MFS_1_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGV0_LEIMA

TriTrypDb:

LmjF.11.1320 , LMJLV39_110020600 , LMJSD75_110021100

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QGV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGV0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	283	285	PF00082	0.339
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.363
CLV_PCSK_SKI1_1	130	134	PF00082	0.417
CLV_PCSK_SKI1_1	368	372	PF00082	0.265
DOC_CYCLIN_RxL_1	127	136	PF00134	0.355
DOC_MAPK_gen_1	287	295	PF00069	0.584
DOC_PP1_RVXF_1	128	134	PF00149	0.258
DOC_PP4_FxxP_1	380	383	PF00568	0.588
DOC_PP4_FxxP_1	66	69	PF00568	0.410
DOC_USP7_MATH_1	14	18	PF00917	0.634
DOC_USP7_MATH_1	205	209	PF00917	0.629
DOC_USP7_MATH_1	319	323	PF00917	0.373
DOC_USP7_MATH_1	49	53	PF00917	0.378
LIG_14-3-3_CanoR_1	111	116	PF00244	0.379
LIG_14-3-3_CanoR_1	197	202	PF00244	0.611
LIG_14-3-3_CanoR_1	206	214	PF00244	0.587
LIG_14-3-3_CanoR_1	227	236	PF00244	0.309
LIG_14-3-3_CanoR_1	368	377	PF00244	0.642
LIG_14-3-3_CanoR_1	385	392	PF00244	0.592
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BRCT_BRCA1_1	113	117	PF00533	0.345
LIG_Clathr_ClatBox_1	334	338	PF01394	0.355
LIG_eIF4E_1	330	336	PF01652	0.295
LIG_eIF4E_1	62	68	PF01652	0.306
LIG_FHA_1	127	133	PF00498	0.434
LIG_FHA_1	142	148	PF00498	0.551
LIG_FHA_1	198	204	PF00498	0.670
LIG_FHA_1	330	336	PF00498	0.351
LIG_FHA_1	372	378	PF00498	0.525
LIG_FHA_1	406	412	PF00498	0.518
LIG_FHA_1	414	420	PF00498	0.555
LIG_FHA_1	426	432	PF00498	0.410
LIG_FHA_1	79	85	PF00498	0.593
LIG_LIR_Gen_1	188	196	PF02991	0.389
LIG_LIR_Gen_1	408	414	PF02991	0.508
LIG_LIR_Nem_3	188	194	PF02991	0.451
LIG_LIR_Nem_3	322	327	PF02991	0.305
LIG_LIR_Nem_3	408	412	PF02991	0.519
LIG_LYPXL_SIV_4	256	264	PF13949	0.262
LIG_MLH1_MIPbox_1	113	117	PF16413	0.345
LIG_PTB_Apo_2	120	127	PF02174	0.273
LIG_RPA_C_Fungi	194	206	PF08784	0.508
LIG_SH2_CRK	226	230	PF00017	0.405
LIG_SH2_CRK	253	257	PF00017	0.472
LIG_SH2_CRK	395	399	PF00017	0.387
LIG_SH2_NCK_1	421	425	PF00017	0.378
LIG_SH2_PTP2	409	412	PF00017	0.424
LIG_SH2_STAP1	211	215	PF00017	0.488
LIG_SH2_STAT5	257	260	PF00017	0.337
LIG_SH2_STAT5	409	412	PF00017	0.464
LIG_SH2_STAT5	50	53	PF00017	0.516
LIG_SH2_STAT5	58	61	PF00017	0.359
LIG_SH3_3	270	276	PF00018	0.334
LIG_SH3_3	334	340	PF00018	0.417
LIG_SH3_3	48	54	PF00018	0.482
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.307
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.372
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.347
LIG_SUMO_SIM_anti_2	428	436	PF11976	0.400
LIG_SUMO_SIM_par_1	102	107	PF11976	0.384
LIG_SUMO_SIM_par_1	198	204	PF11976	0.599
LIG_SUMO_SIM_par_1	33	39	PF11976	0.358
LIG_SUMO_SIM_par_1	332	338	PF11976	0.411
LIG_SUMO_SIM_par_1	428	436	PF11976	0.387
LIG_TRAF2_1	207	210	PF00917	0.509
LIG_TRAF2_1	351	354	PF00917	0.480
LIG_UBA3_1	369	378	PF00899	0.392
LIG_WRC_WIRS_1	437	442	PF05994	0.676
MOD_CK1_1	435	441	PF00069	0.526
MOD_CK1_1	52	58	PF00069	0.398
MOD_CK1_1	97	103	PF00069	0.338
MOD_CK2_1	274	280	PF00069	0.321
MOD_CK2_1	435	441	PF00069	0.502
MOD_GlcNHglycan	146	150	PF01048	0.443
MOD_GlcNHglycan	161	164	PF01048	0.382
MOD_GlcNHglycan	229	232	PF01048	0.457
MOD_GlcNHglycan	297	300	PF01048	0.538
MOD_GlcNHglycan	349	352	PF01048	0.479
MOD_GlcNHglycan	359	362	PF01048	0.572
MOD_GlcNHglycan	38	41	PF01048	0.372
MOD_GlcNHglycan	54	57	PF01048	0.500
MOD_GlcNHglycan	84	87	PF01048	0.542
MOD_GlcNHglycan	99	102	PF01048	0.300
MOD_GSK3_1	141	148	PF00069	0.512
MOD_GSK3_1	197	204	PF00069	0.554
MOD_GSK3_1	343	350	PF00069	0.371
MOD_GSK3_1	431	438	PF00069	0.418
MOD_GSK3_1	78	85	PF00069	0.432
MOD_GSK3_1	90	97	PF00069	0.246
MOD_NEK2_1	106	111	PF00069	0.326
MOD_NEK2_1	116	121	PF00069	0.343
MOD_NEK2_1	126	131	PF00069	0.157
MOD_NEK2_1	140	145	PF00069	0.369
MOD_NEK2_1	159	164	PF00069	0.402
MOD_NEK2_1	195	200	PF00069	0.484
MOD_NEK2_1	237	242	PF00069	0.292
MOD_NEK2_1	264	269	PF00069	0.409
MOD_NEK2_1	347	352	PF00069	0.460
MOD_NEK2_1	426	431	PF00069	0.412
MOD_NEK2_1	432	437	PF00069	0.380
MOD_NEK2_1	71	76	PF00069	0.318
MOD_NEK2_1	82	87	PF00069	0.365
MOD_NEK2_1	90	95	PF00069	0.194
MOD_PIKK_1	106	112	PF00454	0.433
MOD_PIKK_1	205	211	PF00454	0.450
MOD_PIKK_1	371	377	PF00454	0.483
MOD_PIKK_1	413	419	PF00454	0.386
MOD_PKA_2	126	132	PF00069	0.322
MOD_PKA_2	205	211	PF00069	0.475
MOD_Plk_4	111	117	PF00069	0.435
MOD_Plk_4	185	191	PF00069	0.288
MOD_Plk_4	274	280	PF00069	0.444
MOD_Plk_4	301	307	PF00069	0.399
MOD_Plk_4	313	319	PF00069	0.298
MOD_Plk_4	330	336	PF00069	0.280
MOD_Plk_4	405	411	PF00069	0.400
MOD_Plk_4	426	432	PF00069	0.444
MOD_Plk_4	71	77	PF00069	0.316
MOD_SUMO_rev_2	298	304	PF00179	0.360
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.482
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.384
TRG_ENDOCYTIC_2	153	156	PF00928	0.429
TRG_ENDOCYTIC_2	226	229	PF00928	0.417
TRG_ENDOCYTIC_2	409	412	PF00928	0.424
TRG_ENDOCYTIC_2	50	53	PF00928	0.419
TRG_ER_diArg_1	196	199	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ5	Leptomonas seymouri	52%	100%
A0A1X0NUV1	Trypanosomatidae	25%	95%
A0A3Q8I960	Leishmania donovani	90%	100%
A0A3R7NA95	Trypanosoma rangeli	26%	100%
A4H6Q3	Leishmania braziliensis	74%	100%
A4HV38	Leishmania infantum	90%	100%
D0A7B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	96%
E9ANR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5C1D7	Trypanosoma cruzi	26%	95%