SER_THR_PHOSPHATASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific phospho-protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QGT8_LEIMA

TriTrypDb:

LmjF.12.0050 , LMJLV39_120005600 , LMJSD75_120006400

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005955	calcineurin complex	3	3
GO:0008287	protein serine/threonine phosphatase complex	4	3
GO:0016020	membrane	2	3
GO:0032991	protein-containing complex	1	3
GO:0110165	cellular anatomical entity	1	5
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1903293	phosphatase complex	3	3
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QGT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGT8

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	26
GO:0009987	cellular process	1	27
GO:0019722	calcium-mediated signaling	5	26
GO:0019932	second-messenger-mediated signaling	4	26
GO:0035556	intracellular signal transduction	3	26
GO:0050789	regulation of biological process	2	26
GO:0050794	regulation of cellular process	3	26
GO:0065007	biological regulation	1	26
GO:0097720	calcineurin-mediated signaling	6	26
GO:0000082	G1/S transition of mitotic cell cycle	5	1
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044843	cell cycle G1/S phase transition	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	32
GO:0004721	phosphoprotein phosphatase activity	3	32
GO:0004722	protein serine/threonine phosphatase activity	4	32
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	26
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005516	calmodulin binding	3	12
GO:0016787	hydrolase activity	2	32
GO:0016788	hydrolase activity, acting on ester bonds	3	32
GO:0016791	phosphatase activity	5	32
GO:0033192	calmodulin-dependent protein phosphatase activity	6	26
GO:0042578	phosphoric ester hydrolase activity	4	32
GO:0140096	catalytic activity, acting on a protein	2	32
GO:0017018	myosin phosphatase activity	5	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.493
CLV_NRD_NRD_1	24	26	PF00675	0.469
CLV_NRD_NRD_1	388	390	PF00675	0.508
CLV_NRD_NRD_1	401	403	PF00675	0.418
CLV_PCSK_KEX2_1	152	154	PF00082	0.570
CLV_PCSK_KEX2_1	341	343	PF00082	0.540
CLV_PCSK_KEX2_1	390	392	PF00082	0.511
CLV_PCSK_KEX2_1	401	403	PF00082	0.405
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.569
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.407
CLV_PCSK_SKI1_1	165	169	PF00082	0.358
CLV_PCSK_SKI1_1	193	197	PF00082	0.450
CLV_PCSK_SKI1_1	227	231	PF00082	0.490
CLV_PCSK_SKI1_1	44	48	PF00082	0.400
DEG_APCC_DBOX_1	252	260	PF00400	0.429
DEG_APCC_DBOX_1	388	396	PF00400	0.606
DOC_CDC14_PxL_1	414	422	PF14671	0.626
DOC_CKS1_1	344	349	PF01111	0.575
DOC_MAPK_gen_1	191	200	PF00069	0.533
DOC_MAPK_gen_1	23	32	PF00069	0.488
DOC_MAPK_gen_1	253	261	PF00069	0.443
DOC_MAPK_gen_1	389	397	PF00069	0.588
DOC_MAPK_gen_1	399	407	PF00069	0.467
DOC_MAPK_gen_1	85	93	PF00069	0.418
DOC_MAPK_MEF2A_6	255	263	PF00069	0.423
DOC_PP1_RVXF_1	417	423	PF00149	0.423
DOC_PP1_RVXF_1	86	93	PF00149	0.221
DOC_PP4_FxxP_1	275	278	PF00568	0.427
DOC_PP4_FxxP_1	308	311	PF00568	0.338
DOC_SPAK_OSR1_1	118	122	PF12202	0.395
DOC_USP7_MATH_1	100	104	PF00917	0.453
DOC_USP7_MATH_1	225	229	PF00917	0.513
DOC_USP7_MATH_2	4	10	PF00917	0.395
DOC_USP7_UBL2_3	47	51	PF12436	0.522
DOC_WW_Pin1_4	343	348	PF00397	0.525
LIG_14-3-3_CanoR_1	241	245	PF00244	0.347
LIG_14-3-3_CanoR_1	25	31	PF00244	0.273
LIG_14-3-3_CanoR_1	37	46	PF00244	0.209
LIG_14-3-3_CanoR_1	7	17	PF00244	0.321
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BIR_III_1	1	5	PF00653	0.473
LIG_BIR_III_3	1	5	PF00653	0.473
LIG_BRCT_BRCA1_1	135	139	PF00533	0.413
LIG_BRCT_BRCA1_1	188	192	PF00533	0.433
LIG_BRCT_BRCA1_1	207	211	PF00533	0.504
LIG_BRCT_BRCA1_1	283	287	PF00533	0.495
LIG_Clathr_ClatBox_1	45	49	PF01394	0.450
LIG_EH1_1	107	115	PF00400	0.361
LIG_eIF4E_1	339	345	PF01652	0.487
LIG_FHA_1	407	413	PF00498	0.618
LIG_FHA_1	41	47	PF00498	0.435
LIG_FHA_1	48	54	PF00498	0.423
LIG_FHA_1	77	83	PF00498	0.392
LIG_FHA_2	192	198	PF00498	0.405
LIG_FHA_2	381	387	PF00498	0.618
LIG_LIR_Apic_2	273	278	PF02991	0.424
LIG_LIR_Apic_2	306	311	PF02991	0.367
LIG_LIR_Apic_2	355	359	PF02991	0.473
LIG_LIR_Gen_1	117	125	PF02991	0.429
LIG_LIR_Gen_1	158	168	PF02991	0.344
LIG_LIR_Gen_1	271	278	PF02991	0.571
LIG_LIR_Gen_1	72	81	PF02991	0.388
LIG_LIR_LC3C_4	12	17	PF02991	0.502
LIG_LIR_Nem_3	117	122	PF02991	0.341
LIG_LIR_Nem_3	129	135	PF02991	0.340
LIG_LIR_Nem_3	136	142	PF02991	0.360
LIG_LIR_Nem_3	158	163	PF02991	0.346
LIG_LIR_Nem_3	166	171	PF02991	0.321
LIG_LIR_Nem_3	178	184	PF02991	0.288
LIG_LIR_Nem_3	189	195	PF02991	0.301
LIG_LIR_Nem_3	271	275	PF02991	0.545
LIG_LIR_Nem_3	284	290	PF02991	0.396
LIG_LIR_Nem_3	312	316	PF02991	0.475
LIG_LIR_Nem_3	60	66	PF02991	0.417
LIG_LIR_Nem_3	72	76	PF02991	0.354
LIG_LYPXL_S_1	131	135	PF13949	0.257
LIG_LYPXL_yS_3	132	135	PF13949	0.266
LIG_MLH1_MIPbox_1	283	287	PF16413	0.500
LIG_PCNA_yPIPBox_3	75	88	PF02747	0.453
LIG_Pex14_2	240	244	PF04695	0.323
LIG_PTB_Apo_2	176	183	PF02174	0.325
LIG_PTB_Apo_2	86	93	PF02174	0.408
LIG_SH2_SRC	96	99	PF00017	0.321
LIG_SH2_STAP1	160	164	PF00017	0.373
LIG_SH2_STAP1	242	246	PF00017	0.331
LIG_SH2_STAP1	272	276	PF00017	0.592
LIG_SH2_STAT5	242	245	PF00017	0.356
LIG_SH2_STAT5	286	289	PF00017	0.394
LIG_SH2_STAT5	96	99	PF00017	0.331
LIG_SH3_3	412	418	PF00018	0.595
LIG_SH3_3	59	65	PF00018	0.361
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.426
LIG_SUMO_SIM_par_1	303	309	PF11976	0.353
LIG_TRAF2_1	11	14	PF00917	0.278
LIG_WRC_WIRS_1	272	277	PF05994	0.546
MOD_CK1_1	233	239	PF00069	0.469
MOD_CK1_1	306	312	PF00069	0.383
MOD_CK1_1	9	15	PF00069	0.561
MOD_CK2_1	191	197	PF00069	0.447
MOD_CK2_1	8	14	PF00069	0.621
MOD_GlcNHglycan	226	230	PF01048	0.448
MOD_GlcNHglycan	308	311	PF01048	0.318
MOD_GlcNHglycan	40	43	PF01048	0.290
MOD_GSK3_1	187	194	PF00069	0.348
MOD_GSK3_1	201	208	PF00069	0.413
MOD_GSK3_1	26	33	PF00069	0.447
MOD_N-GLC_2	320	322	PF02516	0.353
MOD_N-GLC_2	84	86	PF02516	0.288
MOD_NEK2_1	135	140	PF00069	0.486
MOD_NEK2_1	148	153	PF00069	0.533
MOD_NEK2_1	230	235	PF00069	0.446
MOD_NEK2_1	240	245	PF00069	0.335
MOD_NEK2_1	406	411	PF00069	0.460
MOD_NEK2_2	281	286	PF00069	0.595
MOD_NEK2_2	303	308	PF00069	0.400
MOD_NEK2_2	418	423	PF00069	0.399
MOD_PIKK_1	201	207	PF00454	0.416
MOD_PIKK_1	230	236	PF00454	0.460
MOD_PIKK_1	296	302	PF00454	0.489
MOD_PIKK_1	346	352	PF00454	0.506
MOD_PKA_2	240	246	PF00069	0.356
MOD_PKA_2	6	12	PF00069	0.373
MOD_Plk_1	225	231	PF00069	0.559
MOD_Plk_2-3	380	386	PF00069	0.407
MOD_Plk_4	159	165	PF00069	0.381
MOD_Plk_4	281	287	PF00069	0.495
MOD_Plk_4	303	309	PF00069	0.311
MOD_Plk_4	57	63	PF00069	0.335
MOD_ProDKin_1	343	349	PF00069	0.529
MOD_SUMO_for_1	46	49	PF00179	0.382
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.344
TRG_ENDOCYTIC_2	132	135	PF00928	0.393
TRG_ENDOCYTIC_2	160	163	PF00928	0.339
TRG_ENDOCYTIC_2	272	275	PF00928	0.621
TRG_ER_diArg_1	152	154	PF00400	0.501
TRG_ER_diArg_1	389	392	PF00400	0.504
TRG_ER_diArg_1	400	402	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	21%	100%
A0A0N0P7Y2	Leptomonas seymouri	25%	77%
A0A0N1ILH2	Leptomonas seymouri	27%	100%
A0A0N1P9X9	Leptomonas seymouri	24%	100%
A0A0N1PD03	Leptomonas seymouri	74%	95%
A0A0S4IIW0	Bodo saltans	26%	100%
A0A0S4JDD1	Bodo saltans	25%	94%
A0A0S4JJH3	Bodo saltans	23%	100%
A0A0S4JKZ6	Bodo saltans	24%	85%
A0A0S4KGD7	Bodo saltans	25%	100%
A0A0S4KLF4	Bodo saltans	32%	100%
A0A1X0NMS7	Trypanosomatidae	41%	100%
A0A1X0NS65	Trypanosomatidae	26%	100%
A0A1X0NYR5	Trypanosomatidae	21%	100%
A0A1X0P6J3	Trypanosomatidae	25%	100%
A0A1X0P7H9	Trypanosomatidae	28%	95%
A0A1X0P7Q5	Trypanosomatidae	25%	100%
A0A1X0PA67	Trypanosomatidae	23%	100%
A0A1X0PAK9	Trypanosomatidae	23%	100%
A0A3Q8ID20	Leishmania donovani	25%	88%
A0A3Q8IH18	Leishmania donovani	22%	100%
A0A3R7KQR6	Trypanosoma rangeli	24%	100%
A0A3R7LPS5	Trypanosoma rangeli	42%	100%
A0A3R7MBA3	Trypanosoma rangeli	26%	94%
A0A3R7N275	Trypanosoma rangeli	22%	100%
A0A3S5H6K2	Leishmania donovani	92%	100%
A0A3S7WZ39	Leishmania donovani	28%	100%
A0A3S7X190	Leishmania donovani	21%	100%
A0A3S7X1Y0	Leishmania donovani	24%	100%
A0A3S7X8K6	Leishmania donovani	24%	100%
A0A3S7XAY3	Leishmania donovani	23%	100%
A0A422N9D5	Trypanosoma rangeli	25%	100%
A0C1E4	Paramecium tetraurelia	24%	100%
A0CCD2	Paramecium tetraurelia	24%	100%
A0CNL9	Paramecium tetraurelia	24%	100%
A2X2G3	Oryza sativa subsp. indica	24%	100%
A2YEB4	Oryza sativa subsp. indica	24%	100%
A3C4N5	Oryza sativa subsp. japonica	22%	100%
A4H6S0	Leishmania braziliensis	82%	100%
A4HAI7	Leishmania braziliensis	22%	100%
A4HAI9	Leishmania braziliensis	22%	100%
A4HBE2	Leishmania braziliensis	24%	100%
A4HF98	Leishmania braziliensis	27%	77%
A4HGA9	Leishmania braziliensis	21%	100%
A4HKU9	Leishmania braziliensis	21%	100%
A4HP65	Leishmania braziliensis	23%	100%
A4HV49	Leishmania infantum	92%	100%
A4I1H6	Leishmania infantum	28%	100%
A4I2J0	Leishmania infantum	25%	88%
A4I3E3	Leishmania infantum	21%	100%
A4I400	Leishmania infantum	24%	100%
A4I8C8	Leishmania infantum	22%	100%
A4IAJ0	Leishmania infantum	24%	100%
A4IDH0	Leishmania infantum	23%	100%
A6H772	Bos taurus	22%	100%
A8WGP3	Danio rerio	21%	100%
A9JRC7	Danio rerio	21%	100%
C9ZQD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A805	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9ANT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AXL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AYN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9AZN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B090	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B387	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B4P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B4Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B4Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B5L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O02658	Caenorhabditis elegans	22%	100%
O42773	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	24%	66%
O74789	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P0C5D7	Oryza sativa subsp. indica	22%	100%
P11084	Oryctolagus cuniculus	23%	100%
P11612	Drosophila melanogaster	22%	100%
P12982	Drosophila melanogaster	21%	100%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	70%
P16298	Homo sapiens	23%	81%
P20651	Rattus norvegicus	23%	81%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	76%
P23594	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P23595	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P23635	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P32838	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P32945	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	77%
P48452	Bos taurus	22%	81%
P48453	Mus musculus	23%	81%
P48454	Homo sapiens	23%	83%
P48455	Mus musculus	23%	82%
P48456	Drosophila melanogaster	23%	68%
P48457	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	77%
P48529	Arabidopsis thaliana	24%	100%
P48577	Acetabularia peniculus	24%	100%
P48578	Arabidopsis thaliana	24%	100%
P48579	Helianthus annuus	24%	100%
P60510	Homo sapiens	22%	100%
P63328	Mus musculus	23%	81%
P63329	Rattus norvegicus	23%	81%
P63330	Mus musculus	23%	100%
P63331	Rattus norvegicus	23%	100%
P67774	Bos taurus	23%	100%
P67775	Homo sapiens	23%	100%
P67776	Sus scrofa	23%	100%
P67777	Oryctolagus cuniculus	23%	100%
P91420	Caenorhabditis elegans	22%	100%
P97470	Mus musculus	22%	100%
Q05547	Drosophila melanogaster	22%	100%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	76%
Q06009	Medicago sativa	24%	100%
Q07100	Arabidopsis thaliana	24%	100%
Q08209	Homo sapiens	23%	81%
Q09496	Caenorhabditis elegans	25%	100%
Q0DBD3	Oryza sativa subsp. japonica	24%	100%
Q0E2S4	Oryza sativa subsp. japonica	24%	100%
Q0G819	Caenorhabditis elegans	24%	78%
Q12705	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	76%
Q27889	Drosophila melanogaster	23%	74%
Q4Q1M5	Leishmania major	23%	99%
Q4Q2C2	Leishmania major	25%	100%
Q4Q3C5	Leishmania major	22%	100%
Q4Q3C8	Leishmania major	22%	100%
Q4Q4W8	Leishmania major	22%	100%
Q4Q7Z5	Leishmania major	24%	99%
Q4Q8K1	Leishmania major	21%	100%
Q4Q8T8	Leishmania major	26%	100%
Q4Q9W1	Leishmania major	28%	100%
Q4WUR1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	79%
Q54RD6	Dictyostelium discoideum	24%	100%
Q5BJ92	Rattus norvegicus	22%	100%
Q5R6K8	Pongo abelii	22%	100%
Q6BFF6	Paramecium tetraurelia	23%	100%
Q6CNT6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q6IP91	Xenopus laevis	22%	100%
Q6P861	Xenopus tropicalis	22%	100%
Q7YSW8	Dictyostelium discoideum	25%	68%
Q8WMS6	Canis lupus familiaris	22%	100%
Q8X178	Blumeria hordei	25%	100%
Q9HFQ2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q9VXF1	Drosophila melanogaster	22%	72%
Q9XZE5	Dictyostelium discoideum	24%	100%
V5B3V2	Trypanosoma cruzi	27%	100%
V5B8G5	Trypanosoma cruzi	24%	100%
V5BBR3	Trypanosoma cruzi	24%	100%
V5BKU4	Trypanosoma cruzi	22%	100%