Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 7, putative

Species:

Leishmania major

UniProt:

Q4QGX1_LEIMA

TriTrypDb:

LmjF.11.1090 , LMJLV39_110018500 , LMJSD75_110019000

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	3
GO:0005794	Golgi apparatus	5	3
GO:0016020	membrane	2	17
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4QGX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGX1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	3
GO:0006605	protein targeting	5	3
GO:0006612	protein targeting to membrane	5	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0006897	endocytosis	5	3
GO:0008104	protein localization	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016192	vesicle-mediated transport	4	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018198	peptidyl-cysteine modification	6	3
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	3
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	3
GO:0018345	protein palmitoylation	6	3
GO:0019538	protein metabolic process	3	3
GO:0033036	macromolecule localization	2	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0043543	protein acylation	5	3
GO:0044238	primary metabolic process	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0051668	localization within membrane	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071704	organic substance metabolic process	2	3
GO:0071705	nitrogen compound transport	4	3
GO:0072657	protein localization to membrane	4	3
GO:0090150	establishment of protein localization to membrane	4	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016409	palmitoyltransferase activity	5	17
GO:0016417	S-acyltransferase activity	5	17
GO:0016740	transferase activity	2	17
GO:0016746	acyltransferase activity	3	17
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	17
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	17
GO:0019707	protein-cysteine S-acyltransferase activity	3	17
GO:0140096	catalytic activity, acting on a protein	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.511
CLV_NRD_NRD_1	169	171	PF00675	0.270
CLV_NRD_NRD_1	67	69	PF00675	0.423
CLV_NRD_NRD_1	79	81	PF00675	0.299
CLV_PCSK_FUR_1	77	81	PF00082	0.347
CLV_PCSK_KEX2_1	168	170	PF00082	0.259
CLV_PCSK_KEX2_1	287	289	PF00082	0.327
CLV_PCSK_KEX2_1	67	69	PF00082	0.423
CLV_PCSK_KEX2_1	79	81	PF00082	0.299
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.330
CLV_PCSK_SKI1_1	80	84	PF00082	0.349
DEG_Nend_UBRbox_2	1	3	PF02207	0.568
DOC_MAPK_MEF2A_6	245	253	PF00069	0.419
DOC_PP2B_LxvP_1	24	27	PF13499	0.592
DOC_PP4_FxxP_1	292	295	PF00568	0.532
DOC_PP4_FxxP_1	83	86	PF00568	0.496
DOC_USP7_MATH_1	221	225	PF00917	0.310
DOC_USP7_MATH_1	4	8	PF00917	0.614
DOC_USP7_MATH_1	58	62	PF00917	0.629
DOC_USP7_MATH_1	86	90	PF00917	0.578
DOC_USP7_UBL2_3	179	183	PF12436	0.451
LIG_14-3-3_CanoR_1	277	282	PF00244	0.433
LIG_14-3-3_CanoR_1	85	91	PF00244	0.498
LIG_Actin_WH2_2	263	279	PF00022	0.403
LIG_BIR_III_4	31	35	PF00653	0.616
LIG_BRCT_BRCA1_1	106	110	PF00533	0.381
LIG_BRCT_BRCA1_1	240	244	PF00533	0.311
LIG_FHA_1	289	295	PF00498	0.646
LIG_FHA_2	169	175	PF00498	0.506
LIG_LIR_Apic_2	289	295	PF02991	0.515
LIG_LIR_Gen_1	202	211	PF02991	0.464
LIG_LIR_Gen_1	214	222	PF02991	0.368
LIG_LIR_Gen_1	278	285	PF02991	0.461
LIG_LIR_Nem_3	107	113	PF02991	0.424
LIG_LIR_Nem_3	202	207	PF02991	0.445
LIG_LIR_Nem_3	214	219	PF02991	0.403
LIG_LIR_Nem_3	278	284	PF02991	0.489
LIG_MLH1_MIPbox_1	240	244	PF16413	0.311
LIG_PCNA_yPIPBox_3	121	129	PF02747	0.213
LIG_Pex14_1	106	110	PF04695	0.285
LIG_Pex14_2	131	135	PF04695	0.453
LIG_Pex14_2	147	151	PF04695	0.467
LIG_SH2_CRK	97	101	PF00017	0.401
LIG_SH2_PTP2	113	116	PF00017	0.370
LIG_SH2_SRC	281	284	PF00017	0.505
LIG_SH2_SRC	90	93	PF00017	0.443
LIG_SH2_STAT5	113	116	PF00017	0.232
LIG_SH2_STAT5	117	120	PF00017	0.227
LIG_SH2_STAT5	143	146	PF00017	0.500
LIG_SH2_STAT5	204	207	PF00017	0.490
LIG_SH2_STAT5	243	246	PF00017	0.272
LIG_SH2_STAT5	271	274	PF00017	0.475
LIG_SH2_STAT5	97	100	PF00017	0.386
LIG_SH3_3	20	26	PF00018	0.617
LIG_TYR_ITSM	277	284	PF00017	0.511
LIG_WRC_WIRS_1	216	221	PF05994	0.246
MOD_CK1_1	214	220	PF00069	0.332
MOD_CK1_1	301	307	PF00069	0.689
MOD_CK2_1	4	10	PF00069	0.677
MOD_CK2_1	50	56	PF00069	0.715
MOD_Cter_Amidation	285	288	PF01082	0.295
MOD_GlcNHglycan	10	14	PF01048	0.436
MOD_GlcNHglycan	159	162	PF01048	0.325
MOD_GlcNHglycan	211	214	PF01048	0.360
MOD_GlcNHglycan	240	243	PF01048	0.570
MOD_GSK3_1	168	175	PF00069	0.486
MOD_GSK3_1	211	218	PF00069	0.355
MOD_GSK3_1	298	305	PF00069	0.509
MOD_GSK3_1	69	76	PF00069	0.545
MOD_N-GLC_2	182	184	PF02516	0.280
MOD_N-GLC_2	196	198	PF02516	0.245
MOD_NEK2_1	104	109	PF00069	0.300
MOD_NEK2_1	147	152	PF00069	0.504
MOD_NEK2_1	276	281	PF00069	0.462
MOD_NEK2_1	9	14	PF00069	0.701
MOD_NEK2_2	130	135	PF00069	0.459
MOD_PIKK_1	115	121	PF00454	0.386
MOD_PKA_1	168	174	PF00069	0.525
MOD_PKA_2	168	174	PF00069	0.483
MOD_PKA_2	238	244	PF00069	0.206
MOD_PKA_2	276	282	PF00069	0.449
MOD_PKA_2	73	79	PF00069	0.597
MOD_Plk_1	288	294	PF00069	0.532
MOD_Plk_4	105	111	PF00069	0.316
MOD_Plk_4	130	136	PF00069	0.372
MOD_Plk_4	211	217	PF00069	0.346
MOD_Plk_4	221	227	PF00069	0.472
TRG_ENDOCYTIC_2	113	116	PF00928	0.268
TRG_ENDOCYTIC_2	143	146	PF00928	0.552
TRG_ENDOCYTIC_2	204	207	PF00928	0.451
TRG_ENDOCYTIC_2	271	274	PF00928	0.504
TRG_ENDOCYTIC_2	281	284	PF00928	0.434
TRG_ENDOCYTIC_2	97	100	PF00928	0.390
TRG_ER_diArg_1	168	170	PF00400	0.461
TRG_ER_diArg_1	67	69	PF00400	0.603
TRG_ER_diArg_1	77	80	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	31%	76%
A0A0N1I382	Leptomonas seymouri	49%	76%
A0A1X0NUX2	Trypanosomatidae	30%	84%
A0A3R7RC91	Trypanosoma rangeli	29%	92%
A0A3S5H6J6	Leishmania donovani	91%	96%
A0A3S7WX91	Leishmania donovani	29%	78%
A4H6N3	Leishmania braziliensis	70%	70%
A4HCH5	Leishmania braziliensis	31%	77%
A4HV17	Leishmania infantum	90%	66%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	87%
E9AH03	Leishmania infantum	29%	78%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
Q4QBL2	Leishmania major	30%	78%
Q750R7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	84%
V5B8P9	Trypanosoma cruzi	32%	89%
V5BWI0	Trypanosoma cruzi	45%	90%