Ribonuclease mar1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease mar1

Gene product:

ribonuclease mar1

Species:

Leishmania major

UniProt:

Q4QGT7_LEIMA

TriTrypDb:

LmjF.12.0060 , LMJLV39_120005700 , LMJSD75_120006500

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGT7

PDB structure(s): 1x9g_A , 1xn4_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.508
CLV_PCSK_KEX2_1	125	127	PF00082	0.305
CLV_PCSK_KEX2_1	26	28	PF00082	0.391
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.311
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.391
CLV_PCSK_SKI1_1	12	16	PF00082	0.352
CLV_PCSK_SKI1_1	125	129	PF00082	0.373
CLV_PCSK_SKI1_1	182	186	PF00082	0.705
DOC_MAPK_gen_1	10	18	PF00069	0.440
DOC_MAPK_gen_1	182	192	PF00069	0.729
DOC_MAPK_MEF2A_6	12	20	PF00069	0.449
DOC_MAPK_MEF2A_6	185	192	PF00069	0.701
DOC_MAPK_MEF2A_6	66	73	PF00069	0.535
DOC_USP7_UBL2_3	139	143	PF12436	0.578
DOC_USP7_UBL2_3	178	182	PF12436	0.738
DOC_WW_Pin1_4	150	155	PF00397	0.505
LIG_14-3-3_CanoR_1	84	92	PF00244	0.572
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_FHA_1	11	17	PF00498	0.459
LIG_FHA_1	50	56	PF00498	0.562
LIG_FHA_1	74	80	PF00498	0.552
LIG_FHA_2	114	120	PF00498	0.527
LIG_FHA_2	157	163	PF00498	0.626
LIG_LIR_Gen_1	13	23	PF02991	0.564
LIG_LIR_Gen_1	83	92	PF02991	0.547
LIG_LIR_Nem_3	13	18	PF02991	0.564
LIG_LIR_Nem_3	174	180	PF02991	0.622
LIG_LIR_Nem_3	83	88	PF02991	0.547
LIG_MAD2	66	74	PF02301	0.535
LIG_PDZ_Class_2	187	192	PF00595	0.708
LIG_PTB_Apo_2	30	37	PF02174	0.572
LIG_SH2_STAT5	54	57	PF00017	0.498
LIG_SH3_1	185	191	PF00018	0.697
LIG_SH3_3	124	130	PF00018	0.535
LIG_SH3_3	185	191	PF00018	0.697
LIG_UBA3_1	120	125	PF00899	0.486
LIG_UBA3_1	164	170	PF00899	0.674
MOD_CK2_1	156	162	PF00069	0.599
MOD_GSK3_1	133	140	PF00069	0.551
MOD_GSK3_1	156	163	PF00069	0.597
MOD_GSK3_1	6	13	PF00069	0.581
MOD_GSK3_1	69	76	PF00069	0.524
MOD_NEK2_1	148	153	PF00069	0.687
MOD_PIKK_1	133	139	PF00454	0.511
MOD_PKA_1	178	184	PF00069	0.643
MOD_PKA_2	83	89	PF00069	0.572
MOD_Plk_1	80	86	PF00069	0.551
MOD_Plk_4	160	166	PF00069	0.600
MOD_ProDKin_1	150	156	PF00069	0.505
MOD_SUMO_for_1	184	187	PF00179	0.705
MOD_SUMO_rev_2	136	145	PF00179	0.572
TRG_NES_CRM1_1	119	132	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	31%	80%
A0A0N1HWD2	Leptomonas seymouri	78%	100%
A0A0N1I400	Leptomonas seymouri	33%	80%
A0A0N1IAK4	Leptomonas seymouri	37%	92%
A0A0S4IL71	Bodo saltans	47%	98%
A0A0S4IVV9	Bodo saltans	53%	99%
A0A1X0NQH8	Trypanosomatidae	47%	98%
A0A3S5H641	Leishmania donovani	28%	76%
A0A3S5H642	Leishmania donovani	38%	85%
A0A3S5IQS6	Trypanosoma rangeli	43%	98%
A0JME6	Danio rerio	36%	97%
A4H5A0	Leishmania braziliensis	32%	76%
A4H5A2	Leishmania braziliensis	37%	87%
A4H6S1	Leishmania braziliensis	85%	100%
A4HTI1	Leishmania infantum	28%	76%
A4HTI3	Leishmania infantum	38%	85%
A4HV50	Leishmania infantum	96%	100%
B5X0W9	Salmo salar	36%	68%
D0VWV0	Leishmania donovani	96%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	76%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	70%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	86%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
G4YEI5	Phytophthora sojae (strain P6497)	33%	91%
P85094	Mus musculus	36%	93%
Q08C33	Danio rerio	33%	68%
Q32KX0	Bos taurus	34%	94%
Q4QID7	Leishmania major	38%	85%
Q4QID9	Leishmania major	29%	76%
Q4R826	Macaca fascicularis	35%	94%
Q54NZ6	Dictyostelium discoideum	32%	93%
Q54NZ8	Dictyostelium discoideum	32%	93%
Q54RC7	Dictyostelium discoideum	23%	90%
Q54RF0	Dictyostelium discoideum	24%	96%
Q5PQ71	Xenopus laevis	37%	94%
Q5RC03	Pongo abelii	35%	94%
Q5U3Z3	Rattus norvegicus	35%	91%
Q6DF67	Xenopus tropicalis	38%	94%
Q96AB3	Homo sapiens	35%	94%
Q9DCC7	Mus musculus	36%	91%
V5AQ92	Trypanosoma cruzi	53%	100%