LeishMANIAdb
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Organic solute transporter Ostalpha-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Organic solute transporter Ostalpha-domain-containing protein
Gene product:
Organic solute transporter Ostalpha, putative
Species:
Leishmania major
UniProt:
Q4QGW2_LEIMA
TriTrypDb:
LmjF.11.1200 , LMJLV39_110019500 * , LMJSD75_110019900
Length:
692

Annotations

LeishMANIAdb annotations

Member of the poorly studied TMEM184 family ubiquitious in Eukaryota.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4QGW2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGW2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 562 566 PF00656 0.759
CLV_NRD_NRD_1 138 140 PF00675 0.344
CLV_NRD_NRD_1 306 308 PF00675 0.358
CLV_NRD_NRD_1 351 353 PF00675 0.429
CLV_NRD_NRD_1 463 465 PF00675 0.452
CLV_NRD_NRD_1 510 512 PF00675 0.392
CLV_NRD_NRD_1 530 532 PF00675 0.287
CLV_NRD_NRD_1 685 687 PF00675 0.441
CLV_PCSK_FUR_1 165 169 PF00082 0.283
CLV_PCSK_KEX2_1 138 140 PF00082 0.285
CLV_PCSK_KEX2_1 167 169 PF00082 0.283
CLV_PCSK_KEX2_1 306 308 PF00082 0.377
CLV_PCSK_KEX2_1 463 465 PF00082 0.469
CLV_PCSK_KEX2_1 509 511 PF00082 0.416
CLV_PCSK_KEX2_1 529 531 PF00082 0.293
CLV_PCSK_KEX2_1 685 687 PF00082 0.441
CLV_PCSK_PC1ET2_1 138 140 PF00082 0.285
CLV_PCSK_PC1ET2_1 167 169 PF00082 0.283
CLV_PCSK_PC7_1 505 511 PF00082 0.400
CLV_PCSK_SKI1_1 101 105 PF00082 0.483
CLV_PCSK_SKI1_1 12 16 PF00082 0.666
CLV_PCSK_SKI1_1 135 139 PF00082 0.296
CLV_PCSK_SKI1_1 168 172 PF00082 0.283
CLV_PCSK_SKI1_1 237 241 PF00082 0.296
CLV_PCSK_SKI1_1 301 305 PF00082 0.293
CLV_PCSK_SKI1_1 402 406 PF00082 0.507
CLV_PCSK_SKI1_1 640 644 PF00082 0.362
DEG_MDM2_SWIB_1 250 257 PF02201 0.336
DOC_MAPK_FxFP_2 68 71 PF00069 0.496
DOC_MAPK_gen_1 446 455 PF00069 0.681
DOC_MAPK_MEF2A_6 67 75 PF00069 0.503
DOC_MAPK_MEF2A_6 79 86 PF00069 0.336
DOC_MAPK_RevD_3 217 231 PF00069 0.389
DOC_PP1_RVXF_1 10 16 PF00149 0.405
DOC_PP1_RVXF_1 244 251 PF00149 0.483
DOC_PP1_RVXF_1 400 406 PF00149 0.686
DOC_PP1_RVXF_1 638 644 PF00149 0.658
DOC_PP4_FxxP_1 68 71 PF00568 0.496
DOC_USP7_MATH_1 178 182 PF00917 0.355
DOC_USP7_MATH_1 379 383 PF00917 0.792
DOC_USP7_MATH_1 557 561 PF00917 0.620
DOC_USP7_MATH_1 573 577 PF00917 0.729
DOC_USP7_MATH_1 584 588 PF00917 0.642
DOC_USP7_MATH_1 668 672 PF00917 0.788
DOC_USP7_UBL2_3 237 241 PF12436 0.483
DOC_WW_Pin1_4 489 494 PF00397 0.662
LIG_14-3-3_CanoR_1 12 18 PF00244 0.427
LIG_14-3-3_CanoR_1 395 403 PF00244 0.619
LIG_14-3-3_CanoR_1 654 659 PF00244 0.814
LIG_APCC_ABBA_1 190 195 PF00400 0.313
LIG_BIR_II_1 1 5 PF00653 0.473
LIG_BRCT_BRCA1_1 246 250 PF00533 0.534
LIG_BRCT_BRCA1_1 93 97 PF00533 0.459
LIG_BRCT_BRCA1_2 93 99 PF00533 0.389
LIG_Clathr_ClatBox_1 222 226 PF01394 0.336
LIG_Clathr_ClatBox_1 288 292 PF01394 0.336
LIG_deltaCOP1_diTrp_1 565 570 PF00928 0.702
LIG_eIF4E_1 117 123 PF01652 0.336
LIG_FHA_1 205 211 PF00498 0.294
LIG_FHA_1 214 220 PF00498 0.319
LIG_FHA_1 254 260 PF00498 0.389
LIG_FHA_1 278 284 PF00498 0.372
LIG_FHA_1 323 329 PF00498 0.688
LIG_FHA_1 456 462 PF00498 0.667
LIG_FHA_1 469 475 PF00498 0.658
LIG_FHA_1 476 482 PF00498 0.536
LIG_FHA_1 490 496 PF00498 0.571
LIG_FHA_1 544 550 PF00498 0.788
LIG_FHA_1 554 560 PF00498 0.706
LIG_FHA_2 104 110 PF00498 0.283
LIG_FHA_2 14 20 PF00498 0.481
LIG_FHA_2 369 375 PF00498 0.774
LIG_FHA_2 415 421 PF00498 0.667
LIG_GBD_Chelix_1 9 17 PF00786 0.638
LIG_LIR_Apic_2 565 571 PF02991 0.622
LIG_LIR_Apic_2 592 598 PF02991 0.778
LIG_LIR_Apic_2 66 71 PF02991 0.562
LIG_LIR_Gen_1 109 119 PF02991 0.283
LIG_LIR_Gen_1 181 190 PF02991 0.355
LIG_LIR_Gen_1 205 213 PF02991 0.283
LIG_LIR_Gen_1 238 245 PF02991 0.541
LIG_LIR_Gen_1 252 262 PF02991 0.250
LIG_LIR_Gen_1 57 65 PF02991 0.367
LIG_LIR_Gen_1 630 639 PF02991 0.665
LIG_LIR_Nem_3 109 114 PF02991 0.283
LIG_LIR_Nem_3 205 209 PF02991 0.283
LIG_LIR_Nem_3 238 242 PF02991 0.519
LIG_LIR_Nem_3 247 253 PF02991 0.285
LIG_LIR_Nem_3 256 261 PF02991 0.330
LIG_LIR_Nem_3 343 349 PF02991 0.625
LIG_LIR_Nem_3 57 61 PF02991 0.353
LIG_LIR_Nem_3 630 635 PF02991 0.659
LIG_LIR_Nem_3 69 73 PF02991 0.477
LIG_LYPXL_yS_3 70 73 PF13949 0.483
LIG_PCNA_PIPBox_1 83 92 PF02747 0.351
LIG_Pex14_1 100 104 PF04695 0.362
LIG_Pex14_1 254 258 PF04695 0.389
LIG_Pex14_2 250 254 PF04695 0.336
LIG_Pex14_2 346 350 PF04695 0.644
LIG_REV1ctd_RIR_1 348 357 PF16727 0.636
LIG_SH2_CRK 206 210 PF00017 0.286
LIG_SH2_CRK 44 48 PF00017 0.447
LIG_SH2_CRK 496 500 PF00017 0.562
LIG_SH2_PTP2 595 598 PF00017 0.779
LIG_SH2_SRC 152 155 PF00017 0.562
LIG_SH2_STAP1 111 115 PF00017 0.283
LIG_SH2_STAP1 206 210 PF00017 0.315
LIG_SH2_STAP1 235 239 PF00017 0.559
LIG_SH2_STAP1 44 48 PF00017 0.447
LIG_SH2_STAT5 117 120 PF00017 0.373
LIG_SH2_STAT5 126 129 PF00017 0.292
LIG_SH2_STAT5 152 155 PF00017 0.507
LIG_SH2_STAT5 163 166 PF00017 0.449
LIG_SH2_STAT5 204 207 PF00017 0.293
LIG_SH2_STAT5 221 224 PF00017 0.298
LIG_SH2_STAT5 269 272 PF00017 0.292
LIG_SH2_STAT5 496 499 PF00017 0.557
LIG_SH2_STAT5 595 598 PF00017 0.779
LIG_SH3_3 151 157 PF00018 0.496
LIG_SH3_3 675 681 PF00018 0.806
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.355
LIG_SUMO_SIM_par_1 120 125 PF11976 0.447
LIG_TRAF2_1 272 275 PF00917 0.321
LIG_TRAF2_1 417 420 PF00917 0.681
LIG_TRFH_1 291 295 PF08558 0.408
LIG_TYR_ITIM 219 224 PF00017 0.336
LIG_TYR_ITIM 42 47 PF00017 0.447
LIG_UBA3_1 13 22 PF00899 0.447
LIG_UBA3_1 133 140 PF00899 0.518
LIG_UBA3_1 224 231 PF00899 0.385
LIG_WRC_WIRS_1 111 116 PF05994 0.283
LIG_WRC_WIRS_1 179 184 PF05994 0.355
LIG_WRC_WIRS_1 55 60 PF05994 0.355
MOD_CK1_1 24 30 PF00069 0.535
MOD_CK1_1 576 582 PF00069 0.733
MOD_CK1_1 91 97 PF00069 0.336
MOD_CK2_1 13 19 PF00069 0.426
MOD_CK2_1 368 374 PF00069 0.790
MOD_CK2_1 414 420 PF00069 0.677
MOD_CK2_1 441 447 PF00069 0.669
MOD_CK2_1 462 468 PF00069 0.668
MOD_Cter_Amidation 304 307 PF01082 0.318
MOD_GlcNHglycan 263 266 PF01048 0.546
MOD_GlcNHglycan 380 384 PF01048 0.592
MOD_GlcNHglycan 390 393 PF01048 0.546
MOD_GlcNHglycan 397 400 PF01048 0.495
MOD_GlcNHglycan 619 622 PF01048 0.556
MOD_GlcNHglycan 90 93 PF01048 0.422
MOD_GSK3_1 103 110 PF00069 0.283
MOD_GSK3_1 20 27 PF00069 0.512
MOD_GSK3_1 249 256 PF00069 0.344
MOD_GSK3_1 327 334 PF00069 0.615
MOD_GSK3_1 384 391 PF00069 0.771
MOD_GSK3_1 519 526 PF00069 0.661
MOD_GSK3_1 553 560 PF00069 0.776
MOD_GSK3_1 648 655 PF00069 0.753
MOD_N-GLC_1 20 25 PF02516 0.675
MOD_N-GLC_1 211 216 PF02516 0.350
MOD_N-GLC_1 322 327 PF02516 0.481
MOD_N-GLC_1 557 562 PF02516 0.584
MOD_NEK2_1 103 108 PF00069 0.293
MOD_NEK2_1 122 127 PF00069 0.227
MOD_NEK2_1 13 18 PF00069 0.459
MOD_NEK2_1 133 138 PF00069 0.451
MOD_NEK2_1 261 266 PF00069 0.424
MOD_NEK2_1 462 467 PF00069 0.669
MOD_NEK2_1 480 485 PF00069 0.688
MOD_NEK2_1 553 558 PF00069 0.747
MOD_NEK2_1 653 658 PF00069 0.817
MOD_NEK2_2 253 258 PF00069 0.389
MOD_PIKK_1 468 474 PF00454 0.745
MOD_PIKK_1 521 527 PF00454 0.647
MOD_PIKK_1 658 664 PF00454 0.757
MOD_PKA_2 107 113 PF00069 0.283
MOD_PKA_2 462 468 PF00069 0.654
MOD_PKA_2 653 659 PF00069 0.815
MOD_Plk_1 211 217 PF00069 0.390
MOD_Plk_1 24 30 PF00069 0.475
MOD_Plk_1 32 38 PF00069 0.342
MOD_Plk_1 342 348 PF00069 0.562
MOD_Plk_1 368 374 PF00069 0.723
MOD_Plk_1 591 597 PF00069 0.711
MOD_Plk_1 615 621 PF00069 0.731
MOD_Plk_2-3 368 374 PF00069 0.797
MOD_Plk_2-3 441 447 PF00069 0.656
MOD_Plk_4 110 116 PF00069 0.197
MOD_Plk_4 178 184 PF00069 0.355
MOD_Plk_4 205 211 PF00069 0.272
MOD_Plk_4 235 241 PF00069 0.562
MOD_Plk_4 244 250 PF00069 0.451
MOD_Plk_4 253 259 PF00069 0.336
MOD_Plk_4 32 38 PF00069 0.420
MOD_Plk_4 345 351 PF00069 0.569
MOD_Plk_4 523 529 PF00069 0.641
MOD_Plk_4 591 597 PF00069 0.724
MOD_Plk_4 91 97 PF00069 0.354
MOD_ProDKin_1 489 495 PF00069 0.655
MOD_SUMO_rev_2 19 24 PF00179 0.462
MOD_SUMO_rev_2 646 651 PF00179 0.737
TRG_ENDOCYTIC_2 111 114 PF00928 0.283
TRG_ENDOCYTIC_2 117 120 PF00928 0.336
TRG_ENDOCYTIC_2 142 145 PF00928 0.483
TRG_ENDOCYTIC_2 206 209 PF00928 0.286
TRG_ENDOCYTIC_2 220 223 PF00928 0.355
TRG_ENDOCYTIC_2 44 47 PF00928 0.432
TRG_ENDOCYTIC_2 496 499 PF00928 0.557
TRG_ENDOCYTIC_2 70 73 PF00928 0.483
TRG_ENDOCYTIC_2 87 90 PF00928 0.336
TRG_ER_diArg_1 139 142 PF00400 0.544
TRG_ER_diArg_1 462 464 PF00400 0.673
TRG_ER_diArg_1 508 511 PF00400 0.621
TRG_ER_diArg_1 528 531 PF00400 0.482
TRG_NES_CRM1_1 327 340 PF08389 0.657
TRG_NLS_MonoCore_2 137 142 PF00514 0.558
TRG_NLS_MonoExtC_3 138 143 PF00514 0.558
TRG_NLS_MonoExtN_4 135 142 PF00514 0.502
TRG_Pf-PMV_PEXEL_1 307 311 PF00026 0.374

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Y7 Leptomonas seymouri 66% 98%
A0A0S4KNU2 Bodo saltans 48% 100%
A0A1X0NUV4 Trypanosomatidae 61% 100%
A0A3R7KK37 Trypanosoma rangeli 63% 100%
A0A3S7WRT4 Leishmania donovani 95% 100%
A4H6P0 Leishmania braziliensis 82% 100%
A4HV27 Leishmania infantum 96% 100%
E9ANQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BRV8 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS