Ribosomal protein L4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L4/L1 family, putative

Species:

Leishmania major

UniProt:

Q4QGU6_LEIMA

TriTrypDb:

LmjF.11.1360 , LMJLV39_110021000 , LMJSD75_110021500

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4QGU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGU6

PDB structure(s): 7aih_B , 7am2_B , 7ane_B

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.266
CLV_NRD_NRD_1	166	168	PF00675	0.266
CLV_NRD_NRD_1	427	429	PF00675	0.540
CLV_PCSK_SKI1_1	148	152	PF00082	0.266
CLV_PCSK_SKI1_1	179	183	PF00082	0.388
CLV_PCSK_SKI1_1	264	268	PF00082	0.312
CLV_PCSK_SKI1_1	359	363	PF00082	0.446
CLV_PCSK_SKI1_1	423	427	PF00082	0.504
DEG_Nend_Nbox_1	1	3	PF02207	0.439
DEG_SCF_FBW7_2	256	261	PF00400	0.266
DOC_CYCLIN_yClb5_NLxxxL_5	123	129	PF00134	0.382
DOC_MAPK_gen_1	198	206	PF00069	0.281
DOC_MAPK_gen_1	304	312	PF00069	0.266
DOC_MAPK_JIP1_4	182	188	PF00069	0.221
DOC_MAPK_MEF2A_6	198	206	PF00069	0.268
DOC_PP2B_LxvP_1	186	189	PF13499	0.221
DOC_PP2B_LxvP_1	219	222	PF13499	0.411
DOC_PP4_MxPP_1	347	350	PF00568	0.446
DOC_USP7_MATH_1	40	44	PF00917	0.510
DOC_USP7_UBL2_3	194	198	PF12436	0.300
DOC_USP7_UBL2_3	297	301	PF12436	0.300
DOC_WW_Pin1_4	254	259	PF00397	0.270
DOC_WW_Pin1_4	47	52	PF00397	0.386
LIG_14-3-3_CanoR_1	201	207	PF00244	0.266
LIG_14-3-3_CanoR_1	218	222	PF00244	0.266
LIG_14-3-3_CanoR_1	428	433	PF00244	0.528
LIG_AP2alpha_2	108	110	PF02296	0.300
LIG_Clathr_ClatBox_1	333	337	PF01394	0.325
LIG_deltaCOP1_diTrp_1	145	154	PF00928	0.302
LIG_FHA_1	102	108	PF00498	0.302
LIG_FHA_1	188	194	PF00498	0.278
LIG_FHA_1	323	329	PF00498	0.421
LIG_FHA_1	340	346	PF00498	0.249
LIG_FHA_1	62	68	PF00498	0.510
LIG_FHA_1	74	80	PF00498	0.358
LIG_FHA_2	218	224	PF00498	0.266
LIG_G3BP_FGDF_1	266	271	PF02136	0.266
LIG_IBAR_NPY_1	399	401	PF08397	0.379
LIG_Integrin_isoDGR_2	273	275	PF01839	0.266
LIG_LIR_Apic_2	19	25	PF02991	0.492
LIG_LIR_Gen_1	227	236	PF02991	0.281
LIG_LIR_Nem_3	126	130	PF02991	0.328
LIG_LIR_Nem_3	227	232	PF02991	0.266
LIG_LIR_Nem_3	430	435	PF02991	0.371
LIG_Pex14_2	110	114	PF04695	0.432
LIG_Pex14_2	135	139	PF04695	0.356
LIG_Pex14_2	267	271	PF04695	0.285
LIG_Rb_LxCxE_1	282	300	PF01857	0.325
LIG_REV1ctd_RIR_1	269	279	PF16727	0.281
LIG_SH2_CRK	318	322	PF00017	0.411
LIG_SH2_CRK	397	401	PF00017	0.526
LIG_SH2_GRB2like	141	144	PF00017	0.420
LIG_SH2_GRB2like	397	400	PF00017	0.449
LIG_SH2_NCK_1	262	266	PF00017	0.411
LIG_SH2_NCK_1	397	401	PF00017	0.526
LIG_SH2_SRC	397	400	PF00017	0.543
LIG_SH2_SRC	52	55	PF00017	0.408
LIG_SH2_STAP1	262	266	PF00017	0.411
LIG_SH2_STAP1	341	345	PF00017	0.419
LIG_SH2_STAP1	412	416	PF00017	0.427
LIG_SH2_STAT5	229	232	PF00017	0.281
LIG_SH2_STAT5	341	344	PF00017	0.411
LIG_SH2_STAT5	424	427	PF00017	0.492
LIG_SH2_STAT5	52	55	PF00017	0.453
LIG_SH2_STAT5	62	65	PF00017	0.400
LIG_SH2_STAT5	81	84	PF00017	0.379
LIG_SH3_1	397	403	PF00018	0.528
LIG_SH3_3	177	183	PF00018	0.266
LIG_SH3_3	397	403	PF00018	0.425
LIG_SH3_3	41	47	PF00018	0.404
LIG_SH3_3	48	54	PF00018	0.377
LIG_SH3_3	65	71	PF00018	0.532
LIG_SUMO_SIM_par_1	324	330	PF11976	0.363
LIG_TRAF2_1	224	227	PF00917	0.269
LIG_TYR_ITIM	125	130	PF00017	0.343
LIG_UBA3_1	187	194	PF00899	0.277
LIG_UBA3_1	202	207	PF00899	0.236
LIG_WRC_WIRS_1	268	273	PF05994	0.266
MOD_CDC14_SPxK_1	55	58	PF00782	0.383
MOD_CDK_SPxK_1	52	58	PF00069	0.383
MOD_CK1_1	254	260	PF00069	0.271
MOD_CK1_1	4	10	PF00069	0.510
MOD_CK1_1	427	433	PF00069	0.441
MOD_CK2_1	217	223	PF00069	0.281
MOD_GlcNHglycan	6	9	PF01048	0.439
MOD_GSK3_1	192	199	PF00069	0.266
MOD_GSK3_1	293	300	PF00069	0.411
MOD_GSK3_1	322	329	PF00069	0.331
MOD_GSK3_1	424	431	PF00069	0.511
MOD_N-GLC_1	123	128	PF02516	0.318
MOD_N-GLC_1	133	138	PF02516	0.341
MOD_N-GLC_1	291	296	PF02516	0.281
MOD_N-GLC_1	99	104	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.587
MOD_NEK2_1	202	207	PF00069	0.266
MOD_NEK2_1	232	237	PF00069	0.325
MOD_NEK2_1	267	272	PF00069	0.273
MOD_NEK2_1	73	78	PF00069	0.362
MOD_PIKK_1	222	228	PF00454	0.266
MOD_PKA_1	428	434	PF00069	0.418
MOD_PKA_2	217	223	PF00069	0.281
MOD_PKA_2	279	285	PF00069	0.266
MOD_PKA_2	292	298	PF00069	0.266
MOD_PKA_2	4	10	PF00069	0.431
MOD_PKA_2	427	433	PF00069	0.416
MOD_Plk_1	123	129	PF00069	0.323
MOD_Plk_1	40	46	PF00069	0.567
MOD_Plk_1	408	414	PF00069	0.471
MOD_Plk_2-3	217	223	PF00069	0.266
MOD_Plk_4	123	129	PF00069	0.338
MOD_Plk_4	267	273	PF00069	0.266
MOD_Plk_4	279	285	PF00069	0.266
MOD_Plk_4	322	328	PF00069	0.414
MOD_ProDKin_1	254	260	PF00069	0.270
MOD_ProDKin_1	47	53	PF00069	0.391
TRG_DiLeu_BaEn_2	105	111	PF01217	0.299
TRG_ENDOCYTIC_2	127	130	PF00928	0.328
TRG_ENDOCYTIC_2	229	232	PF00928	0.281
TRG_ENDOCYTIC_2	318	321	PF00928	0.346
TRG_NLS_MonoExtC_3	147	152	PF00514	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F3	Leptomonas seymouri	89%	95%
A0A0S4JS84	Bodo saltans	66%	94%
A0A1X0NV94	Trypanosomatidae	74%	95%
A0A3S5H6K0	Leishmania donovani	97%	100%
A0A422N538	Trypanosoma rangeli	74%	95%
A4H6Q8	Leishmania braziliensis	95%	100%
A4HV42	Leishmania infantum	97%	100%
D0A7A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	95%
E9ANS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BRW7	Trypanosoma cruzi	75%	95%