Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGV2_LEIMA

TriTrypDb:

LmjF.11.1300 , LMJLV39_110020400 , LMJSD75_110020900

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.433
CLV_NRD_NRD_1	166	168	PF00675	0.447
CLV_NRD_NRD_1	40	42	PF00675	0.470
CLV_NRD_NRD_1	62	64	PF00675	0.369
CLV_PCSK_KEX2_1	125	127	PF00082	0.433
CLV_PCSK_KEX2_1	40	42	PF00082	0.485
CLV_PCSK_KEX2_1	62	64	PF00082	0.363
CLV_PCSK_KEX2_1	87	89	PF00082	0.546
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.546
CLV_PCSK_SKI1_1	147	151	PF00082	0.517
DOC_ANK_TNKS_1	42	49	PF00023	0.482
DOC_MAPK_gen_1	112	120	PF00069	0.421
DOC_WW_Pin1_4	181	186	PF00397	0.574
DOC_WW_Pin1_4	3	8	PF00397	0.666
LIG_14-3-3_CanoR_1	139	145	PF00244	0.440
LIG_14-3-3_CanoR_1	147	153	PF00244	0.503
LIG_14-3-3_CanoR_1	31	39	PF00244	0.451
LIG_14-3-3_CanoR_1	62	67	PF00244	0.617
LIG_14-3-3_CanoR_1	76	86	PF00244	0.467
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	52	56	PF00533	0.466
LIG_BRCT_BRCA1_2	52	58	PF00533	0.474
LIG_EVH1_2	145	149	PF00568	0.406
LIG_FHA_1	17	23	PF00498	0.463
LIG_FHA_1	81	87	PF00498	0.555
LIG_FHA_2	149	155	PF00498	0.391
LIG_FHA_2	79	85	PF00498	0.604
LIG_FHA_2	8	14	PF00498	0.566
LIG_SH2_STAT3	113	116	PF00017	0.428
LIG_SH3_3	1	7	PF00018	0.583
LIG_WW_3	144	148	PF00397	0.453
MOD_CK1_1	2	8	PF00069	0.650
MOD_CK1_1	34	40	PF00069	0.519
MOD_CK1_1	80	86	PF00069	0.630
MOD_CK1_1	96	102	PF00069	0.628
MOD_CK2_1	130	136	PF00069	0.428
MOD_CK2_1	148	154	PF00069	0.327
MOD_CK2_1	15	21	PF00069	0.541
MOD_CK2_1	7	13	PF00069	0.587
MOD_CK2_1	78	84	PF00069	0.671
MOD_GlcNHglycan	181	184	PF01048	0.540
MOD_GSK3_1	148	155	PF00069	0.434
MOD_GSK3_1	27	34	PF00069	0.440
MOD_GSK3_1	3	10	PF00069	0.565
MOD_GSK3_1	72	79	PF00069	0.668
MOD_GSK3_1	96	103	PF00069	0.579
MOD_N-GLC_1	100	105	PF02516	0.642
MOD_NEK2_1	148	153	PF00069	0.565
MOD_NEK2_1	77	82	PF00069	0.481
MOD_NEK2_1	95	100	PF00069	0.665
MOD_PIKK_1	31	37	PF00454	0.475
MOD_PKA_1	62	68	PF00069	0.494
MOD_PKA_2	179	185	PF00069	0.564
MOD_PKA_2	27	33	PF00069	0.437
MOD_PKA_2	62	68	PF00069	0.551
MOD_Plk_1	120	126	PF00069	0.503
MOD_Plk_4	34	40	PF00069	0.464
MOD_ProDKin_1	3	9	PF00069	0.652
MOD_SUMO_for_1	86	89	PF00179	0.443
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.403
TRG_ENDOCYTIC_2	128	131	PF00928	0.520
TRG_ER_diArg_1	124	126	PF00400	0.412
TRG_ER_diArg_1	39	41	PF00400	0.491
TRG_ER_diArg_1	49	52	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F7	Leptomonas seymouri	58%	98%
A0A1X0NWA0	Trypanosomatidae	39%	95%
A0A3S7WRU4	Leishmania donovani	91%	100%
A0A422N1X3	Trypanosoma rangeli	34%	91%
A4H6Q1	Leishmania braziliensis	74%	97%
A4HV36	Leishmania infantum	92%	100%
D0A7B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9ANR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%