WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein SEC31, putative

Species:

Leishmania major

UniProt:

Q4QGW6_LEIMA

TriTrypDb:

LmjF.11.1160 , LMJLV39_110019000 , LMJSD75_110019400

Length:

1158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	2
GO:0030120	vesicle coat	4	2
GO:0030127	COPII vesicle coat	5	2
GO:0032991	protein-containing complex	1	2
GO:0070971	endoplasmic reticulum exit site	2	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

Q4QGW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007029	endoplasmic reticulum organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0033036	macromolecule localization	2	2
GO:0035459	vesicle cargo loading	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090110	COPII-coated vesicle cargo loading	4	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	4
GO:0016192	vesicle-mediated transport	4	4
GO:0048193	Golgi vesicle transport	5	4

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.440
CLV_C14_Caspase3-7	160	164	PF00656	0.475
CLV_NRD_NRD_1	1094	1096	PF00675	0.443
CLV_NRD_NRD_1	534	536	PF00675	0.399
CLV_NRD_NRD_1	739	741	PF00675	0.498
CLV_PCSK_KEX2_1	1093	1095	PF00082	0.462
CLV_PCSK_KEX2_1	491	493	PF00082	0.544
CLV_PCSK_KEX2_1	552	554	PF00082	0.432
CLV_PCSK_KEX2_1	739	741	PF00082	0.477
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.544
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.432
CLV_PCSK_SKI1_1	120	124	PF00082	0.617
CLV_PCSK_SKI1_1	215	219	PF00082	0.422
CLV_PCSK_SKI1_1	553	557	PF00082	0.411
CLV_PCSK_SKI1_1	577	581	PF00082	0.411
CLV_PCSK_SKI1_1	669	673	PF00082	0.464
CLV_PCSK_SKI1_1	702	706	PF00082	0.689
CLV_Separin_Metazoa	532	536	PF03568	0.457
DEG_APCC_DBOX_1	119	127	PF00400	0.409
DEG_Nend_UBRbox_1	1	4	PF02207	0.386
DEG_SCF_FBW7_1	1129	1135	PF00400	0.358
DEG_SPOP_SBC_1	967	971	PF00917	0.617
DOC_CKS1_1	1129	1134	PF01111	0.353
DOC_MAPK_HePTP_8	502	514	PF00069	0.459
DOC_MAPK_MEF2A_6	505	514	PF00069	0.386
DOC_PP1_RVXF_1	118	125	PF00149	0.420
DOC_PP1_RVXF_1	71	77	PF00149	0.362
DOC_PP2B_LxvP_1	835	838	PF13499	0.619
DOC_PP4_FxxP_1	1070	1073	PF00568	0.443
DOC_USP7_MATH_1	1048	1052	PF00917	0.617
DOC_USP7_MATH_1	173	177	PF00917	0.471
DOC_USP7_MATH_1	26	30	PF00917	0.355
DOC_USP7_MATH_1	337	341	PF00917	0.342
DOC_USP7_MATH_1	381	385	PF00917	0.407
DOC_USP7_MATH_1	441	445	PF00917	0.407
DOC_USP7_MATH_1	560	564	PF00917	0.423
DOC_USP7_MATH_1	810	814	PF00917	0.703
DOC_USP7_MATH_1	827	831	PF00917	0.537
DOC_USP7_MATH_1	839	843	PF00917	0.736
DOC_USP7_MATH_1	941	945	PF00917	0.618
DOC_USP7_MATH_1	968	972	PF00917	0.693
DOC_USP7_MATH_1	973	977	PF00917	0.761
DOC_USP7_MATH_1	997	1001	PF00917	0.659
DOC_USP7_UBL2_3	366	370	PF12436	0.480
DOC_WW_Pin1_4	1063	1068	PF00397	0.470
DOC_WW_Pin1_4	1069	1074	PF00397	0.400
DOC_WW_Pin1_4	1128	1133	PF00397	0.419
DOC_WW_Pin1_4	12	17	PF00397	0.338
DOC_WW_Pin1_4	401	406	PF00397	0.496
DOC_WW_Pin1_4	421	426	PF00397	0.338
DOC_WW_Pin1_4	723	728	PF00397	0.512
DOC_WW_Pin1_4	74	79	PF00397	0.371
DOC_WW_Pin1_4	868	873	PF00397	0.634
DOC_WW_Pin1_4	882	887	PF00397	0.660
LIG_14-3-3_CanoR_1	1037	1041	PF00244	0.591
LIG_14-3-3_CanoR_1	2	12	PF00244	0.413
LIG_14-3-3_CanoR_1	219	225	PF00244	0.399
LIG_14-3-3_CanoR_1	496	502	PF00244	0.647
LIG_Actin_WH2_2	201	217	PF00022	0.367
LIG_AP2alpha_1	519	523	PF02296	0.374
LIG_AP2alpha_2	480	482	PF02296	0.524
LIG_BRCT_BRCA1_1	39	43	PF00533	0.408
LIG_BRCT_BRCA1_1	562	566	PF00533	0.422
LIG_CSL_BTD_1	13	16	PF09270	0.328
LIG_deltaCOP1_diTrp_1	152	159	PF00928	0.437
LIG_EVH1_1	835	839	PF00568	0.618
LIG_FHA_1	164	170	PF00498	0.462
LIG_FHA_1	200	206	PF00498	0.352
LIG_FHA_1	243	249	PF00498	0.371
LIG_FHA_1	263	269	PF00498	0.306
LIG_FHA_1	275	281	PF00498	0.491
LIG_FHA_1	426	432	PF00498	0.416
LIG_FHA_1	495	501	PF00498	0.495
LIG_FHA_1	641	647	PF00498	0.420
LIG_FHA_1	691	697	PF00498	0.460
LIG_FHA_1	917	923	PF00498	0.699
LIG_FHA_1	996	1002	PF00498	0.603
LIG_FHA_2	147	153	PF00498	0.363
LIG_FHA_2	158	164	PF00498	0.393
LIG_FHA_2	347	353	PF00498	0.423
LIG_FHA_2	354	360	PF00498	0.552
LIG_FHA_2	387	393	PF00498	0.485
LIG_FHA_2	405	411	PF00498	0.583
LIG_FHA_2	432	438	PF00498	0.436
LIG_LIR_Apic_2	302	307	PF02991	0.473
LIG_LIR_Apic_2	77	82	PF02991	0.465
LIG_LIR_Gen_1	1135	1146	PF02991	0.471
LIG_LIR_Gen_1	40	51	PF02991	0.372
LIG_LIR_Gen_1	479	488	PF02991	0.540
LIG_LIR_Gen_1	943	951	PF02991	0.635
LIG_LIR_LC3C_4	245	249	PF02991	0.363
LIG_LIR_Nem_3	1135	1141	PF02991	0.468
LIG_LIR_Nem_3	325	331	PF02991	0.456
LIG_LIR_Nem_3	338	344	PF02991	0.298
LIG_LIR_Nem_3	40	46	PF02991	0.369
LIG_LIR_Nem_3	479	485	PF02991	0.533
LIG_LIR_Nem_3	563	569	PF02991	0.421
LIG_LIR_Nem_3	610	616	PF02991	0.352
LIG_LIR_Nem_3	75	79	PF02991	0.373
LIG_MYND_1	823	827	PF01753	0.625
LIG_MYND_1	847	851	PF01753	0.607
LIG_MYND_1	935	939	PF01753	0.633
LIG_Pex14_1	192	196	PF04695	0.363
LIG_Pex14_2	519	523	PF04695	0.374
LIG_PTB_Apo_2	1151	1158	PF02174	0.359
LIG_PTB_Phospho_1	1151	1157	PF10480	0.359
LIG_SH2_CRK	79	83	PF00017	0.475
LIG_SH2_CRK	802	806	PF00017	0.657
LIG_SH2_NCK_1	196	200	PF00017	0.362
LIG_SH2_SRC	196	199	PF00017	0.369
LIG_SH2_SRC	716	719	PF00017	0.685
LIG_SH2_SRC	796	799	PF00017	0.661
LIG_SH2_STAP1	196	200	PF00017	0.362
LIG_SH2_STAP1	986	990	PF00017	0.692
LIG_SH2_STAT5	322	325	PF00017	0.354
LIG_SH2_STAT5	541	544	PF00017	0.415
LIG_SH2_STAT5	616	619	PF00017	0.338
LIG_SH2_STAT5	658	661	PF00017	0.407
LIG_SH2_STAT5	682	685	PF00017	0.433
LIG_SH2_STAT5	703	706	PF00017	0.484
LIG_SH2_STAT5	716	719	PF00017	0.595
LIG_SH2_STAT5	796	799	PF00017	0.661
LIG_SH2_STAT5	96	99	PF00017	0.481
LIG_SH3_1	1027	1033	PF00018	0.637
LIG_SH3_3	1004	1010	PF00018	0.553
LIG_SH3_3	1025	1031	PF00018	0.610
LIG_SH3_3	1041	1047	PF00018	0.644
LIG_SH3_3	1126	1132	PF00018	0.348
LIG_SH3_3	138	144	PF00018	0.383
LIG_SH3_3	166	172	PF00018	0.447
LIG_SH3_3	327	333	PF00018	0.357
LIG_SH3_3	399	405	PF00018	0.567
LIG_SH3_3	62	68	PF00018	0.390
LIG_SH3_3	712	718	PF00018	0.623
LIG_SH3_3	753	759	PF00018	0.621
LIG_SH3_3	767	773	PF00018	0.627
LIG_SH3_3	783	789	PF00018	0.539
LIG_SH3_3	833	839	PF00018	0.703
LIG_SH3_3	841	847	PF00018	0.729
LIG_SH3_3	854	860	PF00018	0.637
LIG_SH3_3	878	884	PF00018	0.655
LIG_SH3_3	886	892	PF00018	0.636
LIG_SH3_3	927	933	PF00018	0.624
LIG_SH3_3	961	967	PF00018	0.729
LIG_SH3_3	985	991	PF00018	0.670
LIG_SUMO_SIM_par_1	642	650	PF11976	0.391
LIG_SUMO_SIM_par_1	693	699	PF11976	0.441
LIG_SUMO_SIM_par_1	979	987	PF11976	0.569
LIG_TRAF2_1	286	289	PF00917	0.473
LIG_TRAF2_1	735	738	PF00917	0.510
LIG_TRAF2_2	1010	1015	PF00917	0.686
MOD_CDC14_SPxK_1	424	427	PF00782	0.411
MOD_CDK_SPxK_1	421	427	PF00069	0.425
MOD_CK1_1	176	182	PF00069	0.505
MOD_CK1_1	226	232	PF00069	0.450
MOD_CK1_1	274	280	PF00069	0.288
MOD_CK1_1	404	410	PF00069	0.609
MOD_CK1_1	904	910	PF00069	0.650
MOD_CK1_1	943	949	PF00069	0.638
MOD_CK1_1	976	982	PF00069	0.618
MOD_CK1_1	984	990	PF00069	0.610
MOD_CK2_1	283	289	PF00069	0.306
MOD_CK2_1	431	437	PF00069	0.494
MOD_CK2_1	526	532	PF00069	0.420
MOD_CK2_1	96	102	PF00069	0.401
MOD_CMANNOS	156	159	PF00535	0.363
MOD_Cter_Amidation	309	312	PF01082	0.500
MOD_GlcNHglycan	1041	1044	PF01048	0.803
MOD_GlcNHglycan	1050	1053	PF01048	0.619
MOD_GlcNHglycan	1132	1135	PF01048	0.419
MOD_GlcNHglycan	131	134	PF01048	0.442
MOD_GlcNHglycan	183	186	PF01048	0.420
MOD_GlcNHglycan	272	276	PF01048	0.297
MOD_GlcNHglycan	30	33	PF01048	0.406
MOD_GlcNHglycan	443	446	PF01048	0.428
MOD_GlcNHglycan	470	473	PF01048	0.657
MOD_GlcNHglycan	502	505	PF01048	0.475
MOD_GlcNHglycan	528	531	PF01048	0.430
MOD_GlcNHglycan	562	565	PF01048	0.436
MOD_GlcNHglycan	580	583	PF01048	0.488
MOD_GlcNHglycan	654	657	PF01048	0.454
MOD_GlcNHglycan	793	796	PF01048	0.621
MOD_GlcNHglycan	829	832	PF01048	0.809
MOD_GlcNHglycan	841	844	PF01048	0.610
MOD_GlcNHglycan	852	855	PF01048	0.646
MOD_GlcNHglycan	892	895	PF01048	0.820
MOD_GlcNHglycan	901	904	PF01048	0.617
MOD_GlcNHglycan	911	914	PF01048	0.612
MOD_GlcNHglycan	922	925	PF01048	0.616
MOD_GlcNHglycan	964	967	PF01048	0.715
MOD_GlcNHglycan	970	973	PF01048	0.682
MOD_GlcNHglycan	98	101	PF01048	0.341
MOD_GSK3_1	1057	1064	PF00069	0.565
MOD_GSK3_1	1128	1135	PF00069	0.474
MOD_GSK3_1	24	31	PF00069	0.358
MOD_GSK3_1	274	281	PF00069	0.309
MOD_GSK3_1	283	290	PF00069	0.318
MOD_GSK3_1	372	379	PF00069	0.460
MOD_GSK3_1	401	408	PF00069	0.540
MOD_GSK3_1	421	428	PF00069	0.323
MOD_GSK3_1	441	448	PF00069	0.474
MOD_GSK3_1	719	726	PF00069	0.584
MOD_GSK3_1	858	865	PF00069	0.647
MOD_GSK3_1	895	902	PF00069	0.644
MOD_GSK3_1	903	910	PF00069	0.642
MOD_GSK3_1	916	923	PF00069	0.578
MOD_GSK3_1	940	947	PF00069	0.637
MOD_GSK3_1	962	969	PF00069	0.625
MOD_GSK3_1	973	980	PF00069	0.608
MOD_GSK3_1	986	993	PF00069	0.642
MOD_N-GLC_1	223	228	PF02516	0.419
MOD_N-GLC_1	36	41	PF02516	0.446
MOD_N-GLC_1	376	381	PF02516	0.446
MOD_N-GLC_1	868	873	PF02516	0.634
MOD_N-GLC_2	1154	1156	PF02516	0.332
MOD_N-GLC_2	92	94	PF02516	0.347
MOD_NEK2_1	1061	1066	PF00069	0.514
MOD_NEK2_1	146	151	PF00069	0.352
MOD_NEK2_1	223	228	PF00069	0.419
MOD_NEK2_1	24	29	PF00069	0.351
MOD_NEK2_1	292	297	PF00069	0.335
MOD_NEK2_1	3	8	PF00069	0.398
MOD_NEK2_1	345	350	PF00069	0.420
MOD_NEK2_1	431	436	PF00069	0.434
MOD_NEK2_1	500	505	PF00069	0.431
MOD_NEK2_1	646	651	PF00069	0.399
MOD_NEK2_1	899	904	PF00069	0.657
MOD_NEK2_1	909	914	PF00069	0.609
MOD_PIKK_1	1132	1138	PF00454	0.469
MOD_PIKK_1	242	248	PF00454	0.381
MOD_PIKK_1	425	431	PF00454	0.403
MOD_PIKK_1	647	653	PF00454	0.413
MOD_PIKK_1	773	779	PF00454	0.687
MOD_PIKK_1	810	816	PF00454	0.646
MOD_PIKK_1	973	979	PF00454	0.634
MOD_PIKK_1	990	996	PF00454	0.604
MOD_PKA_2	1036	1042	PF00069	0.582
MOD_PKA_2	218	224	PF00069	0.405
MOD_PKA_2	431	437	PF00069	0.414
MOD_PKA_2	495	501	PF00069	0.436
MOD_PKA_2	633	639	PF00069	0.399
MOD_Plk_1	288	294	PF00069	0.306
MOD_Plk_1	376	382	PF00069	0.440
MOD_Plk_1	425	431	PF00069	0.421
MOD_Plk_1	904	910	PF00069	0.595
MOD_Plk_4	1021	1027	PF00069	0.639
MOD_Plk_4	1057	1063	PF00069	0.579
MOD_Plk_4	173	179	PF00069	0.430
MOD_Plk_4	288	294	PF00069	0.315
MOD_Plk_4	640	646	PF00069	0.388
MOD_Plk_4	692	698	PF00069	0.442
MOD_Plk_4	821	827	PF00069	0.641
MOD_Plk_4	862	868	PF00069	0.645
MOD_Plk_4	981	987	PF00069	0.608
MOD_ProDKin_1	1063	1069	PF00069	0.471
MOD_ProDKin_1	1128	1134	PF00069	0.411
MOD_ProDKin_1	12	18	PF00069	0.350
MOD_ProDKin_1	401	407	PF00069	0.486
MOD_ProDKin_1	421	427	PF00069	0.329
MOD_ProDKin_1	723	729	PF00069	0.510
MOD_ProDKin_1	74	80	PF00069	0.377
MOD_ProDKin_1	868	874	PF00069	0.633
MOD_ProDKin_1	882	888	PF00069	0.660
MOD_SUMO_rev_2	45	54	PF00179	0.388
TRG_DiLeu_BaEn_4	507	513	PF01217	0.383
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.376
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.371
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.420
TRG_ENDOCYTIC_2	196	199	PF00928	0.369
TRG_ENDOCYTIC_2	945	948	PF00928	0.696
TRG_ER_diArg_1	1092	1095	PF00400	0.467
TRG_ER_diArg_1	64	67	PF00400	0.386
TRG_ER_diArg_1	739	742	PF00400	0.464
TRG_NES_CRM1_1	578	590	PF08389	0.440
TRG_NES_CRM1_1	58	69	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	1107	1111	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	742	746	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K3	Leptomonas seymouri	64%	97%
A0A3S5H6J7	Leishmania donovani	94%	99%
A1DHK2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	92%
A4H6N8	Leishmania braziliensis	81%	100%
E9ANQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q3TZ89	Mus musculus	23%	100%
Q4X0M4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	92%
Q5F3X8	Gallus gallus	24%	94%