Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome beta-1 subunit, putative

Species:

Leishmania major

UniProt:

Q4QGU1_LEIMA

TriTrypDb:

LmjF.12.0030 , LMJLV39_120005300 , LMJSD75_120006100

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	12
GO:0019774	proteasome core complex, beta-subunit complex	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12

Expansion

Sequence features

Q4QGU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGU1

PDB structure(s): 6qm7_H , 6qm7_V , 6qm8_H , 6qm8_V

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004298	threonine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0070003	threonine-type peptidase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	109	115	PF00089	0.390
CLV_PCSK_KEX2_1	246	248	PF00082	0.454
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.454
CLV_PCSK_SKI1_1	229	233	PF00082	0.479
CLV_PCSK_SKI1_1	33	37	PF00082	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DEG_SPOP_SBC_1	267	271	PF00917	0.448
DOC_CYCLIN_RxL_1	30	39	PF00134	0.651
DOC_PP2B_LxvP_1	241	244	PF13499	0.426
DOC_USP7_MATH_1	199	203	PF00917	0.557
DOC_USP7_MATH_1	267	271	PF00917	0.448
DOC_USP7_MATH_1	69	73	PF00917	0.503
DOC_USP7_UBL2_3	90	94	PF12436	0.501
DOC_WW_Pin1_4	245	250	PF00397	0.441
LIG_14-3-3_CanoR_1	145	154	PF00244	0.559
LIG_14-3-3_CanoR_1	229	234	PF00244	0.489
LIG_14-3-3_CanoR_1	73	81	PF00244	0.490
LIG_14-3-3_CterR_2	278	283	PF00244	0.617
LIG_FHA_1	104	110	PF00498	0.496
LIG_FHA_1	228	234	PF00498	0.534
LIG_FHA_1	53	59	PF00498	0.590
LIG_FHA_1	76	82	PF00498	0.515
LIG_FHA_1	90	96	PF00498	0.523
LIG_LIR_Apic_2	164	169	PF02991	0.501
LIG_Pex14_2	188	192	PF04695	0.520
LIG_PTB_Apo_2	262	269	PF02174	0.455
LIG_SH2_CRK	157	161	PF00017	0.495
LIG_SH2_CRK	166	170	PF00017	0.482
LIG_SH2_GRB2like	142	145	PF00017	0.501
LIG_SH2_NCK_1	157	161	PF00017	0.512
LIG_SH2_NCK_1	166	170	PF00017	0.465
LIG_SH2_SRC	157	160	PF00017	0.584
LIG_SH2_STAT3	258	261	PF00017	0.605
LIG_SH2_STAT5	116	119	PF00017	0.492
LIG_SH2_STAT5	142	145	PF00017	0.519
LIG_SH2_STAT5	250	253	PF00017	0.433
LIG_SH2_STAT5	79	82	PF00017	0.506
LIG_SH2_STAT5	96	99	PF00017	0.490
LIG_SH3_3	10	16	PF00018	0.561
LIG_SH3_3	260	266	PF00018	0.485
LIG_SH3_3	39	45	PF00018	0.597
LIG_SUMO_SIM_par_1	229	234	PF11976	0.475
LIG_SUMO_SIM_par_1	55	61	PF11976	0.567
LIG_WRC_WIRS_1	189	194	PF05994	0.501
MOD_CK1_1	119	125	PF00069	0.515
MOD_CK1_1	164	170	PF00069	0.491
MOD_CK1_1	52	58	PF00069	0.490
MOD_CK1_1	72	78	PF00069	0.434
MOD_CK2_1	199	205	PF00069	0.503
MOD_GlcNHglycan	148	151	PF01048	0.301
MOD_GlcNHglycan	169	172	PF01048	0.299
MOD_GlcNHglycan	183	186	PF01048	0.261
MOD_GlcNHglycan	223	226	PF01048	0.290
MOD_GlcNHglycan	270	273	PF01048	0.539
MOD_GlcNHglycan	75	78	PF01048	0.390
MOD_GlcNHglycan	99	102	PF01048	0.299
MOD_GSK3_1	216	223	PF00069	0.491
MOD_GSK3_1	268	275	PF00069	0.479
MOD_GSK3_1	45	52	PF00069	0.581
MOD_GSK3_1	69	76	PF00069	0.515
MOD_GSK3_1	82	89	PF00069	0.490
MOD_GSK3_1	99	106	PF00069	0.499
MOD_N-GLC_1	146	151	PF02516	0.301
MOD_NEK2_1	181	186	PF00069	0.502
MOD_NEK2_1	188	193	PF00069	0.506
MOD_NEK2_1	227	232	PF00069	0.530
MOD_NEK2_1	268	273	PF00069	0.477
MOD_NEK2_1	53	58	PF00069	0.493
MOD_NEK2_2	183	188	PF00069	0.490
MOD_PIKK_1	103	109	PF00454	0.490
MOD_PKA_2	111	117	PF00069	0.590
MOD_PKA_2	277	283	PF00069	0.524
MOD_PKA_2	72	78	PF00069	0.504
MOD_PKA_2	82	88	PF00069	0.540
MOD_Plk_1	239	245	PF00069	0.418
MOD_Plk_1	5	11	PF00069	0.751
MOD_Plk_4	161	167	PF00069	0.501
MOD_Plk_4	183	189	PF00069	0.490
MOD_Plk_4	5	11	PF00069	0.594
MOD_Plk_4	53	59	PF00069	0.506
MOD_Plk_4	75	81	PF00069	0.501
MOD_ProDKin_1	245	251	PF00069	0.433
MOD_SUMO_rev_2	14	24	PF00179	0.621
TRG_ENDOCYTIC_2	157	160	PF00928	0.501
TRG_ENDOCYTIC_2	190	193	PF00928	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F8	Leptomonas seymouri	33%	93%
A0A0N1HVL0	Leptomonas seymouri	29%	100%
A0A0N1ILF0	Leptomonas seymouri	25%	100%
A0A0N1PB37	Leptomonas seymouri	89%	100%
A0A0S4IX63	Bodo saltans	34%	96%
A0A0S4IXL2	Bodo saltans	29%	100%
A0A0S4J7A1	Bodo saltans	26%	100%
A0A0S4KNR5	Bodo saltans	68%	92%
A0A1X0NNS8	Trypanosomatidae	78%	100%
A0A1X0P5G1	Trypanosomatidae	28%	100%
A0A3Q8IIY4	Leishmania donovani	32%	94%
A0A3Q8IVH0	Leishmania donovani	30%	100%
A0A3R7KX47	Trypanosoma rangeli	26%	100%
A0A3R7M7V4	Trypanosoma rangeli	78%	100%
A0A3S5H6K1	Leishmania donovani	98%	100%
A0A3S7WPD8	Leishmania donovani	27%	100%
A0A3S7X127	Leishmania donovani	25%	100%
A0A422N1Q5	Trypanosoma rangeli	29%	100%
A0B5B1	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A0JWY6	Arthrobacter sp. (strain FB24)	26%	100%
A0LU50	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	28%	98%
A0PQT3	Mycobacterium ulcerans (strain Agy99)	26%	98%
A0QFB5	Mycobacterium avium (strain 104)	29%	93%
A0QZ47	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	93%
A0RU86	Cenarchaeum symbiosum (strain A)	28%	100%
A0RXV1	Cenarchaeum symbiosum (strain A)	25%	100%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	30%	100%
A1UHS7	Mycobacterium sp. (strain KMS)	26%	93%
A1XQU1	Sus scrofa	32%	100%
A3CUS9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	28%	100%
A3DN27	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	28%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	29%	100%
A3Q193	Mycobacterium sp. (strain JLS)	26%	93%
A4H6R7	Leishmania braziliensis	89%	100%
A4HG53	Leishmania braziliensis	24%	100%
A4HN55	Leishmania braziliensis	30%	100%
A4HP29	Leishmania braziliensis	32%	94%
A4HSQ5	Leishmania infantum	27%	100%
A4HV47	Leishmania infantum	98%	100%
A4I384	Leishmania infantum	25%	100%
A4IBS2	Leishmania infantum	30%	100%
A4IDD6	Leishmania infantum	32%	94%
A4TB64	Mycolicibacterium gilvum (strain PYR-GCK)	28%	93%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	28%	100%
A4X3P0	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)	26%	100%
A4X744	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)	28%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	26%	100%
A5UM14	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	27%	100%
A7I841	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	28%	100%
A7KE01	Salmo salar	37%	100%
A7KII6	Salmo salar	37%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	28%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	27%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	27%	100%
A9A4A1	Nitrosopumilus maritimus (strain SCM1)	27%	100%
A9WSI1	Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)	28%	100%
B1MAI2	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	30%	97%
B1YDJ0	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	31%	100%
B2HFV6	Mycobacterium marinum (strain ATCC BAA-535 / M)	26%	98%
B8D673	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	25%	100%
B8D683	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	28%	100%
B8GG66	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	29%	100%
B9LTS6	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	24%	100%
C1ASP7	Rhodococcus opacus (strain B4)	27%	96%
C3MRE5	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	25%	100%
C3MY41	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	25%	100%
C3MZI0	Sulfolobus islandicus (strain M.16.27)	25%	100%
C3N7K2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	25%	100%
C3NFX2	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	25%	100%
C4KIR0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	25%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	26%	100%
C6A3R1	Thermococcus sibiricus (strain DSM 12597 / MM 739)	29%	100%
C6WID8	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)	28%	100%
C7LYP7	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	25%	100%
C9Z4D0	Streptomyces scabiei (strain 87.22)	29%	100%
C9ZQD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
C9ZYV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A7M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0KRX1	Saccharolobus solfataricus (strain 98/2)	26%	100%
D0LDT1	Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)	26%	97%
D2PDG6	Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)	25%	100%
D2RGT4	Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)	28%	100%
D3RX66	Ferroglobus placidus (strain DSM 10642 / AEDII12DO)	29%	100%
D4GYZ1	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	27%	100%
E9AFK8	Leishmania major	31%	100%
E9AKP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ANS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AST7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	94%
E9B6R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O09061	Mus musculus	23%	100%
O24361	Spinacia oleracea	30%	100%
O43063	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O55234	Mus musculus	27%	100%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O64464	Oryza sativa subsp. japonica	24%	100%
O82531	Petunia hybrida	26%	100%
P18421	Rattus norvegicus	24%	100%
P20618	Homo sapiens	24%	100%
P28062	Homo sapiens	28%	100%
P28065	Homo sapiens	47%	100%
P28072	Homo sapiens	48%	100%
P28073	Rattus norvegicus	53%	100%
P28075	Rattus norvegicus	26%	100%
P28077	Rattus norvegicus	42%	100%
P30656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	99%
P34286	Caenorhabditis elegans	23%	100%
P38624	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P40304	Drosophila melanogaster	28%	100%
P40306	Homo sapiens	26%	100%
P42742	Arabidopsis thaliana	26%	100%
P70195	Mus musculus	32%	100%
Q09841	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q0SIF9	Rhodococcus jostii (strain RHA1)	27%	96%
Q0W2D6	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	29%	100%
Q12YV7	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	25%	100%
Q1B797	Mycobacterium sp. (strain MCS)	26%	93%
Q2FQL8	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	26%	100%
Q2J9Q3	Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)	27%	100%
Q2TBP0	Bos taurus	32%	100%
Q2TBX6	Bos taurus	24%	100%
Q3MHN0	Bos taurus	52%	100%
Q3SZC2	Bos taurus	46%	100%
Q3T0T1	Bos taurus	26%	100%
Q4JAA8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	30%	100%
Q4Q1Q9	Leishmania major	32%	94%
Q4Q8Q9	Leishmania major	25%	100%
Q4QJ65	Leishmania major	28%	100%
Q55GJ6	Dictyostelium discoideum	50%	100%
Q5W416	Canis lupus familiaris	28%	100%
Q5YUX2	Nocardia farcinica (strain IFM 10152)	28%	98%
Q60177	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q60692	Mus musculus	46%	100%
Q73YW8	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	29%	93%
Q74MP5	Nanoarchaeum equitans (strain Kin4-M)	29%	100%
Q7AKQ5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	27%	100%
Q86A21	Dictyostelium discoideum	26%	100%
Q8LD27	Arabidopsis thaliana	46%	100%
Q8SQN7	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	27%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	100%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	100%
Q8UW64	Oryzias latipes	47%	100%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	27%	100%
Q975D1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	27%	100%
Q97AZ7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	25%	100%
Q980L4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	26%	100%
Q99436	Homo sapiens	32%	100%
Q9DD33	Salmo salar	45%	100%
Q9IB83	Carassius auratus	24%	100%
Q9IB84	Carassius auratus	24%	100%
Q9JHW0	Rattus norvegicus	32%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
Q9PT26	Oncorhynchus mykiss	45%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9V247	Pyrococcus abyssi (strain GE5 / Orsay)	27%	100%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	25%	100%
V5BCU3	Trypanosoma cruzi	29%	97%
V5BHX1	Trypanosoma cruzi	78%	100%