SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Variant SH3 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGU4_LEIMA

TriTrypDb:

LmjF.11.1380 , LMJLV39_110021300 , LMJSD75_110021800

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.417
CLV_C14_Caspase3-7	34	38	PF00656	0.488
CLV_MEL_PAP_1	80	86	PF00089	0.570
CLV_NRD_NRD_1	117	119	PF00675	0.681
CLV_NRD_NRD_1	177	179	PF00675	0.568
CLV_NRD_NRD_1	190	192	PF00675	0.577
CLV_NRD_NRD_1	342	344	PF00675	0.592
CLV_NRD_NRD_1	352	354	PF00675	0.459
CLV_NRD_NRD_1	379	381	PF00675	0.577
CLV_PCSK_FUR_1	175	179	PF00082	0.391
CLV_PCSK_FUR_1	377	381	PF00082	0.565
CLV_PCSK_KEX2_1	177	179	PF00082	0.389
CLV_PCSK_KEX2_1	242	244	PF00082	0.572
CLV_PCSK_KEX2_1	341	343	PF00082	0.519
CLV_PCSK_KEX2_1	379	381	PF00082	0.578
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.521
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.509
CLV_PCSK_PC7_1	338	344	PF00082	0.477
CLV_PCSK_SKI1_1	178	182	PF00082	0.511
CLV_PCSK_SKI1_1	192	196	PF00082	0.468
CLV_PCSK_SKI1_1	231	235	PF00082	0.470
CLV_PCSK_SKI1_1	329	333	PF00082	0.531
CLV_PCSK_SKI1_1	338	342	PF00082	0.487
CLV_PCSK_SKI1_1	382	386	PF00082	0.549
CLV_PCSK_SKI1_1	51	55	PF00082	0.373
DEG_APCC_DBOX_1	230	238	PF00400	0.556
DEG_SPOP_SBC_1	201	205	PF00917	0.545
DOC_MAPK_gen_1	24	33	PF00069	0.389
DOC_MAPK_gen_1	341	349	PF00069	0.554
DOC_MAPK_MEF2A_6	342	351	PF00069	0.552
DOC_PP1_RVXF_1	270	276	PF00149	0.554
DOC_PP4_FxxP_1	64	67	PF00568	0.587
DOC_SPAK_OSR1_1	83	87	PF12202	0.571
DOC_USP7_MATH_1	202	206	PF00917	0.566
DOC_USP7_MATH_1	217	221	PF00917	0.615
DOC_USP7_MATH_1	229	233	PF00917	0.437
DOC_USP7_MATH_1	265	269	PF00917	0.535
DOC_USP7_MATH_1	307	311	PF00917	0.542
DOC_USP7_MATH_1	36	40	PF00917	0.413
DOC_USP7_UBL2_3	238	242	PF12436	0.547
DOC_WW_Pin1_4	106	111	PF00397	0.689
LIG_14-3-3_CanoR_1	118	122	PF00244	0.694
LIG_14-3-3_CanoR_1	209	214	PF00244	0.476
LIG_14-3-3_CanoR_1	264	270	PF00244	0.517
LIG_BIR_III_4	37	41	PF00653	0.402
LIG_DLG_GKlike_1	353	360	PF00625	0.406
LIG_FHA_1	55	61	PF00498	0.424
LIG_FHA_2	118	124	PF00498	0.615
LIG_FHA_2	254	260	PF00498	0.456
LIG_FHA_2	371	377	PF00498	0.562
LIG_LIR_Apic_2	14	18	PF02991	0.410
LIG_LIR_Apic_2	56	61	PF02991	0.417
LIG_LIR_Gen_1	20	30	PF02991	0.443
LIG_LIR_Gen_1	204	215	PF02991	0.557
LIG_LIR_Nem_3	20	25	PF02991	0.419
LIG_LIR_Nem_3	204	210	PF02991	0.507
LIG_LIR_Nem_3	227	233	PF02991	0.498
LIG_LIR_Nem_3	335	340	PF02991	0.562
LIG_MYND_3	94	98	PF01753	0.644
LIG_Pex14_1	206	210	PF04695	0.513
LIG_SH2_CRK	15	19	PF00017	0.480
LIG_SH2_CRK	337	341	PF00017	0.539
LIG_SH2_CRK	58	62	PF00017	0.553
LIG_SH2_NCK_1	15	19	PF00017	0.447
LIG_SH2_NCK_1	58	62	PF00017	0.553
LIG_SH2_PTP2	62	65	PF00017	0.601
LIG_SH2_SRC	10	13	PF00017	0.403
LIG_SH2_SRC	15	18	PF00017	0.373
LIG_SH2_STAT5	298	301	PF00017	0.452
LIG_SH2_STAT5	58	61	PF00017	0.512
LIG_SH2_STAT5	62	65	PF00017	0.562
LIG_SH3_3	107	113	PF00018	0.710
LIG_SH3_3	60	66	PF00018	0.509
LIG_TRAF2_1	256	259	PF00917	0.508
LIG_TRAF2_1	373	376	PF00917	0.571
MOD_CK1_1	184	190	PF00069	0.495
MOD_CK1_1	220	226	PF00069	0.666
MOD_CK1_1	56	62	PF00069	0.447
MOD_CK2_1	117	123	PF00069	0.637
MOD_CK2_1	202	208	PF00069	0.533
MOD_CK2_1	253	259	PF00069	0.399
MOD_CK2_1	370	376	PF00069	0.552
MOD_GlcNHglycan	19	22	PF01048	0.477
MOD_GlcNHglycan	37	41	PF01048	0.244
MOD_GlcNHglycan	89	92	PF01048	0.619
MOD_GSK3_1	218	225	PF00069	0.699
MOD_GSK3_1	246	253	PF00069	0.590
MOD_NEK2_1	181	186	PF00069	0.529
MOD_NEK2_1	251	256	PF00069	0.528
MOD_NEK2_2	265	270	PF00069	0.486
MOD_PIKK_1	137	143	PF00454	0.606
MOD_PIKK_1	253	259	PF00454	0.361
MOD_PKA_1	353	359	PF00069	0.406
MOD_PKA_2	117	123	PF00069	0.598
MOD_PKA_2	249	255	PF00069	0.574
MOD_Plk_1	181	187	PF00069	0.575
MOD_Plk_1	246	252	PF00069	0.523
MOD_Plk_4	202	208	PF00069	0.521
MOD_ProDKin_1	106	112	PF00069	0.689
MOD_SUMO_for_1	301	304	PF00179	0.413
MOD_SUMO_rev_2	232	240	PF00179	0.512
TRG_DiLeu_BaEn_4	246	252	PF01217	0.609
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.651
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.632
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.401
TRG_ENDOCYTIC_2	207	210	PF00928	0.542
TRG_ENDOCYTIC_2	337	340	PF00928	0.550
TRG_ER_diArg_1	145	148	PF00400	0.608
TRG_ER_diArg_1	269	272	PF00400	0.488
TRG_ER_diArg_1	319	322	PF00400	0.505
TRG_ER_diArg_1	377	380	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ47	Leptomonas seymouri	47%	100%
A0A1X0NUT5	Trypanosomatidae	25%	100%
A0A3Q8I836	Leishmania donovani	84%	100%
A0A3R7RDU1	Trypanosoma rangeli	28%	98%
A4H6R1	Leishmania braziliensis	67%	100%
A4HV44	Leishmania infantum	84%	100%
D0A7A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ANS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5DT68	Trypanosoma cruzi	27%	98%