Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGW8_LEIMA

TriTrypDb:

LmjF.11.1120 , LMJLV39_110018800 , LMJSD75_110019200

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.692
CLV_C14_Caspase3-7	308	312	PF00656	0.644
CLV_C14_Caspase3-7	5	9	PF00656	0.627
CLV_PCSK_SKI1_1	120	124	PF00082	0.674
DEG_APCC_DBOX_1	41	49	PF00400	0.624
DEG_SCF_FBW7_1	242	249	PF00400	0.760
DOC_MAPK_MEF2A_6	318	327	PF00069	0.646
DOC_PP4_FxxP_1	250	253	PF00568	0.635
DOC_USP7_MATH_1	113	117	PF00917	0.696
DOC_USP7_MATH_1	280	284	PF00917	0.716
DOC_USP7_MATH_1	312	316	PF00917	0.682
DOC_WW_Pin1_4	109	114	PF00397	0.655
DOC_WW_Pin1_4	134	139	PF00397	0.748
DOC_WW_Pin1_4	190	195	PF00397	0.677
DOC_WW_Pin1_4	242	247	PF00397	0.762
DOC_WW_Pin1_4	294	299	PF00397	0.654
DOC_WW_Pin1_4	57	62	PF00397	0.636
LIG_14-3-3_CanoR_1	190	194	PF00244	0.751
LIG_14-3-3_CanoR_1	219	229	PF00244	0.690
LIG_14-3-3_CanoR_1	31	40	PF00244	0.613
LIG_14-3-3_CanoR_1	329	337	PF00244	0.667
LIG_Actin_WH2_2	177	192	PF00022	0.721
LIG_Actin_WH2_2	313	331	PF00022	0.625
LIG_Actin_WH2_2	36	51	PF00022	0.571
LIG_Actin_WH2_2	79	97	PF00022	0.601
LIG_BRCT_BRCA1_1	167	171	PF00533	0.658
LIG_BRCT_BRCA1_1	34	38	PF00533	0.543
LIG_CtBP_PxDLS_1	231	235	PF00389	0.531
LIG_DCNL_PONY_1	1	4	PF03556	0.637
LIG_EVH1_2	246	250	PF00568	0.521
LIG_FHA_1	70	76	PF00498	0.722
LIG_FHA_2	172	178	PF00498	0.602
LIG_FHA_2	3	9	PF00498	0.634
LIG_LIR_Apic_2	248	253	PF02991	0.631
LIG_LIR_Apic_2	331	336	PF02991	0.633
LIG_LIR_Gen_1	169	177	PF02991	0.704
LIG_LIR_Gen_1	23	33	PF02991	0.524
LIG_LIR_Nem_3	169	175	PF02991	0.598
LIG_LIR_Nem_3	23	28	PF02991	0.617
LIG_LYPXL_SIV_4	9	17	PF13949	0.706
LIG_PDZ_Class_2	332	337	PF00595	0.644
LIG_Rb_LxCxE_1	324	337	PF01857	0.657
LIG_SH2_CRK	333	337	PF00017	0.645
LIG_SH2_NCK_1	291	295	PF00017	0.763
LIG_SH2_SRC	291	294	PF00017	0.764
LIG_SH2_STAP1	10	14	PF00017	0.566
LIG_SH3_3	107	113	PF00018	0.664
LIG_SH3_3	139	145	PF00018	0.626
LIG_SH3_3	295	301	PF00018	0.650
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.661
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.626
LIG_SUMO_SIM_par_1	158	163	PF11976	0.586
LIG_SUMO_SIM_par_1	2	8	PF11976	0.641
LIG_WRC_WIRS_1	103	108	PF05994	0.657
MOD_CDK_SPK_2	138	143	PF00069	0.561
MOD_CDK_SPxxK_3	190	197	PF00069	0.677
MOD_CK1_1	112	118	PF00069	0.734
MOD_CK1_1	134	140	PF00069	0.759
MOD_CK1_1	193	199	PF00069	0.723
MOD_CK1_1	213	219	PF00069	0.467
MOD_CK2_1	171	177	PF00069	0.605
MOD_CK2_1	193	199	PF00069	0.665
MOD_CK2_1	201	207	PF00069	0.674
MOD_CK2_1	257	263	PF00069	0.767
MOD_DYRK1A_RPxSP_1	109	113	PF00069	0.542
MOD_GlcNHglycan	115	118	PF01048	0.743
MOD_GlcNHglycan	133	136	PF01048	0.463
MOD_GlcNHglycan	162	165	PF01048	0.706
MOD_GlcNHglycan	181	184	PF01048	0.399
MOD_GlcNHglycan	215	218	PF01048	0.722
MOD_GlcNHglycan	265	268	PF01048	0.670
MOD_GlcNHglycan	306	310	PF01048	0.518
MOD_GlcNHglycan	34	37	PF01048	0.529
MOD_GlcNHglycan	54	57	PF01048	0.433
MOD_GlcNHglycan	72	75	PF01048	0.473
MOD_GSK3_1	105	112	PF00069	0.700
MOD_GSK3_1	134	141	PF00069	0.675
MOD_GSK3_1	171	178	PF00069	0.603
MOD_GSK3_1	189	196	PF00069	0.646
MOD_GSK3_1	197	204	PF00069	0.660
MOD_GSK3_1	241	248	PF00069	0.770
MOD_GSK3_1	257	264	PF00069	0.545
MOD_NEK2_1	160	165	PF00069	0.580
MOD_NEK2_1	171	176	PF00069	0.514
MOD_NEK2_1	189	194	PF00069	0.488
MOD_NEK2_1	305	310	PF00069	0.520
MOD_NEK2_1	94	99	PF00069	0.674
MOD_PKA_2	189	195	PF00069	0.749
MOD_PKA_2	207	213	PF00069	0.486
MOD_PKA_2	328	334	PF00069	0.630
MOD_PKA_2	94	100	PF00069	0.726
MOD_Plk_1	123	129	PF00069	0.713
MOD_Plk_1	150	156	PF00069	0.645
MOD_Plk_1	176	182	PF00069	0.603
MOD_Plk_1	197	203	PF00069	0.705
MOD_Plk_1	43	49	PF00069	0.704
MOD_Plk_4	150	156	PF00069	0.619
MOD_Plk_4	2	8	PF00069	0.641
MOD_Plk_4	246	252	PF00069	0.522
MOD_ProDKin_1	109	115	PF00069	0.657
MOD_ProDKin_1	134	140	PF00069	0.744
MOD_ProDKin_1	190	196	PF00069	0.676
MOD_ProDKin_1	242	248	PF00069	0.761
MOD_ProDKin_1	294	300	PF00069	0.656
MOD_ProDKin_1	57	63	PF00069	0.636
TRG_ENDOCYTIC_2	291	294	PF00928	0.741
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ79	Leptomonas seymouri	30%	93%
A0A3Q8I948	Leishmania donovani	90%	100%
A4H6N6	Leishmania braziliensis	63%	100%
A4HV20	Leishmania infantum	89%	100%
E8NHE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%