LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QGT4_LEIMA
TriTrypDb:
LmjF.12.0090 * , LMJLV39_120006100 * , LMJSD75_120006900 *
Length:
568

Annotations

LeishMANIAdb annotations

Consists of a solenoid domain with LRR-like helical repeats. Certainly not TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QGT4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGT4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 310 312 PF00675 0.341
CLV_NRD_NRD_1 419 421 PF00675 0.437
CLV_NRD_NRD_1 76 78 PF00675 0.513
CLV_NRD_NRD_1 84 86 PF00675 0.400
CLV_PCSK_KEX2_1 310 312 PF00082 0.470
CLV_PCSK_KEX2_1 76 78 PF00082 0.513
CLV_PCSK_KEX2_1 84 86 PF00082 0.400
CLV_PCSK_SKI1_1 57 61 PF00082 0.406
CLV_PCSK_SKI1_1 89 93 PF00082 0.493
DEG_APCC_DBOX_1 238 246 PF00400 0.397
DEG_APCC_DBOX_1 56 64 PF00400 0.405
DOC_CDC14_PxL_1 60 68 PF14671 0.410
DOC_CKS1_1 375 380 PF01111 0.549
DOC_CYCLIN_yCln2_LP_2 111 117 PF00134 0.303
DOC_CYCLIN_yCln2_LP_2 65 68 PF00134 0.415
DOC_MAPK_MEF2A_6 20 29 PF00069 0.396
DOC_MAPK_MEF2A_6 38 45 PF00069 0.376
DOC_MAPK_MEF2A_6 465 474 PF00069 0.383
DOC_PP1_RVXF_1 246 253 PF00149 0.435
DOC_PP2B_LxvP_1 111 114 PF13499 0.468
DOC_PP2B_LxvP_1 43 46 PF13499 0.404
DOC_PP2B_LxvP_1 476 479 PF13499 0.375
DOC_PP2B_LxvP_1 65 68 PF13499 0.415
DOC_PP4_FxxP_1 47 50 PF00568 0.414
DOC_USP7_MATH_1 18 22 PF00917 0.419
DOC_USP7_MATH_1 255 259 PF00917 0.481
DOC_USP7_MATH_2 555 561 PF00917 0.467
DOC_WW_Pin1_4 14 19 PF00397 0.422
DOC_WW_Pin1_4 200 205 PF00397 0.294
DOC_WW_Pin1_4 21 26 PF00397 0.385
DOC_WW_Pin1_4 374 379 PF00397 0.490
DOC_WW_Pin1_4 511 516 PF00397 0.501
DOC_WW_Pin1_4 532 537 PF00397 0.447
LIG_14-3-3_CanoR_1 20 28 PF00244 0.398
LIG_14-3-3_CanoR_1 220 228 PF00244 0.397
LIG_14-3-3_CanoR_1 84 91 PF00244 0.488
LIG_Actin_WH2_2 144 159 PF00022 0.490
LIG_Actin_WH2_2 204 222 PF00022 0.268
LIG_Actin_WH2_2 366 384 PF00022 0.276
LIG_Actin_WH2_2 434 449 PF00022 0.413
LIG_Actin_WH2_2 48 63 PF00022 0.404
LIG_BRCT_BRCA1_1 3 7 PF00533 0.427
LIG_Clathr_ClatBox_1 97 101 PF01394 0.450
LIG_CtBP_PxDLS_1 407 412 PF00389 0.368
LIG_FHA_1 141 147 PF00498 0.535
LIG_FHA_1 191 197 PF00498 0.501
LIG_FHA_1 375 381 PF00498 0.456
LIG_FHA_1 496 502 PF00498 0.365
LIG_FHA_1 525 531 PF00498 0.310
LIG_FHA_1 77 83 PF00498 0.528
LIG_FHA_1 90 96 PF00498 0.460
LIG_FHA_2 225 231 PF00498 0.595
LIG_FHA_2 464 470 PF00498 0.346
LIG_LIR_Gen_1 31 42 PF02991 0.390
LIG_LIR_Gen_1 469 479 PF02991 0.389
LIG_LIR_Gen_1 503 513 PF02991 0.429
LIG_LIR_Gen_1 559 568 PF02991 0.454
LIG_LIR_Gen_1 99 104 PF02991 0.392
LIG_LIR_Nem_3 295 299 PF02991 0.335
LIG_LIR_Nem_3 469 474 PF02991 0.373
LIG_LIR_Nem_3 503 508 PF02991 0.469
LIG_LIR_Nem_3 54 59 PF02991 0.397
LIG_LIR_Nem_3 559 564 PF02991 0.478
LIG_LIR_Nem_3 99 103 PF02991 0.382
LIG_MYND_1 64 68 PF01753 0.413
LIG_NRBOX 486 492 PF00104 0.384
LIG_PCNA_yPIPBox_3 477 491 PF02747 0.326
LIG_PCNA_yPIPBox_3 519 532 PF02747 0.286
LIG_Pex14_2 52 56 PF04695 0.398
LIG_Pex14_2 69 73 PF04695 0.422
LIG_SH2_CRK 3 7 PF00017 0.427
LIG_SH2_STAP1 3 7 PF00017 0.427
LIG_SH2_STAP1 383 387 PF00017 0.328
LIG_SH2_STAP1 457 461 PF00017 0.277
LIG_SH2_STAT3 179 182 PF00017 0.378
LIG_SH2_STAT3 383 386 PF00017 0.313
LIG_SH2_STAT5 179 182 PF00017 0.490
LIG_SH3_1 61 67 PF00018 0.411
LIG_SH3_3 107 113 PF00018 0.519
LIG_SH3_3 372 378 PF00018 0.449
LIG_SH3_3 61 67 PF00018 0.411
LIG_SUMO_SIM_anti_2 276 283 PF11976 0.404
LIG_SUMO_SIM_anti_2 332 337 PF11976 0.351
LIG_SUMO_SIM_anti_2 535 541 PF11976 0.374
LIG_SUMO_SIM_par_1 12 17 PF11976 0.410
LIG_TRAF2_1 124 127 PF00917 0.529
LIG_TRAF2_1 466 469 PF00917 0.385
LIG_TRFH_1 444 448 PF08558 0.405
LIG_WRC_WIRS_1 207 212 PF05994 0.369
LIG_WRC_WIRS_1 70 75 PF05994 0.448
LIG_WRC_WIRS_1 97 102 PF05994 0.535
MOD_CDC14_SPxK_1 17 20 PF00782 0.424
MOD_CDK_SPxK_1 14 20 PF00069 0.423
MOD_CK1_1 188 194 PF00069 0.476
MOD_CK1_1 19 25 PF00069 0.406
MOD_CK1_1 223 229 PF00069 0.691
MOD_CK1_1 80 86 PF00069 0.415
MOD_CK2_1 463 469 PF00069 0.479
MOD_GlcNHglycan 134 137 PF01048 0.567
MOD_GlcNHglycan 21 24 PF01048 0.399
MOD_GlcNHglycan 222 225 PF01048 0.612
MOD_GlcNHglycan 322 325 PF01048 0.329
MOD_GlcNHglycan 34 37 PF01048 0.360
MOD_GlcNHglycan 393 396 PF01048 0.430
MOD_GlcNHglycan 457 460 PF01048 0.374
MOD_GlcNHglycan 85 88 PF01048 0.407
MOD_GSK3_1 137 144 PF00069 0.482
MOD_GSK3_1 14 21 PF00069 0.421
MOD_GSK3_1 219 226 PF00069 0.649
MOD_GSK3_1 457 464 PF00069 0.451
MOD_GSK3_1 76 83 PF00069 0.488
MOD_N-GLC_1 433 438 PF02516 0.288
MOD_NEK2_1 1 6 PF00069 0.429
MOD_NEK2_1 104 109 PF00069 0.570
MOD_NEK2_1 130 135 PF00069 0.589
MOD_NEK2_1 187 192 PF00069 0.441
MOD_NEK2_1 219 224 PF00069 0.603
MOD_NEK2_1 260 265 PF00069 0.357
MOD_NEK2_1 319 324 PF00069 0.404
MOD_NEK2_1 430 435 PF00069 0.399
MOD_NEK2_1 490 495 PF00069 0.328
MOD_NEK2_1 69 74 PF00069 0.428
MOD_NEK2_1 7 12 PF00069 0.413
MOD_NEK2_2 71 76 PF00069 0.454
MOD_PK_1 329 335 PF00069 0.359
MOD_PK_1 51 57 PF00069 0.399
MOD_PKA_1 76 82 PF00069 0.427
MOD_PKA_2 19 25 PF00069 0.406
MOD_PKA_2 219 225 PF00069 0.485
MOD_PKA_2 76 82 PF00069 0.434
MOD_PKA_2 83 89 PF00069 0.476
MOD_Plk_1 230 236 PF00069 0.423
MOD_Plk_1 287 293 PF00069 0.446
MOD_Plk_1 433 439 PF00069 0.515
MOD_Plk_4 206 212 PF00069 0.443
MOD_Plk_4 255 261 PF00069 0.351
MOD_Plk_4 376 382 PF00069 0.400
MOD_Plk_4 51 57 PF00069 0.399
MOD_Plk_4 526 532 PF00069 0.390
MOD_Plk_4 557 563 PF00069 0.528
MOD_Plk_4 99 105 PF00069 0.410
MOD_ProDKin_1 14 20 PF00069 0.423
MOD_ProDKin_1 200 206 PF00069 0.285
MOD_ProDKin_1 21 27 PF00069 0.384
MOD_ProDKin_1 374 380 PF00069 0.481
MOD_ProDKin_1 511 517 PF00069 0.496
MOD_ProDKin_1 532 538 PF00069 0.443
MOD_SUMO_for_1 124 127 PF00179 0.407
TRG_DiLeu_BaEn_1 483 488 PF01217 0.405
TRG_DiLeu_BaEn_2 439 445 PF01217 0.466
TRG_DiLeu_BaLyEn_6 54 59 PF01217 0.397
TRG_DiLeu_BaLyEn_6 61 66 PF01217 0.401
TRG_ENDOCYTIC_2 3 6 PF00928 0.427
TRG_ENDOCYTIC_2 34 37 PF00928 0.382
TRG_ENDOCYTIC_2 505 508 PF00928 0.471
TRG_ER_diArg_1 309 311 PF00400 0.476
TRG_ER_diArg_1 75 77 PF00400 0.517
TRG_Pf-PMV_PEXEL_1 465 469 PF00026 0.559

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKK8 Leptomonas seymouri 52% 100%
A0A1X0NM47 Trypanosomatidae 28% 100%
A0A3S5IQL9 Trypanosoma rangeli 31% 100%
A0A3S7WRW4 Leishmania donovani 93% 100%
A4H6S5 Leishmania braziliensis 80% 100%
A4HV53 Leishmania infantum 92% 100%
C9ZQD2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9ANT6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5BDA8 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS