Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like/Major Facilitator Superfamily, putative

Species:

Leishmania major

UniProt:

Q4QGU8_LEIMA

TriTrypDb:

LmjF.11.1340 , LMJLV39_110020800 , LMJSD75_110021300

Length:

627

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 81
NetGPI	no	yes: 0, no: 81

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0016020	membrane	2	75
GO:0110165	cellular anatomical entity	1	75

Expansion

Sequence features

Q4QGU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGU8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	37
GO:0022857	transmembrane transporter activity	2	37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.677
CLV_C14_Caspase3-7	321	325	PF00656	0.776
CLV_C14_Caspase3-7	355	359	PF00656	0.789
CLV_NRD_NRD_1	305	307	PF00675	0.496
CLV_NRD_NRD_1	88	90	PF00675	0.333
CLV_PCSK_KEX2_1	304	306	PF00082	0.484
CLV_PCSK_SKI1_1	157	161	PF00082	0.305
CLV_PCSK_SKI1_1	517	521	PF00082	0.519
CLV_PCSK_SKI1_1	621	625	PF00082	0.363
DEG_SCF_FBW7_2	294	301	PF00400	0.516
DOC_CDC14_PxL_1	497	505	PF14671	0.303
DOC_CKS1_1	212	217	PF01111	0.570
DOC_CKS1_1	295	300	PF01111	0.386
DOC_CKS1_1	544	549	PF01111	0.425
DOC_CYCLIN_yCln2_LP_2	329	332	PF00134	0.724
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.288
DOC_MAPK_MEF2A_6	485	493	PF00069	0.568
DOC_PP1_RVXF_1	515	521	PF00149	0.243
DOC_PP2B_LxvP_1	210	213	PF13499	0.313
DOC_PP2B_LxvP_1	329	332	PF13499	0.724
DOC_PP2B_LxvP_1	498	501	PF13499	0.327
DOC_PP2B_LxvP_1	519	522	PF13499	0.289
DOC_PP4_FxxP_1	240	243	PF00568	0.459
DOC_PP4_FxxP_1	295	298	PF00568	0.466
DOC_PP4_FxxP_1	79	82	PF00568	0.337
DOC_USP7_MATH_1	108	112	PF00917	0.227
DOC_USP7_MATH_1	452	456	PF00917	0.428
DOC_USP7_MATH_1	612	616	PF00917	0.370
DOC_WW_Pin1_4	118	123	PF00397	0.181
DOC_WW_Pin1_4	211	216	PF00397	0.576
DOC_WW_Pin1_4	294	299	PF00397	0.375
DOC_WW_Pin1_4	48	53	PF00397	0.255
DOC_WW_Pin1_4	543	548	PF00397	0.593
DOC_WW_Pin1_4	561	566	PF00397	0.279
LIG_14-3-3_CanoR_1	149	158	PF00244	0.395
LIG_14-3-3_CanoR_1	349	357	PF00244	0.802
LIG_14-3-3_CanoR_1	453	459	PF00244	0.420
LIG_14-3-3_CanoR_1	60	66	PF00244	0.366
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BIR_III_4	358	362	PF00653	0.700
LIG_BIR_III_4	4	8	PF00653	0.525
LIG_BRCT_BRCA1_1	110	114	PF00533	0.349
LIG_BRCT_BRCA1_1	134	138	PF00533	0.330
LIG_BRCT_BRCA1_1	253	257	PF00533	0.367
LIG_deltaCOP1_diTrp_1	24	31	PF00928	0.465
LIG_deltaCOP1_diTrp_1	422	431	PF00928	0.369
LIG_EH1_1	30	38	PF00400	0.289
LIG_FHA_1	11	17	PF00498	0.623
LIG_FHA_1	139	145	PF00498	0.310
LIG_FHA_1	202	208	PF00498	0.381
LIG_FHA_1	215	221	PF00498	0.510
LIG_FHA_1	246	252	PF00498	0.292
LIG_FHA_1	281	287	PF00498	0.366
LIG_FHA_1	289	295	PF00498	0.373
LIG_FHA_1	311	317	PF00498	0.658
LIG_FHA_1	325	331	PF00498	0.681
LIG_FHA_1	378	384	PF00498	0.766
LIG_FHA_1	460	466	PF00498	0.336
LIG_FHA_1	69	75	PF00498	0.372
LIG_FHA_1	81	87	PF00498	0.350
LIG_FHA_1	93	99	PF00498	0.297
LIG_FHA_2	411	417	PF00498	0.561
LIG_GBD_Chelix_1	255	263	PF00786	0.286
LIG_GBD_Chelix_1	470	478	PF00786	0.439
LIG_LIR_Apic_2	265	270	PF02991	0.339
LIG_LIR_Apic_2	77	82	PF02991	0.333
LIG_LIR_Gen_1	254	264	PF02991	0.396
LIG_LIR_Gen_1	289	298	PF02991	0.342
LIG_LIR_Gen_1	413	423	PF02991	0.524
LIG_LIR_Gen_1	445	456	PF02991	0.336
LIG_LIR_Gen_1	462	471	PF02991	0.338
LIG_LIR_Nem_3	111	117	PF02991	0.226
LIG_LIR_Nem_3	150	154	PF02991	0.497
LIG_LIR_Nem_3	164	168	PF02991	0.375
LIG_LIR_Nem_3	254	260	PF02991	0.329
LIG_LIR_Nem_3	413	418	PF02991	0.524
LIG_LIR_Nem_3	445	451	PF02991	0.328
LIG_LIR_Nem_3	462	467	PF02991	0.339
LIG_LIR_Nem_3	48	53	PF02991	0.330
LIG_LIR_Nem_3	615	620	PF02991	0.351
LIG_LYPXL_S_1	482	486	PF13949	0.233
LIG_LYPXL_yS_3	483	486	PF13949	0.431
LIG_MAD2	476	484	PF02301	0.202
LIG_MYND_1	391	395	PF01753	0.605
LIG_NRP_CendR_1	626	627	PF00754	0.297
LIG_Pex14_1	27	31	PF04695	0.465
LIG_Pex14_1	424	428	PF04695	0.355
LIG_Pex14_2	240	244	PF04695	0.506
LIG_Pex14_2	253	257	PF04695	0.373
LIG_Pex14_2	520	524	PF04695	0.356
LIG_REV1ctd_RIR_1	178	187	PF16727	0.334
LIG_SH2_CRK	448	452	PF00017	0.322
LIG_SH2_CRK	554	558	PF00017	0.260
LIG_SH2_CRK	620	624	PF00017	0.523
LIG_SH2_PTP2	267	270	PF00017	0.378
LIG_SH2_SRC	267	270	PF00017	0.371
LIG_SH2_STAP1	554	558	PF00017	0.294
LIG_SH2_STAT5	177	180	PF00017	0.356
LIG_SH2_STAT5	209	212	PF00017	0.332
LIG_SH2_STAT5	21	24	PF00017	0.602
LIG_SH2_STAT5	267	270	PF00017	0.310
LIG_SH2_STAT5	558	561	PF00017	0.361
LIG_SH2_STAT5	617	620	PF00017	0.306
LIG_SH2_STAT5	78	81	PF00017	0.334
LIG_SH3_3	382	388	PF00018	0.714
LIG_SH3_3	389	395	PF00018	0.704
LIG_SH3_3	541	547	PF00018	0.532
LIG_SUMO_SIM_par_1	536	543	PF11976	0.265
LIG_SUMO_SIM_par_1	94	100	PF11976	0.330
LIG_TYR_ITIM	207	212	PF00017	0.344
LIG_TYR_ITIM	618	623	PF00017	0.324
LIG_WRC_WIRS_1	148	153	PF05994	0.544
MOD_CDK_SPxxK_3	211	218	PF00069	0.474
MOD_CDK_SPxxK_3	48	55	PF00069	0.265
MOD_CK1_1	132	138	PF00069	0.364
MOD_CK1_1	143	149	PF00069	0.385
MOD_CK1_1	377	383	PF00069	0.740
MOD_CK1_1	435	441	PF00069	0.311
MOD_CK1_1	442	448	PF00069	0.317
MOD_CK1_1	48	54	PF00069	0.312
MOD_CK1_1	533	539	PF00069	0.325
MOD_CK1_1	543	549	PF00069	0.528
MOD_CK1_1	77	83	PF00069	0.329
MOD_CK2_1	134	140	PF00069	0.333
MOD_CK2_1	259	265	PF00069	0.288
MOD_CK2_1	410	416	PF00069	0.566
MOD_CK2_1	59	65	PF00069	0.325
MOD_CMANNOS	424	427	PF00535	0.396
MOD_GlcNHglycan	114	117	PF01048	0.526
MOD_GlcNHglycan	134	137	PF01048	0.338
MOD_GlcNHglycan	185	188	PF01048	0.476
MOD_GlcNHglycan	198	201	PF01048	0.356
MOD_GlcNHglycan	320	323	PF01048	0.513
MOD_GlcNHglycan	350	353	PF01048	0.529
MOD_GlcNHglycan	434	437	PF01048	0.293
MOD_GlcNHglycan	471	474	PF01048	0.334
MOD_GlcNHglycan	614	617	PF01048	0.392
MOD_GSK3_1	108	115	PF00069	0.377
MOD_GSK3_1	134	141	PF00069	0.346
MOD_GSK3_1	143	150	PF00069	0.326
MOD_GSK3_1	371	378	PF00069	0.734
MOD_GSK3_1	435	442	PF00069	0.344
MOD_GSK3_1	452	459	PF00069	0.390
MOD_GSK3_1	530	537	PF00069	0.371
MOD_GSK3_1	539	546	PF00069	0.414
MOD_GSK3_1	552	559	PF00069	0.503
MOD_N-GLC_1	102	107	PF02516	0.419
MOD_N-GLC_1	442	447	PF02516	0.543
MOD_NEK2_1	112	117	PF00069	0.297
MOD_NEK2_1	134	139	PF00069	0.324
MOD_NEK2_1	168	173	PF00069	0.378
MOD_NEK2_1	181	186	PF00069	0.321
MOD_NEK2_1	201	206	PF00069	0.316
MOD_NEK2_1	251	256	PF00069	0.379
MOD_NEK2_1	259	264	PF00069	0.367
MOD_NEK2_1	286	291	PF00069	0.354
MOD_NEK2_1	293	298	PF00069	0.364
MOD_NEK2_1	323	328	PF00069	0.733
MOD_NEK2_1	376	381	PF00069	0.793
MOD_NEK2_1	45	50	PF00069	0.359
MOD_NEK2_1	456	461	PF00069	0.334
MOD_NEK2_1	539	544	PF00069	0.404
MOD_NEK2_1	556	561	PF00069	0.348
MOD_NEK2_1	59	64	PF00069	0.289
MOD_NEK2_1	97	102	PF00069	0.283
MOD_PIKK_1	129	135	PF00454	0.288
MOD_PIKK_1	399	405	PF00454	0.799
MOD_PIKK_1	59	65	PF00454	0.282
MOD_PK_1	336	342	PF00069	0.585
MOD_PKA_2	348	354	PF00069	0.749
MOD_PKA_2	452	458	PF00069	0.440
MOD_PKA_2	59	65	PF00069	0.344
MOD_Plk_1	181	187	PF00069	0.299
MOD_Plk_1	19	25	PF00069	0.657
MOD_Plk_1	410	416	PF00069	0.609
MOD_Plk_1	442	448	PF00069	0.320
MOD_Plk_4	108	114	PF00069	0.296
MOD_Plk_4	134	140	PF00069	0.333
MOD_Plk_4	161	167	PF00069	0.340
MOD_Plk_4	168	174	PF00069	0.368
MOD_Plk_4	246	252	PF00069	0.355
MOD_Plk_4	259	265	PF00069	0.338
MOD_Plk_4	410	416	PF00069	0.575
MOD_Plk_4	435	441	PF00069	0.335
MOD_Plk_4	459	465	PF00069	0.279
MOD_Plk_4	534	540	PF00069	0.317
MOD_Plk_4	552	558	PF00069	0.512
MOD_Plk_4	74	80	PF00069	0.357
MOD_Plk_4	92	98	PF00069	0.468
MOD_ProDKin_1	118	124	PF00069	0.181
MOD_ProDKin_1	211	217	PF00069	0.576
MOD_ProDKin_1	294	300	PF00069	0.379
MOD_ProDKin_1	48	54	PF00069	0.255
MOD_ProDKin_1	543	549	PF00069	0.591
MOD_ProDKin_1	561	567	PF00069	0.279
MOD_SUMO_for_1	54	57	PF00179	0.193
MOD_SUMO_rev_2	312	321	PF00179	0.761
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.252
TRG_ENDOCYTIC_2	177	180	PF00928	0.326
TRG_ENDOCYTIC_2	198	201	PF00928	0.341
TRG_ENDOCYTIC_2	209	212	PF00928	0.323
TRG_ENDOCYTIC_2	448	451	PF00928	0.310
TRG_ENDOCYTIC_2	483	486	PF00928	0.544
TRG_ENDOCYTIC_2	554	557	PF00928	0.315
TRG_ENDOCYTIC_2	61	64	PF00928	0.322
TRG_ENDOCYTIC_2	620	623	PF00928	0.524
TRG_ENDOCYTIC_2	78	81	PF00928	0.321
TRG_ER_diArg_1	304	306	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	22%	99%
A0A0N1HZC2	Leptomonas seymouri	26%	100%
A0A0N1IKC5	Leptomonas seymouri	25%	100%
A0A0N1PB63	Leptomonas seymouri	23%	95%
A0A0N1PD04	Leptomonas seymouri	61%	98%
A0A0N1PFR4	Leptomonas seymouri	24%	95%
A0A1X0NKK0	Trypanosomatidae	23%	100%
A0A1X0NM09	Trypanosomatidae	24%	100%
A0A1X0NRW5	Trypanosomatidae	23%	90%
A0A1X0NVF9	Trypanosomatidae	47%	94%
A0A1X0NVM7	Trypanosomatidae	24%	97%
A0A1X0NWQ1	Trypanosomatidae	22%	98%
A0A1X0NZU2	Trypanosomatidae	28%	97%
A0A381MMW5	Leishmania infantum	26%	96%
A0A3Q8IEC4	Leishmania donovani	26%	97%
A0A3Q8IF95	Leishmania donovani	23%	99%
A0A3Q8IIT5	Leishmania donovani	24%	93%
A0A3Q8ISY9	Leishmania donovani	23%	99%
A0A3R7MAQ7	Trypanosoma rangeli	23%	89%
A0A3R7N3S6	Trypanosoma rangeli	47%	97%
A0A3R7N415	Trypanosoma rangeli	26%	100%
A0A3S7WRJ4	Leishmania donovani	23%	98%
A0A3S7WRJ5	Leishmania donovani	24%	90%
A0A3S7WRS3	Leishmania donovani	90%	100%
A0A3S7WSR4	Leishmania donovani	24%	100%
A0A3S7WWU1	Leishmania donovani	23%	94%
A0A3S7X2G0	Leishmania donovani	26%	96%
A0A3S7X2K5	Leishmania donovani	26%	100%
A0A3S7XB11	Leishmania donovani	26%	100%
A0A422MSP6	Trypanosoma rangeli	22%	100%
A0A422MU68	Trypanosoma rangeli	24%	100%
A4H6J0	Leishmania braziliensis	25%	98%
A4H6J1	Leishmania braziliensis	25%	96%
A4H6Q5	Leishmania braziliensis	69%	100%
A4HC19	Leishmania braziliensis	22%	97%
A4HHG2	Leishmania braziliensis	25%	93%
A4HHG3	Leishmania braziliensis	26%	97%
A4HHG4	Leishmania braziliensis	26%	96%
A4HJW3	Leishmania braziliensis	23%	98%
A4HPE2	Leishmania braziliensis	26%	100%
A4HUX5	Leishmania infantum	23%	98%
A4HUX6	Leishmania infantum	24%	90%
A4HV40	Leishmania infantum	90%	100%
A4HZF5	Leishmania infantum	23%	99%
A4HZJ4	Leishmania infantum	23%	94%
A4I4L2	Leishmania infantum	24%	93%
A4I7C5	Leishmania infantum	23%	99%
A4ICI3	Leishmania infantum	26%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	92%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AE01	Leishmania major	25%	100%
E9AE09	Leishmania major	24%	100%
E9AE10	Leishmania major	24%	100%
E9AE11	Leishmania major	26%	100%
E9AGK5	Leishmania infantum	24%	100%
E9AHJ0	Leishmania infantum	26%	97%
E9AHJ1	Leishmania infantum	26%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	97%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	93%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	98%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	95%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q1E4	Leishmania major	26%	100%
Q4Q5T8	Leishmania major	23%	100%
Q4QC27	Leishmania major	23%	100%
Q4QC28	Leishmania major	24%	100%
Q4QFY5	Leishmania major	24%	100%
Q4QH14	Leishmania major	24%	96%
Q4QH15	Leishmania major	23%	100%
V5B647	Trypanosoma cruzi	22%	99%
V5B983	Trypanosoma cruzi	25%	100%
V5BVP0	Trypanosoma cruzi	24%	100%