Putative tatD related deoxyribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tatD related deoxyribonuclease, putative

Species:

Leishmania major

UniProt:

Q4QGV4_LEIMA

TriTrypDb:

LmjF.11.1280 , LMJLV39_110020200 , LMJSD75_110020700

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004529	DNA exonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0008296	3'-5'-DNA exonuclease activity	7	2
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.553
CLV_C14_Caspase3-7	229	233	PF00656	0.555
CLV_NRD_NRD_1	140	142	PF00675	0.332
CLV_NRD_NRD_1	306	308	PF00675	0.246
CLV_NRD_NRD_1	337	339	PF00675	0.292
CLV_NRD_NRD_1	355	357	PF00675	0.229
CLV_PCSK_KEX2_1	184	186	PF00082	0.334
CLV_PCSK_KEX2_1	287	289	PF00082	0.328
CLV_PCSK_KEX2_1	337	339	PF00082	0.272
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.336
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.272
CLV_PCSK_SKI1_1	202	206	PF00082	0.328
CLV_PCSK_SKI1_1	260	264	PF00082	0.335
CLV_PCSK_SKI1_1	279	283	PF00082	0.155
CLV_PCSK_SKI1_1	29	33	PF00082	0.635
CLV_PCSK_SKI1_1	356	360	PF00082	0.275
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DEG_SPOP_SBC_1	351	355	PF00917	0.472
DOC_CYCLIN_RxL_1	273	283	PF00134	0.500
DOC_MAPK_gen_1	141	147	PF00069	0.561
DOC_MAPK_gen_1	184	192	PF00069	0.511
DOC_MAPK_MEF2A_6	184	192	PF00069	0.511
DOC_MAPK_MEF2A_6	42	50	PF00069	0.413
DOC_MAPK_NFAT4_5	185	193	PF00069	0.536
DOC_USP7_UBL2_3	169	173	PF12436	0.555
DOC_USP7_UBL2_3	202	206	PF12436	0.389
DOC_USP7_UBL2_3	308	312	PF12436	0.555
DOC_WW_Pin1_4	7	12	PF00397	0.446
LIG_14-3-3_CanoR_1	103	112	PF00244	0.533
LIG_14-3-3_CanoR_1	141	146	PF00244	0.522
LIG_14-3-3_CanoR_1	195	199	PF00244	0.553
LIG_14-3-3_CanoR_1	288	295	PF00244	0.530
LIG_14-3-3_CanoR_1	62	72	PF00244	0.539
LIG_Actin_WH2_2	232	247	PF00022	0.516
LIG_eIF4E_1	175	181	PF01652	0.555
LIG_FHA_1	353	359	PF00498	0.450
LIG_FHA_1	64	70	PF00498	0.526
LIG_FHA_2	195	201	PF00498	0.442
LIG_HCF-1_HBM_1	52	55	PF13415	0.500
LIG_Integrin_isoDGR_2	60	62	PF01839	0.336
LIG_LIR_Gen_1	160	168	PF02991	0.450
LIG_LIR_Gen_1	266	277	PF02991	0.450
LIG_LIR_Nem_3	160	164	PF02991	0.450
LIG_LIR_Nem_3	200	204	PF02991	0.451
LIG_LIR_Nem_3	266	272	PF02991	0.462
LIG_LIR_Nem_3	40	44	PF02991	0.416
LIG_LIR_Nem_3	52	58	PF02991	0.463
LIG_NRBOX	18	24	PF00104	0.451
LIG_PDZ_Class_2	358	363	PF00595	0.500
LIG_SH2_CRK	161	165	PF00017	0.450
LIG_SH2_CRK	55	59	PF00017	0.511
LIG_SH2_CRK	8	12	PF00017	0.451
LIG_SH2_PTP2	236	239	PF00017	0.475
LIG_SH2_SRC	230	233	PF00017	0.536
LIG_SH2_STAT5	132	135	PF00017	0.511
LIG_SH2_STAT5	175	178	PF00017	0.450
LIG_SH2_STAT5	230	233	PF00017	0.489
LIG_SH2_STAT5	236	239	PF00017	0.458
LIG_SH2_STAT5	8	11	PF00017	0.449
LIG_SH3_3	123	129	PF00018	0.536
LIG_SH3_3	162	168	PF00018	0.465
LIG_SH3_3	204	210	PF00018	0.555
LIG_SUMO_SIM_anti_2	20	28	PF11976	0.447
LIG_SUMO_SIM_par_1	20	28	PF11976	0.447
LIG_TYR_ITIM	159	164	PF00017	0.450
LIG_WRC_WIRS_1	217	222	PF05994	0.450
MOD_CK1_1	10	16	PF00069	0.449
MOD_CK1_1	243	249	PF00069	0.475
MOD_CK1_1	291	297	PF00069	0.521
MOD_CK1_1	37	43	PF00069	0.466
MOD_CK2_1	220	226	PF00069	0.468
MOD_CK2_1	339	345	PF00069	0.484
MOD_CK2_1	64	70	PF00069	0.500
MOD_GlcNHglycan	15	18	PF01048	0.450
MOD_GSK3_1	216	223	PF00069	0.462
MOD_GSK3_1	25	32	PF00069	0.353
MOD_GSK3_1	287	294	PF00069	0.513
MOD_GSK3_1	295	302	PF00069	0.497
MOD_GSK3_1	6	13	PF00069	0.446
MOD_GSK3_1	64	71	PF00069	0.541
MOD_N-GLC_1	48	53	PF02516	0.262
MOD_N-GLC_2	240	242	PF02516	0.250
MOD_NEK2_1	111	116	PF00069	0.389
MOD_NEK2_1	220	225	PF00069	0.491
MOD_NEK2_1	24	29	PF00069	0.445
MOD_NEK2_1	272	277	PF00069	0.514
MOD_NEK2_1	352	357	PF00069	0.501
MOD_NEK2_1	84	89	PF00069	0.454
MOD_NEK2_1	91	96	PF00069	0.445
MOD_PIKK_1	288	294	PF00454	0.500
MOD_PK_1	141	147	PF00069	0.522
MOD_PKA_1	141	147	PF00069	0.472
MOD_PKA_1	287	293	PF00069	0.528
MOD_PKA_2	194	200	PF00069	0.462
MOD_PKA_2	287	293	PF00069	0.530
MOD_Plk_1	339	345	PF00069	0.515
MOD_Plk_2-3	194	200	PF00069	0.491
MOD_Plk_2-3	340	346	PF00069	0.474
MOD_Plk_4	17	23	PF00069	0.693
MOD_Plk_4	200	206	PF00069	0.416
MOD_Plk_4	295	301	PF00069	0.522
MOD_Plk_4	68	74	PF00069	0.527
MOD_ProDKin_1	7	13	PF00069	0.447
MOD_SUMO_rev_2	194	204	PF00179	0.500
MOD_SUMO_rev_2	266	275	PF00179	0.498
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.510
TRG_ENDOCYTIC_2	161	164	PF00928	0.450
TRG_ENDOCYTIC_2	236	239	PF00928	0.475
TRG_ENDOCYTIC_2	55	58	PF00928	0.506
TRG_ER_diArg_1	185	188	PF00400	0.532
TRG_ER_diArg_1	336	338	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q2	Leptomonas seymouri	67%	100%
A0A0N1IL51	Leptomonas seymouri	37%	100%
A0A0S4IY84	Bodo saltans	50%	100%
A0A0S4JNN8	Bodo saltans	35%	98%
A0A1X0NWJ2	Trypanosomatidae	60%	100%
A0A1X0P426	Trypanosomatidae	30%	93%
A0A3R7K0P4	Trypanosoma rangeli	33%	100%
A0A3R7LLG2	Trypanosoma rangeli	58%	100%
A0A3S5H6J9	Leishmania donovani	96%	100%
A0A3S7X0L2	Leishmania donovani	29%	96%
A4H6P9	Leishmania braziliensis	82%	100%
A4HFM3	Leishmania braziliensis	30%	96%
A4HV34	Leishmania infantum	96%	100%
A4I2Q1	Leishmania infantum	29%	96%
A7MQN1	Cronobacter sakazakii (strain ATCC BAA-894)	31%	100%
A8G8C4	Serratia proteamaculans (strain 568)	30%	100%
B5XYH5	Klebsiella pneumoniae (strain 342)	38%	100%
B7XJI2	Enterocytozoon bieneusi (strain H348)	26%	100%
C4VAS3	Nosema ceranae (strain BRL01)	31%	100%
C6C4V4	Musicola paradisiaca (strain Ech703)	31%	100%
C6DI71	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	30%	100%
D0A5V3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	95%
D0A7B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0KC77	Pectobacterium parmentieri (strain WPP163)	29%	100%
D0Z9R0	Edwardsiella tarda (strain EIB202)	30%	100%
D4GGR2	Pantoea ananatis (strain LMG 20103)	33%	100%
D8MKW4	Erwinia billingiae (strain Eb661)	32%	100%
E0SLH6	Dickeya dadantii (strain 3937)	37%	100%
E1SKR8	Pantoea vagans (strain C9-1)	31%	100%
E6WHK1	Pantoea sp. (strain At-9b)	31%	100%
E8XYF5	Rahnella sp. (strain Y9602)	32%	100%
E9AD77	Leishmania major	29%	100%
E9ANR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AZ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	96%
P34220	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	87%
P39408	Escherichia coli (strain K12)	27%	100%
P73335	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q148G4	Bos taurus	43%	100%
Q640V9	Xenopus laevis	46%	100%
Q6DAQ1	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	30%	100%
Q6GML7	Danio rerio	47%	100%
Q6P1N9	Homo sapiens	44%	100%
Q6P8M1	Mus musculus	43%	100%
Q8K9J1	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	30%	100%
Q8SW70	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q9UUF1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
V5BRW2	Trypanosoma cruzi	56%	100%