Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGT6_LEIMA

TriTrypDb:

LmjF.12.0070 , LMJLV39_120005800 , LMJSD75_120006600

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.554
CLV_NRD_NRD_1	106	108	PF00675	0.687
CLV_NRD_NRD_1	124	126	PF00675	0.585
CLV_NRD_NRD_1	182	184	PF00675	0.487
CLV_NRD_NRD_1	190	192	PF00675	0.470
CLV_NRD_NRD_1	199	201	PF00675	0.424
CLV_NRD_NRD_1	210	212	PF00675	0.384
CLV_NRD_NRD_1	234	236	PF00675	0.640
CLV_NRD_NRD_1	258	260	PF00675	0.717
CLV_NRD_NRD_1	282	284	PF00675	0.510
CLV_NRD_NRD_1	304	306	PF00675	0.581
CLV_NRD_NRD_1	307	309	PF00675	0.572
CLV_NRD_NRD_1	342	344	PF00675	0.554
CLV_NRD_NRD_1	358	360	PF00675	0.494
CLV_NRD_NRD_1	383	385	PF00675	0.558
CLV_NRD_NRD_1	446	448	PF00675	0.481
CLV_NRD_NRD_1	474	476	PF00675	0.533
CLV_NRD_NRD_1	502	504	PF00675	0.510
CLV_NRD_NRD_1	509	511	PF00675	0.520
CLV_NRD_NRD_1	548	550	PF00675	0.463
CLV_NRD_NRD_1	560	562	PF00675	0.421
CLV_NRD_NRD_1	570	572	PF00675	0.516
CLV_PCSK_FUR_1	208	212	PF00082	0.469
CLV_PCSK_FUR_1	356	360	PF00082	0.525
CLV_PCSK_FUR_1	444	448	PF00082	0.551
CLV_PCSK_KEX2_1	106	108	PF00082	0.661
CLV_PCSK_KEX2_1	124	126	PF00082	0.615
CLV_PCSK_KEX2_1	182	184	PF00082	0.485
CLV_PCSK_KEX2_1	190	192	PF00082	0.475
CLV_PCSK_KEX2_1	210	212	PF00082	0.359
CLV_PCSK_KEX2_1	234	236	PF00082	0.431
CLV_PCSK_KEX2_1	258	260	PF00082	0.656
CLV_PCSK_KEX2_1	281	283	PF00082	0.524
CLV_PCSK_KEX2_1	304	306	PF00082	0.557
CLV_PCSK_KEX2_1	342	344	PF00082	0.475
CLV_PCSK_KEX2_1	358	360	PF00082	0.471
CLV_PCSK_KEX2_1	383	385	PF00082	0.608
CLV_PCSK_KEX2_1	395	397	PF00082	0.479
CLV_PCSK_KEX2_1	410	412	PF00082	0.433
CLV_PCSK_KEX2_1	446	448	PF00082	0.483
CLV_PCSK_KEX2_1	473	475	PF00082	0.452
CLV_PCSK_KEX2_1	502	504	PF00082	0.480
CLV_PCSK_KEX2_1	509	511	PF00082	0.494
CLV_PCSK_KEX2_1	515	517	PF00082	0.507
CLV_PCSK_KEX2_1	560	562	PF00082	0.534
CLV_PCSK_KEX2_1	570	572	PF00082	0.534
CLV_PCSK_KEX2_1	618	620	PF00082	0.504
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.658
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.623
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.439
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.574
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.664
CLV_PCSK_PC7_1	206	212	PF00082	0.470
CLV_PCSK_PC7_1	391	397	PF00082	0.488
CLV_PCSK_PC7_1	505	511	PF00082	0.461
CLV_PCSK_SKI1_1	182	186	PF00082	0.454
CLV_PCSK_SKI1_1	250	254	PF00082	0.662
CLV_PCSK_SKI1_1	77	81	PF00082	0.601
DEG_APCC_DBOX_1	182	190	PF00400	0.475
DOC_CYCLIN_RxL_1	180	188	PF00134	0.510
DOC_CYCLIN_RxL_1	247	257	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.426
DOC_MAPK_DCC_7	474	484	PF00069	0.491
DOC_MAPK_FxFP_2	165	168	PF00069	0.453
DOC_MAPK_gen_1	124	131	PF00069	0.513
DOC_MAPK_gen_1	318	326	PF00069	0.498
DOC_MAPK_gen_1	473	482	PF00069	0.604
DOC_MAPK_MEF2A_6	475	484	PF00069	0.531
DOC_PP2B_LxvP_1	69	72	PF13499	0.560
DOC_PP4_FxxP_1	13	16	PF00568	0.476
DOC_PP4_FxxP_1	165	168	PF00568	0.453
DOC_USP7_MATH_1	110	114	PF00917	0.635
DOC_USP7_MATH_1	16	20	PF00917	0.444
DOC_USP7_MATH_1	351	355	PF00917	0.530
DOC_USP7_MATH_1	371	375	PF00917	0.565
DOC_USP7_MATH_1	6	10	PF00917	0.435
DOC_USP7_MATH_1	72	76	PF00917	0.710
DOC_USP7_UBL2_3	148	152	PF12436	0.377
DOC_WW_Pin1_4	11	16	PF00397	0.491
DOC_WW_Pin1_4	159	164	PF00397	0.569
DOC_WW_Pin1_4	2	7	PF00397	0.471
DOC_WW_Pin1_4	21	26	PF00397	0.448
DOC_WW_Pin1_4	487	492	PF00397	0.574
DOC_WW_Pin1_4	67	72	PF00397	0.604
LIG_14-3-3_CanoR_1	361	369	PF00244	0.602
LIG_14-3-3_CanoR_1	560	564	PF00244	0.486
LIG_BRCT_BRCA1_1	13	17	PF00533	0.476
LIG_BRCT_BRCA1_1	161	165	PF00533	0.502
LIG_BRCT_BRCA1_1	46	50	PF00533	0.503
LIG_FHA_1	116	122	PF00498	0.365
LIG_FHA_1	288	294	PF00498	0.523
LIG_FHA_1	459	465	PF00498	0.391
LIG_FHA_1	601	607	PF00498	0.412
LIG_FHA_1	97	103	PF00498	0.734
LIG_FHA_2	224	230	PF00498	0.494
LIG_FHA_2	251	257	PF00498	0.654
LIG_FHA_2	93	99	PF00498	0.707
LIG_LIR_Apic_2	11	16	PF02991	0.442
LIG_LIR_Apic_2	113	117	PF02991	0.592
LIG_LIR_Apic_2	162	168	PF02991	0.440
LIG_LIR_Gen_1	374	381	PF02991	0.634
LIG_LIR_Gen_1	47	58	PF02991	0.490
LIG_LIR_Gen_1	5	15	PF02991	0.477
LIG_LIR_Nem_3	130	136	PF02991	0.370
LIG_LIR_Nem_3	374	378	PF02991	0.568
LIG_LIR_Nem_3	47	53	PF02991	0.487
LIG_LIR_Nem_3	5	10	PF02991	0.476
LIG_NRP_CendR_1	618	620	PF00754	0.653
LIG_Pex14_2	13	17	PF04695	0.476
LIG_RPA_C_Fungi	337	349	PF08784	0.595
LIG_RPA_C_Plants	323	334	PF08784	0.373
LIG_SH2_CRK	598	602	PF00017	0.411
LIG_SH2_NCK_1	114	118	PF00017	0.609
LIG_SH2_NCK_1	428	432	PF00017	0.492
LIG_SH2_SRC	114	117	PF00017	0.611
LIG_SH2_STAP1	424	428	PF00017	0.459
LIG_SH2_STAP1	536	540	PF00017	0.470
LIG_SH2_STAT5	133	136	PF00017	0.361
LIG_SH3_3	15	21	PF00018	0.449
LIG_SH3_3	79	85	PF00018	0.546
LIG_SUMO_SIM_par_1	167	173	PF11976	0.452
LIG_TRAF2_1	176	179	PF00917	0.579
LIG_TRAF2_1	520	523	PF00917	0.536
LIG_TRAF2_1	95	98	PF00917	0.639
LIG_WRC_WIRS_1	7	12	PF05994	0.448
MOD_CDK_SPxxK_3	159	166	PF00069	0.501
MOD_CK1_1	9	15	PF00069	0.485
MOD_CK2_1	223	229	PF00069	0.466
MOD_CK2_1	250	256	PF00069	0.689
MOD_CK2_1	351	357	PF00069	0.509
MOD_CK2_1	92	98	PF00069	0.707
MOD_GlcNHglycan	18	21	PF01048	0.501
MOD_GlcNHglycan	270	273	PF01048	0.628
MOD_GlcNHglycan	353	356	PF01048	0.470
MOD_GlcNHglycan	363	366	PF01048	0.497
MOD_GlcNHglycan	46	49	PF01048	0.602
MOD_GlcNHglycan	609	612	PF01048	0.475
MOD_GlcNHglycan	64	68	PF01048	0.701
MOD_GlcNHglycan	74	77	PF01048	0.508
MOD_GSK3_1	135	142	PF00069	0.446
MOD_GSK3_1	16	23	PF00069	0.578
MOD_GSK3_1	2	9	PF00069	0.464
MOD_GSK3_1	44	51	PF00069	0.512
MOD_GSK3_1	63	70	PF00069	0.538
MOD_GSK3_1	88	95	PF00069	0.700
MOD_NEK2_1	397	402	PF00069	0.588
MOD_NEK2_2	373	378	PF00069	0.632
MOD_OFUCOSY	93	100	PF10250	0.641
MOD_PIKK_1	83	89	PF00454	0.703
MOD_PK_1	139	145	PF00069	0.420
MOD_PK_1	475	481	PF00069	0.489
MOD_PKA_2	44	50	PF00069	0.479
MOD_PKA_2	559	565	PF00069	0.476
MOD_PKB_1	359	367	PF00069	0.437
MOD_PKB_1	473	481	PF00069	0.575
MOD_Plk_1	397	403	PF00069	0.378
MOD_Plk_1	475	481	PF00069	0.618
MOD_Plk_1	48	54	PF00069	0.562
MOD_Plk_1	584	590	PF00069	0.629
MOD_Plk_4	139	145	PF00069	0.446
MOD_Plk_4	475	481	PF00069	0.528
MOD_ProDKin_1	11	17	PF00069	0.490
MOD_ProDKin_1	159	165	PF00069	0.573
MOD_ProDKin_1	2	8	PF00069	0.471
MOD_ProDKin_1	21	27	PF00069	0.447
MOD_ProDKin_1	487	493	PF00069	0.566
MOD_ProDKin_1	67	73	PF00069	0.600
MOD_SUMO_for_1	429	432	PF00179	0.491
MOD_SUMO_rev_2	302	310	PF00179	0.572
MOD_SUMO_rev_2	543	552	PF00179	0.571
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.524
TRG_ER_diArg_1	123	125	PF00400	0.575
TRG_ER_diArg_1	182	184	PF00400	0.485
TRG_ER_diArg_1	189	191	PF00400	0.519
TRG_ER_diArg_1	208	211	PF00400	0.384
TRG_ER_diArg_1	281	283	PF00400	0.515
TRG_ER_diArg_1	318	321	PF00400	0.465
TRG_ER_diArg_1	358	360	PF00400	0.551
TRG_ER_diArg_1	383	386	PF00400	0.495
TRG_ER_diArg_1	444	447	PF00400	0.516
TRG_ER_diArg_1	473	475	PF00400	0.510
TRG_ER_diArg_1	502	504	PF00400	0.515
TRG_ER_diArg_1	508	510	PF00400	0.520
TRG_ER_diArg_1	559	561	PF00400	0.555
TRG_ER_diArg_1	618	620	PF00400	0.500
TRG_NLS_MonoExtN_4	105	110	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK43	Leptomonas seymouri	48%	100%
A0A1X0NM25	Trypanosomatidae	27%	100%
A0A3Q8I971	Leishmania donovani	83%	100%
A0A422N6D2	Trypanosoma rangeli	29%	100%
A4H6S2	Leishmania braziliensis	70%	100%
A4HV51	Leishmania infantum	83%	100%
C9ZQD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ANT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%