Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGV1_LEIMA

TriTrypDb:

LmjF.11.1310 , LMJLV39_110020500 , LMJSD75_110021000

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.485
CLV_NRD_NRD_1	61	63	PF00675	0.449
CLV_NRD_NRD_1	7	9	PF00675	0.546
CLV_PCSK_KEX2_1	278	280	PF00082	0.502
CLV_PCSK_KEX2_1	6	8	PF00082	0.527
CLV_PCSK_KEX2_1	61	63	PF00082	0.434
CLV_PCSK_KEX2_1	86	88	PF00082	0.508
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.503
CLV_PCSK_SKI1_1	133	137	PF00082	0.565
CLV_PCSK_SKI1_1	180	184	PF00082	0.448
CLV_PCSK_SKI1_1	227	231	PF00082	0.345
CLV_PCSK_SKI1_1	29	33	PF00082	0.502
CLV_PCSK_SKI1_1	341	345	PF00082	0.400
CLV_PCSK_SKI1_1	393	397	PF00082	0.544
CLV_PCSK_SKI1_1	62	66	PF00082	0.503
DEG_APCC_DBOX_1	340	348	PF00400	0.395
DEG_APCC_DBOX_1	364	372	PF00400	0.476
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DOC_CDC14_PxL_1	96	104	PF14671	0.497
DOC_CYCLIN_RxL_1	127	140	PF00134	0.540
DOC_CYCLIN_RxL_1	224	234	PF00134	0.398
DOC_CYCLIN_RxL_1	59	67	PF00134	0.532
DOC_MAPK_gen_1	115	124	PF00069	0.405
DOC_MAPK_HePTP_8	114	126	PF00069	0.476
DOC_MAPK_MEF2A_6	115	124	PF00069	0.463
DOC_MAPK_NFAT4_5	117	125	PF00069	0.493
DOC_USP7_MATH_2	13	19	PF00917	0.506
DOC_USP7_UBL2_3	250	254	PF12436	0.300
DOC_WW_Pin1_4	154	159	PF00397	0.591
DOC_WW_Pin1_4	41	46	PF00397	0.586
LIG_14-3-3_CanoR_1	361	365	PF00244	0.504
LIG_Actin_WH2_2	225	243	PF00022	0.532
LIG_APCC_ABBA_1	80	85	PF00400	0.520
LIG_FHA_1	129	135	PF00498	0.478
LIG_FHA_1	155	161	PF00498	0.565
LIG_FHA_1	193	199	PF00498	0.342
LIG_FHA_1	216	222	PF00498	0.406
LIG_FHA_1	224	230	PF00498	0.333
LIG_FHA_1	247	253	PF00498	0.359
LIG_FHA_1	298	304	PF00498	0.397
LIG_FHA_1	357	363	PF00498	0.522
LIG_FHA_2	111	117	PF00498	0.468
LIG_FHA_2	311	317	PF00498	0.392
LIG_FHA_2	361	367	PF00498	0.500
LIG_GBD_Chelix_1	175	183	PF00786	0.471
LIG_LIR_Gen_1	54	65	PF02991	0.418
LIG_LIR_Gen_1	93	103	PF02991	0.496
LIG_LIR_Nem_3	49	55	PF02991	0.426
LIG_LIR_Nem_3	93	99	PF02991	0.395
LIG_MAD2	393	401	PF02301	0.583
LIG_PDZ_Class_2	397	402	PF00595	0.633
LIG_SH2_CRK	57	61	PF00017	0.526
LIG_SH2_CRK	96	100	PF00017	0.503
LIG_SH2_NCK_1	306	310	PF00017	0.486
LIG_SH2_NCK_1	352	356	PF00017	0.486
LIG_SH2_PTP2	42	45	PF00017	0.581
LIG_SH2_STAP1	306	310	PF00017	0.486
LIG_SH2_STAT3	327	330	PF00017	0.537
LIG_SH2_STAT5	39	42	PF00017	0.561
LIG_SH3_3	322	328	PF00018	0.527
LIG_SH3_3	35	41	PF00018	0.498
LIG_Sin3_3	257	264	PF02671	0.470
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.516
LIG_SUMO_SIM_par_1	204	209	PF11976	0.242
LIG_SUMO_SIM_par_1	99	105	PF11976	0.500
LIG_TYR_ITIM	94	99	PF00017	0.400
LIG_UBA3_1	102	108	PF00899	0.536
MOD_CK1_1	213	219	PF00069	0.452
MOD_CK2_1	101	107	PF00069	0.528
MOD_CK2_1	110	116	PF00069	0.516
MOD_CK2_1	310	316	PF00069	0.382
MOD_CK2_1	360	366	PF00069	0.519
MOD_Cter_Amidation	276	279	PF01082	0.413
MOD_GlcNHglycan	109	113	PF01048	0.501
MOD_GlcNHglycan	306	309	PF01048	0.460
MOD_GSK3_1	211	218	PF00069	0.440
MOD_GSK3_1	356	363	PF00069	0.537
MOD_N-GLC_1	297	302	PF02516	0.512
MOD_NEK2_1	192	197	PF00069	0.445
MOD_NEK2_1	210	215	PF00069	0.477
MOD_NEK2_1	386	391	PF00069	0.432
MOD_NEK2_2	297	302	PF00069	0.490
MOD_NEK2_2	360	365	PF00069	0.523
MOD_PIKK_1	128	134	PF00454	0.514
MOD_PIKK_1	215	221	PF00454	0.440
MOD_PIKK_1	386	392	PF00454	0.434
MOD_PKA_2	360	366	PF00069	0.531
MOD_Plk_1	297	303	PF00069	0.509
MOD_Plk_2-3	110	116	PF00069	0.323
MOD_Plk_4	266	272	PF00069	0.479
MOD_Plk_4	286	292	PF00069	0.450
MOD_ProDKin_1	154	160	PF00069	0.580
MOD_ProDKin_1	41	47	PF00069	0.582
MOD_SUMO_for_1	253	256	PF00179	0.451
TRG_DiLeu_BaEn_1	256	261	PF01217	0.478
TRG_DiLeu_BaEn_1	266	271	PF01217	0.428
TRG_DiLeu_BaEn_1	340	345	PF01217	0.368
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.552
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.466
TRG_ENDOCYTIC_2	52	55	PF00928	0.445
TRG_ENDOCYTIC_2	57	60	PF00928	0.354
TRG_ENDOCYTIC_2	96	99	PF00928	0.391
TRG_ER_diArg_1	5	8	PF00400	0.525
TRG_ER_diArg_1	60	62	PF00400	0.459
TRG_NES_CRM1_1	366	381	PF08389	0.476
TRG_NLS_MonoExtN_4	393	400	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVS3	Leptomonas seymouri	64%	99%
A0A0S4KKN0	Bodo saltans	33%	100%
A0A1X0NUU6	Trypanosomatidae	37%	100%
A0A3R7M4V0	Trypanosoma rangeli	37%	100%
A0A3S7WRS2	Leishmania donovani	95%	100%
A4H6Q2	Leishmania braziliensis	80%	100%
A4HV37	Leishmania infantum	95%	100%
D0A7B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	76%
E9ANR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BWJ3	Trypanosoma cruzi	36%	100%