	25	PF04695	0.593
LIG_Pex14_2	465	469	PF04695	0.504
LIG_PTB_Apo_2	199	206	PF02174	0.431
LIG_Rb_LxCxE_1	455	477	PF01857	0.537
LIG_SH2_CRK	512	516	PF00017	0.541
LIG_SH2_NCK_1	512	516	PF00017	0.541
LIG_SH2_NCK_1	671	675	PF00017	0.378
LIG_SH2_PTP2	331	334	PF00017	0.413
LIG_SH2_PTP2	91	94	PF00017	0.627
LIG_SH2_SRC	331	334	PF00017	0.436
LIG_SH2_SRC	669	672	PF00017	0.446
LIG_SH2_SRC	91	94	PF00017	0.627
LIG_SH2_STAP1	512	516	PF00017	0.541
LIG_SH2_STAP1	669	673	PF00017	0.436
LIG_SH2_STAT5	177	180	PF00017	0.501
LIG_SH2_STAT5	208	211	PF00017	0.411
LIG_SH2_STAT5	303	306	PF00017	0.366
LIG_SH2_STAT5	331	334	PF00017	0.436
LIG_SH2_STAT5	400	403	PF00017	0.403
LIG_SH2_STAT5	91	94	PF00017	0.627
LIG_SH3_1	634	640	PF00018	0.683
LIG_SH3_3	152	158	PF00018	0.620
LIG_SH3_3	178	184	PF00018	0.545
LIG_SH3_3	3	9	PF00018	0.707
LIG_SH3_3	332	338	PF00018	0.557
LIG_SH3_3	58	64	PF00018	0.772
LIG_SH3_3	634	640	PF00018	0.620
LIG_SUMO_SIM_anti_2	35	40	PF11976	0.376
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.525
LIG_SUMO_SIM_par_1	35	40	PF11976	0.376
LIG_SUMO_SIM_par_1	416	423	PF11976	0.486
LIG_TRAF2_1	474	477	PF00917	0.495
LIG_WW_2	6	9	PF00397	0.674
MOD_CDC14_SPxK_1	600	603	PF00782	0.492
MOD_CDK_SPK_2	311	316	PF00069	0.372
MOD_CDK_SPxK_1	597	603	PF00069	0.480
MOD_CDK_SPxxK_3	102	109	PF00069	0.507
MOD_CDK_SPxxK_3	175	182	PF00069	0.487
MOD_CK1_1	127	133	PF00069	0.394
MOD_CK1_1	2	8	PF00069	0.613
MOD_CK1_1	234	240	PF00069	0.670
MOD_CK1_1	263	269	PF00069	0.646
MOD_CK1_1	287	293	PF00069	0.646
MOD_CK1_1	32	38	PF00069	0.433
MOD_CK1_1	322	328	PF00069	0.410
MOD_CK1_1	395	401	PF00069	0.436
MOD_CK1_1	577	583	PF00069	0.661
MOD_CK1_1	644	650	PF00069	0.626
MOD_CK2_1	255	261	PF00069	0.705
MOD_CK2_1	436	442	PF00069	0.415
MOD_CK2_1	471	477	PF00069	0.551
MOD_CK2_1	494	500	PF00069	0.431
MOD_CK2_1	56	62	PF00069	0.710
MOD_Cter_Amidation	401	404	PF01082	0.482
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.544
MOD_GlcNHglycan	129	132	PF01048	0.466
MOD_GlcNHglycan	137	141	PF01048	0.506
MOD_GlcNHglycan	143	146	PF01048	0.606
MOD_GlcNHglycan	15	18	PF01048	0.492
MOD_GlcNHglycan	2	5	PF01048	0.691
MOD_GlcNHglycan	224	227	PF01048	0.471
MOD_GlcNHglycan	233	236	PF01048	0.541
MOD_GlcNHglycan	350	353	PF01048	0.393
MOD_GlcNHglycan	414	418	PF01048	0.396
MOD_GlcNHglycan	526	529	PF01048	0.633
MOD_GlcNHglycan	628	631	PF01048	0.489
MOD_GlcNHglycan	646	649	PF01048	0.605
MOD_GlcNHglycan	651	654	PF01048	0.755
MOD_GlcNHglycan	662	665	PF01048	0.673
MOD_GlcNHglycan	74	78	PF01048	0.693
MOD_GSK3_1	136	143	PF00069	0.563
MOD_GSK3_1	153	160	PF00069	0.613
MOD_GSK3_1	173	180	PF00069	0.576
MOD_GSK3_1	234	241	PF00069	0.638
MOD_GSK3_1	25	32	PF00069	0.551
MOD_GSK3_1	256	263	PF00069	0.749
MOD_GSK3_1	280	287	PF00069	0.684
MOD_GSK3_1	302	309	PF00069	0.376
MOD_GSK3_1	398	405	PF00069	0.375
MOD_GSK3_1	467	474	PF00069	0.542
MOD_GSK3_1	518	525	PF00069	0.633
MOD_GSK3_1	584	591	PF00069	0.734
MOD_GSK3_1	626	633	PF00069	0.534
MOD_GSK3_1	642	649	PF00069	0.739
MOD_GSK3_1	9	16	PF00069	0.668
MOD_N-GLC_1	287	292	PF02516	0.752
MOD_N-GLC_2	377	379	PF02516	0.343
MOD_N-GLC_2	605	607	PF02516	0.551
MOD_NEK2_1	238	243	PF00069	0.730
MOD_NEK2_1	255	260	PF00069	0.731
MOD_NEK2_1	348	353	PF00069	0.391
MOD_NEK2_1	365	370	PF00069	0.383
MOD_NEK2_1	37	42	PF00069	0.485
MOD_NEK2_1	448	453	PF00069	0.537
MOD_NEK2_1	56	61	PF00069	0.645
MOD_PIKK_1	37	43	PF00454	0.423
MOD_PIKK_1	471	477	PF00454	0.551
MOD_PKA_1	256	262	PF00069	0.742
MOD_PKA_2	124	130	PF00069	0.399
MOD_PKA_2	19	25	PF00069	0.688
MOD_PKA_2	213	219	PF00069	0.549
MOD_PKA_2	231	237	PF00069	0.437
MOD_PKA_2	246	252	PF00069	0.600
MOD_PKA_2	255	261	PF00069	0.792
MOD_PKA_2	280	286	PF00069	0.638
MOD_PKA_2	402	408	PF00069	0.354
MOD_PKA_2	574	580	PF00069	0.662
MOD_PKB_1	245	253	PF00069	0.678
MOD_PKB_1	404	412	PF00069	0.308
MOD_Plk_1	413	419	PF00069	0.406
MOD_Plk_2-3	436	442	PF00069	0.415
MOD_Plk_4	124	130	PF00069	0.381
MOD_Plk_4	213	219	PF00069	0.477
MOD_Plk_4	306	312	PF00069	0.357
MOD_Plk_4	32	38	PF00069	0.429
MOD_Plk_4	395	401	PF00069	0.473
MOD_Plk_4	577	583	PF00069	0.535
MOD_Plk_4	87	93	PF00069	0.662
MOD_ProDKin_1	102	108	PF00069	0.514
MOD_ProDKin_1	153	159	PF00069	0.739
MOD_ProDKin_1	175	181	PF00069	0.490
MOD_ProDKin_1	2	8	PF00069	0.640
MOD_ProDKin_1	311	317	PF00069	0.371
MOD_ProDKin_1	393	399	PF00069	0.431
MOD_ProDKin_1	538	544	PF00069	0.622
MOD_ProDKin_1	57	63	PF00069	0.676
MOD_ProDKin_1	584	590	PF00069	0.681
MOD_ProDKin_1	597	603	PF00069	0.480
MOD_SUMO_rev_2	26	35	PF00179	0.588
MOD_SUMO_rev_2	430	440	PF00179	0.370
MOD_SUMO_rev_2	442	448	PF00179	0.428
TRG_DiLeu_BaEn_1	485	490	PF01217	0.401
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.496
TRG_ENDOCYTIC_2	331	334	PF00928	0.413
TRG_ENDOCYTIC_2	512	515	PF00928	0.478
TRG_ENDOCYTIC_2	671	674	PF00928	0.368
TRG_ENDOCYTIC_2	91	94	PF00928	0.627
TRG_ER_diArg_1	255	257	PF00400	0.738
TRG_ER_diArg_1	403	406	PF00400	0.395
TRG_ER_diArg_1	456	459	PF00400	0.384
TRG_ER_diArg_1	478	481	PF00400	0.471
TRG_ER_diArg_1	517	520	PF00400	0.560
TRG_ER_diArg_1	572	575	PF00400	0.800
TRG_NLS_MonoExtN_4	456	461	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E4	Leptomonas seymouri	51%	100%
A0A3S5H6J4	Leishmania donovani	93%	100%
A4H6M7	Leishmania braziliensis	73%	100%
A4HV10	Leishmania infantum	93%	100%
E9ANP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%