Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 7, putative

Species:

Leishmania major

UniProt:

Q4QGX2_LEIMA

TriTrypDb:

LmjF.11.1080 , LMJLV39_110018400 , LMJSD75_110018900

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QGX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGX2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016409	palmitoyltransferase activity	5	9
GO:0016417	S-acyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	9
GO:0019707	protein-cysteine S-acyltransferase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.630
CLV_C14_Caspase3-7	243	247	PF00656	0.691
CLV_C14_Caspase3-7	379	383	PF00656	0.519
CLV_NRD_NRD_1	257	259	PF00675	0.475
CLV_NRD_NRD_1	287	289	PF00675	0.386
CLV_NRD_NRD_1	29	31	PF00675	0.505
CLV_NRD_NRD_1	377	379	PF00675	0.362
CLV_NRD_NRD_1	494	496	PF00675	0.377
CLV_NRD_NRD_1	514	516	PF00675	0.364
CLV_PCSK_KEX2_1	287	289	PF00082	0.396
CLV_PCSK_KEX2_1	376	378	PF00082	0.364
CLV_PCSK_KEX2_1	494	496	PF00082	0.443
CLV_PCSK_KEX2_1	513	515	PF00082	0.392
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.443
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.392
CLV_PCSK_PC7_1	509	515	PF00082	0.412
CLV_PCSK_SKI1_1	105	109	PF00082	0.457
CLV_PCSK_SKI1_1	288	292	PF00082	0.486
CLV_PCSK_SKI1_1	509	513	PF00082	0.385
DOC_MAPK_gen_1	104	110	PF00069	0.614
DOC_MAPK_gen_1	494	501	PF00069	0.603
DOC_PP1_RVXF_1	495	502	PF00149	0.612
DOC_PP4_FxxP_1	291	294	PF00568	0.626
DOC_USP7_MATH_1	266	270	PF00917	0.641
DOC_USP7_MATH_1	294	298	PF00917	0.620
DOC_USP7_MATH_1	57	61	PF00917	0.685
DOC_USP7_MATH_1	80	84	PF00917	0.727
DOC_USP7_MATH_2	131	137	PF00917	0.681
DOC_USP7_UBL2_3	31	35	PF12436	0.660
DOC_USP7_UBL2_3	387	391	PF12436	0.604
DOC_WW_Pin1_4	127	132	PF00397	0.673
DOC_WW_Pin1_4	136	141	PF00397	0.690
DOC_WW_Pin1_4	35	40	PF00397	0.653
DOC_WW_Pin1_4	95	100	PF00397	0.680
LIG_14-3-3_CanoR_1	12	20	PF00244	0.698
LIG_14-3-3_CanoR_1	121	131	PF00244	0.676
LIG_14-3-3_CanoR_1	233	238	PF00244	0.696
LIG_14-3-3_CanoR_1	282	286	PF00244	0.657
LIG_14-3-3_CanoR_1	293	299	PF00244	0.528
LIG_14-3-3_CanoR_1	495	500	PF00244	0.642
LIG_Actin_WH2_2	130	146	PF00022	0.641
LIG_BRCT_BRCA1_1	134	138	PF00533	0.706
LIG_BRCT_BRCA1_1	314	318	PF00533	0.398
LIG_BRCT_BRCA1_1	448	452	PF00533	0.319
LIG_deltaCOP1_diTrp_1	246	253	PF00928	0.691
LIG_FHA_1	168	174	PF00498	0.680
LIG_FHA_1	180	186	PF00498	0.649
LIG_FHA_1	350	356	PF00498	0.416
LIG_FHA_1	459	465	PF00498	0.303
LIG_FHA_1	51	57	PF00498	0.664
LIG_FHA_2	107	113	PF00498	0.661
LIG_FHA_2	124	130	PF00498	0.613
LIG_FHA_2	377	383	PF00498	0.519
LIG_LIR_Gen_1	409	419	PF02991	0.534
LIG_LIR_Gen_1	478	483	PF02991	0.498
LIG_LIR_Gen_1	486	492	PF02991	0.465
LIG_LIR_Nem_3	315	321	PF02991	0.393
LIG_LIR_Nem_3	409	415	PF02991	0.534
LIG_LIR_Nem_3	478	482	PF02991	0.498
LIG_LIR_Nem_3	486	491	PF02991	0.465
LIG_LIR_Nem_3	96	100	PF02991	0.643
LIG_MLH1_MIPbox_1	448	452	PF16413	0.319
LIG_PCNA_PIPBox_1	156	165	PF02747	0.649
LIG_PCNA_yPIPBox_3	329	337	PF02747	0.363
LIG_Pex14_1	314	318	PF04695	0.398
LIG_SH2_CRK	351	355	PF00017	0.335
LIG_SH2_PTP2	321	324	PF00017	0.357
LIG_SH2_SRC	488	491	PF00017	0.564
LIG_SH2_STAP1	351	355	PF00017	0.303
LIG_SH2_STAT5	113	116	PF00017	0.657
LIG_SH2_STAT5	321	324	PF00017	0.320
LIG_SH2_STAT5	325	328	PF00017	0.325
LIG_SH2_STAT5	351	354	PF00017	0.343
LIG_SH2_STAT5	436	439	PF00017	0.376
LIG_SH2_STAT5	451	454	PF00017	0.341
LIG_SH2_STAT5	479	482	PF00017	0.564
LIG_SH3_3	111	117	PF00018	0.709
LIG_SH3_3	125	131	PF00018	0.736
LIG_SH3_3	134	140	PF00018	0.657
LIG_SH3_3	166	172	PF00018	0.668
LIG_SH3_3	17	23	PF00018	0.689
LIG_SH3_3	192	198	PF00018	0.679
LIG_SH3_3	31	37	PF00018	0.660
LIG_SH3_3	496	502	PF00018	0.622
LIG_SH3_3	70	76	PF00018	0.705
LIG_SH3_4	31	38	PF00018	0.657
LIG_Sin3_3	340	347	PF02671	0.303
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.363
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.333
LIG_SUMO_SIM_anti_2	461	466	PF11976	0.303
LIG_SUMO_SIM_par_1	106	112	PF11976	0.625
LIG_SUMO_SIM_par_1	352	358	PF11976	0.440
LIG_TRAF2_1	130	133	PF00917	0.686
LIG_TYR_ITSM	484	491	PF00017	0.541
LIG_UBA3_1	107	115	PF00899	0.661
LIG_UBA3_1	354	360	PF00899	0.350
LIG_WRC_WIRS_1	356	361	PF05994	0.353
LIG_WRC_WIRS_1	415	420	PF05994	0.395
MOD_CK1_1	106	112	PF00069	0.658
MOD_CK1_1	136	142	PF00069	0.693
MOD_CK1_1	417	423	PF00069	0.469
MOD_CK1_1	50	56	PF00069	0.636
MOD_CK1_1	503	509	PF00069	0.649
MOD_CK1_1	83	89	PF00069	0.691
MOD_CK2_1	106	112	PF00069	0.667
MOD_CK2_1	123	129	PF00069	0.638
MOD_CK2_1	139	145	PF00069	0.693
MOD_CK2_1	173	179	PF00069	0.688
MOD_CK2_1	233	239	PF00069	0.651
MOD_CK2_1	57	63	PF00069	0.680
MOD_GlcNHglycan	100	103	PF01048	0.447
MOD_GlcNHglycan	14	17	PF01048	0.547
MOD_GlcNHglycan	164	167	PF01048	0.447
MOD_GlcNHglycan	262	265	PF01048	0.437
MOD_GlcNHglycan	367	370	PF01048	0.411
MOD_GlcNHglycan	419	422	PF01048	0.398
MOD_GlcNHglycan	448	451	PF01048	0.541
MOD_GlcNHglycan	502	505	PF01048	0.496
MOD_GSK3_1	123	130	PF00069	0.679
MOD_GSK3_1	132	139	PF00069	0.695
MOD_GSK3_1	22	29	PF00069	0.688
MOD_GSK3_1	277	284	PF00069	0.656
MOD_GSK3_1	376	383	PF00069	0.617
MOD_GSK3_1	48	55	PF00069	0.662
MOD_N-GLC_1	272	277	PF02516	0.408
MOD_N-GLC_2	390	392	PF02516	0.348
MOD_N-GLC_2	404	406	PF02516	0.265
MOD_NEK2_1	103	108	PF00069	0.683
MOD_NEK2_1	312	317	PF00069	0.408
MOD_NEK2_1	350	355	PF00069	0.486
MOD_NEK2_1	414	419	PF00069	0.366
MOD_NEK2_1	475	480	PF00069	0.420
MOD_PIKK_1	281	287	PF00454	0.622
MOD_PIKK_1	323	329	PF00454	0.383
MOD_PK_1	30	36	PF00069	0.661
MOD_PKA_1	30	36	PF00069	0.695
MOD_PKA_1	376	382	PF00069	0.541
MOD_PKA_1	495	501	PF00069	0.588
MOD_PKA_2	281	287	PF00069	0.679
MOD_PKA_2	376	382	PF00069	0.571
MOD_PKA_2	446	452	PF00069	0.328
MOD_PKA_2	80	86	PF00069	0.696
MOD_PKA_2	90	96	PF00069	0.654
MOD_PKB_1	10	18	PF00069	0.705
MOD_PKB_1	231	239	PF00069	0.692
MOD_Plk_1	132	138	PF00069	0.649
MOD_Plk_1	83	89	PF00069	0.693
MOD_Plk_4	103	109	PF00069	0.651
MOD_Plk_4	133	139	PF00069	0.690
MOD_Plk_4	313	319	PF00069	0.420
MOD_Plk_4	350	356	PF00069	0.465
MOD_Plk_4	423	429	PF00069	0.358
MOD_Plk_4	432	438	PF00069	0.325
MOD_Plk_4	458	464	PF00069	0.354
MOD_Plk_4	475	481	PF00069	0.319
MOD_ProDKin_1	127	133	PF00069	0.674
MOD_ProDKin_1	136	142	PF00069	0.689
MOD_ProDKin_1	35	41	PF00069	0.655
MOD_ProDKin_1	95	101	PF00069	0.678
MOD_SUMO_rev_2	251	261	PF00179	0.656
TRG_ENDOCYTIC_2	321	324	PF00928	0.320
TRG_ENDOCYTIC_2	351	354	PF00928	0.398
TRG_ENDOCYTIC_2	412	415	PF00928	0.564
TRG_ENDOCYTIC_2	479	482	PF00928	0.627
TRG_ENDOCYTIC_2	488	491	PF00928	0.564
TRG_ER_diArg_1	10	13	PF00400	0.707
TRG_ER_diArg_1	286	288	PF00400	0.604
TRG_ER_diArg_1	376	378	PF00400	0.541
TRG_ER_diArg_1	514	516	PF00400	0.638
TRG_NLS_Bipartite_1	494	516	PF00514	0.631
TRG_NLS_MonoCore_2	511	516	PF00514	0.623
TRG_NLS_MonoExtC_3	512	517	PF00514	0.598
TRG_NLS_MonoExtN_4	494	499	PF00514	0.567
TRG_NLS_MonoExtN_4	509	516	PF00514	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRS6	Leishmania donovani	88%	100%
A4H6N2	Leishmania braziliensis	63%	100%
A4HCH5	Leishmania braziliensis	32%	100%
A4HV16	Leishmania infantum	88%	100%
A4HV17	Leishmania infantum	52%	100%
E9ANQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	83%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%