RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGX5_LEIMA

TriTrypDb:

LmjF.11.1040 , LMJLV39_110017500 , LMJSD75_110018000

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	380	384	PF00656	0.741
CLV_C14_Caspase3-7	429	433	PF00656	0.580
CLV_C14_Caspase3-7	511	515	PF00656	0.693
CLV_C14_Caspase3-7	517	521	PF00656	0.700
CLV_NRD_NRD_1	306	308	PF00675	0.661
CLV_NRD_NRD_1	374	376	PF00675	0.608
CLV_NRD_NRD_1	458	460	PF00675	0.755
CLV_NRD_NRD_1	791	793	PF00675	0.591
CLV_PCSK_KEX2_1	306	308	PF00082	0.595
CLV_PCSK_KEX2_1	458	460	PF00082	0.755
CLV_PCSK_SKI1_1	218	222	PF00082	0.564
CLV_PCSK_SKI1_1	225	229	PF00082	0.551
CLV_PCSK_SKI1_1	307	311	PF00082	0.461
CLV_PCSK_SKI1_1	562	566	PF00082	0.611
CLV_PCSK_SKI1_1	600	604	PF00082	0.759
CLV_PCSK_SKI1_1	737	741	PF00082	0.556
CLV_PCSK_SKI1_1	763	767	PF00082	0.620
CLV_PCSK_SKI1_1	796	800	PF00082	0.588
CLV_PCSK_SKI1_1	96	100	PF00082	0.706
DEG_SPOP_SBC_1	10	14	PF00917	0.734
DEG_SPOP_SBC_1	134	138	PF00917	0.729
DEG_SPOP_SBC_1	234	238	PF00917	0.698
DEG_SPOP_SBC_1	492	496	PF00917	0.716
DEG_SPOP_SBC_1	583	587	PF00917	0.718
DEG_SPOP_SBC_1	618	622	PF00917	0.736
DOC_CDC14_PxL_1	171	179	PF14671	0.411
DOC_CKS1_1	630	635	PF01111	0.758
DOC_CKS1_1	639	644	PF01111	0.730
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.590
DOC_MAPK_gen_1	199	208	PF00069	0.618
DOC_MAPK_gen_1	792	800	PF00069	0.596
DOC_PP1_RVXF_1	202	209	PF00149	0.602
DOC_PP1_RVXF_1	784	791	PF00149	0.578
DOC_PP2B_LxvP_1	239	242	PF13499	0.561
DOC_PP2B_LxvP_1	398	401	PF13499	0.665
DOC_PP2B_LxvP_1	446	449	PF13499	0.600
DOC_PP2B_LxvP_1	766	769	PF13499	0.672
DOC_PP2B_PxIxI_1	656	662	PF00149	0.557
DOC_PP4_FxxP_1	572	575	PF00568	0.690
DOC_PP4_FxxP_1	765	768	PF00568	0.655
DOC_USP7_MATH_1	134	138	PF00917	0.729
DOC_USP7_MATH_1	153	157	PF00917	0.522
DOC_USP7_MATH_1	244	248	PF00917	0.800
DOC_USP7_MATH_1	334	338	PF00917	0.782
DOC_USP7_MATH_1	426	430	PF00917	0.586
DOC_USP7_MATH_1	510	514	PF00917	0.692
DOC_USP7_MATH_1	558	562	PF00917	0.647
DOC_USP7_MATH_1	80	84	PF00917	0.801
DOC_USP7_MATH_1	92	96	PF00917	0.615
DOC_WW_Pin1_4	14	19	PF00397	0.601
DOC_WW_Pin1_4	154	159	PF00397	0.740
DOC_WW_Pin1_4	274	279	PF00397	0.782
DOC_WW_Pin1_4	31	36	PF00397	0.697
DOC_WW_Pin1_4	339	344	PF00397	0.719
DOC_WW_Pin1_4	346	351	PF00397	0.668
DOC_WW_Pin1_4	404	409	PF00397	0.754
DOC_WW_Pin1_4	414	419	PF00397	0.648
DOC_WW_Pin1_4	45	50	PF00397	0.601
DOC_WW_Pin1_4	451	456	PF00397	0.740
DOC_WW_Pin1_4	629	634	PF00397	0.756
DOC_WW_Pin1_4	638	643	PF00397	0.740
DOC_WW_Pin1_4	644	649	PF00397	0.653
DOC_WW_Pin1_4	67	72	PF00397	0.642
DOC_WW_Pin1_4	670	675	PF00397	0.783
DOC_WW_Pin1_4	679	684	PF00397	0.696
DOC_WW_Pin1_4	728	733	PF00397	0.732
DOC_WW_Pin1_4	81	86	PF00397	0.666
LIG_14-3-3_CanoR_1	152	158	PF00244	0.786
LIG_14-3-3_CanoR_1	197	206	PF00244	0.629
LIG_14-3-3_CanoR_1	459	469	PF00244	0.799
LIG_14-3-3_CanoR_1	741	747	PF00244	0.583
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_4	573	577	PF00653	0.653
LIG_BIR_III_4	63	67	PF00653	0.793
LIG_BRCT_BRCA1_1	103	107	PF00533	0.567
LIG_BRCT_BRCA1_1	270	274	PF00533	0.794
LIG_BRCT_BRCA1_1	32	36	PF00533	0.783
LIG_BRCT_BRCA1_1	752	756	PF00533	0.566
LIG_CSL_BTD_1	410	413	PF09270	0.738
LIG_deltaCOP1_diTrp_1	118	125	PF00928	0.695
LIG_FHA_1	106	112	PF00498	0.746
LIG_FHA_1	166	172	PF00498	0.561
LIG_FHA_1	234	240	PF00498	0.507
LIG_FHA_1	292	298	PF00498	0.700
LIG_FHA_1	455	461	PF00498	0.741
LIG_FHA_1	561	567	PF00498	0.618
LIG_FHA_1	602	608	PF00498	0.759
LIG_FHA_1	632	638	PF00498	0.739
LIG_FHA_1	639	645	PF00498	0.669
LIG_FHA_1	653	659	PF00498	0.707
LIG_FHA_1	680	686	PF00498	0.820
LIG_LIR_Apic_2	122	128	PF02991	0.707
LIG_LIR_Apic_2	698	703	PF02991	0.589
LIG_LIR_Apic_2	764	768	PF02991	0.644
LIG_LIR_Gen_1	136	147	PF02991	0.726
LIG_LIR_Gen_1	383	392	PF02991	0.743
LIG_LIR_Gen_1	563	572	PF02991	0.616
LIG_LIR_Nem_3	136	142	PF02991	0.803
LIG_LIR_Nem_3	287	291	PF02991	0.670
LIG_LIR_Nem_3	33	39	PF02991	0.787
LIG_LIR_Nem_3	563	568	PF02991	0.590
LIG_LIR_Nem_3	736	742	PF02991	0.620
LIG_LIR_Nem_3	753	759	PF02991	0.324
LIG_Pex14_2	752	756	PF04695	0.566
LIG_PTB_Apo_2	439	446	PF02174	0.682
LIG_REV1ctd_RIR_1	737	745	PF16727	0.609
LIG_SH2_CRK	211	215	PF00017	0.587
LIG_SH2_CRK	671	675	PF00017	0.683
LIG_SH2_NCK_1	120	124	PF00017	0.702
LIG_SH2_NCK_1	211	215	PF00017	0.587
LIG_SH2_PTP2	187	190	PF00017	0.516
LIG_SH2_SRC	187	190	PF00017	0.516
LIG_SH2_STAP1	120	124	PF00017	0.702
LIG_SH2_STAP1	211	215	PF00017	0.587
LIG_SH2_STAP1	288	292	PF00017	0.707
LIG_SH2_STAP1	624	628	PF00017	0.749
LIG_SH2_STAT3	577	580	PF00017	0.690
LIG_SH2_STAT5	187	190	PF00017	0.516
LIG_SH2_STAT5	291	294	PF00017	0.712
LIG_SH2_STAT5	577	580	PF00017	0.759
LIG_SH2_STAT5	751	754	PF00017	0.561
LIG_SH3_1	523	529	PF00018	0.741
LIG_SH3_1	671	677	PF00018	0.681
LIG_SH3_2	557	562	PF14604	0.697
LIG_SH3_3	155	161	PF00018	0.748
LIG_SH3_3	183	189	PF00018	0.602
LIG_SH3_3	272	278	PF00018	0.741
LIG_SH3_3	344	350	PF00018	0.748
LIG_SH3_3	354	360	PF00018	0.642
LIG_SH3_3	398	404	PF00018	0.713
LIG_SH3_3	415	421	PF00018	0.728
LIG_SH3_3	463	469	PF00018	0.715
LIG_SH3_3	496	502	PF00018	0.701
LIG_SH3_3	50	56	PF00018	0.601
LIG_SH3_3	523	529	PF00018	0.807
LIG_SH3_3	554	560	PF00018	0.750
LIG_SH3_3	612	618	PF00018	0.675
LIG_SH3_3	671	677	PF00018	0.681
LIG_SUMO_SIM_par_1	106	112	PF11976	0.697
LIG_SUMO_SIM_par_1	226	232	PF11976	0.579
LIG_SUMO_SIM_par_1	277	282	PF11976	0.564
LIG_UBA3_1	227	231	PF00899	0.570
LIG_WW_1	768	771	PF00397	0.661
LIG_WW_2	53	56	PF00397	0.593
LIG_WW_2	557	560	PF00397	0.724
MOD_CDK_SPxK_1	629	635	PF00069	0.666
MOD_CDK_SPxxK_3	451	458	PF00069	0.728
MOD_CDK_SPxxK_3	679	686	PF00069	0.818
MOD_CK1_1	129	135	PF00069	0.790
MOD_CK1_1	137	143	PF00069	0.681
MOD_CK1_1	157	163	PF00069	0.535
MOD_CK1_1	318	324	PF00069	0.712
MOD_CK1_1	338	344	PF00069	0.554
MOD_CK1_1	386	392	PF00069	0.740
MOD_CK1_1	412	418	PF00069	0.625
MOD_CK1_1	45	51	PF00069	0.818
MOD_CK1_1	454	460	PF00069	0.736
MOD_CK1_1	464	470	PF00069	0.564
MOD_CK1_1	58	64	PF00069	0.635
MOD_CK1_1	586	592	PF00069	0.744
MOD_CK1_1	647	653	PF00069	0.730
MOD_CK1_1	673	679	PF00069	0.719
MOD_CK1_1	706	712	PF00069	0.763
MOD_CK1_1	728	734	PF00069	0.652
MOD_CK1_1	78	84	PF00069	0.510
MOD_CK2_1	274	280	PF00069	0.781
MOD_Cter_Amidation	373	376	PF01082	0.610
MOD_GlcNHglycan	246	249	PF01048	0.801
MOD_GlcNHglycan	262	265	PF01048	0.530
MOD_GlcNHglycan	446	449	PF01048	0.631
MOD_GlcNHglycan	463	466	PF01048	0.721
MOD_GlcNHglycan	592	595	PF01048	0.788
MOD_GlcNHglycan	60	63	PF01048	0.829
MOD_GlcNHglycan	649	652	PF01048	0.794
MOD_GlcNHglycan	80	83	PF01048	0.503
MOD_GlcNHglycan	88	91	PF01048	0.728
MOD_GSK3_1	101	108	PF00069	0.756
MOD_GSK3_1	129	136	PF00069	0.791
MOD_GSK3_1	153	160	PF00069	0.752
MOD_GSK3_1	161	168	PF00069	0.514
MOD_GSK3_1	244	251	PF00069	0.797
MOD_GSK3_1	27	34	PF00069	0.499
MOD_GSK3_1	334	341	PF00069	0.782
MOD_GSK3_1	342	349	PF00069	0.657
MOD_GSK3_1	38	45	PF00069	0.632
MOD_GSK3_1	460	467	PF00069	0.661
MOD_GSK3_1	582	589	PF00069	0.787
MOD_GSK3_1	607	614	PF00069	0.801
MOD_GSK3_1	640	647	PF00069	0.748
MOD_GSK3_1	673	680	PF00069	0.773
MOD_GSK3_1	691	698	PF00069	0.531
MOD_GSK3_1	702	709	PF00069	0.588
MOD_GSK3_1	9	16	PF00069	0.748
MOD_LATS_1	598	604	PF00433	0.702
MOD_N-GLC_1	807	812	PF02516	0.675
MOD_NEK2_1	105	110	PF00069	0.724
MOD_NEK2_1	444	449	PF00069	0.671
MOD_NEK2_1	696	701	PF00069	0.596
MOD_NEK2_1	742	747	PF00069	0.546
MOD_NEK2_1	9	14	PF00069	0.723
MOD_NEK2_2	560	565	PF00069	0.620
MOD_OFUCOSY	425	430	PF10250	0.586
MOD_PIKK_1	291	297	PF00454	0.701
MOD_PIKK_1	318	324	PF00454	0.677
MOD_PIKK_1	38	44	PF00454	0.733
MOD_PIKK_1	383	389	PF00454	0.749
MOD_PIKK_1	412	418	PF00454	0.625
MOD_PIKK_1	691	697	PF00454	0.751
MOD_PIKK_1	703	709	PF00454	0.662
MOD_PIKK_1	83	89	PF00454	0.601
MOD_PKA_1	375	381	PF00069	0.593
MOD_PKA_2	112	118	PF00069	0.762
MOD_PKA_2	248	254	PF00069	0.716
MOD_PKA_2	58	64	PF00069	0.828
MOD_PKA_2	583	589	PF00069	0.792
MOD_Plk_1	807	813	PF00069	0.693
MOD_Plk_2-3	112	118	PF00069	0.762
MOD_Plk_4	165	171	PF00069	0.607
MOD_Plk_4	219	225	PF00069	0.591
MOD_Plk_4	27	33	PF00069	0.672
MOD_Plk_4	300	306	PF00069	0.649
MOD_Plk_4	742	748	PF00069	0.576
MOD_ProDKin_1	14	20	PF00069	0.601
MOD_ProDKin_1	154	160	PF00069	0.735
MOD_ProDKin_1	274	280	PF00069	0.781
MOD_ProDKin_1	31	37	PF00069	0.700
MOD_ProDKin_1	339	345	PF00069	0.720
MOD_ProDKin_1	346	352	PF00069	0.671
MOD_ProDKin_1	404	410	PF00069	0.756
MOD_ProDKin_1	414	420	PF00069	0.645
MOD_ProDKin_1	45	51	PF00069	0.602
MOD_ProDKin_1	451	457	PF00069	0.742
MOD_ProDKin_1	629	635	PF00069	0.759
MOD_ProDKin_1	638	644	PF00069	0.741
MOD_ProDKin_1	67	73	PF00069	0.641
MOD_ProDKin_1	670	676	PF00069	0.784
MOD_ProDKin_1	679	685	PF00069	0.697
MOD_ProDKin_1	728	734	PF00069	0.722
MOD_ProDKin_1	81	87	PF00069	0.667
TRG_AP2beta_CARGO_1	754	763	PF09066	0.575
TRG_DiLeu_BaEn_1	27	32	PF01217	0.565
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.600
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.665
TRG_ENDOCYTIC_2	211	214	PF00928	0.581
TRG_ENDOCYTIC_2	385	388	PF00928	0.752
TRG_ENDOCYTIC_2	666	669	PF00928	0.561
TRG_ENDOCYTIC_2	762	765	PF00928	0.576
TRG_ER_diArg_1	305	307	PF00400	0.596
TRG_ER_diArg_1	458	460	PF00400	0.755
TRG_ER_diArg_1	56	59	PF00400	0.816
TRG_ER_diArg_1	93	96	PF00400	0.728
TRG_NES_CRM1_1	219	232	PF08389	0.550
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	375	380	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBB5	Leishmania donovani	88%	100%
A4H6N0	Leishmania braziliensis	63%	100%
A4HV13	Leishmania infantum	87%	100%
E9ANP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%