LeishMANIAdb
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Putative 60S ribosomal protein L28

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 60S ribosomal protein L28
Gene product:
60S ribosomal protein L28, putative
Species:
Leishmania major
UniProt:
Q4QGW7_LEIMA
TriTrypDb:
LmjF.11.1130 , LMJLV39_110018700 , LMJSD75_110019300 *
Length:
147

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0015934 large ribosomal subunit 4 2
GO:0022625 cytosolic large ribosomal subunit 5 2
GO:0032991 protein-containing complex 1 11
GO:0044391 ribosomal subunit 3 2
GO:0110165 cellular anatomical entity 1 14
GO:1990904 ribonucleoprotein complex 2 11
GO:0005840 ribosome 5 12
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12

Expansion

Sequence features

Q4QGW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW7

PDB structure(s): 6az3_Z

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 11
GO:0006518 peptide metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0019538 protein metabolic process 3 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 11
GO:0043043 peptide biosynthetic process 5 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043603 amide metabolic process 3 11
GO:0043604 amide biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 11
GO:0005198 structural molecule activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 64 68 PF00656 0.505
CLV_NRD_NRD_1 109 111 PF00675 0.379
CLV_NRD_NRD_1 112 114 PF00675 0.379
CLV_NRD_NRD_1 127 129 PF00675 0.390
CLV_NRD_NRD_1 138 140 PF00675 0.643
CLV_PCSK_FUR_1 110 114 PF00082 0.512
CLV_PCSK_FUR_1 143 147 PF00082 0.649
CLV_PCSK_KEX2_1 109 111 PF00082 0.393
CLV_PCSK_KEX2_1 112 114 PF00082 0.379
CLV_PCSK_KEX2_1 145 147 PF00082 0.655
CLV_PCSK_KEX2_1 21 23 PF00082 0.379
CLV_PCSK_KEX2_1 40 42 PF00082 0.379
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.655
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.389
CLV_PCSK_PC1ET2_1 40 42 PF00082 0.379
CLV_PCSK_PC7_1 17 23 PF00082 0.508
CLV_PCSK_SKI1_1 120 124 PF00082 0.582
CLV_PCSK_SKI1_1 54 58 PF00082 0.483
DEG_APCC_DBOX_1 99 107 PF00400 0.379
DOC_MAPK_gen_1 128 137 PF00069 0.574
DOC_MAPK_gen_1 54 63 PF00069 0.402
DOC_MAPK_MEF2A_6 57 65 PF00069 0.512
DOC_MAPK_RevD_3 97 110 PF00069 0.395
DOC_PP1_RVXF_1 132 138 PF00149 0.614
DOC_USP7_MATH_1 104 108 PF00917 0.434
DOC_USP7_UBL2_3 136 140 PF12436 0.693
LIG_14-3-3_CanoR_1 128 137 PF00244 0.637
LIG_14-3-3_CanoR_1 75 79 PF00244 0.428
LIG_14-3-3_CanoR_1 88 96 PF00244 0.434
LIG_AP2alpha_2 30 32 PF02296 0.395
LIG_BIR_II_1 1 5 PF00653 0.650
LIG_FHA_1 119 125 PF00498 0.605
LIG_FHA_2 62 68 PF00498 0.502
LIG_LIR_Nem_3 6 12 PF02991 0.389
LIG_PTB_Apo_2 26 33 PF02174 0.508
LIG_RPA_C_Fungi 134 146 PF08784 0.749
LIG_SH3_3 49 55 PF00018 0.516
MOD_CK1_1 138 144 PF00069 0.760
MOD_CK1_1 90 96 PF00069 0.401
MOD_GlcNHglycan 140 143 PF01048 0.747
MOD_GSK3_1 74 81 PF00069 0.404
MOD_N-GLC_1 36 41 PF02516 0.376
MOD_NEK2_2 104 109 PF00069 0.495
MOD_NEK2_2 78 83 PF00069 0.507
MOD_PKA_2 138 144 PF00069 0.690
MOD_PKA_2 25 31 PF00069 0.369
MOD_PKA_2 74 80 PF00069 0.428
MOD_PKA_2 87 93 PF00069 0.434
MOD_Plk_1 104 110 PF00069 0.495
TRG_ER_diArg_1 108 110 PF00400 0.379
TRG_ER_diArg_1 112 114 PF00400 0.379
TRG_NLS_Bipartite_1 112 132 PF00514 0.604
TRG_NLS_MonoExtC_3 127 133 PF00514 0.660

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HQW7 Leptomonas seymouri 86% 100%
A0A0S4IQT0 Bodo saltans 60% 100%
A0A1X0NUX0 Trypanosomatidae 71% 100%
A0A3Q8I930 Leishmania donovani 97% 100%
A0A3Q8I959 Leishmania donovani 97% 100%
A0A3R7M2X2 Trypanosoma rangeli 68% 100%
A0A422NRH0 Trypanosoma rangeli 68% 100%
A4H6N5 Leishmania braziliensis 85% 100%
A4H6N7 Leishmania braziliensis 84% 100%
A4HV19 Leishmania infantum 97% 100%
D0A7C8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E8NHE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O00822 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS