60Kd inner membrane protein-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania major

UniProt:

Q4QGW4_LEIMA

TriTrypDb:

LmjF.11.1180 , LMJLV39_110019200 , LMJSD75_110019600

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QGW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0007006	mitochondrial membrane organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0032978	protein insertion into membrane from inner side	6	2
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051205	protein insertion into membrane	5	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0061024	membrane organization	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:0090151	establishment of protein localization to mitochondrial membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140597	protein carrier chaperone	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.734
CLV_NRD_NRD_1	224	226	PF00675	0.476
CLV_NRD_NRD_1	36	38	PF00675	0.713
CLV_NRD_NRD_1	371	373	PF00675	0.406
CLV_PCSK_KEX2_1	181	183	PF00082	0.276
CLV_PCSK_KEX2_1	2	4	PF00082	0.734
CLV_PCSK_KEX2_1	224	226	PF00082	0.476
CLV_PCSK_KEX2_1	36	38	PF00082	0.713
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.276
CLV_PCSK_SKI1_1	136	140	PF00082	0.350
CLV_PCSK_SKI1_1	182	186	PF00082	0.276
CLV_PCSK_SKI1_1	192	196	PF00082	0.276
CLV_PCSK_SKI1_1	205	209	PF00082	0.276
CLV_PCSK_SKI1_1	242	246	PF00082	0.501
CLV_PCSK_SKI1_1	329	333	PF00082	0.354
CLV_PCSK_SKI1_1	81	85	PF00082	0.568
CLV_Separin_Metazoa	106	110	PF03568	0.367
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DOC_CDC14_PxL_1	138	146	PF14671	0.386
DOC_CDC14_PxL_1	233	241	PF14671	0.287
DOC_CYCLIN_RxL_1	133	143	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.344
DOC_MAPK_FxFP_2	332	335	PF00069	0.564
DOC_MAPK_gen_1	109	119	PF00069	0.394
DOC_MAPK_gen_1	19	29	PF00069	0.502
DOC_MAPK_gen_1	273	283	PF00069	0.476
DOC_MAPK_MEF2A_6	22	31	PF00069	0.501
DOC_MAPK_MEF2A_6	288	297	PF00069	0.386
DOC_PP1_RVXF_1	34	41	PF00149	0.443
DOC_PP2B_LxvP_1	211	214	PF13499	0.372
DOC_PP2B_LxvP_1	244	247	PF13499	0.276
DOC_PP4_FxxP_1	332	335	PF00568	0.553
DOC_PP4_FxxP_1	97	100	PF00568	0.364
DOC_USP7_MATH_1	340	344	PF00917	0.642
DOC_USP7_MATH_1	79	83	PF00917	0.378
DOC_USP7_UBL2_3	181	185	PF12436	0.476
LIG_14-3-3_CanoR_1	136	141	PF00244	0.322
LIG_14-3-3_CanoR_1	148	152	PF00244	0.456
LIG_14-3-3_CanoR_1	174	184	PF00244	0.490
LIG_14-3-3_CanoR_1	22	29	PF00244	0.527
LIG_14-3-3_CanoR_1	273	283	PF00244	0.476
LIG_14-3-3_CanoR_1	288	293	PF00244	0.329
LIG_14-3-3_CanoR_1	36	41	PF00244	0.395
LIG_14-3-3_CanoR_1	376	384	PF00244	0.693
LIG_AP2alpha_1	328	332	PF02296	0.567
LIG_BRCT_BRCA1_1	302	306	PF00533	0.287
LIG_Clathr_ClatBox_1	262	266	PF01394	0.363
LIG_deltaCOP1_diTrp_1	88	97	PF00928	0.359
LIG_EVH1_1	334	338	PF00568	0.557
LIG_FHA_1	210	216	PF00498	0.329
LIG_FHA_1	248	254	PF00498	0.276
LIG_FHA_1	312	318	PF00498	0.344
LIG_FHA_2	229	235	PF00498	0.292
LIG_FHA_2	243	249	PF00498	0.241
LIG_FHA_2	359	365	PF00498	0.630
LIG_FHA_2	384	390	PF00498	0.673
LIG_FHA_2	69	75	PF00498	0.488
LIG_LIR_Apic_2	248	254	PF02991	0.276
LIG_LIR_Apic_2	330	335	PF02991	0.567
LIG_LIR_Apic_2	74	79	PF02991	0.427
LIG_LIR_Apic_2	96	100	PF02991	0.376
LIG_LIR_Gen_1	114	121	PF02991	0.463
LIG_LIR_Gen_1	186	195	PF02991	0.487
LIG_LIR_Gen_1	218	228	PF02991	0.367
LIG_LIR_Gen_1	353	360	PF02991	0.652
LIG_LIR_Gen_1	389	398	PF02991	0.642
LIG_LIR_Gen_1	8	13	PF02991	0.508
LIG_LIR_Gen_1	82	90	PF02991	0.353
LIG_LIR_Nem_3	114	119	PF02991	0.419
LIG_LIR_Nem_3	202	207	PF02991	0.539
LIG_LIR_Nem_3	218	223	PF02991	0.228
LIG_LIR_Nem_3	330	334	PF02991	0.568
LIG_LIR_Nem_3	353	358	PF02991	0.656
LIG_LIR_Nem_3	389	393	PF02991	0.630
LIG_LIR_Nem_3	39	43	PF02991	0.517
LIG_LIR_Nem_3	8	12	PF02991	0.506
LIG_LIR_Nem_3	82	87	PF02991	0.355
LIG_NRP_CendR_1	406	407	PF00754	0.611
LIG_Pex14_1	124	128	PF04695	0.276
LIG_Pex14_1	93	97	PF04695	0.361
LIG_Pex14_2	261	265	PF04695	0.329
LIG_Pex14_2	328	332	PF04695	0.542
LIG_SH2_CRK	251	255	PF00017	0.363
LIG_SH2_NCK_1	251	255	PF00017	0.476
LIG_SH2_NCK_1	390	394	PF00017	0.685
LIG_SH2_PTP2	76	79	PF00017	0.485
LIG_SH2_STAP1	229	233	PF00017	0.276
LIG_SH2_STAP1	355	359	PF00017	0.657
LIG_SH2_STAP1	388	392	PF00017	0.622
LIG_SH2_STAT5	193	196	PF00017	0.411
LIG_SH2_STAT5	282	285	PF00017	0.476
LIG_SH2_STAT5	296	299	PF00017	0.328
LIG_SH2_STAT5	76	79	PF00017	0.485
LIG_SH3_3	332	338	PF00018	0.559
LIG_SxIP_EBH_1	134	148	PF03271	0.363
LIG_TRAF2_1	360	363	PF00917	0.551
LIG_UBA3_1	345	350	PF00899	0.631
LIG_WRC_WIRS_1	116	121	PF05994	0.401
MOD_CK1_1	143	149	PF00069	0.476
MOD_CK1_1	161	167	PF00069	0.431
MOD_CK1_1	206	212	PF00069	0.347
MOD_CK1_1	68	74	PF00069	0.504
MOD_CK2_1	174	180	PF00069	0.469
MOD_CK2_1	228	234	PF00069	0.278
MOD_CK2_1	350	356	PF00069	0.568
MOD_CK2_1	358	364	PF00069	0.571
MOD_CK2_1	79	85	PF00069	0.370
MOD_GlcNHglycan	177	180	PF01048	0.317
MOD_GlcNHglycan	19	22	PF01048	0.756
MOD_GlcNHglycan	217	220	PF01048	0.329
MOD_GlcNHglycan	24	27	PF01048	0.713
MOD_GlcNHglycan	276	279	PF01048	0.305
MOD_GlcNHglycan	302	305	PF01048	0.490
MOD_GlcNHglycan	379	382	PF01048	0.508
MOD_GlcNHglycan	402	405	PF01048	0.559
MOD_GSK3_1	136	143	PF00069	0.329
MOD_GSK3_1	17	24	PF00069	0.487
MOD_GSK3_1	199	206	PF00069	0.506
MOD_GSK3_1	209	216	PF00069	0.292
MOD_N-GLC_1	199	204	PF02516	0.289
MOD_NEK2_1	207	212	PF00069	0.384
MOD_NEK2_2	219	224	PF00069	0.329
MOD_NEK2_2	79	84	PF00069	0.392
MOD_PIKK_1	199	205	PF00454	0.516
MOD_PIKK_1	358	364	PF00454	0.640
MOD_PIKK_1	65	71	PF00454	0.365
MOD_PK_1	288	294	PF00069	0.406
MOD_PKA_1	36	42	PF00069	0.439
MOD_PKA_2	147	153	PF00069	0.510
MOD_PKA_2	21	27	PF00069	0.530
MOD_PKA_2	287	293	PF00069	0.414
MOD_PKA_2	36	42	PF00069	0.502
MOD_PKA_2	400	406	PF00069	0.615
MOD_Plk_1	172	178	PF00069	0.476
MOD_Plk_1	199	205	PF00069	0.489
MOD_Plk_1	242	248	PF00069	0.281
MOD_Plk_1	363	369	PF00069	0.684
MOD_Plk_1	79	85	PF00069	0.380
MOD_Plk_4	136	142	PF00069	0.335
MOD_Plk_4	203	209	PF00069	0.489
MOD_Plk_4	288	294	PF00069	0.362
MOD_Plk_4	350	356	PF00069	0.573
MOD_Plk_4	383	389	PF00069	0.533
MOD_Plk_4	79	85	PF00069	0.387
MOD_Plk_4	93	99	PF00069	0.342
MOD_SUMO_rev_2	343	352	PF00179	0.640
TRG_DiLeu_BaEn_2	233	239	PF01217	0.276
TRG_DiLeu_BaEn_4	363	369	PF01217	0.630
TRG_ENDOCYTIC_2	188	191	PF00928	0.487
TRG_ENDOCYTIC_2	355	358	PF00928	0.656
TRG_ENDOCYTIC_2	390	393	PF00928	0.623
TRG_ER_diArg_1	1	3	PF00400	0.545
TRG_ER_diArg_1	223	225	PF00400	0.276
TRG_ER_diArg_1	36	38	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y9	Leptomonas seymouri	84%	90%
A0A0S4IZY1	Bodo saltans	60%	93%
A0A1X0NWK5	Trypanosomatidae	70%	100%
A0A3R7NUU3	Trypanosoma rangeli	71%	91%
A0A3S7WRQ0	Leishmania donovani	97%	92%
A4H6P4	Leishmania braziliensis	89%	100%
A4HV25	Leishmania infantum	97%	92%
D0A7C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	97%
E9ANQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	91%
V5C1D0	Trypanosoma cruzi	74%	95%