LeishMANIAdb
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Putative 40S ribosomal protein S15A

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein S15A
Gene product:
40S ribosomal protein S15A, putative
Species:
Leishmania major
UniProt:
Q4QGW3_LEIMA
TriTrypDb:
LmjF.11.1190 , LMJLV39_110019400 , LMJSD75_290025600
Length:
130

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S15A

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 40
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0015935 small ribosomal subunit 4 2
GO:0022627 cytosolic small ribosomal subunit 5 2
GO:0032991 protein-containing complex 1 14
GO:0044391 ribosomal subunit 3 2
GO:0110165 cellular anatomical entity 1 14
GO:1990904 ribonucleoprotein complex 2 14
GO:0005840 ribosome 5 12
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12

Expansion

Sequence features

Q4QGW3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW3

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 14
GO:0006518 peptide metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009058 biosynthetic process 2 14
GO:0009059 macromolecule biosynthetic process 4 14
GO:0009987 cellular process 1 14
GO:0019538 protein metabolic process 3 14
GO:0034641 cellular nitrogen compound metabolic process 3 14
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 14
GO:0043043 peptide biosynthetic process 5 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043603 amide metabolic process 3 14
GO:0043604 amide biosynthetic process 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0044249 cellular biosynthetic process 3 14
GO:0044260 obsolete cellular macromolecule metabolic process 3 14
GO:0044271 cellular nitrogen compound biosynthetic process 4 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1901566 organonitrogen compound biosynthetic process 4 14
GO:1901576 organic substance biosynthetic process 3 14
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 14
GO:0005198 structural molecule activity 1 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.253
CLV_PCSK_FUR_1 20 24 PF00082 0.253
CLV_PCSK_KEX2_1 19 21 PF00082 0.253
CLV_PCSK_KEX2_1 22 24 PF00082 0.253
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.253
CLV_PCSK_SKI1_1 23 27 PF00082 0.253
CLV_PCSK_SKI1_1 88 92 PF00082 0.273
DEG_SPOP_SBC_1 103 107 PF00917 0.453
DOC_MAPK_gen_1 19 27 PF00069 0.453
DOC_MAPK_gen_1 57 65 PF00069 0.453
DOC_MAPK_HePTP_8 25 37 PF00069 0.453
DOC_MAPK_MEF2A_6 28 37 PF00069 0.453
DOC_MAPK_MEF2A_6 57 65 PF00069 0.453
DOC_PP1_RVXF_1 122 129 PF00149 0.455
DOC_USP7_UBL2_3 32 36 PF12436 0.453
LIG_BRCT_BRCA1_1 95 99 PF00533 0.453
LIG_FHA_1 103 109 PF00498 0.453
LIG_FHA_2 82 88 PF00498 0.480
LIG_GBD_Chelix_1 61 69 PF00786 0.253
LIG_Integrin_isoDGR_2 66 68 PF01839 0.253
LIG_LIR_Gen_1 49 58 PF02991 0.453
LIG_LIR_Nem_3 49 53 PF02991 0.453
LIG_LIR_Nem_3 96 102 PF02991 0.453
LIG_SH2_STAP1 86 90 PF00017 0.516
LIG_SH2_STAT5 46 49 PF00017 0.453
MOD_CK1_1 118 124 PF00069 0.559
MOD_CK2_1 81 87 PF00069 0.522
MOD_Cter_Amidation 20 23 PF01082 0.253
MOD_GlcNHglycan 15 18 PF01048 0.293
MOD_N-GLC_2 70 72 PF02516 0.253
MOD_NEK2_1 104 109 PF00069 0.453
MOD_PKA_2 118 124 PF00069 0.453
MOD_PKA_2 27 33 PF00069 0.453
MOD_Plk_4 2 8 PF00069 0.412

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4J0M6 Bodo saltans 89% 100%
A0A0S4KI65 Bodo saltans 89% 85%
A0A1X0P063 Trypanosomatidae 95% 100%
A0A3Q8IFF7 Leishmania donovani 100% 100%
A0A3R7NIE4 Trypanosoma rangeli 95% 100%
A0B9V5 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 46% 100%
A0RVY8 Cenarchaeum symbiosum (strain A) 41% 100%
A1KRI7 Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) 27% 100%
A1RVN1 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 45% 100%
A1RWS0 Thermofilum pendens (strain DSM 2475 / Hrk 5) 48% 100%
A2BMD4 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 48% 98%
A2RC28 Streptococcus pyogenes serotype M5 (strain Manfredo) 24% 98%
A2SPL7 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 43% 100%
A3CT12 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 44% 100%
A3DNC2 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 48% 98%
A3M970 Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 28% 99%
A3MSJ6 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 46% 100%
A4FWA6 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 42% 100%
A4H6P5 Leishmania braziliensis 100% 100%
A4HIY3 Leishmania braziliensis 100% 100%
A4HV26 Leishmania infantum 100% 100%
A4WMD9 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 42% 100%
A4XLR6 Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) 30% 98%
A4YCY1 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 47% 98%
A5UL73 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 45% 100%
A6UQ59 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 42% 100%
A6UWV3 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 42% 100%
A6VH00 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 43% 100%
A7I5Q4 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 43% 100%
A8ACD7 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 45% 98%
A8EZK2 Rickettsia canadensis (strain McKiel) 29% 98%
A8MAJ5 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) 49% 100%
A8YXL9 Lactobacillus helveticus (strain DPC 4571) 27% 98%
A9A5I0 Nitrosopumilus maritimus (strain SCM1) 41% 100%
A9A9P9 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 44% 100%
A9M3V2 Neisseria meningitidis serogroup C (strain 053442) 27% 100%
B0R671 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 40% 100%
B0V6V9 Acinetobacter baumannii (strain AYE) 28% 99%
B0VQT2 Acinetobacter baumannii (strain SDF) 28% 99%
B1I8L2 Streptococcus pneumoniae (strain Hungary19A-6) 27% 98%
B1L781 Korarchaeum cryptofilum (strain OPF8) 43% 100%
B1MW01 Leuconostoc citreum (strain KM20) 26% 98%
B1Y8V5 Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) 45% 100%
B2A4F3 Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) 29% 98%
B2IS54 Streptococcus pneumoniae (strain CGSP14) 27% 98%
B3WAK4 Lacticaseibacillus casei (strain BL23) 26% 98%
B5E6G9 Streptococcus pneumoniae serotype 19F (strain G54) 27% 98%
B5XJ50 Streptococcus pyogenes serotype M49 (strain NZ131) 24% 98%
B6YQ71 Azobacteroides pseudotrichonymphae genomovar. CFP2 28% 99%
B6YSM9 Thermococcus onnurineus (strain NA1) 48% 100%
B7GW16 Acinetobacter baumannii (strain AB307-0294) 28% 99%
B7IA25 Acinetobacter baumannii (strain AB0057) 28% 99%
B8D5V5 Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) 43% 98%
B8GKE8 Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) 42% 100%
B8ZKP4 Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) 27% 98%
B9LSR2 Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) 39% 100%
B9MKG7 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) 29% 98%
C1CAM6 Streptococcus pneumoniae (strain 70585) 27% 98%
C1CC20 Streptococcus pneumoniae (strain JJA) 27% 98%
C1CIB1 Streptococcus pneumoniae (strain P1031) 27% 98%
C1CPA2 Streptococcus pneumoniae (strain Taiwan19F-14) 27% 98%
C3MQ74 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 46% 98%
C3MVJ3 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 46% 98%
C3N5U2 Sulfolobus islandicus (strain M.16.27) 46% 98%
C3NEF8 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 46% 98%
C3NH94 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 46% 98%
C4KHH1 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 46% 98%
C5A270 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 49% 100%
C6A175 Thermococcus sibiricus (strain DSM 12597 / MM 739) 49% 100%
C9ZLC5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 92% 100%
D0A7C3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 93% 100%
E9ALP4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
O05636 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 45% 98%
O26126 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 47% 100%
O28369 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 43% 100%
O59432 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 53% 100%
O80646 Arabidopsis thaliana 67% 100%
O82205 Arabidopsis thaliana 48% 100%
P0C0W1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 72% 100%
P0CT58 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 68% 100%
P0CT59 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 68% 100%
P0CU35 Candida albicans (strain SC5314 / ATCC MYA-2876) 71% 100%
P0DF00 Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) 24% 98%
P0DF01 Streptococcus pyogenes serotype M3 (strain SSI-1) 24% 98%
P12742 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 40% 100%
P14038 Methanococcus vannielii 42% 100%
P33095 Strongylocentrotus purpuratus 73% 100%
P33953 Kluyveromyces marxianus 72% 100%
P42798 Arabidopsis thaliana 71% 100%
P46792 Agaricus bisporus 65% 100%
P46793 Dictyostelium discoideum 68% 100%
P48149 Drosophila melanogaster 72% 100%
P50891 Paracentrotus lividus 72% 100%
P54041 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 51% 100%
P62244 Homo sapiens 75% 100%
P62245 Mus musculus 75% 100%
P62246 Rattus norvegicus 75% 100%
P66627 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 27% 100%
P66628 Neisseria meningitidis serogroup B (strain MC58) 27% 100%
P66632 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 27% 98%
P66633 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 27% 98%
P66634 Streptococcus pyogenes serotype M1 24% 98%
P66636 Streptococcus pyogenes serotype M18 (strain MGAS8232) 24% 98%
Q00332 Brassica napus 71% 100%
Q034Z7 Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) 26% 98%
Q03ZN2 Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y) 27% 98%
Q04MM2 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 27% 98%
Q0W1X3 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 47% 100%
Q12ZT6 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 46% 100%
Q18GG4 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 42% 100%
Q1J8Z9 Streptococcus pyogenes serotype M4 (strain MGAS10750) 24% 98%
Q1JE45 Streptococcus pyogenes serotype M12 (strain MGAS2096) 24% 98%
Q1JJ48 Streptococcus pyogenes serotype M2 (strain MGAS10270) 24% 98%
Q1JP03 Streptococcus pyogenes serotype M12 (strain MGAS9429) 24% 98%
Q21M44 Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) 29% 100%
Q2FSG2 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) 34% 100%
Q2NFX2 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 42% 100%
Q3E7Y3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 72% 100%
Q3IMX3 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 38% 100%
Q3K3V5 Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) 25% 98%
Q46GB0 Methanosarcina barkeri (strain Fusaro / DSM 804) 50% 100%
Q48VT5 Streptococcus pyogenes serotype M28 (strain MGAS6180) 24% 98%
Q4A8I5 Mesomycoplasma hyopneumoniae (strain 7448) 29% 99%
Q4AAF4 Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) 29% 99%
Q5F5U1 Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) 27% 100%
Q5FM77 Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) 27% 98%
Q5JJG3 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 49% 100%
Q5L409 Geobacillus kaustophilus (strain HTA426) 27% 98%
Q5R938 Pongo abelii 75% 100%
Q5XEC1 Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) 24% 98%
Q601K0 Mesomycoplasma hyopneumoniae (strain 232) 29% 99%
Q6CW21 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 72% 100%
Q6FMW9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 72% 100%
Q6L1B2 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 41% 100%
Q6LXD8 Methanococcus maripaludis (strain S2 / LL) 42% 100%
Q6Q420 Danio rerio 75% 100%
Q6XIM8 Drosophila yakuba 72% 100%
Q74NG1 Nanoarchaeum equitans (strain Kin4-M) 30% 100%
Q752J5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 71% 100%
Q76I82 Bos taurus 75% 100%
Q7KR04 Drosophila melanogaster 72% 100%
Q7RV75 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 67% 100%
Q83FZ9 Tropheryma whipplei (strain Twist) 26% 98%
Q83I65 Tropheryma whipplei (strain TW08/27) 26% 98%
Q8E2C0 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) 25% 98%
Q8E7S7 Streptococcus agalactiae serotype III (strain NEM316) 25% 98%
Q8PV35 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 49% 100%
Q8TRT2 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 48% 100%
Q8TW15 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 45% 100%
Q8U014 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 51% 100%
Q8ZVW0 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 42% 100%
Q90YQ8 Ictalurus punctatus 75% 100%
Q96W54 Candida albicans (strain SC5314 / ATCC MYA-2876) 71% 100%
Q975J5 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 45% 98%
Q977U8 Methanothermococcus thermolithotrophicus 42% 100%
Q977U9 Methanococcus voltae 42% 100%
Q977V0 Methanotorris igneus 48% 100%
Q97BW1 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 40% 100%
Q98PZ6 Mycoplasmopsis pulmonis (strain UAB CTIP) 28% 98%
Q9AT34 Daucus carota 72% 100%
Q9HIS2 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 41% 100%
Q9HPB9 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 40% 100%
Q9LX88 Arabidopsis thaliana 71% 100%
Q9M0E0 Arabidopsis thaliana 52% 100%
Q9UX92 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 46% 98%
Q9V1V0 Pyrococcus abyssi (strain GE5 / Orsay) 52% 100%
Q9YF89 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 42% 98%
V5C1F5 Trypanosoma cruzi 95% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS