TRUD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA pseudouridine synthase D (TruD), putative

Species:

Leishmania major

UniProt:

Q4QGU5_LEIMA

TriTrypDb:

LmjF.11.1370 , LMJLV39_110021100 , LMJSD75_110021600

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGU5

PDB structure(s): 7am2_CA

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.518
CLV_C14_Caspase3-7	87	91	PF00656	0.402
CLV_NRD_NRD_1	106	108	PF00675	0.433
CLV_NRD_NRD_1	143	145	PF00675	0.507
CLV_NRD_NRD_1	299	301	PF00675	0.439
CLV_NRD_NRD_1	359	361	PF00675	0.508
CLV_NRD_NRD_1	508	510	PF00675	0.486
CLV_NRD_NRD_1	574	576	PF00675	0.532
CLV_NRD_NRD_1	577	579	PF00675	0.544
CLV_PCSK_FUR_1	575	579	PF00082	0.470
CLV_PCSK_KEX2_1	143	145	PF00082	0.549
CLV_PCSK_KEX2_1	299	301	PF00082	0.439
CLV_PCSK_KEX2_1	508	510	PF00082	0.486
CLV_PCSK_KEX2_1	576	578	PF00082	0.511
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.466
CLV_PCSK_SKI1_1	113	117	PF00082	0.466
CLV_PCSK_SKI1_1	152	156	PF00082	0.455
CLV_PCSK_SKI1_1	249	253	PF00082	0.315
CLV_PCSK_SKI1_1	356	360	PF00082	0.528
CLV_PCSK_SKI1_1	416	420	PF00082	0.467
CLV_PCSK_SKI1_1	601	605	PF00082	0.349
CLV_Separin_Metazoa	235	239	PF03568	0.521
CLV_Separin_Metazoa	357	361	PF03568	0.469
DEG_APCC_DBOX_1	248	256	PF00400	0.315
DEG_APCC_DBOX_1	355	363	PF00400	0.468
DEG_Nend_UBRbox_1	1	4	PF02207	0.436
DOC_CDC14_PxL_1	233	241	PF14671	0.494
DOC_CYCLIN_RxL_1	107	120	PF00134	0.467
DOC_CYCLIN_RxL_1	246	256	PF00134	0.385
DOC_MAPK_gen_1	107	117	PF00069	0.431
DOC_MAPK_gen_1	172	179	PF00069	0.419
DOC_MAPK_gen_1	482	488	PF00069	0.514
DOC_PP1_RVXF_1	407	414	PF00149	0.477
DOC_PP2B_LxvP_1	453	456	PF13499	0.365
DOC_PP4_FxxP_1	21	24	PF00568	0.426
DOC_PP4_FxxP_1	588	591	PF00568	0.457
DOC_USP7_MATH_1	190	194	PF00917	0.392
DOC_USP7_MATH_1	212	216	PF00917	0.363
DOC_USP7_MATH_1	302	306	PF00917	0.523
DOC_USP7_MATH_1	330	334	PF00917	0.436
DOC_USP7_MATH_1	393	397	PF00917	0.367
DOC_USP7_MATH_1	404	408	PF00917	0.325
DOC_USP7_MATH_1	468	472	PF00917	0.487
DOC_USP7_MATH_1	530	534	PF00917	0.462
DOC_USP7_MATH_1	591	595	PF00917	0.409
DOC_USP7_MATH_2	543	549	PF00917	0.514
DOC_WW_Pin1_4	119	124	PF00397	0.469
DOC_WW_Pin1_4	129	134	PF00397	0.370
DOC_WW_Pin1_4	314	319	PF00397	0.488
DOC_WW_Pin1_4	457	462	PF00397	0.480
DOC_WW_Pin1_4	494	499	PF00397	0.613
DOC_WW_Pin1_4	592	597	PF00397	0.371
DOC_WW_Pin1_4	62	67	PF00397	0.676
LIG_14-3-3_CanoR_1	11	21	PF00244	0.406
LIG_14-3-3_CanoR_1	111	116	PF00244	0.456
LIG_14-3-3_CanoR_1	134	139	PF00244	0.431
LIG_14-3-3_CanoR_1	238	242	PF00244	0.532
LIG_14-3-3_CanoR_1	267	275	PF00244	0.430
LIG_14-3-3_CanoR_1	409	414	PF00244	0.475
LIG_14-3-3_CanoR_1	499	505	PF00244	0.526
LIG_14-3-3_CanoR_1	51	56	PF00244	0.540
LIG_14-3-3_CanoR_1	78	86	PF00244	0.495
LIG_Actin_WH2_2	141	158	PF00022	0.397
LIG_APCC_ABBA_1	157	162	PF00400	0.321
LIG_APCC_ABBAyCdc20_2	156	162	PF00400	0.341
LIG_BIR_III_4	90	94	PF00653	0.458
LIG_BRCT_BRCA1_1	270	274	PF00533	0.482
LIG_BRCT_BRCA1_1	484	488	PF00533	0.355
LIG_BRCT_BRCA1_1	532	536	PF00533	0.447
LIG_BRCT_BRCA1_1	563	567	PF00533	0.399
LIG_EH1_1	217	225	PF00400	0.414
LIG_eIF4E_1	218	224	PF01652	0.382
LIG_eIF4E_1	246	252	PF01652	0.427
LIG_FHA_1	112	118	PF00498	0.427
LIG_FHA_1	353	359	PF00498	0.456
LIG_FHA_1	467	473	PF00498	0.543
LIG_FHA_2	287	293	PF00498	0.467
LIG_FHA_2	310	316	PF00498	0.472
LIG_FHA_2	445	451	PF00498	0.449
LIG_FHA_2	608	614	PF00498	0.461
LIG_FHA_2	85	91	PF00498	0.396
LIG_HP1_1	596	600	PF01393	0.437
LIG_LIR_Gen_1	193	202	PF02991	0.469
LIG_LIR_Gen_1	227	237	PF02991	0.463
LIG_LIR_Gen_1	341	349	PF02991	0.481
LIG_LIR_Gen_1	474	481	PF02991	0.432
LIG_LIR_Gen_1	594	604	PF02991	0.354
LIG_LIR_Gen_1	610	617	PF02991	0.306
LIG_LIR_Nem_3	137	141	PF02991	0.403
LIG_LIR_Nem_3	193	197	PF02991	0.335
LIG_LIR_Nem_3	227	233	PF02991	0.448
LIG_LIR_Nem_3	271	277	PF02991	0.326
LIG_LIR_Nem_3	341	345	PF02991	0.470
LIG_LIR_Nem_3	474	480	PF02991	0.442
LIG_LIR_Nem_3	594	600	PF02991	0.349
LIG_LIR_Nem_3	610	614	PF02991	0.298
LIG_Pex14_1	547	551	PF04695	0.537
LIG_Pex14_2	274	278	PF04695	0.317
LIG_Pex14_2	476	480	PF04695	0.420
LIG_SH2_CRK	507	511	PF00017	0.379
LIG_SH2_GRB2like	327	330	PF00017	0.383
LIG_SH2_NCK_1	327	331	PF00017	0.512
LIG_SH2_SRC	175	178	PF00017	0.496
LIG_SH2_SRC	327	330	PF00017	0.383
LIG_SH2_STAT5	141	144	PF00017	0.433
LIG_SH2_STAT5	185	188	PF00017	0.466
LIG_SH2_STAT5	246	249	PF00017	0.493
LIG_SH2_STAT5	277	280	PF00017	0.321
LIG_SH2_STAT5	309	312	PF00017	0.384
LIG_SH2_STAT5	324	327	PF00017	0.276
LIG_SH2_STAT5	446	449	PF00017	0.491
LIG_SH3_3	448	454	PF00018	0.350
LIG_SH3_3	508	514	PF00018	0.370
LIG_SH3_3	552	558	PF00018	0.409
LIG_SUMO_SIM_par_1	112	120	PF11976	0.426
LIG_TRAF2_1	40	43	PF00917	0.398
LIG_TYR_ITIM	275	280	PF00017	0.319
LIG_WRC_WIRS_1	280	285	PF05994	0.361
LIG_WRC_WIRS_1	410	415	PF05994	0.495
LIG_WRC_WIRS_1	608	613	PF05994	0.419
MOD_CDK_SPK_2	129	134	PF00069	0.389
MOD_CDK_SPK_2	494	499	PF00069	0.583
MOD_CK1_1	127	133	PF00069	0.463
MOD_CK1_1	165	171	PF00069	0.353
MOD_CK1_1	373	379	PF00069	0.502
MOD_CK1_1	412	418	PF00069	0.543
MOD_CK1_1	444	450	PF00069	0.507
MOD_CK2_1	134	140	PF00069	0.402
MOD_CK2_1	253	259	PF00069	0.428
MOD_CK2_1	309	315	PF00069	0.428
MOD_CK2_1	37	43	PF00069	0.426
MOD_CK2_1	468	474	PF00069	0.477
MOD_GlcNHglycan	255	258	PF01048	0.448
MOD_GlcNHglycan	38	42	PF01048	0.354
MOD_GlcNHglycan	394	398	PF01048	0.376
MOD_GlcNHglycan	491	494	PF01048	0.561
MOD_GSK3_1	107	114	PF00069	0.431
MOD_GSK3_1	370	377	PF00069	0.416
MOD_GSK3_1	47	54	PF00069	0.480
MOD_GSK3_1	541	548	PF00069	0.481
MOD_N-GLC_1	561	566	PF02516	0.410
MOD_NEK2_1	12	17	PF00069	0.571
MOD_NEK2_1	489	494	PF00069	0.560
MOD_NEK2_1	55	60	PF00069	0.525
MOD_NEK2_2	286	291	PF00069	0.467
MOD_PIKK_1	195	201	PF00454	0.332
MOD_PIKK_1	365	371	PF00454	0.518
MOD_PIKK_1	404	410	PF00454	0.346
MOD_PIKK_1	475	481	PF00454	0.554
MOD_PKA_1	107	113	PF00069	0.431
MOD_PKA_1	482	488	PF00069	0.421
MOD_PKA_2	237	243	PF00069	0.517
MOD_PKA_2	352	358	PF00069	0.420
MOD_PKA_2	569	575	PF00069	0.510
MOD_PKB_1	105	113	PF00069	0.551
MOD_PKB_1	265	273	PF00069	0.481
MOD_PKB_1	554	562	PF00069	0.511
MOD_Plk_1	127	133	PF00069	0.525
MOD_Plk_1	330	336	PF00069	0.434
MOD_Plk_1	373	379	PF00069	0.421
MOD_Plk_1	441	447	PF00069	0.525
MOD_Plk_1	580	586	PF00069	0.479
MOD_Plk_2-3	162	168	PF00069	0.483
MOD_Plk_2-3	436	442	PF00069	0.539
MOD_Plk_2-3	545	551	PF00069	0.537
MOD_Plk_4	111	117	PF00069	0.419
MOD_Plk_4	286	292	PF00069	0.468
MOD_Plk_4	484	490	PF00069	0.375
MOD_ProDKin_1	119	125	PF00069	0.472
MOD_ProDKin_1	129	135	PF00069	0.369
MOD_ProDKin_1	314	320	PF00069	0.485
MOD_ProDKin_1	457	463	PF00069	0.491
MOD_ProDKin_1	494	500	PF00069	0.614
MOD_ProDKin_1	592	598	PF00069	0.369
MOD_ProDKin_1	62	68	PF00069	0.670
TRG_DiLeu_BaEn_1	354	359	PF01217	0.376
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.341
TRG_DiLeu_LyEn_5	150	155	PF01217	0.465
TRG_ENDOCYTIC_2	230	233	PF00928	0.469
TRG_ENDOCYTIC_2	277	280	PF00928	0.332
TRG_ENDOCYTIC_2	507	510	PF00928	0.374
TRG_ENDOCYTIC_2	608	611	PF00928	0.358
TRG_ER_diArg_1	142	144	PF00400	0.539
TRG_ER_diArg_1	172	175	PF00400	0.449
TRG_ER_diArg_1	298	300	PF00400	0.323
TRG_ER_diArg_1	507	509	PF00400	0.496
TRG_ER_diArg_1	551	554	PF00400	0.502
TRG_ER_diArg_1	574	577	PF00400	0.540
TRG_NLS_MonoCore_2	574	579	PF00514	0.460
TRG_NLS_MonoExtC_3	575	581	PF00514	0.459
TRG_NLS_MonoExtN_4	575	580	PF00514	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P414	Leptomonas seymouri	61%	98%
A0A0S4JV05	Bodo saltans	39%	94%
A0A1X0NUT8	Trypanosomatidae	43%	100%
A0A3S7WRT6	Leishmania donovani	92%	100%
A0A422N563	Trypanosoma rangeli	45%	100%
A4H6R0	Leishmania braziliensis	79%	100%
A4HV43	Leishmania infantum	92%	100%
D0A7A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9ANS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BBF7	Trypanosoma cruzi	44%	100%