LeishMANIAdb
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Putative eukaryotic release factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative eukaryotic release factor 3
Gene product:
eukaryotic release factor 3, putative
Species:
Leishmania major
UniProt:
Q4QGW5_LEIMA
TriTrypDb:
LmjF.11.1170 , LMJLV39_110019100 * , LMJSD75_110019500 *
Length:
763

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 2
Silverman et al. yes yes: 2
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0018444 translation release factor complex 2 2
GO:0032991 protein-containing complex 1 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QGW5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW5

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 2
GO:0006518 peptide metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009058 biosynthetic process 2 2
GO:0009059 macromolecule biosynthetic process 4 2
GO:0009987 cellular process 1 2
GO:0019538 protein metabolic process 3 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 2
GO:0043043 peptide biosynthetic process 5 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043603 amide metabolic process 3 2
GO:0043604 amide biosynthetic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0044271 cellular nitrogen compound biosynthetic process 4 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901566 organonitrogen compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003676 nucleic acid binding 3 3
GO:0003747 translation release factor activity 5 2
GO:0003824 catalytic activity 1 11
GO:0003924 GTPase activity 7 11
GO:0005488 binding 1 11
GO:0005525 GTP binding 5 11
GO:0008079 translation termination factor activity 4 2
GO:0008135 translation factor activity, RNA binding 3 3
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0019001 guanyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032561 guanyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0045182 translation regulator activity 1 3
GO:0090079 translation regulator activity, nucleic acid binding 2 3
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003746 translation elongation factor activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 178 182 PF00656 0.778
CLV_C14_Caspase3-7 407 411 PF00656 0.481
CLV_NRD_NRD_1 300 302 PF00675 0.615
CLV_NRD_NRD_1 362 364 PF00675 0.295
CLV_NRD_NRD_1 404 406 PF00675 0.281
CLV_NRD_NRD_1 689 691 PF00675 0.320
CLV_PCSK_KEX2_1 300 302 PF00082 0.655
CLV_PCSK_KEX2_1 320 322 PF00082 0.356
CLV_PCSK_KEX2_1 362 364 PF00082 0.281
CLV_PCSK_KEX2_1 403 405 PF00082 0.282
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.653
CLV_PCSK_PC1ET2_1 403 405 PF00082 0.292
CLV_PCSK_SKI1_1 388 392 PF00082 0.292
CLV_PCSK_SKI1_1 404 408 PF00082 0.245
CLV_PCSK_SKI1_1 492 496 PF00082 0.281
CLV_PCSK_SKI1_1 667 671 PF00082 0.295
CLV_PCSK_SKI1_1 732 736 PF00082 0.281
DEG_SPOP_SBC_1 269 273 PF00917 0.725
DOC_ANK_TNKS_1 739 746 PF00023 0.585
DOC_CKS1_1 244 249 PF01111 0.726
DOC_CYCLIN_yCln2_LP_2 715 721 PF00134 0.561
DOC_MAPK_gen_1 199 208 PF00069 0.669
DOC_MAPK_gen_1 210 216 PF00069 0.671
DOC_MAPK_gen_1 320 331 PF00069 0.346
DOC_MAPK_gen_1 504 513 PF00069 0.512
DOC_MAPK_gen_1 534 541 PF00069 0.549
DOC_MAPK_MEF2A_6 740 748 PF00069 0.505
DOC_PP1_RVXF_1 504 511 PF00149 0.495
DOC_PP1_RVXF_1 642 649 PF00149 0.407
DOC_PP2B_LxvP_1 409 412 PF13499 0.481
DOC_PP2B_LxvP_1 545 548 PF13499 0.490
DOC_PP4_FxxP_1 557 560 PF00568 0.473
DOC_USP7_MATH_1 112 116 PF00917 0.537
DOC_USP7_MATH_1 12 16 PF00917 0.599
DOC_USP7_MATH_1 168 172 PF00917 0.738
DOC_USP7_MATH_1 175 179 PF00917 0.689
DOC_USP7_MATH_1 228 232 PF00917 0.813
DOC_USP7_MATH_1 242 246 PF00917 0.806
DOC_USP7_MATH_1 337 341 PF00917 0.481
DOC_USP7_MATH_1 64 68 PF00917 0.774
DOC_USP7_MATH_2 221 227 PF00917 0.720
DOC_USP7_UBL2_3 290 294 PF12436 0.699
DOC_USP7_UBL2_3 316 320 PF12436 0.639
DOC_USP7_UBL2_3 566 570 PF12436 0.520
DOC_USP7_UBL2_3 683 687 PF12436 0.481
DOC_USP7_UBL2_3 725 729 PF12436 0.480
DOC_WW_Pin1_4 15 20 PF00397 0.731
DOC_WW_Pin1_4 226 231 PF00397 0.759
DOC_WW_Pin1_4 243 248 PF00397 0.791
DOC_WW_Pin1_4 253 258 PF00397 0.805
DOC_WW_Pin1_4 293 298 PF00397 0.632
DOC_WW_Pin1_4 35 40 PF00397 0.670
LIG_14-3-3_CanoR_1 404 409 PF00244 0.511
LIG_14-3-3_CanoR_1 483 491 PF00244 0.414
LIG_14-3-3_CanoR_1 80 84 PF00244 0.578
LIG_APCC_ABBA_1 721 726 PF00400 0.533
LIG_APCC_ABBAyCdc20_2 80 86 PF00400 0.725
LIG_BIR_II_1 1 5 PF00653 0.639
LIG_BIR_III_2 241 245 PF00653 0.699
LIG_BIR_III_4 410 414 PF00653 0.481
LIG_BRCT_BRCA1_1 605 609 PF00533 0.539
LIG_BRCT_BRCA1_2 605 611 PF00533 0.530
LIG_FHA_1 203 209 PF00498 0.681
LIG_FHA_1 459 465 PF00498 0.481
LIG_FHA_1 5 11 PF00498 0.726
LIG_FHA_1 690 696 PF00498 0.481
LIG_FHA_1 739 745 PF00498 0.481
LIG_FHA_2 217 223 PF00498 0.756
LIG_FHA_2 230 236 PF00498 0.831
LIG_FHA_2 265 271 PF00498 0.809
LIG_FHA_2 286 292 PF00498 0.681
LIG_FHA_2 294 300 PF00498 0.555
LIG_FHA_2 405 411 PF00498 0.481
LIG_FHA_2 424 430 PF00498 0.481
LIG_FHA_2 442 448 PF00498 0.481
LIG_FHA_2 535 541 PF00498 0.506
LIG_FHA_2 550 556 PF00498 0.449
LIG_FHA_2 591 597 PF00498 0.463
LIG_FHA_2 605 611 PF00498 0.383
LIG_FXI_DFP_1 724 728 PF00024 0.295
LIG_IRF3_LxIS_1 430 436 PF10401 0.481
LIG_LIR_Apic_2 2 6 PF02991 0.649
LIG_LIR_Apic_2 554 560 PF02991 0.490
LIG_LIR_Apic_2 82 87 PF02991 0.568
LIG_LIR_Gen_1 374 381 PF02991 0.481
LIG_LIR_Gen_1 482 491 PF02991 0.499
LIG_LIR_Gen_1 678 688 PF02991 0.495
LIG_LIR_Gen_1 726 735 PF02991 0.473
LIG_LIR_Nem_3 374 378 PF02991 0.481
LIG_LIR_Nem_3 482 487 PF02991 0.499
LIG_LIR_Nem_3 571 577 PF02991 0.508
LIG_LIR_Nem_3 678 684 PF02991 0.495
LIG_LIR_Nem_3 726 730 PF02991 0.517
LIG_PCNA_APIM_2 730 736 PF02747 0.481
LIG_Pex14_1 373 377 PF04695 0.481
LIG_Pex14_2 327 331 PF04695 0.495
LIG_Pex14_2 442 446 PF04695 0.481
LIG_REV1ctd_RIR_1 646 656 PF16727 0.533
LIG_SH2_CRK 100 104 PF00017 0.812
LIG_SH2_CRK 37 41 PF00017 0.665
LIG_SH2_CRK 375 379 PF00017 0.481
LIG_SH2_GRB2like 24 27 PF00017 0.688
LIG_SH2_GRB2like 63 66 PF00017 0.715
LIG_SH2_NCK_1 37 41 PF00017 0.730
LIG_SH2_SRC 24 27 PF00017 0.696
LIG_SH2_SRC 375 378 PF00017 0.481
LIG_SH2_SRC 84 87 PF00017 0.751
LIG_SH2_STAP1 110 114 PF00017 0.548
LIG_SH2_STAP1 375 379 PF00017 0.481
LIG_SH2_STAP1 484 488 PF00017 0.445
LIG_SH2_STAT3 122 125 PF00017 0.694
LIG_SH2_STAT3 141 144 PF00017 0.337
LIG_SH2_STAT3 28 31 PF00017 0.709
LIG_SH2_STAT3 49 52 PF00017 0.682
LIG_SH2_STAT3 74 77 PF00017 0.705
LIG_SH2_STAT5 17 20 PF00017 0.738
LIG_SH2_STAT5 24 27 PF00017 0.749
LIG_SH2_STAT5 377 380 PF00017 0.481
LIG_SH2_STAT5 398 401 PF00017 0.481
LIG_SH2_STAT5 634 637 PF00017 0.388
LIG_SH3_3 241 247 PF00018 0.783
LIG_SH3_3 717 723 PF00018 0.533
LIG_SUMO_SIM_par_1 431 437 PF11976 0.481
LIG_SUMO_SIM_par_1 652 657 PF11976 0.481
LIG_SUMO_SIM_par_1 716 722 PF11976 0.561
LIG_SxIP_EBH_1 632 644 PF03271 0.445
LIG_TRAF2_1 220 223 PF00917 0.757
LIG_TRAF2_1 257 260 PF00917 0.722
LIG_TRAF2_1 296 299 PF00917 0.582
LIG_TRAF2_1 382 385 PF00917 0.512
LIG_TRAF2_1 674 677 PF00917 0.470
LIG_UBA3_1 467 473 PF00899 0.495
LIG_UBA3_1 538 546 PF00899 0.585
LIG_UBA3_1 684 691 PF00899 0.533
MOD_CDK_SPxxK_3 293 300 PF00069 0.722
MOD_CK1_1 15 21 PF00069 0.542
MOD_CK1_1 191 197 PF00069 0.741
MOD_CK1_1 226 232 PF00069 0.800
MOD_CK1_1 340 346 PF00069 0.470
MOD_CK1_1 436 442 PF00069 0.495
MOD_CK1_1 603 609 PF00069 0.520
MOD_CK1_1 638 644 PF00069 0.422
MOD_CK1_1 663 669 PF00069 0.561
MOD_CK2_1 216 222 PF00069 0.755
MOD_CK2_1 229 235 PF00069 0.697
MOD_CK2_1 264 270 PF00069 0.747
MOD_CK2_1 293 299 PF00069 0.587
MOD_CK2_1 379 385 PF00069 0.481
MOD_CK2_1 441 447 PF00069 0.481
MOD_CK2_1 534 540 PF00069 0.491
MOD_CK2_1 547 553 PF00069 0.405
MOD_CK2_1 590 596 PF00069 0.429
MOD_CK2_1 604 610 PF00069 0.422
MOD_CK2_1 671 677 PF00069 0.585
MOD_CK2_1 750 756 PF00069 0.482
MOD_Cter_Amidation 208 211 PF01082 0.694
MOD_GlcNHglycan 110 113 PF01048 0.793
MOD_GlcNHglycan 177 180 PF01048 0.758
MOD_GlcNHglycan 190 193 PF01048 0.718
MOD_GlcNHglycan 262 265 PF01048 0.764
MOD_GlcNHglycan 276 279 PF01048 0.692
MOD_GlcNHglycan 342 345 PF01048 0.281
MOD_GlcNHglycan 578 581 PF01048 0.389
MOD_GlcNHglycan 662 665 PF01048 0.361
MOD_GlcNHglycan 673 676 PF01048 0.361
MOD_GSK3_1 108 115 PF00069 0.547
MOD_GSK3_1 226 233 PF00069 0.722
MOD_GSK3_1 260 267 PF00069 0.807
MOD_GSK3_1 270 277 PF00069 0.715
MOD_GSK3_1 384 391 PF00069 0.512
MOD_GSK3_1 600 607 PF00069 0.430
MOD_GSK3_1 634 641 PF00069 0.417
MOD_GSK3_1 750 757 PF00069 0.499
MOD_N-GLC_1 112 117 PF02516 0.786
MOD_N-GLC_1 12 17 PF02516 0.551
MOD_N-GLC_1 64 69 PF02516 0.712
MOD_NEK2_1 433 438 PF00069 0.481
MOD_NEK2_1 458 463 PF00069 0.481
MOD_NEK2_1 750 755 PF00069 0.469
MOD_NEK2_2 69 74 PF00069 0.568
MOD_PIKK_1 223 229 PF00454 0.727
MOD_PIKK_1 264 270 PF00454 0.816
MOD_PIKK_1 423 429 PF00454 0.481
MOD_PKA_1 300 306 PF00069 0.649
MOD_PKA_1 404 410 PF00069 0.481
MOD_PKA_2 300 306 PF00069 0.540
MOD_PKA_2 391 397 PF00069 0.490
MOD_PKA_2 404 410 PF00069 0.461
MOD_PKA_2 482 488 PF00069 0.434
MOD_PKA_2 689 695 PF00069 0.528
MOD_PKA_2 79 85 PF00069 0.578
MOD_PKB_1 310 318 PF00069 0.708
MOD_Plk_1 112 118 PF00069 0.557
MOD_Plk_1 12 18 PF00069 0.550
MOD_Plk_1 677 683 PF00069 0.495
MOD_Plk_2-3 549 555 PF00069 0.476
MOD_Plk_2-3 600 606 PF00069 0.425
MOD_Plk_4 112 118 PF00069 0.539
MOD_Plk_4 404 410 PF00069 0.490
MOD_Plk_4 417 423 PF00069 0.461
MOD_Plk_4 534 540 PF00069 0.499
MOD_Plk_4 69 75 PF00069 0.565
MOD_Plk_4 79 85 PF00069 0.527
MOD_ProDKin_1 15 21 PF00069 0.731
MOD_ProDKin_1 226 232 PF00069 0.761
MOD_ProDKin_1 243 249 PF00069 0.793
MOD_ProDKin_1 253 259 PF00069 0.806
MOD_ProDKin_1 293 299 PF00069 0.626
MOD_ProDKin_1 35 41 PF00069 0.671
MOD_SUMO_for_1 236 239 PF00179 0.727
MOD_SUMO_for_1 304 307 PF00179 0.589
MOD_SUMO_rev_2 229 238 PF00179 0.783
MOD_SUMO_rev_2 239 245 PF00179 0.793
MOD_SUMO_rev_2 475 480 PF00179 0.559
MOD_SUMO_rev_2 540 548 PF00179 0.589
MOD_SUMO_rev_2 567 571 PF00179 0.519
TRG_DiLeu_BaEn_1 454 459 PF01217 0.481
TRG_ENDOCYTIC_2 375 378 PF00928 0.481
TRG_ENDOCYTIC_2 484 487 PF00928 0.481
TRG_ENDOCYTIC_2 574 577 PF00928 0.402
TRG_ER_diArg_1 361 363 PF00400 0.495
TRG_ER_diArg_1 404 406 PF00400 0.480
TRG_NLS_Bipartite_1 199 214 PF00514 0.778
TRG_NLS_MonoExtN_4 198 203 PF00514 0.649
TRG_Pf-PMV_PEXEL_1 623 627 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAZ5 Leptomonas seymouri 79% 100%
A0A0S4IX91 Bodo saltans 63% 100%
A0A1X0NV54 Trypanosomatidae 71% 100%
A0A3Q8ICH2 Leishmania donovani 94% 100%
A0A3R7MLL0 Trypanosoma rangeli 71% 100%
A0A3S7X9T0 Leishmania donovani 30% 100%
A4H6P3 Leishmania braziliensis 88% 100%
A4HN87 Leishmania braziliensis 32% 100%
A4HV24 Leishmania infantum 94% 100%
A4IBV5 Leishmania infantum 30% 100%
C9ZYQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A7C5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AFP2 Leishmania major 31% 100%
E9ANQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 99%
E9B6U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O74718 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%
P05453 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P23637 Ogataea pini 40% 100%
Q9HGI7 Candida maltosa 38% 100%
Q9HGI8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 38% 100%
Q9W074 Drosophila melanogaster 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS